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Review

The different functions and clinical significances of caveolin-1 in human adenocarcinoma and squamous cell carcinoma

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Pages 819-835 | Published online: 14 Feb 2017

References

  • ChenDCheGValue of caveolin-1 in cancer progression and prognosis: emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review)Oncol Lett2014841409142125202343
  • Van den EyndenGGVan LaereSJVan der AuweraIOverexpres-sion of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancerBreast Cancer Res Treat200695321922816244790
  • SugieSMukaiSYamasakiKKamibeppuTTsukinoHKamotoTSignificant association of caveolin-1 and caveolin-2 with prostate cancer progressionCancer Genomics Proteomics201512639139626543085
  • AndoTIshiguroHKimuraMThe overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinomaOncol Rep200718360160917671707
  • GoetzJGLajoiePWisemanSMNabiIRCaveolin-1 in tumor progression: the good, the bad and the uglyCancer Metastasis Rev200827471573518506396
  • HanFGuDChenQZhuHCaveolin-1 acts as a tumor suppressor by down-regulating epidermal growth factor receptor-mitogen-activated protein kinase signaling pathway in pancreatic carcinoma cell linesPancreas200938776677419893453
  • WiechenKDiatchenkoLAgoulnikACaveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor geneAm J Pathol200115951635164311696424
  • SloanEKStanleyKLAndersonRLCaveolin-1 inhibits breast cancer growth and metastasisOncogene200423477893789715334058
  • GuDLiHWangZChenQJiangJZhuHCaveolin-1 inhibits the growth of human laryngeal squamous cell carcinoma and down regulates EGFR-MAPKs signaling pathwayLaryngoscope2007117101782178917906498
  • KatoTMiyamotoMKatoKDifference of caveolin-1 expression pattern in human lung neoplastic tissue. Atypical adenomatous hyper-plasia, adenocarcinoma and squamous cell carcinomaCancer Lett2004214112112815331180
  • PradeETobiaschMHitkovaIBile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding proteinMol Endocrinol201226581983222474125
  • HurlstoneAFReidGReevesJRAnalysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell linesOncogene199918101881189010086342
  • YangGGoltsovAARenCCaveolin-1 upregulation contributes to c-Myc-induced high-grade prostatic intraepithelial neoplasia and prostate cancerMol Cancer Res201210221822922144662
  • LiangWHaoZHanJLZhuDJJinZFXieWLCAV-1 contributes to bladder cancer progression by inducing epithelial-to-mesenchymal transitionUrol Oncol201432685586324968949
  • CampbellLAl-JayyoussiGGutteridgeRCaveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined diseaseJ Transl Med20131125524119769
  • KatoKHidaYMiyamotoMOverexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stageCancer200294492993311920460
  • NohataNHanazawaTKikkawaNCaveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinomaInt J Oncol201138120921721109942
  • SunJGaoJHuJBExpression of Cav-1 in tumour cells, rather than in stromal tissue, may promote cervical squamous cell carcinoma proliferation, and correlates with high-risk HPV infectionOncol Rep20122761733174022378247
  • XueJChenHDiaoLChenXXiaDExpression of caveolin-1 in tongue squamous cell carcinoma by quantum dotsEur J Histochem2010542e2020558341
  • CarverLASchnitzerJECaveolae: mining little caves for new cancer targetsNat Rev Cancer20033857158112894245
  • ZhaoXHeYChenHAutophagic tumor stroma: mechanisms and roles in tumor growth and progressionInt J Cancer201313211822684793
  • WitkiewiczAKDasguptaASotgiaFAn absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancersAm J Pathol200917462023203419411448
  • JiaYWangNWangJDown-regulation of stromal caveolin-1 expression in esophageal squamous cell carcinoma: a potent predictor of lymph node metastases, early tumor recurrence, and poor prognosisAnn Surg Oncol201421132933623982252
  • KooJSParkSKimSILeeSParkBWThe impact of caveolin protein expression in tumor stroma on prognosis of breast cancerTumour Biol201132478779921584795
  • Martinez-OutschoornUETrimmerCLinZAutophagy in cancer associated fibroblasts promotes tumor cell survival: role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microen-vironmentCell Cycle20109173515353320855962
  • PavlidesSWhitaker-MenezesDCastello-CrosRThe reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stromaCell Cycle20098233984400119923890
  • PavlidesSTsirigosAMignecoGThe autophagic tumor stroma model of cancer: role of oxidative stress and ketone production in fueling tumor cell metabolismCell Cycle20109173485350520861672
  • Martinez-OutschoornUEPavlidesSHowellAStromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironmentInt J Biochem Cell Biol20114371045105121300172
  • WitkiewiczAKKlineJQueenanMMolecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancersCell Cycle201110111794180921521946
  • El-GendiSMMostafaMFEl-GendiAMStromal caveolin-1 expression in breast carcinoma. Correlation with early tumor recurrence and clinical outcomePathol Oncol Res201218245946922057638
  • GumulecJSochorJHlavnaMCaveolin-1 as a potential high-risk prostate cancer biomarkerOncol Rep201227383184122159333
  • ZhaoZHanFHYangSBHuaLXWuJHZhanWHLoss of stromal caveolin-1 expression in colorectal cancer predicts poor survivalWorld J Gastroenterol20152141140114725632186
  • VeredMLehtonenMHotakainenLCaveolin-1 accumulation in the tongue cancer tumor microenvironment is significantly associated with poor prognosis: an in-vivo and in-vitro studyBMC Cancer2015152525633184
  • SchererPETangZChunMSargiacomoMLodishHFLisantiMPCaveolin isoforms differ in their N-terminal protein sequence and sub-cellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probeJ Biol Chem19952702716395164017608210
  • PodarKTaiYTColeCEEssential role of caveolae in interleukin- 6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cellsJ Biol Chem200327885794580112482878
  • SargiacomoMSchererPETangZOligomeric structure of caveolin: implications for caveolae membrane organizationProc Natl Acad Sci U S A19959220940794117568142
  • OkamotoTSchlegelASchererPELisantiMPCaveolins, a family of scaffolding proteins for organizing “preassembled signaling complexes” at the plasma membraneJ Biol Chem199827310541954229488658
  • LiSCouetJLisantiMPSrc tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinasesJ Biol Chem19962714629182291908910575
  • CouetJLiSOkamotoTIkezuTLisantiMPIdentification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteinsJ Biol Chem199727210652565339045678
  • SahaiEMarshallCJRHO-GTPases and cancerNat Rev Cancer20022213314212635176
  • NarumiyaSTanjiMIshizakiTRho signaling, ROCK and mDia1, in transformation, metastasis and invasionCancer Metastasis Rev2009281–2657619160018
  • ArpaiaEBlaserHQuintela-FandinoMThe interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and ErkOncogene201231788489621765460
  • JoglekarMElbazantiWOWeitzmanMDLehmanHLvan GolenKLCaveolin-1 mediates inflammatory breast cancer cell invasion via the Akt1 pathway and RhoC GTPaseJ Cell Biochem2015116692393325559359
  • LinMDiVitoMMMerajverSDBoyanapalliMvan GolenKLRegulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1Mol Cancer2005412115969750
  • CokakliMErdalENartDDifferential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasionBMC Cancer200996519239691
  • KannanAKrishnanAAliMSubramaniamSHalagowderDSivasithamparamNDCaveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic conditionEur J Cancer201450120421524070739
  • LuZGhoshSWangZHunterTDownregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasionCancer Cell20034649951514706341
  • AnnabiBLachambreMBousquet-GagnonNPageMGingrasDBeliveauRLocalization of membrane-type 1 matrix metalloproteinase in caveolae membrane domainsBiochem J2001353Pt 354755311171051
  • TangYZengXHeFLiaoYQianNToiMCaveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancerMed Oncol201229297798421416157
  • YehDChenCSunMZCaveolin-1 is an important factor for the metastasis and proliferation of human small cell lung cancer NCI-H446 cellAnat Rec (Hoboken)2009292101584159219718715
  • WengYCaiMZhuJMatrix metalloproteinase activity in early-stage lung cancerOnkologie201336525625923689219
  • MakinenLKHayryVHagstromJMatrix metalloproteinase-7 and matrix metalloproteinase-25 in oral tongue squamous cell carcinomaHead Neck201436121783178824488688
  • PuyraimondAFridmanRLemesleMArbeilleBMenashiSMMP-2 colocalizes with caveolae on the surface of endothelial cellsExp Cell Res20012621283611120602
  • NimriLBarakHGraeveLSchwartzBRestoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteinase expression and metastasis-associated activities in colon cancer cellsMol Carcinog2013521185987022674854
  • WilliamsTMMedinaFBadanoICaveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretionJ Biol Chem200427949516305164615355971
  • QinLYangYBTuoQHEffects and underlying mechanisms of curcumin on the proliferation of vascular smooth muscle cells induced by Chol:MbetaCDBiochem Biophys Res Commun2009379227728219101502
  • HulitJBashTFuMThe cyclin D1 gene is transcriptionally repressed by caveolin-1J Biol Chem200027528212032120910747899
  • PancottiFRoncuzziLMaggioliniMGasperi-CampaniACaveolin-1 silencing arrests the proliferation of metastatic lung cancer cells through the inhibition of STAT3 signalingCell Signal20122471390139722406084
  • GalbiatiFVolonteDLiuJCaveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanismMol Biol Cell20011282229224411514613
  • TorresVATapiaJCRodriguezDACaveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivinJ Cell Sci2006119Pt 91812182316608879
  • MeyerCLiuYKaulAPeipeIDooleySCaveolin-1 abrogates TGF-beta mediated hepatocyte apoptosisCell Death Dis20134e46623328673
  • RavidDMaorSWernerHLiscovitchMCaveolin-1 inhibits anoikis and promotes survival signaling in cancer cellsAdv Enzyme Regul20064616317516857240
  • LiLRenCHTahirSARenCThompsonTCCaveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2AMol Cell Biol200323249389940414645548
  • WuPQiBZhuHZhengYLiFChenJSuppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1Cancer Lett20072561647217618736
  • ItoYYoshidaHNakanoKCaveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroidBr J Cancer200286691291611953823
  • PaskasSJankovicJMareckoICaveolin-1 expression in papillary thyroid carcinoma: correlation with clinicopathological parameters and BRAF mutation statusOtolaryngol Head Neck Surg2014150220120924255086
  • KimDKimHKooJSExpression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stromaPathobiology201279111022236542
  • ShankarJWisemanSMMengFCoordinated expression of galectin-3 and caveolin-1 in thyroid cancerJ Pathol20122281566622513979
  • JinZWangLCaoZTemporal evolution in caveolin 1 methy-lation levels during human esophageal carcinogenesisBMC Cancer20141434524885118
  • ChenHLFanLFGaoJOuyangJPZhangYXDifferential expression and function of the caveolin-1 gene in non-small cell lung carcinomaOncol Rep201125235936621165568
  • ZhanPShenXKQianQExpression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomasOncol Rep20122741072107822200856
  • HoCCHuangPHHuangHYChenYHYangPCHsuSMUp-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formationAm J Pathol200216151647165612414512
  • YangCPGalbiatiFVolonteDHorwitzSBLisantiMPUpregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cellsFEBS Lett199843933683729845355
  • LingeAMeleadyPHenryMClynesMKasperMBarthKBleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid raftsInt J Biochem Cell Biol20114319810520937408
  • WangNNZhaoLJWuLNMechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell lineAsian Pac J Cancer Prev20131494983498824175763
  • LeeCYLaiTYTsaiMKThe influence of a caveolin-1 mutant on the function of P-glycoproteinSci Rep201662048626843476
  • HanFZhangLZhouYYiXCaveolin-1 regulates cell apoptosis and invasion ability in paclitaxel-induced multidrug-resistant A549 lung cancer cellsInt J Clin Exp Pathol2015888937894726464635
  • ShimizuKKiritaKAokageKClinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinomaJ Cancer Res Clin Oncol Epub20161022
  • ChiuWTLeeHTHuangFJCaveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibitionCancer Res201171144932494321622714
  • DuCChenLZhangHCaveolin-1 limits the contribution of BKCa channel to MCF-7 breast cancer cell proliferation and invasionInt J Mol Sci20141511207062072225397596
  • HartPCRattiBAMaoMCaveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysisOncotarget20167130832226543228
  • YamaguchiHTakeoYYoshidaSKouchiZNakamuraYFukamiKLipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cellsCancer Res200969228594860219887621
  • HerzogMStorchCHGutPKnockdown of caveolin-1 decreases activity of breast cancer resistance protein (BCRP/ABCG2) and increases chemotherapeutic sensitivityNaunyn Schmiedeberg’s Arch Pharmacol2011383111120936466
  • WangZWangNLiWCaveolin-1 mediates chemoresistance in breast cancer stem cells via beta-catenin/ABCG2 signaling pathwayCarcinogenesis201435102346235625085904
  • RaoXEvansJChaeHCpG island shore methylation regulates caveolin-1 expression in breast cancerOncogene201332384519452823128390
  • LiTSotgiaFVuoloMACaveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive statusAm J Pathol200616861998201316723714
  • BonuccelliGCasimiroMCSotgiaFCaveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signatureAm J Pathol200917451650166219395651
  • KoikeSKoderaYNakaoAIwataHYatabeYAbsence of the caveolin-1 P132L mutation in cancers of the breast and other organsJ Mol Diagn201012571271720581046
  • LiedtkeCKerstingCBurgerHKieselLWulfingPCaveolin-1 expression in benign and malignant lesions of the breastWorld J Surg Oncol2007511017915016
  • ElsheikhSEGreenARRakhaEACaveolin 1 and caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotypeBr J Cancer200899232733418612310
  • MaXLiuLNieWPrognostic role of caveolin in breast cancer: a meta-analysisBreast201322446246923639584
  • QianNUenoTKawaguchi-SakitaNPrognostic significance of tumor/stromal caveolin-1 expression in breast cancer patientsCancer Sci201110281590159621585620
  • BurgermeisterEXingXRockenCDifferential expression and function of caveolin-1 in human gastric cancer progressionCancer Res200767188519852617875691
  • NamKHLeeBLParkJHCaveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancerPathobiology2013802879423038627
  • BarresiVGiuffreGVitarelliETodaroPTuccariGCaveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypothesesVirchows Arch2008453657157818936967
  • YeYMiaoSHLuRZZhouJWPrognostic value of caveolin-1 expression in gastric cancer: a meta-analysisAsian Pac J Cancer Prev201415198367837025339030
  • HeYZhaoXGaoJQuantum dots-based immunofluorescent imaging of stromal fibroblasts caveolin-1 and light chain 3B expression and identification of their clinical significance in human gastric cancerInt J Mol Sci20121311137641378023203033
  • ShenXJZhangHTangGSCaveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancerInt J Biol Sci201511437037925798057
  • HanFZhuHGCaveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cellsJ Surg Res2010159144345020031158
  • SalemAFBonuccelliGBevilacquaGCaveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transitionCell Cycle201110213692370022041584
  • SuzuokiMMiyamotoMKatoKImpact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinomaBr J Cancer200287101140114412402154
  • TanaseCPCaveolin-1: a marker for pancreatic cancer diagnosisExpert Rev Mol Diagn20088439540418598222
  • ChatterjeeMBen-JosefEThomasDGCaveolin-1 is associated with tumor progression and confers a multi-modality resistance phenotype in pancreatic cancerSci Rep201551086726065715
  • LiuLXuHXWangWQCavin-1 is essential for the tumorpromoting effect of caveolin-1 and enhances its prognostic potency in pancreatic cancerOncogene201433212728273623770857
  • ShanTLuHJiHLoss of stromal caveolin-1 expression: a novel tumor microenvironment biomarker that can predict poor clinical outcomes for pancreatic cancerPLoS One201496e9723924949874
  • TseEYKoFCTungEKCaveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasisJ Pathol2012226464565322072235
  • LiuWRJinLTianMXCaveolin-1 promotes tumor growth and metastasis via autophagy inhibition in hepatocellular carcinomaClin Res Hepatol Gastroenterol201640216917826206578
  • ZhangZBCaiLZhengSGXiongYDongJHOverexpression of caveolin-1 in hepatocellular carcinoma with metastasis and worse prognosis: correlation with vascular endothelial growth factor, microvessel density and unpaired arteryPathol Oncol Res200915349550219434519
  • YuHShenHZhangYCAV1 promotes HCC cell progression and metastasis through Wnt/beta-catenin pathwayPLoS One201499e10645125180681
  • GaiXLuZTuKLiangZZhengXCaveolin-1 is up-regulated by GLI1 and contributes to GLI1-driven EMT in hepatocellular carcinomaPLoS One201491e8455124454730
  • KorhanPErdalEKandemisEReciprocal activating crosstalk between c-Met and caveolin 1 promotes invasive phenotype in hepa-tocellular carcinomaPLoS One201498e10527825148256
  • ZhaoXLiuYMaQCaveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cellsBiochem Biophys Res Commun20093781212618992712
  • YangSFYangJYHuangCHIncreased caveolin-1 expression associated with prolonged overall survival rate in hepatocellular carcinomaPathology201042543844520632820
  • FineSWLisantiMPGalbiatiFLiMElevated expression of caveolin-1 in adenocarcinoma of the colonAm J Clin Pathol2001115571972411345836
  • PatlollaJMSwamyMVRajuJRaoCVOverexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell linesOncol Rep200411595796315069532
  • DiazJMendozaPOrtizRRab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasionJ Cell Sci2014127Pt 112401240624659799
  • RoyUKHenkhausRSIgnatenkoNAMoraJFultzKEGernerEWWild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-mycMol Carcinog2008471294795518444242
  • CampbellLGumbletonMGriffithsDFCaveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinomaBr J Cancer200389101909191314612902
  • WaalkesSEggersHBlasigHCaveolin 1 mRNA is overexpressed in malignant renal tissue and might serve as a novel diagnostic marker for renal cancerBiomark Med20115221922521473727
  • CampbellLJasaniBEdwardsKGumbletonMGriffithsDFCombined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinomaBr J Cancer200898593194018283322
  • JooHJOhDKKimYSLeeKBKimSJIncreased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinomaBJU Int200493329129614764125
  • KaramJALotanYRoehrbornCGAshfaqRKarakiewiczPIShariatSFCaveolin-1 overexpression is associated with aggressive prostate cancer recurrenceProstate200767661462217299799
  • YangGTimmeTLFrolovAWheelerTMThompsonTCCombined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progressionCancer200510361186119415712208
  • YangGAddaiJWheelerTMCorrelative evidence that prostate cancer cell-derived caveolin-1 mediates angiogenesisHum Pathol200738111688169517707459
  • ZhangXLingMTWangQIdentification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cellsJ Biol Chem200728246332843329417855368
  • HuangCQiuZWangLA novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasisCancer Res201272365566522194465
  • Di VizioDMorelloMSotgiaFPestellRGFreemanMRLisantiMPAn absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activationCell Cycle20098152420242419556867
  • AyalaGMorelloMFrolovALoss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progressionJ Pathol20132311778723729330
  • LangloisSCowanKNShaoQCowanBJLairdDWThe tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1Cancer Res201070104222423220406988
  • TrimmerCBonuccelliGKatiyarSCav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activationAm J Pathol20131823992100423267770
  • HuangCFYuGTWangWMLiuBSunZJPrognostic and predictive values of SPP1, PAI and caveolin-1 in patients with oral squamous cell carcinomaInt J Clin Exp Pathol2014796032603925337248
  • AuzairLBVincent-ChongVKGhaniWMCaveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC)Eur Arch Otorhinolaryngol201627371885189326138391
  • NakataniKWadaTNakamuraMUzawaKTanzawaHFujitaSExpression of caveolin-1 and its correlation with cisplatin sensitivity in oral squamous cell carcinomaJ Cancer Res Clin Oncol2005131744545215856296
  • HanSEParkKHLeeGHuhYJMinBMMutation and aberrant expression of Caveolin-1 in human oral squamous cell carcinomas and oral cancer cell linesInt J Oncol200424243544014719121
  • HungKFLinSCLiuCJChangCSChangKWKaoSYThe biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesisJ Oral Pathol Med200332846146712901727
  • JensenDHTherkildsenMHDabelsteenEA reverse Warburg metabolism in oral squamous cell carcinoma is not dependent upon myofibroblastsJ Oral Pathol Med201544971472125420473
  • MartinsDBecaFFSousaBBaltazarFParedesJSchmittFLoss of caveolin-1 and gain of MCT4 expression in the tumor stroma: key events in the progression from an in situ to an invasive breast carcinomaCell Cycle201312162684269023907124
  • RoutraySCaveolin-1 in oral squamous cell carcinoma microenvironment: an overviewTumour Biol201435109487949525123270
  • GoetzJGMinguetSNavarro-LeridaIBiomechanical remod-eling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasisCell2011146114816321729786
  • YeQMengCShenYCaveolin-1 mediates low-intensity ultrasound-induced apoptosis via downregulation of signal transducer and activator of transcription 3 phosphorylation in laryngeal carcinoma cellsUltrasound Med Biol20164292253226027289429
  • GrecoADe VirgilioARizzoMIPandolfiFRosatiDde VincentiisMThe prognostic role of E-cadherin and beta-catenin overexpression in laryngeal squamous cell carcinomaLaryngoscope20161264E148E15526511677
  • MasuelliLBudillonAMarzocchellaLCaveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/alpha-beta catenins complex and multiple ErbB receptors and with lymph nodes metastasis in head and neck squamous cell carcinomasJ Cell Physiol201222793344335322213373
  • MasoodRHochstimCCervenkaBA novel orthotopic mouse model of head and neck cancer and lymph node metastasisOncogenesis20132e6824018643
  • ZhangHSuLMullerSRestoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinomaBr J Cancer200899101684169419002186
  • JungACRayAMRamoluLCaveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic propertiesOncotarget2015639418844190126474461
  • HuYCLamKYLawSWongJSrivastavaGProfiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCCClin Cancer Res20017113519352511705871
  • ZhangSCaoWYueMCaveolin-1 affects tumor drug resistance in esophageal squamous cell carcinoma by regulating expressions of P-gp and MRP1Tumour Biol20163779189919626768616
  • GongHSongLLinCDownregulation of miR-138 sustains NF-kappaB activation and promotes lipid raft formation in esophageal squamous cell carcinomaClin Cancer Res20131951083109323319823
  • ZhuXZhangYLiQBeta-carotene induces apoptosis in human esophageal squamous cell carcinoma cell lines via the Cav-1/AKT/NF-kappaB signaling pathwayJ Biochem Mol Toxicol201630314815726733226
  • CassoniPDanieleLMaldiECaveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastasesHistopathology2009551202719614763
  • YooSHParkYSKimHRExpression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lungLung Cancer200342219520214568687
  • KunzeEVon BoninFWernerCWendtMSchlottTTransitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elementsInt J Mol Med200617131316328005
  • KunzeESchlottTHigh frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladderInt J Mol Med200720455756317786288
  • RazaniBAltschulerYZhuLPestellRGMostovKELisantiMPCaveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformationBiochemistry20003945139161392411076533
  • ChengYMaDZhangYLiZGengLCervical squamous cancer mRNA profiles reveal the key genes of metastasis and invasionEur J Gynaecol Oncol201536330931726189259
  • AgelakiSSpiliotakiMMarkomanolakiHCaveolin-1 regulates EGFR signaling in MCF-7 breast cancer cells and enhances gefitinib-induced tumor cell inhibitionCancer Biol Ther20098151470147719483462
  • SavageKLambrosMBRobertsonDCaveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysisClin Cancer Res20071319010117200343