Autologous Platelet‐Rich Plasma Drops for Evaporative Dry Eye Disease from Meibomian Gland Dysfunction: A Pilot Study

References

• Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017;15(3):276–283. doi:10.1016/j.jtos.2017.05.008
   PubMed Web of Science ®Google Scholar
• Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II epidemiology report. Ocul Surf. 2017;15(3):334–365. doi:10.1016/j.jtos.2017.05.003
   PubMed Web of Science ®Google Scholar
• Geerling G, Tauber J, Baudouin C, et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2011;52(4):2050–2064. doi:10.1167/iovs.10-6997g
   PubMed Web of Science ®Google Scholar
• Qiao J, Yan X. Emerging treatment options for meibomian gland dysfunction. Clin Ophthalmol. 2013;7:1797–1803. doi:10.2147/OPTH.S33182
   PubMedGoogle Scholar
• Kojima T, Dogru M, Kawashima M, Nakamura S, Tsubota K. Advances in the diagnosis and treatment of dry eye. Prog Retin Eye Res. 2020;78:100842. doi:10.1016/j.preteyeres.2020.100842
   Web of Science ®Google Scholar
• Murtaza F, Toameh D, Al-Habib S, et al. Safety and efficacy of broadband intense pulsed light therapy for dry eye disease with meibomian gland dysfunction. Clin Ophthalmol. 2021;15:3983–3991. doi:10.2147/OPTH.S331289
   PubMed Web of Science ®Google Scholar
• Pan Q, Angelina A, Marrone M, Stark WJ, Akpek EK. Autologous serum eye drops for dry eye. Cochrane Database Syst Rev. 2017;2(2):CD009327. doi:10.1002/14651858.CD009327.pub3
   PubMed Web of Science ®Google Scholar
• Alio JL, Rodriguez AE, Ferreira-Oliveira R, Wróbel-Dudzińska D, Abdelghany AA. Treatment of dry eye disease with autologous platelet-rich plasma: a prospective, interventional, non-randomized study. Ophthalmol Ther. 2017;6(2):285–293. doi:10.1007/s40123-017-0100-z
   PubMed Web of Science ®Google Scholar
• Cole BJ, Seroyer ST, Filardo G, Bajaj S, Fortier LA. Platelet-rich plasma: where are we now and where are we going? Sports Health. 2010;2(3):203–210. doi:10.1177/1941738110366385
   PubMedGoogle Scholar
• Wroblewski AP, Mejia HA, Wright VJ. Application of platelet-rich plasma to enhance tissue repair. Oper Tech Orthop. 2010;20(2):98–105. doi:10.1053/j.oto.2009.10.006
   Google Scholar
• Brass L. Understanding and evaluating platelet function. Hematology Am Soc Hematol Educ Program. 2010;2010:387–396. doi:10.1182/asheducation-2010.1.387
   PubMed Web of Science ®Google Scholar
• Alio JL, Abad M, Artola A, Rodriguez-Prats JL, Pastor S, Ruiz-Colecha J. Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers. Ophthalmology. 2007;114(7):1286–1293.e1. doi:10.1016/j.ophtha.2006.10.044
   PubMed Web of Science ®Google Scholar
• Alio JL, Rodriguez AE, Martinez LM. Bovine pericardium membrane (tutopatch) combined with solid platelet-rich plasma for the management of perforated corneal ulcers. Cornea. 2013;32(5):619–624. doi:10.1097/ICO.0b013e31825a6d9a
   PubMed Web of Science ®Google Scholar
• Ronci C, Ferraro AS, Lanti A, et al. Platelet-rich plasma as treatment for persistent ocular epithelial defects. Transfus Apher Sci. 2015;52(3):300–304. doi:10.1016/j.transci.2014.12.027
   PubMed Web of Science ®Google Scholar
• Marquez De Aracena Del Cid R, Montero De Espinosa Escoriaza I. Subconjunctival application of regenerative factor-rich plasma for the treatment of ocular alkali burns. Eur J Ophthalmol. 2009;19(6):909–915. doi:10.1177/112067210901900603
   PubMed Web of Science ®Google Scholar
• Panda A, Jain M, Vanathi M, Velpandian T, Khokhar S, Dada T. Topical autologous platelet-rich plasma eyedrops for acute corneal chemical injury. Cornea. 2012;31(9):989–993. doi:10.1097/ICO.0b013e3182114661
   PubMed Web of Science ®Google Scholar
• Avila MY. Restoration of human lacrimal function following platelet-rich plasma injection. Cornea. 2014;33(1):18–21. doi:10.1097/ICO.0000000000000016
   PubMed Web of Science ®Google Scholar
• Alio JL, Pastor S, Ruiz-Colecha J, Rodriguez A, Artola A. Treatment of ocular surface syndrome after LASIK with autologous platelet-rich plasma. J Refract Surg. 2007;23(6):617–619. doi:10.3928/1081-597X-20070601-13
   PubMed Web of Science ®Google Scholar
• Vick VL, Holds JB, Hartstein ME, Rich RM, Davidson BR. Use of autologous platelet concentrate in blepharoplasty surgery. Ophthalmic Plast Reconstr Surg. 2006;22(2):102–104. doi:10.1097/01.iop.0000202092.73888.4c
   PubMed Web of Science ®Google Scholar
• Pezzotta S, Del Fante C, Scudeller L, Cervio M, Antoniazzi ER, Perotti C. Autologous platelet lysate for treatment of refractory ocular GVHD. Bone Marrow Transplant. 2012;47(12):1558–1563. doi:10.1038/bmt.2012.64
   PubMed Web of Science ®Google Scholar
• Alio JL, Colecha JR, Pastor S, Rodriguez A, Artola A. Symptomatic dry eye treatment with autologous platelet-rich plasma. Ophthalmic Res. 2007;39(3):124–129. doi:10.1159/000100933
   PubMed Web of Science ®Google Scholar
• Bernabei F, Roda M, Buzzi M, Pellegrini M, Giannaccare G, Versura P. Blood-based treatments for severe dry eye disease: the need of a consensus. J Clin Med. 2019;8(9):1478. doi:10.3390/jcm8091478
   PubMed Web of Science ®Google Scholar
• Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the ocular surface disease index. Arch Ophthalmol. 2000;118(5):615–621. doi:10.1001/archopht.118.5.615
   PubMedGoogle Scholar
• Jackson WB. Management of dysfunctional tear syndrome: a Canadian consensus. Can J Ophthalmol. 2009;44(4):385–394. doi:10.3129/i09-015
   PubMed Web of Science ®Google Scholar
• Hong J, Sun X, Wei A, et al. Assessment of tear film stability in dry eye with a newly developed keratograph. Cornea. 2013;32(5):716–721. doi:10.1097/ICO.0b013e3182714425
   PubMed Web of Science ®Google Scholar
• Alfaro-Juárez A, Caro-Magdaleno M, Montero-Iruzubieta J, et al. Keratograph 5M as a useful and objective tool for evaluating the ocular surface in limbal stem cell deficiency. Clin Ophthalmol. 2019;13:2025–2033. doi:10.2147/OPTH.S218313
   PubMed Web of Science ®Google Scholar
• Yokoi N, Komuro A. Non-invasive methods of assessing the tear film. Exp Eye Res. 2004;78(3):399–407. doi:10.1016/j.exer.2003.09.020
   PubMed Web of Science ®Google Scholar
• Wu S, Hong J, Tian L, Cui X, Sun X, Xu J. Assessment of Bulbar redness with a newly developed keratograph. Optom Vis Sci. 2015;92(8):892–899. doi:10.1097/OPX.0000000000000643
   PubMed Web of Science ®Google Scholar
• Nichols JJ, Berntsen DA, Mitchell GL, Nichols KK. An assessment of grading scales for meibography images. Cornea. 2005;24(4):382–388. doi:10.1097/01.ico.0000148291.38076.59
   PubMed Web of Science ®Google Scholar
• García-Conca V, Abad-Collado M, Hueso-Abancens JR, et al. Efficacy and safety of treatment of hyposecretory dry eye with platelet-rich plasma. Acta Ophthalmol. 2019;97(2):e170–e178. doi:10.1111/aos.13907
   PubMed Web of Science ®Google Scholar
• Sanchez-Avila RM, Merayo-Lloves J, Riestra AC, et al. The effect of immunologically safe plasma rich in growth factor eye drops in patients with Sjögren syndrome. J Ocul Pharmacol Ther. 2017;33(5):391–399. doi:10.1089/jop.2016.0166
   PubMed Web of Science ®Google Scholar
• Fea AM, Aragno V, Testa V, et al. The effect of autologous platelet lysate eye drops: an in vivo confocal microscopy study. Biomed Res Int. 2016;2016:8406832. doi:10.1155/2016/8406832
   PubMed Web of Science ®Google Scholar
• Kyei S, Dzasimatu SK, Asiedu K, Ayerakwah PA. Association between dry eye symptoms and signs. J Curr Ophthalmol. 2018;30(4):321–325. doi:10.1016/j.joco.2018.05.002
   PubMed Web of Science ®Google Scholar
• Avila MY, Igua AM, Mora AM. Randomised, prospective clinical trial of platelet-rich plasma injection in the management of severe dry eye. Br J Ophthalmol. 2018;103(5). doi:10.1136/bjophthalmol-2018-312072
   Web of Science ®Google Scholar
• Ribeiro MVMR, Barbosa FT, Ribeiro LEF, et al. Platelet-rich plasma in diabetic dry eye disease. Rev Bras Oftalmol. 2016;75(4):308–313. doi:10.5935/0034-7280.20160061
   Google Scholar
• Watanabe K, Nakagawa S, Nishida T. Stimulatory effects of fibronectin and EGF on migration of corneal epithelial cells. Invest Ophthalmol Vis Sci. 1987;28(2):205–211.
   PubMed Web of Science ®Google Scholar
• Klenkler B, Sheardown H, Jones L. Growth factors in the tear film: role in tissue maintenance, wound healing, and ocular pathology. Ocul Surf. 2007;5(3):228–239.
   PubMed Web of Science ®Google Scholar
• Mandić JJ, Kozmar A, Kusačić-Kuna S, et al. The levels of 12 cytokines and growth factors in tears: hyperthyreosis vs euthyreosis. Graefes Arch Clin Exp Ophthalmol. 2018;256(4):845–852. doi:10.1007/s00417-017-3892-6
   PubMed Web of Science ®Google Scholar
• Lubkowska A, Dolegowska B, Banfi G. Growth factor content in PRP and their applicability in medicine. J Biol Regul Homeost Agents. 2012;26(2Suppl 1):3S–22S.
   PubMedGoogle Scholar
• Holland EJ, Mannis MJ, Lee WB. Ocular Surface Disease: Cornea, Conjunctiva and Tear Film: Expert Consult-Online and Print. Elsevier Health Sciences; 2013.
   Google Scholar
• Barbosa FL, Xiao Y, Bian F, et al. Goblet cells contribute to ocular surface immune tolerance-implications for dry eye disease. Int J Mol Sci. 2017;18(5):978. doi:10.3390/ijms18050978
   PubMed Web of Science ®Google Scholar
• Gipson IK. Goblet cells of the conjunctiva: a review of recent findings. Prog Retin Eye Res. 2016;54:49–63. doi:10.1016/j.preteyeres.2016.04.005
   PubMed Web of Science ®Google Scholar
• Roubelakis MG, Trohatou O, Roubelakis A, et al. Platelet-rich plasma (PRP) promotes fetal mesenchymal stem/stromal cell migration and wound healing process. Stem Cell Rev Rep. 2014;10(3):417–428. doi:10.1007/s12015-013-9494-8
   PubMed Web of Science ®Google Scholar
• Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004;45(12):4293–4301. doi:10.1167/iovs.03-1145
   PubMed Web of Science ®Google Scholar
• Tan X, Sun S, Liu Y, et al. Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome. Eye. 2014;28(5):608–613. doi:10.1038/eye.2014.38
   PubMed Web of Science ®Google Scholar