Focal adhesion kinases crucially regulate TGFβ-induced migration and invasion of bladder cancer cells via Src kinase and E-cadherin

References

• JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
   PubMed Web of Science ®Google Scholar
• AntoniSFerlayJSoerjomataramIZnaorAJemalABrayFBladder cancer incidence and mortality: a global overview and recent trendsEur Urol20177119610827370177
   PubMed Web of Science ®Google Scholar
• BlackPCFine-tuning risk stratification for non-muscle-invasive bladder cancerEur Urol2016691707126256521
   PubMedGoogle Scholar
• ProutGRJrGriffinPPShipleyWUBladder carcinoma as a systemic diseaseCancer197943625322539455239
   PubMedGoogle Scholar
• LechertierTHodivala-DilkeKFocal adhesion kinase and tumour angiogenesisJ Pathol2012226240441221984450
   PubMed Web of Science ®Google Scholar
• OkamotoHYasuiKZhaoCAriiSInazawaJPTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomasHepatology20033851242124914578863
   PubMedGoogle Scholar
• ParkJHLeeBLYoonJFocal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancerHum Pathol201041121664167320869748
   PubMedGoogle Scholar
• SulzmaierFJJeanCSchlaepferDDFAK in cancer: mechanistic findings and clinical applicationsNat Rev Cancer201414959861025098269
   PubMed Web of Science ®Google Scholar
• LuHWangLGaoWIGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cellsMol Cancer Ther201312122864287324130049
   PubMedGoogle Scholar
• Cancer Genome Atlas Research NetworkIntegrated genomic analyses of ovarian carcinomaNature2011474735360961521720365
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas NetworkComprehensive molecular portraits of human breast tumoursNature20124907418617023000897
   PubMed Web of Science ®Google Scholar
• OktayMHOktayKHamele-BenaDBuyukAKossLGFocal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomasHum Pathol200334324024512673558
   PubMedGoogle Scholar
• WendtMKSmithJASchiemannWPTransforming growth factor-beta-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progressionOncogene201029496485649820802523
   PubMed Web of Science ®Google Scholar
• SchoberMFuchsETumor-initiating stem cells of squamous cell carcinomas and their control by TGF-beta and integrin/focal adhesion kinase (FAK) signalingProc Natl Acad Sci U S A201110826105441054921670270
   PubMed Web of Science ®Google Scholar
• LuoMGuanJLFocal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisCancer Lett2010289212713919643531
   PubMedGoogle Scholar
• SimaNWangWKongDRNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53Apoptosis200813227328118060502
   PubMedGoogle Scholar
• LiBHZhouJSYeFReduced miR-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 proteinEur J Cancer201147142166217421636267
   PubMedGoogle Scholar
• PelletierAJKunickiTQuarantaVActivation of the integrin alpha v beta 3 involves a discrete cation-binding site that regulates conformationJ Biol Chem19962713136413708576125
   PubMedGoogle Scholar
• SimaNWangSWangWAntisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cellsGynecol Oncol2007106229930417586029
   PubMed Web of Science ®Google Scholar
• SchallerMDBorgmanCACobbBSVinesRRReynoldsABParsonsJTpp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesionsProc Natl Acad Sci U S A19928911519251961594631
   PubMedGoogle Scholar
• HanksSKCalalbMBHarperMCPatelSKFocal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectinProc Natl Acad Sci U S A19928918848784911528852
   PubMedGoogle Scholar
• SchallerMDHildebrandJDShannonJDFoxJWVinesRRParsonsJTAutophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60srcMol Cell Biol1994143168016887509446
   PubMed Web of Science ®Google Scholar
• ClementeCFTornatoreTFTheizenTHTargeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in miceCirc Res2007101121339134817947798
   PubMedGoogle Scholar
• DuxburyMSItoHBenoitEZinnerMJAshleySWWhangEERNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivityBiochem Biophys Res Commun2003311378679214623342
   PubMed Web of Science ®Google Scholar
• ChanKTCortesioCLHuttenlocherAFAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasionJ Cell Biol2009185235737019364917
   PubMedGoogle Scholar
• ThamilselvanVCraigDHBassonMDFAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathwayFASEB J20072181730174117317726
   PubMed Web of Science ®Google Scholar
• ShiQBaoSSongLTargeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinasesOncogene200726284084409417213807
   PubMed Web of Science ®Google Scholar
• Van SlambrouckSGrijelmoCDe WeverOActivation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1integrins during colon cancer cell invasionInt J Oncol20073161501150817982677
   PubMedGoogle Scholar
• SoodAKCoffinJESchneiderGBBiological significance of focal adhesion kinase in ovarian cancer: role in migration and invasionAm J Pathol200416541087109515466376
   PubMed Web of Science ®Google Scholar
• MengXNJinYYuYCharacterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasionBr J Cancer2009101232733419568240
   PubMed Web of Science ®Google Scholar
• HoYTYangJSLiTCBerberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9Cancer Lett2009279215516219251361
   PubMedGoogle Scholar
• NowickiTSZhaoHDarzynkiewiczZDownregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cellsCell Cycle201110110010721191179
   PubMed Web of Science ®Google Scholar
• LeaskAFocal adhesion kinase: a key mediator of transforming growth factor beta signaling in fibroblastsAdv Wound Care (New Rochelle)20132524724924527346
   PubMedGoogle Scholar
• WalshMFAmpasalaDRHatfieldJTransforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanismsAm J Pathol2008173238539918583311
   PubMed Web of Science ®Google Scholar
• WangHRadjendiraneVWaryKKChakrabartySTransforming growth factor beta regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cellsOncogene200423325558556115133493
   PubMedGoogle Scholar
• XuZMaDZWangLYSuJMZhaXLTransforming growth factor-beta1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cellsBiochem Biophys Res Commun2003312238839614637150
   PubMedGoogle Scholar
• WangSEXiangBZentRQuarantaVPozziAArteagaCLTransforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeletonCancer Res200969247548219147560
   PubMed Web of Science ®Google Scholar
• LiSHuaZCFAK expression regulation and therapeutic potentialAdv Cancer Res2008101456119055942
   PubMed Web of Science ®Google Scholar
• SchallerMDCellular functions of FAK kinases: insight into molecular mechanisms and novel functionsJ Cell Sci2010123pt 71007101320332118
   PubMed Web of Science ®Google Scholar
• MitraSKSchlaepferDDIntegrin-regulated FAK-Src signaling in normal and cancer cellsCurr Opin Cell Biol200618551652316919435
   PubMed Web of Science ®Google Scholar
• ChiangGJBillmeyerBRCanesDThe src-family kinase inhibitor PP2 suppresses the in vitro invasive phenotype of bladder carcinoma cells via modulation of AktBJU Int200596341642216042741
   PubMedGoogle Scholar
• SerrelsACanelMBruntonVGFrameMCSrc/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imagingCell Adh Migr20115436036521836391
   PubMed Web of Science ®Google Scholar
• Arimoto-IshidaESakataMSawadaKUp-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantationEndocrinology200915094306431519497979
   PubMedGoogle Scholar