Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer

References

• TorreLABrayFSiegelRLFerlayJLortet-TieulentJJemalAGlobal cancer statistics, 2012CA Cancer J Clin20156528710825651787
   PubMed Web of Science ®Google Scholar
• JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
   PubMed Web of Science ®Google Scholar
• LouDYFongLNeoadjuvant therapy for localized prostate cancer: Examining mechanism of action and efficacy within the tumorUrol Oncol201634418219224495446
   PubMed Web of Science ®Google Scholar
• GrossmannMCheungASZajacJDAndrogens and prostate cancer; pathogenesis and deprivation therapyBest Pract Res Clin Endocrinol Metab201327460361624054933
   PubMedGoogle Scholar
• WangLTangHThayanithyVGene networks and microRNAs implicated in aggressive prostate cancerCancer Res200969249490949719996289
   PubMed Web of Science ®Google Scholar
• VainioPMpindiJPKohonenPHigh-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancerPLoS One201276e3980122761906
   PubMed Web of Science ®Google Scholar
• HeidebrechtHJBuckFSteinmannJSprengerRWackerHHParwareschRp100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and MBlood19979012262339207457
   PubMed Web of Science ®Google Scholar
• GrussOJVernosIThe mechanism of spindle assembly: functions of Ran and its target TPX2J Cell Biol2004166794995515452138
   PubMed Web of Science ®Google Scholar
• BrunetSDumontJLeeKWMeiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytesPLoS One2008310e333818833336
   PubMedGoogle Scholar
• TanakaKHirotaTChromosomal instability: A common feature and a therapeutic target of cancerBiochim Biophys Acta201618661647527345585
   PubMed Web of Science ®Google Scholar
• HanahanDWeinbergRAHallmarks of cancer: the next generationCell2011144564667421376230
   PubMed Web of Science ®Google Scholar
• WeaverBAClevelandDWDoes aneuploidy cause cancer?Curr Opin Cell Biol200618665866717046232
   PubMed Web of Science ®Google Scholar
• TanakaKHirotaTChromosome segregation machinery and cancerCancer Sci200910071158116519432891
   PubMedGoogle Scholar
• DuijfPHBenezraRThe cancer biology of whole-chromosome instabilityOncogene201332404727473623318433
   PubMed Web of Science ®Google Scholar
• JanssenAMedemaRHGenetic instability: tipping the balanceOncogene201332384459447023246960
   PubMedGoogle Scholar
• McGranahanNBurrellRAEndesfelderDNovelliMRSwantonCCancer chromosomal instability: therapeutic and diagnostic challengesEMBO Rep201213652853822595889
   PubMed Web of Science ®Google Scholar
• SilkADZasadilLMHollandAJVitreBClevelandDWWeaverBAChromosome missegregation rate predicts whether aneuploidy will promote or suppress tumorsProc Natl Acad Sci U S A201311044E4134E414124133140
   PubMed Web of Science ®Google Scholar
• JanssenAKopsGJMedemaRHElevating the frequency of chromosome mis-segregation as a strategy to kill tumor cellsProc Natl Acad Sci U S A200910645191081911319855003
   PubMed Web of Science ®Google Scholar
• SchimmerADThomasMPHurrenRIdentification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptorsCancer Res20066642367237516489043
   PubMedGoogle Scholar
• Wilkie-GranthamRPMatsuzawaSReedJCNovel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP proteinJ Biol Chem201328818127771279023519470
   PubMed Web of Science ®Google Scholar
• PanHWOuYHPengSYOverexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinomaCancer200398111912712833464
   PubMed Web of Science ®Google Scholar
• PanHWChouHYLiuSHPengSYLiuCLHsuHCRole of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinomaCell Cycle20065222676268717106265
   PubMed Web of Science ®Google Scholar
• LeeYCPanHWPengSYOverexpression of tumour-associated trypsin inhibitor (TATI) enhances tumour growth and is associated with portal vein invasion, early recurrence and a stage-independent prognostic factor of hepatocellular carcinomaEur J Cancer200743473674417267202
   PubMed Web of Science ®Google Scholar
• LinSYPanHWLiuSHASPM is a novel marker for vascular invasion, early recurrence, and poor prognosis of hepatocellular carcinomaClin Cancer Res200814154814482018676753
   PubMed Web of Science ®Google Scholar
• LeeAJEndesfelderDRowanAJChromosomal instability confers intrinsic multidrug resistanceCancer Res20117151858187021363922
   PubMed Web of Science ®Google Scholar
• GalimbertiFThompsonSLRaviSComptonDADmitrovskyEAnaphase catastrophe is a target for cancer therapyClin Cancer Res20111761218122221288923
   PubMed Web of Science ®Google Scholar
• HollandAJClevelandDWLosing balance: the origin and impact of aneuploidy in cancerEMBO Rep201213650151422565320
   PubMedGoogle Scholar
• NorppaHFalckGCWhat do human micronuclei contain?Mutagenesis200318322123312714687
   PubMed Web of Science ®Google Scholar
• HuangXHatcherRYorkJPZhangPSecurin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cellsMol Biol Cell200516104725473216030258
   PubMedGoogle Scholar
• Lara-GonzalezPWesthorpeFGTaylorSSThe spindle assembly checkpointCurr Biol20122222R966R98023174302
   PubMed Web of Science ®Google Scholar
• ShindoNKumadaKHirotaTSeparase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibitionDev Cell201223111212322814604
   PubMedGoogle Scholar
• MeadowsJCMillarJBSharpening the anaphase switchBiochem Soc Trans2015431192225619242
   PubMed Web of Science ®Google Scholar
• KumariGUlrichTKrauseMFinkernagelFGaubatzSInduction of p21CIP1 protein and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen speciesJ Biol Chem201428923160721608424782314
   PubMed Web of Science ®Google Scholar
• RamakrishnaMWilliamsLHBoyleSEIdentification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysisPLoS One201054e998320386695
   PubMedGoogle Scholar
• SatowRShitashigeMKanaiYCombined functional genome survey of therapeutic targets for hepatocellular carcinomaClin Cancer Res20101692518252820388846
   PubMed Web of Science ®Google Scholar
• WarnerSLStephensBJNwokenkwoSValidation of TPX2 as a potential therapeutic target in pancreatic cancer cellsClin Cancer Res200915216519652819861455
   PubMed Web of Science ®Google Scholar
• HsuCWChenYCSuHHTargeting TPX2 suppresses the tumorigenesis of hepatocellular carcinoma cells resulting in arrested mitotic phase progression and increased genomic instabilityJ Cancer2017881378139428638452
   PubMed Web of Science ®Google Scholar