References
- KamisawaTWoodLDItoiTTakaoriKPancreatic cancerLancet201638810039738526830752
- SiegelRLMillerKDJemalACancer statistics, 2015CA Cancer J Clin201565152925559415
- SimardEPWardEMSiegelRJemalACancers with increasing incidence trends in the United States: 1999 through 2008CA Cancer J Clin201262211812822281605
- HavsteenBHThe biochemistry and medical significance of the flavonoidsPharmacol Ther2002962–36720212453566
- OkamotoTSafety of quercetin for clinical application (Review)Int J Mol Med200516227527816012761
- NwaeburuCCAbukiwanAZhaoZHerrIQuercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancerMol Cancer20171612328137273
- ShenXSiYWangZGuoYZhangXQuercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signalingInt J Mol Med201638261962627278820
- RanganathanSHalagowderDSivasithambaramNDQuercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cellsPLoS One20151010e014137026491966
- BaruahMMKhandwekarAPSharmaNQuercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastasesTumour Biol20163710140251403427495232
- TangSNFuJNallDRodovaMShankarSSrivastavaRKInhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristicsInt J Cancer20121311304021796625
- NietoMAHuangRYJacksonRAThieryJPEMT: 2016Cell20161661214527368099
- ThieryJPEpithelial-mesenchymal transitions in tumour progressionNat Rev Cancer20022644245412189386
- AgiostratidouGHulitJPhillipsGRHazanRBDifferential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progressionJ Mammary Gland Biol Neoplasia2007122–312713317564818
- WongIYJavaidSWongEACollective and individual migration following the epithelial-mesenchymal transitionNat Mater201413111063107125129619
- YinYGrabowskaAMClarkePAHelicobacter pylori potentiates epithelial: mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrixmetalloproteinase-7Gut20105981037104520584780
- LiYYangJDaiCWuCLiuYRole for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesisJ Clin Invest2003112450351612925691
- OrlichenkoLSRadiskyDCMatrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor developmentClin Exp Metastasis200825659360018286378
- NagaseHVisseRMurphyGStructure and function of matrix metaloproteinases and TIMPsCardiovasc Res200669356257316405877
- SansonePBrombergJTargeting the interleukin-6/Jak/stat pathway in human malignanciesJ Clin Oncol20123091005101422355058
- YuHLeeHHerrmannABuettnerRJoveRRevisiting STAT3 signaling in cancer: new and unexpected biological functionsNat Rev Cancer2014141173674625342631
- LimSJLiWXPhospho- and Unphospho-STATs in Signal Transduction and Gene Regulation (STAT)Encyclopedia of Signaling MoleculesSpringerNew York201213771380
- YuHJoveRThe STATs of cancer – new molecular targets come of ageNat Rev Cancer2004429710514964307
- SongLTurksonJKarrasJGJoveRHauraEBActivation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cellsOncogene200322274150416512833138
- HeinrichPCBehrmannIHaanSHermannsHMMüller-NewenGSchaperFPrinciples of interleukin (IL)-6-type cytokine signaling and its regulationBiochem J2003374Pt 112012773095
- RokavecMÖnerMGLiHIL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasisJ Clin Invest201412441853186724642471
- WuYSChungIWongWFMasamuneASimMSLooiCYParacrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cellsBiochim Biophys Acta20171861229630627750041
- WangKLiuRLiJQuercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signalingAutophagy20117996697821610320
- BaruahMMKhandwekarAPSharmaNQuercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastasesTumour Biol20163710140251403427495232
- RhimADMirekETAielloNMEMT and dissemination precede pancreatic tumor formationCell20121481–234936122265420
- LiYVandenBoomTGKongDUp-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsCancer Res200969166704671219654291
- ArumugamTRamachandranVFournierKFEpithelial to mesenchymal transition contributes to drug resistance in pancreatic cancerCancer Res200969145820582819584296
- CanoCEMotooYIovannaJLEpithelial-to-mesenchymal transition in pancreatic adenocarcinomaScientificWorldJournal2010101947195720890584
- BrooksSALomax-BrowneHJCarterTMKinchCEHallDMMolecular interactions in cancer cell metastasisActa Histochem2010112132519162308
- BloomstonMZervosEERosemurgyAS2ndMatrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trialsAnn Surg Oncol20029766867412167581
- ZhangCHGuoFLXuGLJiaWDGeYSSTAT3 activation mediates epithelial-to-mesenchymal transition in human hepatocellular carcinoma cellsHepatogastroenterology2014611321082108926158169
- ZhangCGuoFXuGMaJShaoFSTAT3 cooperates with Twist to mediate epithelial-mesenchymal transition in human hepatocellular carcinoma cellsOncol Rep20153341872188225653024
- FukudaAWangSCMorrisJP4thStat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progressionCancer Cell201119444145521481787
- OrgazJLPandyaPDalmeidaRDiverse matrix metalloproteinase functions regulate cancer amoeboid migrationNat Commun20145425524963846
- XieTXHuangFJAldapeKDActivation of stat3 in human melanoma promotes brain metastasisCancer Res20066663188319616540670
- YangJChatterjee-KishoreMStaugaitisSMNovel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulationCancer Res200565393994715705894
- HolmerRGoumasFAWaetzigGHRose-JohnSKalthoffHInterleukin-6: a villain in the drama of pancreatic cancer development and progressionHepatobiliary Pancreat Dis Int201413437138025100121
- JonesSAHoriuchiSTopleyNYamamotoNFullerGMThe soluble interleukin 6 receptor: mechanisms of production and implications in diseaseFASEB J2001151435811149892
- LesinaMKurkowskiMULudesKStat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancerCancer Cell201119445646921481788
- ItoYSasakiYHorimotoMActivation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinomaHepatology19982749519589537433
- GironellaMCalvoCFernandezAReg3β deficiency impairs pancreatic tumor growth by skewing macrophage polarizationCancer Res201373185682569423867474
- KujawskiMKortylewskiMLeeHHermannAKayHYuHStat3 mediates myeloid cell-dependent tumor angiogenesis in miceJ Clin Invest2008118103367337718776941