Recent progress on the effects of microRNAs and natural products on tumor epithelial–mesenchymal transition

References

• WendtMKAllingtonTMSchiemannWPMechanisms of the epithelial-mesenchymal transition by TGF-betaFuture Oncol2009581145116819852727
   PubMedGoogle Scholar
• BediUMishraVKWasilewskiDScheelCJohnsenSAEpigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancerOncotarget2014582016202924840099
   PubMedGoogle Scholar
• SubramanyamDBlellochRFrom microRNAs to targets: pathway discovery in cell fate transitionsCurr Opin Genet Dev201121449850321636265
   PubMedGoogle Scholar
• LamouilleSSubramanyamDBlellochRDerynckRRegulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAsCurr Opin Cell Biol201325220020723434068
   PubMed Web of Science ®Google Scholar
• CraggGMNewmanDJNatural products: a continuing source of novel drug leadsBiochim Biophys Acta2013183063670369523428572
   PubMed Web of Science ®Google Scholar
• LuoMBrooksMWichaMSEpithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistanceCurr Pharm Des201521101301131025506895
   PubMedGoogle Scholar
• NantajitDLinDLiJJThe network of epithelial-mesenchymal transition: potential new targets for tumor resistanceJ Cancer Res Clin Oncol2015141101697171325270087
   PubMedGoogle Scholar
• TsaiJHYangJEpithelial-mesenchymal plasticity in carcinoma metastasisGenes Dev201327202192220624142872
   PubMed Web of Science ®Google Scholar
• JollyMKBoaretoMHuangBImplications of the hybrid epithelial/mesenchymal phenotype in metastasisFront Oncol2015515526258068
   PubMed Web of Science ®Google Scholar
• LiuHRenGWangTAberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transitionCarcinogenesis201536445946825750173
   PubMed Web of Science ®Google Scholar
• WaldmeierLMeyer-SchallerNDiepenbruckMChristoforiGPy2T murine breast cancer cells, a versatile model of TGFbeta-induced EMT in vitro and in vivoPLoS One2012711e4865123144919
   PubMedGoogle Scholar
• DrakeJMStrohbehnGBairTBMorelandJGHenryMDZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cellsMol Biol Cell20092082207221719225155
   PubMedGoogle Scholar
• TanTZMiowQHMikiYEpithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patientsEMBO Mol Med20146101279129325214461
   PubMed Web of Science ®Google Scholar
• FischerKRDurransALeeSEpithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistanceNature2015527757947247626560033
   PubMed Web of Science ®Google Scholar
• ZhengXCarstensJLKimJEpithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancerNature2015527757952553026560028
   PubMed Web of Science ®Google Scholar
• ObaSMizutaniTSuzukiEA useful method of identifying of miRNAs which can down-regulate Zeb-2BMC Res Notes2013647024245745
   PubMedGoogle Scholar
• LuMJollyMKLevineHOnuchicJNBen-JacobEMicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determinationProc Natl Acad Sci U S A201311045181441814924154725
   PubMedGoogle Scholar
• LinCPChoiYJHicksGGHeLThe emerging functions of the p53-miRNA network in stem cell biologyCell Cycle201211112063207222580472
   PubMed Web of Science ®Google Scholar
• ChangCJChaoCHXiaWp53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAsNat Cell Biol201113331732321336307
   PubMed Web of Science ®Google Scholar
• JonesRWatsonKBruceANersesianSKitzJMooreheadRRe-expression of miR-200c suppresses proliferation, colony formation and in vivo tumor growth of murine claudin-low mammary tumor cellsOncotarget2017814237272374928423599
   PubMedGoogle Scholar
• KnoufECGargKArroyoJDAn integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcriptionNucleic Acids Res201240249951021917857
   PubMed Web of Science ®Google Scholar
• SuhSOChenYZamanMSMicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancerCarcinogenesis201132577277821349819
   PubMed Web of Science ®Google Scholar
• SekhonKBucayNMajidSDahiyaRSainiSMicroRNAs and epithelial-mesenchymal transition in prostate cancerOncotarget2016741675976761127588490
   PubMedGoogle Scholar
• KimTVeroneseAPichiorriFp53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2J Exp Med2011208587588321518799
   PubMed Web of Science ®Google Scholar
• PichiorriFSuhSSRocciADownregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma developmentCancer Cell201018436738120951946
   PubMed Web of Science ®Google Scholar
• JinYChenDCabayRJWangACroweDLZhouXRole of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinomaInt Rev Cell Mol Biol201330335738523445815
   PubMedGoogle Scholar
• RhodesLVMartinECSegarHCDual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancerOncotarget2015618166381665226062653
   PubMedGoogle Scholar
• KongXDingXLiXGaoSYangQ53BP1 suppresses epithelial-mesenchymal transition by downregulating ZEB1 through microRNA-200b/429 in breast cancerCancer Sci2015106898298926011542
   PubMedGoogle Scholar
• ChoiSKKimHSJinTHwangEHJungMMoonWKOverexpression of the miR-141/200c cluster promotes the migratory and invasive ability of triple-negative breast cancer cells through the activation of the FAK and PI3K/AKT signaling pathways by secreting VEGF-ABMC Cancer20161657027484639
   PubMed Web of Science ®Google Scholar
• YeZBMaGZhaoYHmiR-429 inhibits migration and invasion of breast cancer cells in vitroInt J Oncol201546253153825405387
   PubMed Web of Science ®Google Scholar
• LeeCGMcCarthySGruidlMTimmeCYeatmanTJMicroRNA-147 induces a mesenchymal-to-epithelial transition (MET) and reverses EGFR inhibitor resistancePLoS One201491e8459724454732
   PubMedGoogle Scholar
• KunduSTByersLAPengDHThe miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancersOncogene201635217318625798833
   PubMedGoogle Scholar
• NaritaMShimuraENagasawaAChronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200cPLoS One2017122e017211528225782
   PubMedGoogle Scholar
• ZhangNLiuYWangYZhaoMTuLLuoFDecitabine reverses TGF-beta1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axisDrug Des Devel Ther201711969983
   PubMed Web of Science ®Google Scholar
• ChenDHuangJZhangKMicroRNA-451 induces epithelial-mesenchymal transition in docetaxel-resistant lung adenocarcinoma cells by targeting proto-oncogene c-MycEur J Cancer201450173050306725310895
   PubMed Web of Science ®Google Scholar
• SassSDietmannSBurkUCMicroRNAs coordinately regulate protein complexesBMC Syst Biol2011513621867514
   PubMedGoogle Scholar
• LuYLuJLiXMiR-200a inhibits epithelial-mesenchymal transition of pancreatic cancer stem cellBMC Cancer2014148524521357
   PubMedGoogle Scholar
• HarazonoYMuramatsuTEndoHmiR-655 is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2PLoS One201385e6275723690952
   PubMedGoogle Scholar
• LiuWQiLLvHMiRNA-141 and miRNA-200b are closely related to invasive ability and considered as decision-making biomarkers for the extent of PLND during cystectomyBMC Cancer2015159225884322
   PubMed Web of Science ®Google Scholar
• Diaz-LopezAMoreno-BuenoGCanoARole of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectivesCancer Manag Res2014620521624812525
   PubMed Web of Science ®Google Scholar
• LiangJLiYDanielsGLEF1 targeting EMT in prostate cancer invasion is regulated by miR-34aMol Cancer Res201513468168825587085
   PubMedGoogle Scholar
• KimNHKimHSLiXYA p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transitionJ Cell Biol2011195341743322024162
   PubMed Web of Science ®Google Scholar
• HahnSJackstadtRSiemensHHuntenSHermekingHSNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transitionEMBO J201332233079309524185900
   PubMed Web of Science ®Google Scholar
• DongCWuYYaoJG9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancerJ Clin Invest201212241469148622406531
   PubMed Web of Science ®Google Scholar
• LiuSYeDGuoWG9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinomaOncotarget2015696887690125749385
   PubMedGoogle Scholar
• HuangJYZhangKChenDQMicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinomaOncotarget2015621186131863026164082
   PubMedGoogle Scholar
• ChenSPLiuBXXuJMiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targetsBMC Cancer20151570626471185
   PubMedGoogle Scholar
• YanMDYaoCJChowJMFucoidan elevates microRNA-29b to regulate DNMT3B-MTSS1 axis and inhibit EMT in human hepatocellular carcinoma cellsMar Drugs201513106099611626404322
   PubMedGoogle Scholar
• ChenKJHouYWangKReexpression of Let-7g microRNA inhibits the proliferation and migration via K-Ras/HMGA2/snail axis in hepatocellular carcinomaBiomed Res Int2014201474241724724096
   PubMedGoogle Scholar
• ChanSHWangLHRegulation of cancer metastasis by microRNAsJ Biomed Sci201522925614041
   PubMed Web of Science ®Google Scholar
• SuhSSYooJYCuiRFHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAsPLoS Genet20141010e100465225340791
   PubMed Web of Science ®Google Scholar
• ZuoQFCaoLYYuTMicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and SnailCell Death Dis20156e200026610210
   PubMedGoogle Scholar
• RuPSteeleRNewhallPPhillipsNJTothKRayRBmiRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signalingMol Cancer Ther20121151166117322402125
   PubMed Web of Science ®Google Scholar
• YuJXieFBaoXChenWXuQmiR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancerMol Cancer20141312124885626
   PubMed Web of Science ®Google Scholar
• YuYZhaoYSunXHDown-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancerOncotarget2015633344233443626460733
   PubMedGoogle Scholar
• LinYLiuAYFanCMicroRNA-33b inhibits breast cancer metastasis by targeting HMGA2, SALL4 and Twist1Sci Rep20155999525919570
   PubMed Web of Science ®Google Scholar
• XiangXZhuangXJuSmiR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMTOncogene201130313440345321460854
   PubMed Web of Science ®Google Scholar
• WangRLiYHouYThe PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cellsOncotarget2015697000701025760076
   PubMedGoogle Scholar
• ZhaoXWangYDengRmiR186 suppresses prostate cancer progression by targeting Twist1Oncotarget2016722331363315127121312
   PubMedGoogle Scholar
• WenYCLeeWJTanPBy inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancerOncotarget2015625211202113626110567
   PubMedGoogle Scholar
• LiLWuDmiR-32 inhibits proliferation, epithelial-mesenchymal transition, and metastasis by targeting TWIST1 in non-small-cell lung cancer cellsOnco Targets Ther201691489149827042117
   PubMed Web of Science ®Google Scholar
• YangLYangJLiJMircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancerSci Rep201551367726330060
   PubMedGoogle Scholar
• SongYLiJZhuYMicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinomaOncotarget2014522116691168025375090
   PubMedGoogle Scholar
• LuMHHuangCCPanMRChenHHHungWCProspero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9Clin Cancer Res201218236416642523045246
   PubMedGoogle Scholar
• SunZHanQZhouNMicroRNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinomaMol Oncol20137588489423684102
   PubMedGoogle Scholar
• XuMZhuCZhaoXAtypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factorsOncotarget20156297999425460509
   PubMedGoogle Scholar
• ChenDDangBLHuangJZMiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1alpha-TWIST signaling axis in breast cancerOncotarget2015632327013271226196741
   PubMedGoogle Scholar
• KeJZhaoZHongSHRole of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cellsOncotarget2015663709372125686829
   PubMedGoogle Scholar
• SarkarSDubayboHAliSDown-regulation of miR-221 inhibits proliferation of pancreatic cancer cells through up-regulation of PTEN, p27(kip1), p57(kip2), and PUMAAm J Cancer Res20133546547724224124
   PubMed Web of Science ®Google Scholar
• PivaRSpandidosDAGambariRFrom microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment (Review)Int J Oncol201343498599423939688
   PubMed Web of Science ®Google Scholar
• LongHWangZChenJmicroRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu)Oncotarget2015636387053871826462018
   PubMedGoogle Scholar
• SunCCLiSJYuanZPLiDJMicroRNA-346 facilitates cell growth and metastasis, and suppresses cell apoptosis in human non-small cell lung cancer by regulation of XPC/ERK/Snail/E-cadherin pathwayAging (Albany NY)20168102509252427777383
   PubMedGoogle Scholar
• BaoLYanYXuCMicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathwaysCancer Lett2013337222623623684551
   PubMed Web of Science ®Google Scholar
• LiuZJinZYLiuCHXieFLinXSHuangQMicroRNA-21 regulates biological behavior by inducing EMT in human cholangiocarcinomaInt J Clin Exp Pathol2015854684469426191158
   PubMedGoogle Scholar
• CaoJLiuJXuRZhuXLiuLZhaoXMicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cellsMol Med Rep2016131758226572589
   PubMedGoogle Scholar
• CufiSBonaviaRVazquez-MartinASilibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivoSci Rep20133245923963283
   PubMed Web of Science ®Google Scholar
• ChangSChenBWangXWuKSunYLong non-coding RNA XIST regulates PTEN expression by sponging miR-181a and promotes hepatocellular carcinoma progressionBMC Cancer201717124828388883
   PubMedGoogle Scholar
• YadavAKumarBDattaJTeknosTNKumarPIL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathwayMol Cancer Res20119121658166721976712
   PubMed Web of Science ®Google Scholar
• KimHAKooBKChoJHNotch1 counteracts WNT/beta-catenin signaling through chromatin modification in colorectal cancerJ Clin Invest201212293248325922863622
   PubMed Web of Science ®Google Scholar
• XieGKaracaGSwiderska-SynMCross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in miceHepatology20135851801181323703657
   PubMed Web of Science ®Google Scholar
• DoyleAJRedmondEMGillespieDLDifferential expression of Hedgehog/Notch and transforming growth factor-beta in human abdominal aortic aneurysmsJ Vasc Surg201562246447024768363
   PubMedGoogle Scholar
• LiLGrausamKBWangJSonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cellsNat Cell Biol201618441843026999738
   PubMedGoogle Scholar
• SchreckKCTaylorPMarchionniLThe Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistanceClin Cancer Res201016246060607021169257
   PubMed Web of Science ®Google Scholar
• RinguetteRAtkinsMLagaliPSA Notch-Gli2 axis sustains Hedgehog responsiveness of neural progenitors and Muller gliaDev Biol201641118510026795056
   PubMed Web of Science ®Google Scholar
• MinCEddySFSherrDHSonensheinGENF-kappaB and epithelial to mesenchymal transition of cancerJ Cell Biochem2008104373374418253935
   PubMed Web of Science ®Google Scholar
• CarpenterRLLoHWSTAT3 target genes relevant to human cancersCancers (Basel)20146289792524743777
   PubMed Web of Science ®Google Scholar
• JiaoDWangJLuWCurcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancerMol Ther Oncolytics201631601827525306
   PubMed Web of Science ®Google Scholar
• MukherjeeSMazumdarMChakrabortySCurcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/beta-catenin negative feedback loopStem Cell Res Ther20145511625315241
   PubMed Web of Science ®Google Scholar
• Al-HowailHAHakamiHAAl-OtaibiBPAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cellsBMC Cancer20161654027465411
   PubMed Web of Science ®Google Scholar
• BakiriLMacho-MaschlerSCusticIFra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFbeta expressionCell Death Differ201522233635025301070
   PubMed Web of Science ®Google Scholar
• YangSDuJWangZDual mechanism of deltaEF1 expression regulated by bone morphogenetic protein-6 in breast cancerInt J Biochem Cell Biol200941485386118805502
   PubMedGoogle Scholar
• HuangTSLeeSCLinJKSuppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cellsProc Natl Acad Sci U S A19918812529252961905019
   PubMed Web of Science ®Google Scholar
• LiuZLiuJZhaoLCurcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cellsInt J Oncol20175041321132928259934
   PubMed Web of Science ®Google Scholar
• YinDLLiangYJZhengTSEF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinomaSci Rep201663216727571770
   PubMed Web of Science ®Google Scholar
• ZhangPBaiHLiuGMicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2Toxicol Lett2015234315116125725129
   PubMed Web of Science ®Google Scholar
• ZhaoRTinLZhangYEF24 suppresses invasion and migration of hepatocellular carcinoma cells in vitro via inhibiting the phosphorylation of SrcBiomed Res Int20162016856968427999817
   PubMedGoogle Scholar
• SunXDLiuXEHuangDSCurcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathwayOncol Rep20132962401240723563640
   PubMed Web of Science ®Google Scholar
• LiWMaJMaQResveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-kappaB pathwayCurr Med Chem201320334185419423992306
   PubMed Web of Science ®Google Scholar
• AliSAhmadABanerjeeSGemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDFCancer Res20107093606361720388782
   PubMed Web of Science ®Google Scholar
• BaoBAliSBanerjeeSCurcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expressionCancer Res201272133534522108826
   PubMed Web of Science ®Google Scholar
• BaoBAhmadAKongDHypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF, IL-6 and miRNAs that are attenuated by CDFPLoS One201278e4372622952749
   PubMed Web of Science ®Google Scholar
• BaoBAliSKongDAnti-tumor activity of a novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancerPLoS One201163e1785021408027
   PubMed Web of Science ®Google Scholar
• AliSAhmadAAboukameelAIncreased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cellsCancer Lett2012319217318122261338
   PubMed Web of Science ®Google Scholar
• ZhangZChenHXuCCurcumin inhibits tumor epithelial-mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cellsOncol Rep20163552615262326985708
   PubMed Web of Science ®Google Scholar
• TodenSOkugawaYJascurTCurcumin mediates chemo-sensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancerCarcinogenesis201536335536725653233
   PubMed Web of Science ®Google Scholar
• MontgomeryAAdeyeniTSanKHeuertzRMEzekielURCurcumin sensitizes silymarin to exert synergistic anticancer activity in colon cancer cellsJ Cancer20167101250125727390600
   PubMed Web of Science ®Google Scholar
• DuRLiuZHouXFuGAnNWangLTrichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cellsMol Med Rep20161365045505227121018
   PubMedGoogle Scholar
• BaoBWangZAliSNotch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cellsCancer Lett20113071263621463919
   PubMed Web of Science ®Google Scholar
• MaJFangBZengFDown-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cellsOncotarget2015631740174925638153
   PubMedGoogle Scholar
• PhillipCJGiardinaCKBilirBGenistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cellsBMC Cancer20121214522494660
   PubMed Web of Science ®Google Scholar
• LiYKongDAhmadABaoBDysonGSarkarFHEpigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasionEpigenetics20127894094922805767
   PubMed Web of Science ®Google Scholar
• KimYSChoiKCHwangKAGenistein suppressed epithelial-mesenchymal transition and migration efficacies of BG-1 ovarian cancer cells activated by estrogenic chemicals via estrogen receptor pathway and downregulation of TGF-beta signaling pathwayPhytomedicine2015221199399926407941
   PubMed Web of Science ®Google Scholar
• WangYLuPZhangWGEN-27, a newly synthetic isoflavonoid, inhibits the proliferation of colon cancer cells in inflammation microenvironment by suppressing NF-kappaB pathwayMediators Inflamm20162016285304027057094
   PubMedGoogle Scholar
• ChangYCLinCWYuCCResveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expressionOncotarget2016711121371214926934322
   PubMedGoogle Scholar
• ChenMCChangWWKuanYDLinSTHsuHCLeeCHResvera-trol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma modelInnate Immun201218568569322344225
   PubMed Web of Science ®Google Scholar
• ChenJChangHPengX3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathwaySci Rep201662885827345219
   PubMedGoogle Scholar
• VergaraDValenteCMTinelliAResveratrol inhibits the epidermal growth factor-induced epithelial mesenchymal transition in MCF-7 cellsCancer Lett201131011821794976
   PubMed Web of Science ®Google Scholar
• LeoneLMazzettaFMartinelliDKlebsiella pneumoniae is able to trigger epithelial-mesenchymal transition process in cultured airway epithelial cellsPLoS One2016111e014636526812644
   PubMedGoogle Scholar
• HarrisDMBesselinkEHenningSMGoVLHeberDPhytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cellsExp Biol Med (Maywood)2005230855856816118406
   PubMed Web of Science ®Google Scholar
• JiQLiuXHanZResveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-beta1/Smads signaling pathway mediated Snail/E-cadherin expressionBMC Cancer2015159725884904
   PubMed Web of Science ®Google Scholar
• BuhrmannCShayanPPopperBGoelAShakibaeiMSirt1 is required for resveratrol-mediated chemopreventive effects in colorec-tal cancer cellsNutrients20168314526959057
   PubMedGoogle Scholar
• BosuttiAZanconatiFGrassiGDapasBPassamontiSScaggianteBEpigenetic and miRNAs dysregulation in prostate cancer: the role of nutraceuticalsAnticancer Agents Med Chem201616111385140227109021
   PubMedGoogle Scholar
• ZhangPLiHYangBBiological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cellsGenes Cancer201455–615416425061499
   PubMedGoogle Scholar
• KothaASekharamMCilentiLResveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 proteinMol Cancer Ther20065362162916546976
   PubMed Web of Science ®Google Scholar
• YingZLiYWuJLoss of miR-204 expression enhances glioma migration and stem cell-like phenotypeCancer Res201373299099923204229
   PubMed Web of Science ®Google Scholar
• XiangLPWangAYeJHSuppressive effects of tea catechins on breast cancerNutrients201688 pii: E458
   Google Scholar
• OliveiraMRNabaviSFDagliaMRastrelliLNabaviSMEpigallo-catechin gallate and mitochondria-A story of life and deathPharmacol Res2016104708526731017
   PubMed Web of Science ®Google Scholar
• KimJZhangXRieger-ChristKMSuppression of Wnt signaling by the green tea compound (−)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1J Biol Chem200628116108651087516495219
   PubMedGoogle Scholar
• KoHSoYJeonHTGF-beta1-induced epithelial-mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in human A549 lung cancer cellsCancer Lett2013335120521323419524
   PubMed Web of Science ®Google Scholar
• LuLChenJTangHEGCG suppresses ERK5 activation to reverse tobacco smoke-triggered gastric epithelial-mesenchymal transition in BALB/c miceNutrients20168713026950143
   PubMedGoogle Scholar
• TodenSTranHMTovar-CamargoOAOkugawaYGoelAEpigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancerOncotarget2016713161581617126930714
   PubMedGoogle Scholar
• ChenKCChenCYLinCRLuteolin attenuates TGF-beta1- induced epithelial-mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt-NF-kappaB-Snail pathwayLife Sci2013932492493324140887
   PubMedGoogle Scholar
• RuanJSLiuYPZhangLLuteolin reduces the invasive potential of malignant melanoma cells by targeting beta3 integrin and the epithelial-mesenchymal transitionActa Pharmacol Sin201233101325133122983392
   PubMed Web of Science ®Google Scholar
• RuanJZhangLYanLInhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cellsMol Med Rep20126123223822552526
   PubMedGoogle Scholar
• HuangXDaiSDaiJLuteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial-mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cellsOnco Targets Ther201582989300126527884
   PubMed Web of Science ®Google Scholar
• ShuklaSSinhaSKhanSCucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/beta-catenin signaling axisSci Rep201662186026905250
   PubMedGoogle Scholar
• QinYZhaoDZhouHGApigenin inhibits NF-kappaB and snail signaling, EMT and metastasis in human hepatocellular carcinomaOncotarget2016727414214143127203387
   PubMedGoogle Scholar
• VermaRKYuWShrivastavaAShankarSSrivastavaRKα-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) miceSci Rep201663274327624879
   PubMed Web of Science ®Google Scholar
• LinLSunYWangDZhengSZhangJZhengCCelastrol ameliorates ulcerative colitis-related colorectal cancer in mice via suppressing inflammatory responses and epithelial-mesenchymal transitionFront Pharmacol2015632026793111
   PubMed Web of Science ®Google Scholar