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Original Research

Effectiveness of Netarsudil as an Additional Therapy for Glaucoma in Patients Already on Maximally Tolerated Medical Therapy

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Pages 4367-4372 | Published online: 02 Nov 2021

References

  • Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121(11):2081–2090. doi:10.1016/j.ophtha.2014.05.013
  • Leske MC, Heijl A, Hyman L, Bengtsson B. Early manifest glaucoma trial: design and baseline data. Ophthalmology. 1999;106(11):2144–2153. doi:10.1016/S0161-6420(99)90497-9
  • Mehran NA, Sinha S, Razeghinejad R. New glaucoma medications: latanoprostene bunod, netarsudil, and fixed combination netarsudil-latanoprost. Eye. 2020;34(1):72–88. PMID: 31695162; PMCID: PMC7002400. doi:10.1038/s41433-019-0671-0
  • Ren R, Li G, Le TD, Kopczynski C, Stamer WD, Gong H. Netarsudil increases outflow facility in human eyes through multiple mechanisms. Invest Ophthalmol Vis Sci. 2016;57(14):6197–6209. PMID: 27842161; PMCID: PMC5114035. doi:10.1167/iovs.16-20189
  • Serle JB, Katz LJ, McLaurin E, et al; ROCKET-1 and ROCKET-2 Study Groups. Two Phase 3 clinical trials comparing the safety and efficacy of netarsudil to timolol in patients with elevated intraocular pressure: rho kinase elevated iop treatment trial 1 and 2 (ROCKET-1 and ROCKET-2). Am J Ophthalmol. 2018;186:116–127. Epub 2017 Dec 1. PMID: 29199013. doi:10.1016/j.ajo.2017.11.019
  • Khouri AS, Serle JB, Bacharach J, et al; Rocket-4 Study Group. Once-daily netarsudil versus twice-daily timolol in patients with elevated intraocular pressure: the randomized phase 3 ROCKET-4 Study. Am J Ophthalmol. 2019;204:97–104. PMID: 30862500. doi:10.1016/j.ajo.2019.03.002
  • Bacharach J, Dubiner HB, Levy B, Kopczynski CC, Novack GD; AR-13324-CS202 Study Group. Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure. Ophthalmology. 2015;122(2):302–307. doi:10.1016/j.ophtha.2014.08.022
  • Prager AJ, Tang M, Pleet AL, Petito LC, Tanna AP. Effectiveness and tolerability of netarsudil in combination with other ocular hypotensive agents. Ophthalmol Glaucoma. 2021. doi:10.1016/j.ogla.2021.03.014
  • Mehta AA, Kanu LN, Sood-Mendiratta S, et al. Experience with netarsudil 0.02% and latanoprostene bunod 0.024% as adjunctive therapy for glaucoma. Eur J Ophthalmol. 2021;1120672121998913. doi:10.1177/1120672121998913
  • Ustaoglu M, Shiuey E, Sanvicente C, et al. The efficacy and safety profile of netarsudil 0.02% in glaucoma treatment: real-world outcomes. Invest Ophthalmol Vis Sci. 2019;60:2393.
  • Tang M, Prager A, Pleet A, et al. Retrospective analysis of the efficacy and safety of netarsudil in clinical practice. Invest Ophthalmol Vis Sci. 2020;61:1241.
  • Woolf S, Bahr T, Waldman C. The addition of latanoprostene bunod or netarsudil to glaucoma patients on standard maximum medical therapy. Invest Ophthalmol Vis Sci. 2020;61:1224.
  • Mehta P, Kaplowitz K, Lenoci J, et al. IOP lowering efficacy of adjunctive netarsudil (Rhopressa): a retrospective chart review. Invest Ophthalmol Vis Sci. 2020;61:1237.
  • Lin MM, Moster SJ, Zheng CX, et al. Netarsudil’s effect in eyes with a history of selective laser trabeculoplasty. Ophthalmol Glaucoma. 2020;3(4):306–308. doi:10.1016/j.ogla.2020.01.005
  • Ming X-F, Viswambharan H, Barandier C, et al. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol. 2002;22:8467–8477. doi:10.1128/MCB.22.24.8467-8477.2002
  • Weiss M, Levy B, Kopczynski C, et al. Evaluation of AR-13324, a novel dual mechanism agent, in lowering of IOP in glaucoma and ocular hypertension. Investig Ophthalmol Vis Sci. 2013;54(15):754.