179
Views
14
CrossRef citations to date
0
Altmetric
Original Research

Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) model

&
Pages 877-884 | Published online: 20 May 2015

References

  • No authors listedReport of the International Dry Eye Workshop (DEWS)Ocul Surf2007565204
  • CrockfordDTurjmanNAllanCAngelJThymosin beta4: structure, function, and biological properties supporting current and future clinical applicationsAnn N Y Acad Sci2010119417918920536467
  • GoldsteinALHannappelESosneGKleinmanHKThymosin beta 4: a multifunctional regenerative peptide. Basic properties and clinical applicationsExpert Opin Biol Ther201212375122074294
  • HuffTMüllerCSOttoAMNetzkerRHannappelEBeta-thymosins, small acidic peptides with multiple functionsInt J Biochem Cell Biol20103320522011311852
  • LowTLGoldsteinALChemical characterization of thymosin beta 4J Biol Chem1982257100010067054160
  • Bock-MarquetteISaxenaAWhiteMDThymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repairNature200443246647215565145
  • MalindaKMSidhuGSManiHThymosin β4 accelerates wound healingJ Invest Dermatol199911336436810469335
  • SosneGSiddiqiAKurpakus-WheaterMThymosin-β4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitroInvest Ophthalmol Vis Sci2004451095110015037574
  • MorrisDChoppMZhangLTβ4 Improves functional neurological outcome in a rat model of embolic strokeNeuroscience201016967468220627173
  • SosneGHafeezSGreenberryA2ndKurpakus-WheaterMThymosin beta 4 promotes human conjunctival epithelial cell migrationCurr Eye Res20022426827312324865
  • SosneGSliterEABarrettRThymosin β4 promotes corneal wound healing and decreases inflammation in vivo following alkali injuryExp Eye Res20027429329911950239
  • SosneGXuLPrachLThymosin β4 stimulates laminin-5 production independent of TGF-betaExp Cell Res200429317518314729067
  • ZhangJZhangZGMorrisDNeurological function recovery after Tβ4 treatment in mice with experimental auto encephalomyelitisNeuroscience20091641887189319782721
  • PhilpDBadamchianMScheremetaBThymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged miceWound Repair Regen200311192412581423
  • SosneGQiuPChristophersonPLWheaterMKThymosin β4 suppression of corneal NFκB. A potential anti-inflammatory pathwayExp Eye Res20078466366917254567
  • HinkelREl-AouniCOlsonTThymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotectionCirculation20081172232224018427126
  • SmartNRisebroCAMelvilleAAThymosin β4 induces adult epicardial progenitor mobilization and neovascularizationNature200744517718217108969
  • SosneGChanCCThaiKThymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivoExp Eye Res20017260560811311052
  • SosneGChristophersonPLBarrettRPFriedmanRThymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injuryInvest Ophthalmol Vis Sci2005462388239515980226
  • AllanCBCockcroftDCrawfordKSBelenLJEffects of thymosin β4 in a murine CAE™ model of experimental dry eyeInvest Ophthalmol Vis Sci201152E3782
  • DunnSPHeidemannDGChowCYTreatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin β4Ann NY Acad Sci2010119419920620536469
  • SosneGDunnSCrockfordDKimCDixonEThymosin beta 4 eye drops significantly improve signs and symptoms of severe dry eye in a physician-sponsored phase-2 clinical trialInvest Ophthalmol Vis Sci201354E6033
  • RuffDCrockfordDGirardiGZhangYA randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteersAnn N Y Acad Sci2010119422322920536472
  • AbelsonRLaneKJRodriguezJA single-center study evaluating the effect of the controlled adverse environment (CAE™) model on tear film stabilityClin Ophthalmol201261865187223185114
  • WilsonSEMohanRRMohanRRThe corneal wound healing response; cytokine mediated interaction of the epithelium, stroma and inflammatory cellsProg Retin Eye Res20012062563711470453