Analysis of Glaucoma Associated Genes in Response to Inflammation, an Examination of a Public Data Set Derived from Peripheral Blood from Patients with Hepatitis C

References

• Levy JH. The human inflammatory response. J Cardiovasc Pharmacol. 1996;27(Suppl 1):S31–7. doi:10.1097/00005344-199600001-00008
   PubMedGoogle Scholar
• Conti P, Caraffa A, Tetè G, et al. Mast cells activated by SARS-CoV-2 release histamine which increases IL-1 levels causing cytokine storm and inflammatory reaction in COVID-19. J Biol Regul Homeost Agents. 2020;34(5):1629–1632. doi:10.23812/20-2edit
   PubMed Web of Science ®Google Scholar
• Allison K, Patel D, Alabi O. Epidemiology of glaucoma: the past, present, and predictions for the future. Cureus. 2020;12(11):e11686. doi:10.7759/cureus.11686
   PubMed Web of Science ®Google Scholar
• Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901–1911. doi:10.1001/jama.2014.3192
   PubMed Web of Science ®Google Scholar
• Cohen LP, Pasquale LR. Clinical characteristics and current treatment of glaucoma. Cold Spring Harb Perspect Med. 2014;4(6):a017236–a017236. doi:10.1101/cshperspect.a017236
   PubMed Web of Science ®Google Scholar
• Sng CC, Ang M, Barton K. Uveitis and glaucoma: new insights in the pathogenesis and treatment. Prog Brain Res. 2015;221:243–269. doi:10.1016/bs.pbr.2015.06.008
   PubMed Web of Science ®Google Scholar
• Harun-Or-Rashid M, Inman DM. Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma. J Neuroinflammation. 2018;15(1):313. doi:10.1186/s12974-018-1346-7
   PubMed Web of Science ®Google Scholar
• Shestopalov VI, Spurlock M, Gramlich OW, Kuehn MH. Immune responses in the glaucomatous retina: regulation and dynamics. Cells. 2021;10(8):Aug. doi:10.3390/cells10081973
   Web of Science ®Google Scholar
• Williams PA, Marsh-Armstrong N, Howell GR, Lasker II. Neuroinflammation in glaucoma: a new opportunity. Exp Eye Res. 2017;157:20–27. doi:10.1016/j.exer.2017.02.014
   PubMed Web of Science ®Google Scholar
• Doucette LP, Walter MA. Prostaglandins in the eye: function, expression, and roles in glaucoma. Ophthalmic Genet. 2017;38(2):108–116. doi:10.3109/13816810.2016.1164193
   PubMed Web of Science ®Google Scholar
• Lorenzo MM, Devlin J, Saini C, et al. The prevalence of autoimmune diseases in patients with primary open-angle glaucoma undergoing ophthalmic surgeries. Ophthalmol Glaucoma. 2022;5(2):128–136. doi:10.1016/j.ogla.2021.08.003
   PubMedGoogle Scholar
• Gramlich OW, Godwin CR, Wadkins D, Elwood BW, Kuehn MH. Early functional impairment in experimental glaucoma is accompanied by disruption of the GABAergic system and inceptive neuroinflammation. Int J Mol Sci. 2021;22(14):7581. doi:10.3390/ijms22147581
   PubMed Web of Science ®Google Scholar
• Miserocchi E, Waheed NK, Dios E, et al. Visual outcome in herpes simplex virus and varicella zoster virus uveitis: a clinical evaluation and comparison. Ophthalmology. 2002;109(8):1532–1537. doi:10.1016/s0161-6420(02)01113-2
   PubMed Web of Science ®Google Scholar
• Thean JH, Hall AJ, Stawell RJ. Uveitis in Herpes zoster ophthalmicus. Clin Exp Ophthalmol. 2001;29(6):406–410. doi:10.1046/j.1442-9071.2001.d01-29.x
   PubMed Web of Science ®Google Scholar
• Morris RW, Dunbar MT. Atypical presentation and review of the ICE syndrome. Optometry. 2004;75(1):13–25. doi:10.1016/s1529-1839(04)70007-x
   PubMedGoogle Scholar
• Keorochana N, Treesit I, Funarunart P. Characteristics and clinical outcomes of hypertensive anterior uveitis. Ocul Immunol Inflamm. 2020;28(4):538–548. doi:10.1080/09273948.2019.1587471
   PubMed Web of Science ®Google Scholar
• Singh PK, Kasetti RB, Zode GS, Goyal A, Juzych MS, Kumar A. Zika virus infects trabecular meshwork and causes trabeculitis and glaucomatous pathology in mouse eyes. mSphere. 2019;4(3). doi:10.1128/mSphere.00173-19
   Web of Science ®Google Scholar
• Lim LL, Scarborough JD, Thorne JE, et al. Uveitis in patients with autoimmune hepatitis. Am J Ophthalmol. 2009;147(2):332–338 e1. doi:10.1016/j.ajo.2008.08.019
   PubMed Web of Science ®Google Scholar
• Thrift AP, El-Serag HB, Kanwal F. Global epidemiology and burden of HCV infection and HCV-related disease. Nat Rev Gastroenterol Hepatol. 2017;14(2):122–132. doi:10.1038/nrgastro.2016.176
   PubMed Web of Science ®Google Scholar
• Grebely J, Prins M, Hellard M, et al. Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine. Lancet Infect Dis. 2012;12(5):408–414. doi:10.1016/S1473-3099(12)70010-5
   PubMed Web of Science ®Google Scholar
• Qian F, Bolen CR, Jing C, et al. Impaired toll-like receptor 3-mediated immune responses from macrophages of patients chronically infected with hepatitis C virus. Clin Vaccine Immunol. 2013;20(2):146–155. doi:10.1128/CVI.00530-12
   PubMedGoogle Scholar
• Fortier ME, Kent S, Ashdown H, Poole S, Boksa P, Luheshi GN. The viral mimic, polyinosinic: polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2004;287(4):R759–66. doi:10.1152/ajpregu.00293.2004
   PubMed Web of Science ®Google Scholar
• Tang B, Li S, Cao W, Sun X. The association of oxidative stress status with open-angle glaucoma and exfoliation glaucoma: a systematic review and meta-analysis. J Ophthalmol. 2019;2019:1803619. doi:10.1155/2019/1803619
   PubMed Web of Science ®Google Scholar
• Sobot V, Stamenkovic M, Simic T, et al. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. Exp Eye Res. 2022;214:108863. doi:10.1016/j.exer.2021.108863
   PubMed Web of Science ®Google Scholar
• Santana-Garrido A, Reyes-Goya C, Fernandez-Bobadilla C, et al. NADPH oxidase-induced oxidative stress in the eyes of hypertensive rats. Mol Vis. 2021;27:161–178.
   PubMed Web of Science ®Google Scholar
• Kim CD, Gudiseva HV, McGeehan B, et al. Association of the SNP rs112369934 near TRIM66 gene with POAG endophenotypes in African Americans. Genes. 2021;12(9):1420. doi:10.3390/genes12091420
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yang A, Huang J. Identification of gene changes induced by dexamethasone in the anterior segment of the human eye using bioinformatics analysis. Med Sci Monit. 2019;25:5501–5509. doi:10.12659/MSM.915591
   PubMed Web of Science ®Google Scholar
• Liu H, Qi S, He W, Chang C, Chen Y, Yu J. Association of single-nucleotide polymorphisms in TLR4 gene and gene-environment interaction with primary open angle glaucoma in a Chinese northern population. J Gene Med. 2020;22(1):e3139. doi:10.1002/jgm.3139
   PubMed Web of Science ®Google Scholar
• Huang P, Qi Y, Xu YS, et al. Serum cytokine alteration is associated with optic neuropathy in human primary open angle glaucoma. J Glaucoma. 2010;19(5):324–330. doi:10.1097/IJG.0b013e3181b4cac7
   PubMed Web of Science ®Google Scholar
• Wong M, Huang P, Li W, Li Y, Zhang SS, Zhang C. T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. PLoS One. 2015;10(3):e0122184. doi:10.1371/journal.pone.0122184
   PubMed Web of Science ®Google Scholar
• Jiang B, Harper MM, Kecova H, et al. Neuroinflammation in advanced canine glaucoma. Mol Vis. 2010;16:2092–2108.
   PubMed Web of Science ®Google Scholar
• Barbosa-Breda J, Himmelreich U, Ghesquiere B, Rocha-Sousa A, Stalmans I. Clinical metabolomics and glaucoma. Ophthalmic Res. 2018;59(1):1–6. doi:10.1159/000479158
   PubMed Web of Science ®Google Scholar
• Beutgen VM, Perumal N, Pfeiffer N, Grus FH. Autoantibody biomarker discovery in primary open angle glaucoma using Serological Proteome Analysis (SERPA). Front Immunol. 2019;10:381. doi:10.3389/fimmu.2019.00381
   PubMed Web of Science ®Google Scholar
• Chang D, Sha Q, Zhang X, et al. The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma. PLoS One. 2011;6(11):e27218. doi:10.1371/journal.pone.0027218
   PubMed Web of Science ®Google Scholar
• Duncan RS, Rohowetz L, Vogt A, Koulen P. Repeat exposure to polyinosinic: polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFkappaB-RelA signaling in ARPE-19 cells. Cell Signal. 2020;66:109494. doi:10.1016/j.cellsig.2019.109494
   PubMed Web of Science ®Google Scholar
• Engin KN, Yemisci B, Yigit U, Agachan A, Coskun C. Variability of serum oxidative stress biomarkers relative to biochemical data and clinical parameters of glaucoma patients. Mol Vis. 2010;16:1260–1271.
   PubMed Web of Science ®Google Scholar
• Fraenkl SA, Muser J, Groell R, et al. Plasma citrate levels as a potential biomarker for glaucoma. J Ocul Pharmacol Ther. 2011;27(6):577–580. doi:10.1089/jop.2011.0062
   PubMed Web of Science ®Google Scholar
• Hindle AG, Thoonen R, Jasien JV, et al. Identification of candidate miRNA biomarkers for glaucoma. Invest Ophthalmol Vis Sci. 2019;60(1):134–146. doi:10.1167/iovs.18-24878
   PubMed Web of Science ®Google Scholar
• Romano GL, Platania CB, Forte S, Salomone S, Drago F, Bucolo C. MicroRNA target prediction in glaucoma. Prog Brain Res. 2015;220:217–240. doi:10.1016/bs.pbr.2015.04.013
   PubMed Web of Science ®Google Scholar
• Tezel G, Thornton IL, Tong MG, et al. Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma. Invest Ophthalmol Vis Sci. 2012;53(13):8222–8231. doi:10.1167/iovs.12-10076
   PubMed Web of Science ®Google Scholar
• Bodh SA, Kumar V, Raina UK, Ghosh B, Thakar M. Inflammatory glaucoma. Oman J Ophthalmol. 2011;4(1):3–9. doi:10.4103/0974-620X.77655
   PubMedGoogle Scholar
• Vohra R, Tsai JC, Kolko M. The role of inflammation in the pathogenesis of glaucoma. Surv Ophthalmol. 2013;58(4):311–320. doi:10.1016/j.survophthal.2012.08.010
   PubMed Web of Science ®Google Scholar
• Tezel G, Wax MB. Glaucoma. Chem Immunol Allergy. 2007;92:221–227. doi:10.1159/000099273
   PubMedGoogle Scholar
• Tezel G. The immune response in glaucoma: a perspective on the roles of oxidative stress. Exp Eye Res. 2011;93(2):178–186. doi:10.1016/j.exer.2010.07.009
   PubMed Web of Science ®Google Scholar
• Lorenzini T, Fliegauf M, Klammer N, et al. Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations. J Allergy Clin Immunol. 2020;146(4):901–911. doi:10.1016/j.jaci.2019.11.051
   PubMed Web of Science ®Google Scholar
• Wah LP, Singh D, Abdul Ghani S, Shoeb Ahmad S. The dynamics of aqueous humor outflow—A major review. US Ophthalmic Review. 2014;07(02). doi:10.17925/usor.2014.07.02.137
   Google Scholar
• Goel M, Picciani RG, Lee RK, Bhattacharya SK. Aqueous humor dynamics: a review. Open Ophthalmol J. 2010;4:52–59. doi:10.2174/1874364101004010052
   PubMedGoogle Scholar
• Luo J, Wang S, Zhou Z, Zhao ZY. Ad- and AAV8-mediated ABCA1 gene therapy in a murine model with retinal ischemia/reperfusion injuries. Mol Ther Methods Clin Dev. 2021;20:551–558. doi:10.1016/j.omtm.2021.01.012
   PubMed Web of Science ®Google Scholar
• Li L, Xu L, Chen W, et al. Reduced Annexin A1 secretion by ABCA1 causes retinal inflammation and ganglion cell apoptosis in a murine glaucoma model. Front Cell Neurosci. 2018;12:347. doi:10.3389/fncel.2018.00347
   PubMed Web of Science ®Google Scholar
• Mohd Nasir NA, Agarwal R, Krasilnikova A, Sheikh Abdul Kadir SH, Iezhitsa I. Effect of dexamethasone on the expression of MMPs, adenosine A1 receptors and NFKB by human trabecular meshwork cells. J Basic Clin Physiol Pharmacol. 2020;31(6). doi:10.1515/jbcpp-2019-0373
   PubMedGoogle Scholar
• Howell GR, Macalinao DG, Sousa GL, et al. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest. 2011;121(4):1429–1444. doi:10.1172/JCI44646
   PubMed Web of Science ®Google Scholar
• Marola OJ, Syc-Mazurek SB, Howell GR, Libby RT. Endothelin signaling in glaucomatous neurodegeneration. Invest Ophthalmol Vis Sci. 2019;60(9):661.
   PubMed Web of Science ®Google Scholar
• van Koolwijk LM, Ramdas WD, Ikram MK, et al. Common genetic determinants of intraocular pressure and primary open-angle glaucoma. PLoS Genet. 2012;8(5):e1002611. doi:10.1371/journal.pgen.1002611
   PubMed Web of Science ®Google Scholar
• Coca-Prados M, Escribano J, Ortego J. Differential gene expression in the human ciliary epithelium. Prog Retin Eye Res. 1999;18(3):403–429. doi:10.1016/S1350-9462(98)00026-3
   PubMed Web of Science ®Google Scholar
• Prasanna G, Dibas A, Hulet C, Yorio T. Inhibition of Na(+)/K(+)-ATPase by endothelin-1 in human nonpigmented ciliary epithelial cells. J Pharmacol Exp Ther. 2001;296(3):966–971.
   PubMed Web of Science ®Google Scholar
• Golubnitschaja O, Wunderlich K, Decker C, Monkemann H, Schild HH, Flammer J. Molecular imaging of perfusion disturbances in glaucoma. Amino Acids. 2002;23(1–3):293–299. doi:10.1007/s00726-001-0141-3
   PubMed Web of Science ®Google Scholar
• Agapova OA, Ricard CS, Salvador-Silva M, Hernandez MR. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia. 2001;33(3):205–216. doi:10.1002/1098-1136(200103)33:3<205::aid-glia1019>3.0.co;2-d
   PubMed Web of Science ®Google Scholar
• Hu C, Niu L, Li L, et al. ABCA1 regulates IOP by modulating Cav1/eNOS/NO signaling pathway. Invest Ophthalmol Vis Sci. 2020;61(5):33. doi:10.1167/iovs.61.5.33
   PubMed Web of Science ®Google Scholar
• Chen Y, Lin Y, Vithana EN, et al. Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. Nat Genet. 2014;46(10):1115–1119. doi:10.1038/ng.3078
   PubMed Web of Science ®Google Scholar
• van Oterendorp C. Endocrine dysfunction in open angle glaucoma. [Endokrine Auffalligkeiten beim Offenwinkelglaukom]. Klin Monbl Augenheilkd. 2021;238(2):128–131. doi:10.1055/a-1306-1033
   PubMed Web of Science ®Google Scholar
• Janssen SF, Gorgels TG, Ramdas WD, et al. The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology. Prog Retin Eye Res. 2013;37:31–67. doi:10.1016/j.preteyeres.2013.09.001
   PubMed Web of Science ®Google Scholar
• Joe MK, Tomarev SI. Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis. Am J Pathol. 2010;176(6):2880–2890. doi:10.2353/ajpath.2010.090853
   PubMed Web of Science ®Google Scholar
• Mayer U. Comparative investigations of catalase activity in different ocular tissues of cattle and man. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1980;213(4):261–265. doi:10.1007/BF00417548
   PubMedGoogle Scholar
• Micera A, Quaranta L, Esposito G, et al. Differential protein expression profiles in glaucomatous trabecular meshwork: an evaluation study on a small primary open angle glaucoma population. Adv Ther. 2016;33(2):252–267. doi:10.1007/s12325-016-0285-x
   PubMed Web of Science ®Google Scholar
• Moazzeni H, Mirrahimi M, Moghadam A, Banaei-Esfahani A, Yazdani S, Elahi E. Identification of genes involved in glaucoma pathogenesis using combined network analysis and empirical studies. Hum Mol Genet. 2019;28(21):3637–3663. doi:10.1093/hmg/ddz222
   PubMed Web of Science ®Google Scholar
• Beutgen VM, Schmelter C, Pfeiffer N, Grus FH. Autoantigens in the trabecular meshwork and glaucoma-specific alterations in the natural autoantibody repertoire. Clin Transl Immunol. 2020;9(3):e01101. doi:10.1002/cti2.1101
   PubMed Web of Science ®Google Scholar
• Wang DY, Ray A, Rodgers K, et al. Global gene expression changes in rat retinal ganglion cells in experimental glaucoma. Invest Ophthalmol Vis Sci. 2010;51(8):4084–4095. doi:10.1167/iovs.09-4864
   PubMed Web of Science ®Google Scholar
• Zanon-Moreno V, Asensio-Marquez EM, Ciancotti-Oliver L, et al. Effects of polymorphisms in vitamin E-, vitamin C-, and glutathione peroxidase-related genes on serum biomarkers and associations with glaucoma. Mol Vis. 2013;19:231–242.
   PubMed Web of Science ®Google Scholar
• Fairless E, Kooragayala K, Karakulah G, et al. Distinct expression of heat shock proteins in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci. 2016;57(12):2258.
   Web of Science ®Google Scholar
• Golubnitschaja O, Flammer J. What are the biomarkers for glaucoma? Surv Ophthalmol. 2007;52 Suppl 2(6):S155–61. doi:10.1016/j.survophthal.2007.08.011
   PubMed Web of Science ®Google Scholar
• Nath AP, Ritchie SC, Byars SG, et al. An interaction map of circulating metabolites, immune gene networks, and their genetic regulation. Genome Biol. 2017;18(1):146. doi:10.1186/s13059-017-1279-y
   PubMed Web of Science ®Google Scholar
• Bhattacharya SK, Lee RK, Grus FH. Molecular biomarkers in glaucoma. Invest Ophthalmol Vis Sci. 2013;54(1):121–131. doi:10.1167/iovs.12-11067
   PubMed Web of Science ®Google Scholar
• Ghaffariyeh A, Honarpisheh N, Heidari MH, Puyan S, Abasov F. Brain-derived neurotrophic factor as a biomarker in primary open-angle glaucoma. Optom Vis Sci. 2011;88(1):80–85. doi:10.1097/OPX.0b013e3181fc329f
   PubMed Web of Science ®Google Scholar
• Schmelter C, Perumal N, Funke S, Bell K, Pfeiffer N, Grus FH. Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG). Hum Mol Genet. 2017;26(22):4451–4464. doi:10.1093/hmg/ddx332
   PubMed Web of Science ®Google Scholar
• Fourgeux C, Martine L, Bjorkhem I, et al. Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. Invest Ophthalmol Vis Sci. 2009;50(12):5712–5717. doi:10.1167/iovs.09-3655
   PubMed Web of Science ®Google Scholar
• Sun C, Zhang H, Jiang J, et al. Angiogenic and inflammatory biomarker levels in aqueous humor and vitreous of neovascular glaucoma and proliferative diabetic retinopathy. Int Ophthalmol. 2020;40(2):467–475. doi:10.1007/s10792-019-01207-4
   PubMed Web of Science ®Google Scholar