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Review

Recent developments in the management of dry age-related macular degeneration

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Pages 563-574 | Published online: 01 Apr 2015

References

  • AllikmetsRShroyerNFSinghNMutation of the stargardt disease gene (ABCR) in age-related macular degenerationScience19972775333180518079295268
  • KleinRKleinEKBJensenSCMeuerSMThe five-year incidence and progression of age-related maulopathy: the Beaver Dam Eye StudyOphthalmology199710417219022098
  • ZarbinMACurrent concepts in the pathogenesis of age-related macular degenerationArch Ophthalmol2004122459861415078679
  • DonosoLAKimDFrostACallahanAHagemanGThe role of inflammation in the pathogenesis of age-related macular degenerationSurv Ophthalmol200651213715216500214
  • PenfoldPLMadiganMCGilliesMCProvisJMImmunological and aetiological aspects of macular degenerationProgr Retin Eye Res2001203385414
  • ClemonsTEMiltonRCKleinRSeddonJMFerrisFL3rdAge-Related Eye Disease Study Research GroupRisk factors for the incidence of Advanced age-related macular degeneration in the age-related eye disease study (AREDS) AREDS report 19Ophthalmology2005112453353915808240
  • BlumenkranzMSRussellSRRobeyMGKott-BlumenkranzRPenneysNRisk factors in age-related maculopathy complicated by choroidal neovascularizationOphthalmology19869355525582425325
  • EvansJRRisk factors for age-related macular degenerationProg Retin Eye Res200120222725311173253
  • The Eye Disease Case-Control Study GroupRisk factors for neovascular age-related macular degenerationArch Ophthalmol199211012170117081281403
  • LofflerKULeeWRBasal linear deposit in the human maculaGraefes Arch Clin Exp Ophthalmol198622464935013792844
  • CurcioCAMillicanCLBasal linear deposit and large drusen are specific for early age-related maculopathyArch Ophthalmol1999117332933910088810
  • SarksSHCouncil LectureDrusen and their relationship to senile macular degenerationAust J Ophthalmol1980821171306160841
  • MunchICSanderBKesselLHeredity of small hard drusen in twins aged 20 – 46 yearsInvest Ophthalmol Vis Sci200748283383817251485
  • MullinsRFRussellSRAndersonDHHagemanGSDrusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit diseaseFASEB J200014783584610783137
  • NowakJZAge-related macular degeneration (AMD): pathogenesis and therapyPharmacol Rep200658335336316845209
  • KleinRKleinBETomanySCMeuerSMHuangGHTen-year incidence and progression of age-related maculopathy: the Beaver Dam eye studyOphthalmology2002109101767177912359593
  • MalekGLiCMGuidryCMedeirosNECurcioCAApolipoprotein B in cholesterol containing drusen and basal deposits of human eyes with age-related maculopathyAm J Pathol2003162241342512547700
  • HaimoviciRGantzDLRumeltSFreddoTFSmallDMThe lipid composition of drusen, Bruch’s membrane, and sclera by hot stage polarizing light microscopyInvest Ophthalmol Vis Sci20014271592159911381066
  • RussellSRMullinsRFSchneiderBLHagemanGSLocation, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degenerationAm J Ophthalmol2000129220521410682974
  • SivaprasadSChongNVThe complement system and age related macular degenerationEye (Lond)200620886787216410816
  • AndersonDHRadekeMJGalloNBThe pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visitedProg Retin Eye Res20102929511219961953
  • SarksSHAgeing and degeneration in the macular region: a clinico-pathological studyBr J Ophthalmol1976605324341952802
  • Schmitz-ValckenbergSBindewald-WittichADolar-SzczasnyJFundus Autofluorescence in Age-Related Macular Degeneration Study GroupCorrelation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMDInvest Ophthalmol Vis Sci20064762648265416723482
  • SunnessJSGonzalez-BaronJBresslerNMHawkinsBApplegateCAThe development of choroidal neovascularisation in eyes with the geographic atrophy form of age-related macular degenerationOphthalmology1999106591091910328389
  • SchatzHMcDonaldHRAtrophic macular degeneration. Rate of spread of geographic atrophy and visual lossOphthalmology19899610154115512587050
  • HolzFGBellmannCMargaritidisMSchüttFOttoTPVölckerHEPatterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degenerationGraefes Arch Clin Exp Ophthalmol199923721451529987631
  • VelillaSGarcía-MedinaJJGarcía-LayanaASmoking and age-related macular degeneration: review and updateJ Ophthalmol2013201389514724368940
  • ChongEWKreisAJWongTYSimpsonJAGuymerRHAlcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysisAm J Ophthalmol2008145470771518242575
  • PeetersAMaglianoDJStevensJDuncanBBKleinRWongTYChanges in abdominal obesity and age-related macular degeneration: the atherosclerosis risk in communities studyArch Ophthalmol2008126111554156019001224
  • MerleBDelyferMNKorobelnikJFDietary omega-3 fatty acids and the risk for age-related maculopathy: the Alienor StudyInvest Ophthalmol Vis Sci20115286004601121705687
  • CookHLPatelPJTufailAAge-related macular degeneration: diagnosis and managementBr Med Bull20088512714918334518
  • HooperPJutaiJWStrongGRussell-MindaEAge-related macular degeneration and low-vision rehabilitation: a systematic reviewCan J Ophthalmol200843218018718347620
  • Age-Related Eye Disease Study Research GroupA randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8Arch Ophthalmol20011191014171436 Erratum in Arch Ophthalmol. 2008 Sep;126(9):125111594942
  • Age-Related Eye Disease Study 2 Research GroupLutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the age-related eye disease study 2 (AREDS2) randomized clinical trialJAMA2013309192005201523644932
  • CanoMThimmalappulaRFujiharaMCigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and age-related macular degenerationVision Res201050765266419703486
  • KleveringBJZinc and the complement systemAntioxidants and AMD: into the mechanismsPaper presented at: The Annual Meeting of the Association for Research in Vision and OphthalmologyMay; 2013Seattle, Washington
  • VishwanathanRChungMJohnsonEJA systematic review on zinc for the prevention and treatment of age-related macular degenerationInvest Ophthalmol Vis Sci20135463985399823652490
  • SinHPLiuDTLamDSLifestyle modification, nutritional and vitamins supplements for age-related macular degenerationActa Ophthalmol201391161122268800
  • ChongEWTWongTYKreisAJSimpsonJAGuymerRHDietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysisBMJ2007335762375517923720
  • ChongEWKreisAJWongTYSimpsonJAGuymerRHDietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysisArch Ophthalmol2008126682683318541848
  • MaccaroneRDi MarcoSBistiSSaffron supplement maintains morphology and function after exposure to damaging light in mammalian retinaInvest Ophthalmol Vis Sci20084931254126118326756
  • FalsiniBPiccardiMMinnellaAInfluence of saffron supplementation on retinal flicker sensitivity in early age-related macular degenerationInvest Ophthalmol Vis Sci201051126118612420688744
  • MandalMNPatlollaJMZhengLCurcumin protects retinal cells from light-and oxidant stress-induced cell deathFree Radic Biol Med200946567267919121385
  • ChangYCChangWCHungKHThe generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stressFront Aging Neurosci2014619125136316
  • ChristenWGGlynnRJChewEYAlbertCMMansonJEFolic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the women’s antioxidant and folic acid cardiovascular studyArch Intern Med2009169433534119237716
  • KingREKentKDBomserJAResveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibitionChem Biol Interact2005151214314915698585
  • NagineniCNRajuRNagineniKKResveratrol suppresses expression of VEGF by human retinal pigment epithelial cells: potential nutraceutical for age-related macular degenerationAging Dis2014528810024729934
  • KleinMLFerrisFL3rdArmstrongJAREDS Research GroupRetinal precursors and the development of geographic atrophy in age-related macular degenerationOphthalmology200811561026103117981333
  • HolzFGStraussECSchmitz-ValckenbergSvan Lookeren CampagneMGeographic atrophy: clinical features and potential therapeutic approachesOphthalmology201412151079109124433969
  • AmbatiJAtkinsonJPGelfandBDImmunology of age-related macular degenerationNat Rev Immunol20131343845123702979
  • WangJOhno-MatsuiKYoshidaTAmyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: another mechanism of complement activation in age-related macular degenerationJ Cell Physiol2009220111912819277984
  • AndersonDHMullinsRFHagemanGSJohnsonLVA role for local inflammation in the formation of drusen in the aging eyeAm J Ophthalmol2002134341143112208254
  • LoefflerKEdwardDTsoMImmunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retinaInvest Oph-thalmol Vis Sci19953612431
  • JohnsonLVLeitnerWPRivestAJStaplesMKRadekeMJAndersonDHThe Alzheimer’s A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degenerationProc Natl Acad Sci U S A20029918118301183512189211
  • Ohno-MatsuiKParallel findings in age-related macular degeneration and Alzheimer’s diseaseProg Retin Eye Res201130421723821440663
  • DingJDLinJMaceBEHerrmannRSullivanPBowes RickmanCTargeting age-related macular degeneration with Alzheimer’s disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse modelVision Res200848333934517888483
  • DingJDJohnsonLVHerrmannRAnti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degenerationProc Natl Acad Sci U S A201110828E279E28721690377
  • CatchpoleIGermaschewskiVHoh KamJSystemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse modelPLoS One201386e6551823799019
  • ButovskyOKoronyo-HamaouiMKunisGGlatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1Proc Natl Acad Sci U S A200610331117841178916864778
  • LandaGButovskyOShoshaniJSchwartzMPollackAWeekly vaccination with Copaxone (glatiramer acetate) as a potential therapy for dry age-related macular degenerationCurr Eye Res200833111011101319085384
  • LandaGRosenRBPatelAQualitative spectral OCT/SLO analysis of drusen change in dry age-related macular degeneration patients treated with CopaxoneJ Ocul Pharmacol Ther2011271778221254921
  • RatnapriyaRChewEYAge-related macular degeneration-clinical review and genetics updateClin Genet201384216016623713713
  • TuoJGrobSZhangKChanCCGenetics of immunological and inflammatory components in age-related macular degenerationOcul Immunol Inflamm2012201273622324898
  • MonesJThe MAHALO Phase II Results. Lampalizumab (Anti-factor D) in Patients with Geographic AtrophySouth San Francisco, CAGenentech, Inc2014
  • WongWTDresnerSForooghianFTreatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trialInvest Ophthalmol Vis Sci20135442941295023548622
  • BowesRickman CFarsiuSTothCAKlingebornMDry age-related macular degeneration: mechanisms, therapeutic targets, and imagingInvest Ophthalmol Vis Sci20135414ORSF68ORSF8024335072
  • CombadièreCFeumiCRaoulWCX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degenerationJ Clin Invest20071172920292817909628
  • LuttyGABhuttoISeddonJMcLeodDMast cell degranulation in AMD choroidInvest Ophtalmol Vis Sci201354 ARVO E-Abstract 3051
  • EbrahimiKBHandaJTLipids, lipoproteins, and age-related macular degenerationJ Lipids2011201180205921822496
  • TabasIWilliamsKJBorénJSubendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implicationsCirculation2007116161832184417938300
  • CurcioCAJohnsonMHuangJDRudolfMApolipoprotein B-containing lipoproteins in retinal aging and age-related macular degenerationJ Lipid Res201051345146719797256
  • GehlbachPLiTHatefEStatins for age-related macular degenerationCochrane Database Syst Rev20123CD00692722419318
  • MataNLLichterJBVogelRHanYBuiTVSingermanLJInvestigation of oral fenretinide for treatment of geographic atrophy in age-related macular degenerationRetina201333349850723023528
  • ZhangKHopkinsJJHeierJSCiliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degenerationProc Natl Acad Sci U S A2011108156241624521444807
  • LaiRKChunTHassonDLeeSMehrbodFWheelerLAlpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the ratVis Neurosci200219217518512385629
  • CollierRJWangYSmithSSComplement deposition and microglial activation in the outer retina in light-induced retin-opathy: inhibition by a 5-HT1A agonistInvest Ophthalmol Vis Sci201152118108811621467172
  • CohenSYBourgeoisHCorbeCRandomized clinical trial France DMLA2: effect of trimetazidine on exudative and nonexudative age-related macular degenerationRetina201232483484321822162
  • PempBGarhoferGLastaMSchmidlDWolztMSchmettererLThe effects of moxaverine on ocular blood flow in patients with age-related macular degeneration or primary open angle glaucoma and in healthy control subjectsActa Ophthalmol201290213914520456253
  • HarrisAKagemannLEhrlichREhrlichYLópezCRPurvinVAThe effect of sildenafil on ocular blood flowBr J Opthalmol2008924469473
  • PanCKHeilweilGLanzaRSchwartzSDEmbryonic stem cells as a treatment for macular degenerationExpert Opin Biol Ther20131381125113323705996
  • CarrAJSmartMJRamsdenCMPownerMBDa CruzLCoffeyPJDevelopment of human embryonic stem cell therapies for age-related macular degenerationTrends Neurosci201336738539523601133
  • PearsonRABarberACRizziMRestoration of vision after transplantation of photoreceptorsNature20124859910322522934
  • SinghMSCharbel IssaPButlerRReversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantationProc Natl Acad Sci U S A201311031101110623288902
  • PriyaRRChewEYSwaroopAGenetic studies of age-related macular degeneration: lessons, challenges, and opportunities for disease managementOphthalmology2012119122526253623009893
  • GorinMBGenetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeuticsMol Aspects Med201233446748622561651
  • YehoshuaZde Amorim Garcia FilhoCANunesRPSystemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE studyOphthalmology2014121369370124289920