MTHFR C677T polymorphism and breast, ovarian cancer risk: a meta-analysis of 19,260 patients and 26,364 controls

References

• Cancer Genome Atlas NetworkComprehensive molecular portraits of human breast tumoursNature2012490617023000897
   PubMed Web of Science ®Google Scholar
• LajinBAlhajSAGhabreauLAlachkarAAssociation of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian womenTumour Biol2012331133113922373582
   PubMedGoogle Scholar
• FordDEastonDFThe genetics of breast and ovarian cancerBr J Cancer1995728058127547224
   PubMed Web of Science ®Google Scholar
• PetrucelliNDalyMBFeldmanGLHereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2Genet Med20101224525920216074
   PubMed Web of Science ®Google Scholar
• MarshallMSolomonSHereditary breast-ovarian cancer: clinical findings and medical managementPlast Surg Nurs20072712412717901820
   PubMedGoogle Scholar
• RuarkESnapeKHumburgPMosaic PPM1D mutations are associated with predisposition to breast and ovarian cancerNature201349340641023242139
   PubMed Web of Science ®Google Scholar
• RosenbergNMurataMIkedaYThe frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and AfricansAm J Hum Genet20027075876211781870
   PubMed Web of Science ®Google Scholar
• Parle-McDermottAMillsJLMolloyAMThe MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levelsMol Genet Metab20068829029416621645
   PubMed Web of Science ®Google Scholar
• NazkiFHSameerASGanaieBAFolate: metabolism, genes, polymorphisms and the associated diseasesGene2014533112024091066
   PubMed Web of Science ®Google Scholar
• QiXMaXYangXMethylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controlsBreast Cancer Res Treat201012349950620135343
   PubMed Web of Science ®Google Scholar
• PanigrahiIChatterjeeTBiswasABehariMChoudhryPVSaxenaRRole of MTHFR C677T polymorphism in ischemic strokeNeurol India200654485216679643
   PubMed Web of Science ®Google Scholar
• SauerJMasonJBChoiSWToo much folate: a risk factor for cancer and cardiovascular disease?Curr Opin Clin Nutr Metab Care200912303619057184
   PubMed Web of Science ®Google Scholar
• WoolfBOn estimating the relation between blood group and diseaseAnn Hum Genet19551925125314388528
   PubMed Web of Science ®Google Scholar
• HigginsJPThompsonSGDeeksJJAltmanDGMeasuring inconsistency in meta-analysesBMJ200332755756012958120
   PubMed Web of Science ®Google Scholar
• HigginsJPThompsonSGQuantifying heterogeneity in a meta-analysisStat Med2002211539155812111919
   PubMed Web of Science ®Google Scholar
• MantelNHaenszelWStatistical aspects of the analysis of data from retrospective studies of diseaseJ Natl Cancer Inst19592271974813655060
   PubMed Web of Science ®Google Scholar
• DerSimonianRLairdNMeta-analysis in clinical trialsControl Clin Trials198671771883802833
   PubMed Web of Science ®Google Scholar
• EggerMDaveySGSchneiderMMinderCBias in meta-analysis detected by a simple, graphical testBMJ19973156296349310563
   PubMed Web of Science ®Google Scholar
• LissowskaJGaudetMMBrintonLAGenetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analysesInt J Cancer20071202696270317311260
   PubMed Web of Science ®Google Scholar
• KanXXZouTNWuXYXuWangAssociation between mTHFR genotype polymorphism and breast cancer susceptibility in human population from YunnanCancer Res Prev Treat200734716718
   Google Scholar
• StevensVLMcCulloughMLPavluckALAssociation of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidenceCancer Epidemiol Biomarkers Prev2007161140114717548676
   PubMed Web of Science ®Google Scholar
• Le MarchandLHaimanCAWilkensLRKolonelLNHendersonBEMTHFR polymorphisms, diet, HRT, and breast cancer risk: the multiethnic cohort studyCancer Epidemiol Biomarkers Prev2004132071207715598763
   PubMed Web of Science ®Google Scholar
• HanHHanLLGaoHDHouLGenetic polymorphisms of methylenetetrahydrofolate reductase, methionine synthase, methylation of NF2, and their association with breast cancer morbidityChin J Curr Adv Gen Surg201114846850
   Google Scholar
• JakubowskaAGronwaldJMenkiszakJMethylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risksBreast Cancer Res Treat200710429930817063264
   PubMed Web of Science ®Google Scholar
• HuaZPWangYBNiJGeFZouTNFolic acid, Vitamin B12, MTHFR, MS gene polymorphisms associate with the risk of breast cancerMod Oncol20111904280431
   Google Scholar
• WuYYWuLWangYCaoWHHouLRelation between the SNPs in methylenetetrahydrofolate reductase gene C677T and G1793A and the susceptibility of sporadic breast cancerProg Mod Biomed20121226092614
   Google Scholar
• RenwickAThompsonDSealSATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility allelesNat Genet20063887387516832357
   PubMed Web of Science ®Google Scholar
• SealSThompsonDRenwickATruncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility allelesNat Genet2006381239124117033622
   PubMed Web of Science ®Google Scholar
• ErogluAAkarNMethylenetetrahydrofolate reductase C677T polymorphism in breast cancer riskBreast Cancer Res Treat201012289789820467892
   PubMedGoogle Scholar
• KimYI5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and diseaseNutr Rev20056339840716370225
   PubMed Web of Science ®Google Scholar
• JakubowskaARozkrutDAntoniouAAssociation of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter studyBr J Cancer20121062016202422669161
   PubMedGoogle Scholar
• Gershoni-BaruchRDaganEIsraeliDKasinetzLKadouriEFriedmanEAssociation of the C677T polymorphism in the MTHFR gene with breast and/or ovarian cancer risk in Jewish womenEur J Cancer2000362313231611094304
   PubMed Web of Science ®Google Scholar
• LuQJiangKLiQJiYJChenWLXueXHPolymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese populationTumour Biol2015363757376225566964
   PubMedGoogle Scholar
• QiJMiaoXPTanW亚甲基四氢叶酸还原酶基因单核苷酸 多态与乳腺癌风险 [Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer]Chin J Oncol200426287289 Chinese
   Google Scholar
• YuanHXuXYWangZLThe relation between polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of breast cancerJ MuDanJiang Med Univ20093024
   Google Scholar
• GaoCMTangJHCaoHXMTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese womenJ Hum Genet20095441441819557016
   PubMedGoogle Scholar
• LangsenlehnerUKripplPRennerWThe common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer riskBreast Cancer Res Treat20038116917214572159
   PubMed Web of Science ®Google Scholar
• CampbellIGBaxterSWEcclesDMChoongDYMethylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancerBreast Cancer Res20024R1412473175
   PubMed Web of Science ®Google Scholar
• GrieuFPowellBBeilbyJIacopettaBMethylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotypeAnticancer Res2004243215321915510613
   PubMed Web of Science ®Google Scholar
• ForstiAAngeliniSFestaFSingle nucleotide polymorphisms in breast cancerOncol Rep20041191792215010895
   PubMed Web of Science ®Google Scholar
• SemenzaJCDelfinoRJZiogasAAnton-CulverHBreast cancer risk and methylenetetrahydrofolate reductase polymorphismBreast Cancer Res Treat20037721722312602921
   PubMed Web of Science ®Google Scholar
• LiWDChenSQAssociation of methylenetetrahydrofolate reductase C677T polymorphism and breast cancer riskJ Pract Med20092520312033
   Google Scholar
• JinZLuQGeDZongMZhuQEffect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancerMol Med Rep2009228328921475826
   PubMedGoogle Scholar
• PoojaSCarlusJSekharDMTHFR 677C>T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controlsPLoS One201510e120654
   Google Scholar
• GaoSLiuNMaYYingLMethylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers in ovarian cancer riskAsian Pac J Cancer Prev20121356957322524826
   PubMedGoogle Scholar
• WuYZhangJYZuoWJAssociation between genetic polymorphisms of methylenetetrahydrofolate reductase C677T and susceptibility to ovarian cancerProg Obstet Gynecol200716811813
   Google Scholar
• PrasadVVWilkhooHAssociation of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian, and cervical cancersOnkologie20113442242621934341
   PubMedGoogle Scholar
• TerryKLTworogerSSGoodeELMTHFR polymorphisms in relation to ovarian cancer riskGynecol Oncol201011931932420817226
   PubMedGoogle Scholar
• SchnekenburgerMDicatoMDiederichMPlant-derived epigenetic modulators for cancer treatment and preventionBiotechnol Adv2014321123113224699435
   PubMed Web of Science ®Google Scholar
• SharpLLittleJSchofieldACFolate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)Cancer Lett2002181657112430180
   PubMed Web of Science ®Google Scholar
• ErgulESazciAUtkanZCanturkNZPolymorphisms in the MTHFR gene are associated with breast cancerTumour Biol20032428629015004488
   PubMed Web of Science ®Google Scholar
• LeeSAKangDNishioHMethylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean womenExp Mol Med20043611612115150439
   PubMed Web of Science ®Google Scholar
• LinWYChouYCWuMHThe MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in TaiwanAnticancer Res2004243863386815736423
   PubMed Web of Science ®Google Scholar
• ShrubsoleMJGaoYTCaiQMTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer StudyCancer Epidemiol Biomarkers Prev20041319019614973091
   PubMed Web of Science ®Google Scholar
• JustenhovenCHamannUPierlCBOne-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA study from GermanyCancer Epidemiol Biomarkers Prev2005143015301816365030
   PubMed Web of Science ®Google Scholar
• KalemiTGLambropoulosAFGueorguievMChrisafiSPapazisisKTKotsisAThe association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern GreeceCancer Lett2005222576515837541
   PubMedGoogle Scholar
• DeligezerUAkisikEEDalayNHomozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish populationIn Vivo20051988989316097444
   PubMed Web of Science ®Google Scholar
• ChouYCWuMHYuJCGenetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in TaiwanCarcinogenesis2006272295230016777985
   PubMed Web of Science ®Google Scholar
• ReljicASimundicAMTopicENikolacNJustinicDStefanovicMThe methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control studyClin Biochem20074098198517573062
   PubMedGoogle Scholar
• HekimNErgenAYaylimINo association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancerCell Biochem Funct20072511511716134079
   PubMed Web of Science ®Google Scholar
• XuXGammonMDZhangHPolymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based studyCarcinogenesis2007281504150917372271
   PubMed Web of Science ®Google Scholar
• MacisDMaisonneuvePJohanssonHMethylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysisBreast Cancer Res Treat200710626327117260091
   PubMed Web of Science ®Google Scholar
• YuCPWuMHChouYCBreast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in TaiwanAnticancer Res2007271727173217595805
   PubMed Web of Science ®Google Scholar
• KotsopoulosJZhangWWZhangSPolymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancerBreast Cancer Res Treat200811258559318204969
   PubMed Web of Science ®Google Scholar
• LangsenlehnerTRennerWYazdani-BiukiBLangsenlehnerUMethylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysisBreast Cancer Res Treat200810745946017453338
   PubMedGoogle Scholar
• ChengCWYuJCHuangCSPolymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in TaiwanBreast Cancer Res Treat200811114515517896178
   PubMedGoogle Scholar
• InoueMRobienKWangRVan Den BergDJKohWPYuMCGreen tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health StudyCarcinogenesis2008291967197218669903
   PubMed Web of Science ®Google Scholar
• SuzukiTMatsuoKHiroseKOne-carbon metabolism-related gene polymorphisms and risk of breast cancerCarcinogenesis20082935636218174236
   PubMed Web of Science ®Google Scholar
• CamRErogluAEginYAkarNDihydrofolate reductase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancerBreast Cancer Res Treat200911543143218498051
   PubMedGoogle Scholar
• Henriquez-HernandezLAMurias-RosalesAHernandezGAGene polymorphisms in TYMS, MTHFR, p53 and MDR1 as risk factors for breast cancer: a case-control studyOncol Rep2009221425143319885596
   PubMed Web of Science ®Google Scholar
• PlatekMEShieldsPGMarianCAlcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer riskCancer Epidemiol Biomarkers Prev2009182453245919706843
   PubMedGoogle Scholar
• EricsonUSonestedtEIvarssonMIFolate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmo Diet and Cancer cohortCancer Epidemiol Biomarkers Prev2009181101111019336565
   PubMed Web of Science ®Google Scholar
• MarutiSSUlrichCMJupeERWhiteEMTHFR C677T and post-menopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control studyBreast Cancer Res200911R9120030812
   PubMed Web of Science ®Google Scholar
• MaEIwasakiMJunkoIDietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian womenBMC Cancer2009912219389261
   PubMed Web of Science ®Google Scholar
• MaEIwasakiMKobayashiMDietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in JapanNutr Cancer20096144745619838916
   PubMed Web of Science ®Google Scholar
• BentleyARRaiszadehFStoverPJHunterDJHankinsonSECassanoPANo association between cSHMT genotypes and the risk of breast cancer in the Nurses’ Health StudyEur J Clin Nutr20106410811019707223
   PubMedGoogle Scholar
• WuXYNiJXuWJZhouTWangXInteractions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese populationAsian Pac J Cancer Prev2012132199220622901194
   PubMed Web of Science ®Google Scholar
• AkilzhanovaANurkinaZMomynalievKGenetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancerAnticancer Res2013334049405924023349
   PubMedGoogle Scholar
• AwwadNYousefAMAbuhaliemaAAbdallaIYousefMRelationship between genetic polymorphisms in MTHFR (C677T, A1298C and their haplotypes) and the incidence of breast cancer among Jordanian females – case-control studyAsian Pac J Cancer Prev2015165007501126163632
   PubMedGoogle Scholar
• WebbPMIbiebeleTIHughesMCFolate and related micronutrients, folate-metabolising genes and risk of ovarian cancerEur J Clin Nutr2011651133114021629268
   PubMed Web of Science ®Google Scholar
• PawlikPMostowskaALianeriMSajdakSKedziaHJagodzinskiPPFolate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish populationMol Biol Rep2012395553556022183302
   PubMedGoogle Scholar
• ZhangLLiuWHaoQBaoLWangKFolate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer riskInt J Mol Sci2012134009402022605962
   PubMed Web of Science ®Google Scholar