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Original Research

The prognostic impact of K-RAS mutations in adult acute myeloid leukemia patients treated with high-dose cytarabine

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Pages 115-121 | Published online: 15 Jul 2011

References

  • ChanITKatoJLWilliamslRConditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative diseaseJ Clin Invest2004113452853814966562
  • DownwardJTargeting RAS signaling pathways in cancer therapyNat Rev Cancer200331112212509763
  • HaferlachTMolecular genetic pathways as therapeutic targets in acute myeloid leukemiaHematology Am Soc Hematol Educ Program200840041119074117
  • ChangFSteelmanLSLeeJTSignal transduction mediated by the Ras/Raf, MEK, and ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic interventionLeukemia20031771263129312835716
  • IllmerTThiedeCFredersdorfAActivation of the RAS pathway for a chemosensitive phenotype of acute myelogenous leukemia blastsClin Cancer Res20051193217322415867216
  • BarlettaEGoriniGVineisPRAS gene mutations in patients with acute myeloid leukemia and exposure to chemical agentsCarcinogenesis200425574975514688017
  • BenantiJAGallowayDAThe normal response to RAS: senescence or transformation?Cell Cycle20043671571715153805
  • MilellaMKomblauSMEstrovZTherapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemiaJ Clin Invest2001108685185911560954
  • RodenhuisSBoerrigterLTopBMutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective studyJ Clin Oncol19971512852918996154
  • KiyoiHNaoeTNakanoYPrognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemiaBlood19999393074308010216104
  • StirewaltDLKopeckyKJMeshinchiSFLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemiaBlood200197113589359511369655
  • SeabrightMA rapid banding technique for human chromosomesLancet1971277319719724107917
  • CoghlanDWMorleyAAMatthewsJPBishopJFThe incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemiaLeukemia1994810168216877934163
  • TynerJWErichsonHDeiningerMWHigh-throughput sequencing screen reveals novel transforming RAS mutations in myeloid leukemia patientsBlood200911381749175519075190
  • RitterMKimTDLisskePThiedeCSchaichMNeubauerAPrognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemiaHaematologica200489111397139915531466
  • NeubauerADodgeRKGeorgeSLPrognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemiaBlood1994836160316118123851
  • BowenDTFrewMEHillsRRAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 yearsBlood200510662113211915951308
  • ValkPJBowenDTFrewMEGoodeveACLowenbergBReillyJTSecond hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16)Haematologica200489110614754614
  • SchaichMRitterMIllmerTMutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukemiaBr J Haematol2001112230030711167822
  • MeshinchiSStirewaltDLAlonzoTAActivating mutations of RTK/RAS signal transduction pathway in pediatric acute myeloid leukemiaBlood200310241474147912702504
  • BraunBSTuvesonDAKongNSomatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorderProc Natl Acad Sci U S A2004101259760214699048
  • BacherUHaferlachTSchochCKernWSchnittgerSImplications of NRAS mutations in AML: a study of 2502 patientsBlood2006107103847385316434492
  • KooHMMonksAMikheevAEnhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenesCancer Res19965622521152168912859
  • KooHMMcWilliamsMJAlvordWGVande WoudeGFRAS oncogene-induced sensitization to 1-beta-D-arabinofuranosylcytosineCancer Res199959246057606210626790
  • Di MiccoRFumagalliMCicaleseAOncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationNature2006444711963864217136094
  • KnaufJAOuyangBKnudsenESFukasawaKBabcockGFaginJAOncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpointsJ Biol Chem200628173800380916316983
  • FikarisAJLewisAEAbulaitiATsygankovaOMMeinkothJLRas triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signalingJ Biol Chem200628146347593476716968694