74
Views
3
CrossRef citations to date
0
Altmetric
Review

Sipuleucel-T for therapy of asymptomatic or minimally symptomatic, castrate-refractory prostate cancer: an update and perspective among other treatments

, &
Pages 79-96 | Published online: 29 Jun 2011

References

  • National Cancer InstituteCancer of the prostate. SEER Sata Fact Sheets Available at: http://seer.cancer.gov/statfacts/html/prost.htmlAccessed June 3, 2011
  • GuralnikJMLaCroixAZEverettDFAging in the eighties: the prevalence of comorbidity and its association with disabilityAdvance Data17019898 Publication No. PHS 89–1250
  • YancikRCancer burden in the aged: an epidemiologic and demographic overviewCancer1997807127312839317180
  • KattanMWWheelerTMScardinoPTPostoperative nomogram for disease recurrence after radical prostatectomy for prostate cancerJ Clin Oncol19991751499150710334537
  • JemalASiegelRWardECancer statisticsCA Cancer J Clin20106027730020610543
  • PowellIJEpidemiology and pathophysiology of prostate cancer in African-American menJ Urol2007177244444917222606
  • ParisPLKupelianPAHallJMAssociation between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patientsCancer Epidemiol Biomarkers Prev199981090190510548319
  • WiltTJMacDonaldRRutksIShamliyanTATaylorBCKaneRLSystematic review: comparative effectiveness and harms of treatments for clinically localized prostate cancerAnn Intern Med2008148643544818252677
  • ZeliadtSBRamseySDPensonDFWhy do men choose one treatment over another?: a review of patient decision making for localized prostate cancerCancer200610691865187416568450
  • FowlerFJJrMcNaughton CollinsMAlbertsenPCComparison of recommendations by urologists and radiation oncologists for treatment of clinically localized prostate cancerJAMA2000283243217322210866869
  • TolisGAckmanDStellosATumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonistsProc Natl Acad Sci U S A1982795165816626461861
  • KlotzLBoccon-GibodLShoreNDThe efficacy and safety of degarelix: a 12-month, comparative, randomized, open-label, parallel-group phase III study in patients with prostate cancerBJU Int2008102111531153819035858
  • ShoreNDMoulJWCrawfordEProstate-specific antigen (PSA) progression-free survival (PFS): a comparison of degarelix versus leuprolide in patients with prostate cancerJ Clin OncolGenitourinary Cancers Symposium201129Suppl 7 Abstr 12
  • van AndelGKurthKHThe impact of androgen deprivation therapy on health related quality of life in asymptomatic men with lymph node positive prostate cancerEur Urol200344220921412875940
  • WilkeDRParkerCAndonowskiATestosterone and erectile function recovery after radiotherapy and long-term androgen deprivation with luteinizing hormone-releasing hormone agonistsBJU Int200697596396816542340
  • LoblawDAVirgoKSNamRInitial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guidelineJ Clin Oncol200725121596160517404365
  • BalesGTChodakGWA controlled trial of bicalutamide versus castration in patients with advanced prostate cancerUrology199647Suppl 1A38438560677
  • KassoufWTanguaySAprikianAGNilutamide as second line hormone therapy for prostate cancer after androgen ablation failsJ Urol200316951742174412686822
  • WhitakerHCHanrahanSTottyNAndrogen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogensClin Cancer Res200410217392740115534116
  • AkakuraKBruchovskyNGoldenbergSLRenniePSBuckleyARSullivanLDEffects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigenCancer1993719278227907682149
  • Boccon-GibodLHammererPMadersbacherSMottetNPrayer- GalettiTTunnUThe role of intermittent androgen deprivation in prostate cancerBJU Int2007100473874317662079
  • KlotzLHHerrHWMorseMJWhitmoreWFIntermittent endocrine therapy for advanced prostate cancerCancer19865811254625502429759
  • GoldenbergSLBruchovskyNGleaveMEIntermittent androgen suppression in the treatment of prostate cancer: a preliminary reportUrology1995455839844 discussion 44–457538246
  • CrookJMSzumacherEMaloneSHuanSSegalRIntermittent androgen suppression in the management of prostate cancerUrology199953353053410096379
  • KlotzLO’CallaghanCJDingKA phase III randomized trial comparing intermittent versus continuous androgen suppression for patients with PSA progression after radical therapy: NCIC CTG PR.7/SWOG JPR.7/CTSU JPR.7/UK Intercontinental Trial CRUKE/01/013J Clin Oncol201129Suppl 7 Abstr 3
  • TunnUEckartOKienleECan intermittent androgen deprivation be an alternative to continuous androgen withdrawal in patients with PSA relapse? First results of the randomized prospective phase III clinical trial EC 507J Urol2003169Suppl 41481a
  • SmallEJVogelzangNJSecond-line hormonal therapy for advanced prostate cancer: a shifting paradigmJ Clin Oncol19971513823888996165
  • SmallEJHalabiSDawsonNAAntiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583)J Clin Oncol20042261025103315020604
  • NishimuraKNonomuraNYasunagaYLow doses of oral dexamethasone for hormone-refractory prostate carcinomaCancer200089122570257611135218
  • PetrylakDPTangenCMHussainMHDocetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancerN Engl J Med2004351151513152015470214
  • TannockIFde WitRBerryWRDocetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancerN Engl J Med2004351151502151215470213
  • BertholdDRPondGRSobanFdeWitREisenbergerMTannockIFDocetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the TAX 327 studyJ Clin Oncol200826224224518182665
  • BerryWDakhilSModianoMGregurichMAsmarLPhase III study of mitoxantrone plus low dose prednisone versus low dose prednisone alone in patients with asymptomatic hormone refractory prostate cancerJ Urol200216862439244312441935
  • TannockIFOsobaDStocklerMRChemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end pointsJ Clin Oncol1996146175617648656243
  • de BonoJSOudardSOzgurogluMPrednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trialLancet201037697471147115420888992
  • KellyWKHalabiSCarducciMAA randomized, double-blind, placebo-controlled phase III trial comparing docetaxel, prednisone, and placebo with docetaxel, prednisone, and bevacizumab in men with metastatic castration-resistant prostate cancer (mCRPC): survival results of CALGB 90401J Clin Oncol201028Suppl 18LBA4511
  • SternbergCNPetrylakDPSartorOMultinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trialJ Clin Oncol200927325431543819805692
  • ScherHIBeerTMHiganoCSAntitumour activity of MDV3100 in castration-resistant prostate cancer: a phase1–2 studyLancet201037597241437144620398925
  • O’DonnellAJudsonIDowsettMHormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancerBr J Cancer200490122317232515150570
  • PotterGABarrieSEJarmanMNovel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancerJ Med Chem19953813246324717608911
  • AttardGReidAHA’HernRSelective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancerJ Clin Oncol200927233742374819470933
  • DanilaDCMorrisMJde BonoJSPhase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancerJ Clin Oncol20102891496150120159814
  • ReidAHAttardGDanilaDCSignificant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetateJ Clin Oncol20102891489149520159823
  • de BonoJSLogothetisCFizaziKAbiraterone acetate plus low dose prednisone improves overall survival in patients with metastatic castration-resistant prostate cancer who have progressed after docetaxel-based chemotherapy: results of COU-AA-301, a randomized double-blind placebo-controlled Phase III studyAnn Oncol201021LBA5
  • MolinaABelldegrunANovel therapeutic strategies for castration resistant prostate cancer: inhibition of persistent androgen production and androgen receptor mediated signalingJ Urol2011185378779421239012
  • BodeCJGuptaMLJrReiffEAEpothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubulesBiochemistry200241123870387411900528
  • LinAMRosenbergJEWeinbergVKClinical outcome of taxane resistant hormone refractory prostate cancer patients treated with subsequent chemotherapy (ixabepilone (Ix) or mitoxantrone/prednisone (MP))Proc Am Soc Clin Oncol200624Suppl231s
  • DrakeCGAntonarakisESUpdate: immunological strategies for prostate cancerCurr Urol Rep201011320220720425628
  • MoonCParkJCChaeYKYunJHKimSCurrent status of experimental therapeutics for prostate cancerCancer Lett2008266211613418440696
  • WangXYuJSreekumarAAutoantibody signatures in prostate cancerN Engl J Med2005353121224123516177248
  • PalenaCSchlomJVaccines against human carcinomas: strategies to improve antitumor immune responsesJ Biomed Biotechnol2010201038069720300434
  • BanchereauJSteinmanRMDendritic cells and the control of immunityNature199839266732452529521319
  • FishmanMA changing world for DCvax: a PSMA loaded autologous dendritic cell vaccine for prostate cancerExpert Opin Biol Ther20099121565157519916735
  • ZhangHMelamedJWeiPConcordant down-regulation of proto-oncogene PML and major histocompatibility antigen HLA class I expression in high-grade prostate cancerCancer Immun20033212747744
  • SandaMGRestifoNPWalshJCMolecular characterization of defective antigen processing in human prostate cancerJ Natl Cancer Inst19958742802857707419
  • ZhangLGajewskiTFKlineJPD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia modelBlood200911481545155219417208
  • AhmadzadehMJohnsonLAHeemskerkBTumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impairedBlood200911481537154419423728
  • ChappellDBRestifoNPT cell-tumor cell: a fatal interaction?Cancer Immunol Immunother199847265719769114
  • CurtiATrabanelliSSalvestriniVBaccaraniMLemoliRMThe role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematologyBlood2009113112394240119023117
  • FukumuraDKashiwagiSJainRKThe role of nitric oxide in tumour progressionNat Rev Cancer20066752153416794635
  • LahdenrantaJHagendoornJPaderaTPEndothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasisCancer Res20096972801280819318557
  • SmallEJFratesiPReeseDMImmunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cellsJ Clin Oncol200018233894390311099318
  • BanchereauJSteinmanRMDendritic cells and the control of immunityNature199839266732452529521319
  • BurchPABreenJKBucknerJCPriming tissue-specific cellular immunity in a phase I trial of autologous dendritic cells for prostate cancerClin Cancer Res2000662175218210873066
  • HsuFJBenikeCFagnoniFVaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cellsNat Med19962152588564842
  • NestleFOAlijagicSGillietMVaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cellsNat Med1998433283329500607
  • CarballidoEFishmanMSipuleucel-T. Prototype for Development of Anti-tumor VaccinesCurr Oncol Rep201113211211921243538
  • FinnOJCancer vaccines: between the idea and the realityNat Rev Immunol20033863064112974478
  • MillerRAChrispCT cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in miceJ Immunol200216931619162512133992
  • KapasiZFMurali-KrishnaKMcRaeMLAhmedRDefective generation but normal maintenance of memory T cells in old miceEur J Immunol20023261567157312115639
  • SmallEJSchellhammerPFHiganoCSPlacebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancerJ Clin Oncol200624193089309416809734
  • BubleyGJCarducciMDahutWEligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working GroupJ Clin Oncol199917113461346710550143
  • KantoffPWHiganoCSShoreNDSipuleucel-T immunotherapy for castration-resistant prostate cancerN Engl J Med2010363541142220818862
  • Dendreon company: product information Available at: www.provenge.comAccessed June 3, 2011
  • StewartFPdela RosaCPSheikhNACorrelation between product parameters and overall survival in three trials of sipuleucel-T, an autologous active cellular immunotherapy for the treatment of prostate cancerJ Clin Oncol201028Suppl 15 Abst 4552
  • BeerTMRyanCWVennerPMDouble-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT InvestigatorsJ Clin Oncol200725666967417308271
  • HiganoCSSchellhammerPFSmallEJIntegrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancerCancer2009115163670367919536890
  • ZhuMTerasawaHGulleyJEnhanced activation of human T cells via avipox vector-mediated hyperexpression of a triad of costimulatory molecules in human dendritic cellsCancer Res20016193725373411325845
  • GulleyJLToddNDahutWSchlomJArlenPA phase II study of PROSTVAC-VF vaccine, and the role of GM-CSF, in patients (pts) with metastatic androgen insensitive prostate cancer (AIPC)J Clin OncolASCO Annual Meeting Proceedings200523Suppl 16 Pt I Abst 2504
  • SteinWDGulleyJLSchlomJTumor Regression and Growth Rates Determined in Five Intramural NCI Prostate Cancer Trials: The Growth Rate Constant as an Indicator of Therapeutic EfficacyClin Cancer Res201117490791721106727
  • GulleyJLArlenPMTsangKYPilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinomaClin Cancer Res200814103060306918483372
  • SanghaRNorthSL-BLP25: a MUC1-targeted peptide vaccine therapy in prostate cancerExpert Opin Biol Ther20077111723173017961094
  • LubaroffDMKonetyBRLinkBPhase I clinical trial of an adenovirus/prostate-specific antigen vaccine for prostate cancer: safety and immunologic resultsClin Cancer Res200915237375738019920098
  • ChangSSReuterVEHestonWDFive different anti-prostate- specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculatureCancer Res199959133192319810397265
  • BaccalaASerciaLLiJExpression of prostate-specific membrane antigen in tumor-associated neovasculature of renal neoplasmsUrology200770238539017826525
  • Elsässer-BeileUBühlerPWolfPTargeted therapies for prostate cancer against the prostate specific membrane antigenCurr Drug Targets200910211812519199907
  • TjoaBALodgePASalgallerMLBoyntonALMurphyGPDendritic cell-based immunotherapy for prostate cancerCA Cancer J Clin19994921171286511198886
  • WheelerTMZhaoBSonpavdeGAntigen-specific immunity and tumor inflammation after vaccination with BPX-101, a drug-activated dendritic cell vaccine for metastatic castration-resistant prostate cancer (mCRPC)J Clin Oncol201129Suppl 7 Abstr 176
  • SheuBCHsuSMHoHNLienHCHuangSCLinRHA novel role of metalloproteinase in cancer-mediated immunosuppressionCancer Res200161123724211196168
  • SmallEJSacksNNemunaitisJGranulocyte macrophage colony-stimulating factor – secreting allogeneic cellular immunotherapy for hormone-refractory prostate cancerClin Cancer Res200713133883389117606721
  • HiganoCSCormanJMSmithDCPhase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancerCancer2008113597598418646045
  • SimonsJWCarducciMAMikhakBPhase I/II trial of an allogeneic cellular immunotherapy in hormone-naive prostate cancerClin Cancer Res20061211 Pt 13394340116740763
  • Cell Genesys Available at: http://phx.corporate-ir.net/phoenix.zhtml?c=98399&p=irol-newsArticle&ID=1191052Accessed June 3, 2011
  • O’DaySHodiFSMcDermottDFA phase III, randomized, double-blind, multicenter study comparing monotherapy with ipilimumab or gp100 peptide vaccine and the combination in patients with previously treated, unresectable stage III or IV melanomaJ Clin Oncol2010 ASCO Annual Meeting Proceedings201028Suppl 18 Abst 4
  • TarhiniALoEMinorDRReleasing the brake on the immune system: ipilimumab in melanoma and other tumorsCancer Biother Radiopharm201025660161321204754
  • CooperbergMRHinotsuSNamikiMRisk assessment among prostate cancer patients receiving primary androgen deprivation therapyJ Clin Oncol200927264306431319667269
  • ScherHIHalabiSTannockIProstate Cancer Clinical Trials Working GroupDesign and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working GroupJ Clin Oncol20082671148115918309951
  • ChambersJDNeumannPJListening to Provenge – what a costly cancer treatment says about future Medicare policyN Engl J Med2011364181687168921470004
  • PetrylakDPDawsonNAGardnerTPersistence of immunotherapy survival effects of sipuleucel-T and relationship to postrandomization docetaxel use in phase III studiesJ Clin Oncol2010 ASCO Annual Meeting Proceedings201028Suppl 15 Abst 4551