Advanced search
Publication Cover
OncoTargets and Therapy Volume 10, 2017 - Issue
Submit an article Journal homepage
97
Views
20
CrossRef citations to date
0
Altmetric
Original Research

Inhibition of PCSK9 protects against radiation-induced damage of prostate cancer cells

Si-Shun GanDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of China
,
Jian-Qing YeDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of China
,
Lei WangDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of China
,
Fa-Jun QuDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of China
,
Chuan-Min ChuDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of China
,
Yi-Jun TianDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of China
,
Wei YangDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of China
&
Xin-Gang CuiDepartment of Urinary Surgery of Third Affiliated Hospital, Second Military Medical University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 2139-2146 | Published online: 12 Apr 2017

References

  • Cancer Research [webpage on the Internet]Prostate Cancer Statistics, Cancer Stat2011 Available from: http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/prostate-cancer#heading-ZeroAccessed March 9, 2017
  • FerlayJParkinDMSteliarova-FoucherEEstimates of cancer incidence and mortality in Europe in 2008Eur J Cancer201046476578120116997
  • SriprasadSFeneleyMRThompsonPMHistory of prostate cancer treatmentSurg Oncol200918318511891
  • BaumanGRumbleRBChenJLoblawAWardePMembers of the IMRT Indications Expert PanelIntensity-modulated radiotherapy in the treatment of prostate cancerClin Oncol (R Coll Radiol)201224746147322673744
  • LagendijkJJRaaymakersBWvan VulpenMThe magnetic resonance imaging-linac systemSemin Radiat Oncol201424320720924931095
  • KeallPJBartonMCrozierSAustralian MRI-Linac Program, including contributors from Ingham Institute, Illawarra Cancer Care Centre, Liverpool Hospital, Stanford University, Universities of Newcastle, Queensland, Sydney, Western Sydney, and WollongongThe Australian magnetic resonance imaging-linac programSemin Radiat Oncol201424320320624931094
  • ShaoYHDemissieKShihWContemporary risk profile of prostate cancer in the United StatesJ Natl Cancer Inst2009101181280128319713548
  • SeidahNGBenjannetSWickhamLThe secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiationProc Natl Acad Sci U S A2003100392893312552133
  • SchmidliRPCSK9 inhibitors – clinical applicationsAust Prescr201639516817027789928
  • PageMMWattsGFPCSK9 inhibitors – mechanisms of actionAust Prescr201639516416727789927
  • HeZMangalaLSTheriotCARohdeLHWuHZhangYCell killing and radiosensitizing effects of atorvastatin in PC3 prostate cancer cellsJ Radiat Res201253222523322510595
  • OhDSKoontzBFreedlandSJStatin use is associated with decreased prostate cancer recurrence in men treated with brachytherapyWorld J Urol2015331939724671610
  • SunXEssalmaniRDayRKhatibAMSeidahNGPratAProprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liverNeoplasia201214121122113123308045
  • TangZJiangLPengJPCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-κB activation in THP-1-derived macrophagesInt J Mol Med201230493193822825241
  • LanHPangLSmithMMProprotein convertase subtilisin/kexin type 9 (PCSK9) affects gene expression pathways beyond cholesterol metabolism in liver cellsJ Cell Physiol2010224127328120333646
  • MbikayMSiroisFMayneJPCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalitiesFEBS Lett2010584470170620026049
  • HortonJDCohenJCHobbsHHMolecular biology of PCSK9: its role in LDL metabolismTrends Biochem Sci2007322717717215125
  • PageMMStefanuttiCSnidermanARecent advances in the understanding and care of familial hypercholesterolaemia: significance of the biology and therapeutic regulation of proprotein convertase subtilisin/kexin type 9Clin Sci (Lond)20151291637925881720
  • ZaidARoubtsovaAEssalmaniRProprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regenerationHepatology200848264665418666258
  • RanheimTMattingsdalMLindvallJMGenome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9J Cell Physiol2008217245946718570182
  • PiaoMXBaiJWZhangPFZhangYZPCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathwaysInt J Clin Exp Pathol2015832787279426045785
  • ThompsonCBApoptosis in the pathogenesis and treatment of diseaseScience19952675203145614627878464
  • MohamadNGutiérrezANúñezMMitochondrial apoptotic pathwaysBiocell200529214916116187493
  • CotterTGApoptosis and cancer: the genesis of a research fieldNat Rev Cancer20099750150719550425
  • AdamsJMCorySThe Bcl-2 apoptotic switch in cancer development and therapyOncogene20072691324133717322918
  • PetterssonFDalgleishAGBissonnetteRPColstonKWRetinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/BaxBr J Cancer200287555556112189556

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.