Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy

Marianela RobainasDepartment of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA

Rafael OtanoDepartment of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA

Stephen BuenoDepartment of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USA

Sihem Ait-OudhiaDepartment of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, USACorrespondence[email protected]

Pages 1803-1807 | Published online: 23 Mar 2017

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LorinSHamaiAMehrpourMCodognoPAutophagy regulation and its role in cancerSemin Cancer Biol201323536137923811268
PubMed Web of Science ®Google Scholar
KondoYKanzawaTSawayaRKondoSThe role of autophagy in cancer development and response to therapyNat Rev Cancer20055972673416148885
PubMed Web of Science ®Google Scholar
LiangXHJacksonSSeamanMInduction of autophagy and inhibition of tumorigenesis by beclin 1Nature1999402676267267610604474
PubMed Web of Science ®Google Scholar
ChenNKarantza-WadsworthVRole and regulation of autophagy in cancerBiochim Biophys Acta2009179391516152319167434
PubMed Web of Science ®Google Scholar
AmaravadiRKLippincott-SchwartzJYinXMPrinciples and current strategies for targeting autophagy for cancer treatmentClin Cancer Res201117465466621325294
PubMed Web of Science ®Google Scholar
BrownCTargeted therapy: an elusive cancer targetNature20165377620S106S10827626779
PubMedGoogle Scholar
BlankCBrownIPetersonACPD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+T cellsCancer Res20046431140114514871849
PubMed Web of Science ®Google Scholar
IshidaMIwaiYTanakaYDifferential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissuesImmunol Lett2002841576212161284
PubMed Web of Science ®Google Scholar
ChenDSIrvingBAHodiFSMolecular pathways: next-generation immunotherapy – inhibiting programmed death-ligand 1 and programmed death-1Clin Cancer Res201218246580658723087408
PubMed Web of Science ®Google Scholar
ChenDSMellmanIOncology meets immunology: the cancer-immunity cycleImmunity201339111023890059
PubMed Web of Science ®Google Scholar
HanahanDWeinbergRAHallmarks of cancer: the next generationCell2011144564667421376230
PubMed Web of Science ®Google Scholar
ClarkCAGuptaHBSareddyGTumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis, and autophagy in ovarian cancer and melanomaCancer Res201676236964697427671674
PubMed Web of Science ®Google Scholar
ParryRVCTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanismsMol Cell Biol200525219543955316227604
PubMed Web of Science ®Google Scholar
MorunoFPérez-JiménezEKnechtERegulation of autophagy by glucose in mammalian cellsCells20121337239524710481
PubMedGoogle Scholar
LuBFinnOJT-cell death and cancer immune toleranceCell Death Differ2008151707918007660
PubMedGoogle Scholar
FallarinoFGrohmannUVaccaCT cell apoptosis by tryptophan catabolismCell Death Differ20029101069107712232795
PubMed Web of Science ®Google Scholar
ViryEPaggettiJBaginskaJAutophagy: an adaptive metabolic response to stress shaping the antitumor immunityBiochem Pharmacol2014921314225044308
PubMed Web of Science ®Google Scholar
RaoSTortolaLPerlotTA dual role for autophagy in a murine model of lung cancerNat Commun20145305624445999
PubMed Web of Science ®Google Scholar
YangSImamuraYJenkinsRWAutophagy inhibition dysregulates TBK1 signaling and promotes pancreatic inflammationCancer Immunol Res20164652053027068336
PubMed Web of Science ®Google Scholar
StarobinetsHYeJBrozMAntitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatmentJ Clin Invest2016126124417442927775547
PubMed Web of Science ®Google Scholar
PengWChenJQLiuCLoss of PTEN promotes resistance to T cell-mediated immunotherapyCancer Discov20166220221626645196
PubMed Web of Science ®Google Scholar

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