RNAi for contactin 2 inhibits proliferation of U87-glioma stem cells by downregulating AICD, EGFR, and HES1

References

• OstromQTGittlemanHFulopJCBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008–2012Neuro Oncol201517suppl 4iv1iv6226511214
   PubMed Web of Science ®Google Scholar
• GalliRBindaEOrfanelliUIsolation and characterization of tumorigenic, stem-like neural precursors from human glioblastomaCancer Res200464197011702115466194
   PubMed Web of Science ®Google Scholar
• GilbertCARossAHCancer stem cells: cell culture, markers, and targets for new therapiesJ Cell Biochem200910851031103819760641
   PubMed Web of Science ®Google Scholar
• SundarSJHsiehJKManjilaSLathiaJDSloanAThe role of cancer stem cells in glioblastomaNeurosurg Focus2014376E6
   PubMed Web of Science ®Google Scholar
• CruzMHSidenACalafGMDelwarZMYakisichJSThe stemness phenotype modelISRN Oncol2012201239264722928120
   PubMedGoogle Scholar
• ClarkMJHomerNO’ConnorBDU87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell linePLoS Genet201061e100083220126413
   PubMed Web of Science ®Google Scholar
• ChenLChenXRChenFFMicroRNA-107 inhibits U87 glioma stem cells growth and invasionCell Mol Neurobiol201333565165723572380
   PubMed Web of Science ®Google Scholar
• ChenXChenLChenJADAM17 promotes U87 glioblastoma stem cell migration and invasionBrain Res2013153815115823470260
   PubMed Web of Science ®Google Scholar
• ChenXChenLZhangRADAM17 regulates self-renewal and differentiation of U87 glioblastoma stem cellsNeurosci Lett2013537444923356982
   PubMedGoogle Scholar
• KannoHSatoHYokoyamaTAYoshizumiTYamadaSThe VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathwayInt J Oncol201342388188623338840
   PubMedGoogle Scholar
• LiPLuXWangYMiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cellsJ Biomed Res201024643644323554660
   PubMedGoogle Scholar
• QiuBSunXZhangDWangYTaoJOuSTRAIL and paclitaxel synergize to kill U87 cells and U87-derived stem-like cells in vitroInt J Mol Sci20121379142915622942757
   PubMedGoogle Scholar
• Sassi FdeACaesarLJaegerMInhibitory activities of trichostatin A in U87 glioblastoma cells and tumorsphere-derived cellsJ Mol Neurosci2014541274024464841
   PubMedGoogle Scholar
• YuSCPingYFYiLIsolation and characterization of cancer stem cells from a human glioblastoma cell line U87Cancer Lett2008265112413418343028
   PubMed Web of Science ®Google Scholar
• LamszusKGuntherHSGlioma stem cells as a target for treatmentTarget Oncol20105321121520737293
   PubMedGoogle Scholar
• ChenJLiYYuTSA restricted cell population propagates glioblastoma growth after chemotherapyNature2012488741252252622854781
   PubMed Web of Science ®Google Scholar
• WangJWakemanTPLathiaJDNotch promotes radioresistance of glioma stem cellsStem Cells2010281172819921751
   PubMed Web of Science ®Google Scholar
• WeiYJiangYZouFActivation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cellsProc Natl Acad Sci U S A2013110176829683423569237
   PubMedGoogle Scholar
• ZhouKSongYZhouWmGlu3 receptor blockade inhibits proliferation and promotes astrocytic phenotype in glioma stem cellsCell Biol Int201438442643424482010
   PubMedGoogle Scholar
• MaQHBagnardDXiaoZCDaweGSA TAG on to the neurogenic functions of APPCell Adh Migr2008212819262125
   PubMed Web of Science ®Google Scholar
• MaQHFutagawaTYangWLA TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesisNat Cell Biol200810328329418278038
   PubMedGoogle Scholar
• BizzocaAVirgintinoDLorussoLTransgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neuronsDevelopment20031301294312441289
   PubMedGoogle Scholar
• FalkJBonnonCGiraultJAFaivre-SarrailhCF3/contactin, a neuronal cell adhesion molecule implicated in axogenesis and myelinationBiol Cell200294632733412500940
   PubMedGoogle Scholar
• FujitaNSaitoRWatanabeKNagataSAn essential role of the neuronal cell adhesion molecule contactin in development of the Xenopus primary sensory systemDev Biol2000221230832010790328
   PubMedGoogle Scholar
• StogmannEReinthalerEEltawilSAutosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2Brain2013136pt 41155116023518707
   PubMedGoogle Scholar
• EckerichCZapfSUlbrichtUContactin is expressed in human astrocytic gliomas and mediates repulsive effectsGlia200653111216078236
   PubMedGoogle Scholar
• RickmanDSTyagiRZhuXXThe gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomasCancer Res20016152162216811280781
   PubMedGoogle Scholar
• XenakiDMartinIBYoshidaLF3/contactin and TAG1 play antagonistic roles in the regulation of sonic hedgehog-induced cerebellar granule neuron progenitor proliferationDevelopment2011138351952921205796
   PubMedGoogle Scholar
• LeissringMAMurphyMPMeadTRA physiologic signaling role for the gamma-secretase-derived intracellular fragment of APPProc Natl Acad Sci U S A20029974697470211917117
   PubMed Web of Science ®Google Scholar
• ZhouFGongKSongBThe APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowthBiochim Biophys Acta2012182381233124122613765
   PubMedGoogle Scholar
• CulicchiaFCuiJGLiYYLukiwWJUpregulation of beta-amyloid precursor protein expression in glioblastoma multiformeNeuroreport200819998198518521005
   PubMedGoogle Scholar
• ShimojoHOhtsukaTKageyamaRDynamic expression of notch signaling genes in neural stem/progenitor cellsFront Neurosci201157821716644
   PubMedGoogle Scholar
• KanamoriMKawaguchiTNigroJMContribution of Notch signaling activation to human glioblastoma multiformeJ Neurosurg2007106341742717367064
   PubMed Web of Science ®Google Scholar
• ShenYChenHZhangJIncreased Notch signaling enhances radioresistance of malignant stromal cells induced by glioma stem/progenitor cellsPLoS One20151011e014259426599017
   PubMed Web of Science ®Google Scholar
• YaoJZhengKLiCLiuHShanXInterference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathwayMed Oncol201532661025920606
   PubMedGoogle Scholar
• FischerDFvan DijkRSluijsJAActivation of the Notch pathway in Down syndrome: cross-talk of Notch and APPFASEB J200519111451145816126912
   PubMedGoogle Scholar
• KahlertUDBenderNOMaciaczykDCD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like componentFolia Neuropathol201250435736823319191
   PubMedGoogle Scholar
• BaoSWuQSathornsumeteeSStem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factorCancer Res200666167843784816912155
   PubMed Web of Science ®Google Scholar
• ZhangYWWangRLiuQZhangHLiaoFFXuHPresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionProc Natl Acad Sci U S A200710425106131061817556541
   PubMed Web of Science ®Google Scholar
• LiuGYuanXZengZAnalysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastomaMol Cancer200656717140455
   PubMed Web of Science ®Google Scholar
• LjungkvistASBussinkJKaandersJHvan der KogelAJDynamics of tumor hypoxia measured with bioreductive hypoxic cell markersRadiat Res2007167212714517390721
   PubMedGoogle Scholar
• PersanoLRampazzoEDella PuppaAPistollatoFBassoGThe three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implicationsScientific World Journal2011111829184122125441
   PubMedGoogle Scholar
• KonietzkoUAICD nuclear signaling and its possible contribution to Alzheimer’s diseaseCurr Alzheimer Res20129220021621605035
   PubMedGoogle Scholar