The crossroads of breast cancer progression: insights into the modulation of major signaling pathways

References

• SiegelRLMillerKDJemalACancer statistics, 2017CA Cancer J Clin201767173028055103
   PubMed Web of Science ®Google Scholar
• World Health OrganizationCancer2017 Available from: http://www.who.int/cancer/enAccessed July 14, 2017
   Google Scholar
• ParkinDMBrayFFerlayJPisaniPGlobal cancer statistics, 2002CA Cancer J Clin20055527410815761078
   PubMed Web of Science ®Google Scholar
• DeSantisCMaJBryanLJemalABreast cancer statistics, 2013CA Cancer J Clin2014641526224114568
   PubMed Web of Science ®Google Scholar
• MedinaDThe mammary gland: a unique organ for the study of development and tumorigenesisJ Mammary Gland Biol Neoplasia19961151910887477
   PubMedGoogle Scholar
• SharmaGNDaveRSanadyaJSharmaPSharmaKKVarious types and management of breast cancer: an overviewJ Adv Pharm Technol Res20101210912622247839
   PubMedGoogle Scholar
• MalhotraGKZhaoXBandHBandVHistological, molecular and functional subtypes of breast cancersCancer Biol Ther2010101095596021057215
   PubMed Web of Science ®Google Scholar
• IqbalNIqbalNHuman epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implicationsMol Biol Int2014201485274825276427
   PubMedGoogle Scholar
• DaiXLiTBaiZBreast cancer intrinsic subtype classification, clinical use and future trendsAm J Cancer Res20155102929294326693050
   PubMed Web of Science ®Google Scholar
• CareyLAPerouCMLivasyCARace, breast cancer subtypes, and survival in the Carolina Breast Cancer StudyJAMA2006295212492250216757721
   PubMed Web of Science ®Google Scholar
• PerouCMSørlieTEisenMBMolecular portraits of human breast tumoursNature2000406679774775210963602
   PubMed Web of Science ®Google Scholar
• SørlieTPerouCMTibshiraniRGene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProc Natl Acad Sci U S A20019819108691087411553815
   PubMed Web of Science ®Google Scholar
• PratAParkerJSKarginovaOPhenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancerBreast Cancer Res2010125R6820813035
   PubMed Web of Science ®Google Scholar
• SabatierRFinettiPGuilleAClaudin-low breast cancers: clinical, pathological, molecular and prognostic characterizationMol Cancer20141322825277734
   PubMed Web of Science ®Google Scholar
• DiasKDvorkin-GhevaAHallettRMClaudin-low breast cancer: clinical and pathological characteristicsPLoS One20171210168669
   PubMed Web of Science ®Google Scholar
• McPhersonKSteelCMDixonJMABC of breast diseases – breast cancer: epidemiology, risk factors, and geneticsBMJ2000321726162462810977847
   PubMed Web of Science ®Google Scholar
• MikiYSwensenJShattuck-EidensDA strong candidate for the breast and ovarian cancer susceptibility gene BRCA1Science1994266518266717545954
   PubMed Web of Science ®Google Scholar
• EastonDFordDPetoJInherited susceptibility to breast cancerCancer Surv199318951138013003
   PubMedGoogle Scholar
• GustafssonJAWhat pharmacologists can learn from recent advances in estrogen signallingTrends Pharmacol Sci200324947948512967773
   PubMed Web of Science ®Google Scholar
• ShenMShiHSex hormones and their receptors regulate liver energy homeostasisInt J Endocrinol2015201529427826491440
   PubMed Web of Science ®Google Scholar
• KnowltonAALeeAREstrogen and the cardiovascular systemPharmacol Ther20121351547022484805
   PubMed Web of Science ®Google Scholar
• SanchezRNguyenDRochaWWhiteJHMaderSDiversity in the mechanisms of gene regulation by estrogen receptorsBioessays200224324425411891761
   PubMedGoogle Scholar
• McDonnellDPNorrisJDConnections and regulation of the human estrogen receptorScience200229655731642164412040178
   PubMed Web of Science ®Google Scholar
• BourdeauVDeschênesJMétivierRGenome-wide identification of high-affinity estrogen response elements in human and mouseMol Endocrinol20041861411142715001666
   PubMedGoogle Scholar
• BolgerRWieseTEErvinKNestichSChecovichWRapid screening of environmental chemicals for estrogen receptor binding capacityEnviron Health Perspect199810695515579721254
   PubMed Web of Science ®Google Scholar
• RuffMGangloffMWurtzJMMorasDEstrogen receptor transcription and transactivation: structure-function relationship in DNA- and ligand-binding domains of estrogen receptorsBreast Cancer Res20002535335911250728
   PubMedGoogle Scholar
• McBryanJYoungLLigand-independent signalling through estrogen receptor pathways in breast cancerLarionovAResistance to Aromatase Inhibitors in Breast CancerHeidelbergSpringer2015115144
   Google Scholar
• WeigelNLZhangYLigand-independent activation of steroid hormone receptorsJ Mol Med19987674694799660165
   PubMedGoogle Scholar
• CenniBPicardDLigand-independent activation of steroid receptors: new roles for old playersTrends Endocrinol Metab1999102414610322393
   PubMedGoogle Scholar
• AliSMetzgerDBornertJChambonPModulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B regionEMBO J1993123115311608458328
   PubMed Web of Science ®Google Scholar
• MigliaccioADi DomenicoMCastoriaGTyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cellsEMBO J1996156129213008635462
   PubMedGoogle Scholar
• BunoneGBriandPAMiksicekRJPicardDActivation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylationEMBO J1996159217421838641283
   PubMed Web of Science ®Google Scholar
• BologaCGRevankarCMYoungSMVirtual and biomolecular screening converge on a selective agonist for GPR30Nat Chem Biol20062420721216520733
   PubMed Web of Science ®Google Scholar
• RevankarCMCiminoDFSklarLAArterburnJBProssnitzERA transmembrane intracellular estrogen receptor mediates rapid cell signalingScience200530757151625163015705806
   PubMed Web of Science ®Google Scholar
• TengJWangZYJarrardDFBjorlingDERoles of estrogen receptor α and β in modulating urothelial cell proliferationEndocr Relat Cancer200815135136418310301
   PubMedGoogle Scholar
• LiuMMAlbaneseCAndersonCMOpposing action of estrogen receptors α and β on cyclin D1 gene expressionJ Biol Chem200227727243532436011986316
   PubMed Web of Science ®Google Scholar
• PaechKDifferential ligand activation of estrogen receptors ER and ER at AP1 sitesScience19972775331150815109278514
   PubMed Web of Science ®Google Scholar
• HallJMMcDonnellDPThe estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogensEndocrinology1999140125566557810579320
   PubMed Web of Science ®Google Scholar
• PoolaIKoduriSChatraSClarkeRIdentification of twenty alternatively spliced estrogen receptor alpha mRNAs in breast cancer cell lines and tumors using splice targeted primer approachJ Steroid Biochem Mol Biol200072524925810822014
   PubMedGoogle Scholar
• HerynkMHFuquaSAEstrogen receptor mutations in human diseaseEndocr Rev200425686989815583021
   PubMed Web of Science ®Google Scholar
• TaylorSEMartin-HirschPLMartinFLOestrogen receptor splice variants in the pathogenesis of diseaseCancer Lett2010288213314819608332
   PubMedGoogle Scholar
• LiCBriggsMRAhlbornTEKraemerFBLiuJRequirement of Sp1 and estrogen receptor α interaction in 17β-estradiol-mediated transcriptional activation of the low density lipoprotein receptor gene expressionEndocrinology200114241546155311250935
   PubMedGoogle Scholar
• FilardoEJQuinnJAFrackeltonARBlandKIEstrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axisMol Endocrinol2002161708411773440
   PubMed Web of Science ®Google Scholar
• KumarPWuQChamblissKLDirect interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor αMol Endocrinol20072161370138017405905
   PubMedGoogle Scholar
• VivacquaABonofiglioDRecchiaAGThe G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17β-estradiol and hydroxytamoxifen in endometrial cancer cellsMol Endocrinol200620363164616239258
   PubMedGoogle Scholar
• ProssnitzERArterburnJBSklarLAGPR30: a G protein-coupled receptor for estrogenMol Cell Endocrinol2007265–266138142
   PubMed Web of Science ®Google Scholar
• MarquezDCLeeJLinTPietrasRJEpidermal growth factor receptor and tyrosine phosphorylation of estrogen receptorEndocrine2001162738111887937
   PubMedGoogle Scholar
• RazandiMPedramAParkSTLevinERProximal events in signaling by plasma membrane estrogen receptorsJ Biol Chem200327842701271212421825
   PubMed Web of Science ®Google Scholar
• SongRXZhangZSantenRJEstrogen rapid action via protein complex formation involving ERα and SrcTrends Endocrinol Metab200516834735316126407
   PubMedGoogle Scholar
• BaloghPSzabóAKatzSLikóIPatócsAKissALEstrogen receptor alpha is expressed in mesenteric mesothelial cells and is internalized in caveolae upon Freund’s adjuvant treatmentPLoS One2013811e7950824244516
   PubMedGoogle Scholar
• ChaudhriRASchwartzNElbaradieKSchwartzZBoyanBDRole of ERα36 in membrane-associated signaling by estrogenSteroids201481748024252378
   PubMedGoogle Scholar
• ShaulPWRegulation of endothelial nitric oxide synthase: location, location, locationAnnu Rev Physiol200264174977411826287
   PubMedGoogle Scholar
• DavisNMSokoloskyMStadelmanKDeregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic interventionOncotarget20145134603465025051360
   PubMedGoogle Scholar
• MurphyLJGhaharyAUterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferationEndocr Rev19901134434532226350
   PubMedGoogle Scholar
• CookePSBuchananDLYoungPStromal estrogen receptors mediate mitogenic effects of estradiol on uterine epitheliumProc Natl Acad Sci U S A19979412653565409177253
   PubMedGoogle Scholar
• BaiWOliveros-SaundersBWangQAcevedo-DuncanMENicosiaSVEstrogen stimulation of ovarian surface epithelial cell proliferationIn Vitro Cell Dev Biol Anim2000361065766611229598
   PubMedGoogle Scholar
• MallepellSKrustAChambonPBriskenCParacrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary glandProc Natl Acad Sci U S A200610372196220116452162
   PubMed Web of Science ®Google Scholar
• AschimELSætherTWigerRGrotmolTHaugenTBDifferential distribution of splice variants of estrogen receptor β in human testicular cells suggests specific functions in spermatogenesisJ Steroid Biochem Mol Biol2004921–29710615544935
   PubMedGoogle Scholar
• ChenMYehCRShyrCRLinHHDaJYehSReduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout miceAsian J Androl201214454655522609821
   PubMedGoogle Scholar
• PrinsGSBirchLCouseJFEstrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor α: studies with αERKO and βERKO miceCancer Res200161166089609711507058
   PubMed Web of Science ®Google Scholar
• MuellerSOMammary gland development in adult mice requires epithelial and stromal estrogen receptorEndocrinology200214362357236512021201
   PubMed Web of Science ®Google Scholar
• RuanWKleinbergLDInsulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary developmentEndocrinology1999140115178518410537147
   PubMedGoogle Scholar
• JoshiPAJacksonHWBeristainAGProgesterone induces adult mammary stem cell expansionNature2010465729980380720445538
   PubMed Web of Science ®Google Scholar
• RussoJAoXGrillCRussoIHPattern of distribution of cells positive for estrogen receptor a and progesterone receptor in relation to proliferating cells in the mammary glandBreast Cancer Res Treat199953321722710369068
   PubMedGoogle Scholar
• LimEVaillantFWuDAberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersNat Med200915890791319648928
   PubMed Web of Science ®Google Scholar
• AndersonEClarkeRBHowellAEstrogen responsiveness and control of normal human breast proliferationJ Mammary Gland Biol Neoplasia199831233510819502
   PubMedGoogle Scholar
• CunhaGRYoungPHomYKCookePSTaylorJALubahnDBElucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinantsJ Mammary Gland Biol Neoplasia19972439340210935027
   PubMedGoogle Scholar
• ZepsNBentelJMPapadimitriouJMD’AntuonoMFDawkinsHJEstrogen receptor-negative epithelial cells in mouse mammary gland development and growthDifferentiation19986252212269566307
   PubMedGoogle Scholar
• LuettekeNCQiuTHFentonSETargeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland developmentDevelopment1999126122739275010331984
   PubMed Web of Science ®Google Scholar
• WilsonCLSimsAHHowellAMillerCJClarkeRBEffects of oestrogen on gene expression in epithelium and stroma of normal human breast tissueEndocr Relat Cancer200613261762816728587
   PubMed Web of Science ®Google Scholar
• SternlichtMDSunnarborgSWKouros-MehrHYuYLeeDCWerbZMammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulinDevelopment2005132173923393316079154
   PubMedGoogle Scholar
• KleinbergDLRuanWIGF-I, GH, and sex steroid effects in normal mammary gland developmentJ Mammary Gland Biol Neoplasia200813435336019034633
   PubMed Web of Science ®Google Scholar
• HoveyRTrottJVonderhaarBEstablishing a framework for the functional mammary gland: from endocrinology to establishing a framework for the functional mammary gland: from endocrinology to morphologyJ Mammary Gland Biol Neoplasia200271173812160083
   PubMed Web of Science ®Google Scholar
• RowsonARDanielsKMEllisSEHoveyRCGrowth and development of the mammary glands of livestock: a veritable barnyard of opportunitiesSemin Cell Dev Biol201223555756622504021
   PubMed Web of Science ®Google Scholar
• LeeSMedinaDTsimelzonAAlterations of gene expression in the development of early hyperplastic precursors of breast cancerAm J Pathol2007171125226217591970
   PubMedGoogle Scholar
• El-AshryDMillerDKharbandaSLippmanMEKernFConstitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosisOncogene19971544234359242379
   PubMedGoogle Scholar
• PietrasRJArboledaJReeseDMHER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cellsOncogene19951012243524467784095
   PubMed Web of Science ®Google Scholar
• RakhaEAPinderSEBartlettJMUpdated UK recommendations for HER2 assessment in breast cancerJ Clin Pathol2015682939925488926
   PubMed Web of Science ®Google Scholar
• TognonCKnezevichSRHuntsmanDExpression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinomaCancer Cell20022536737612450792
   PubMed Web of Science ®Google Scholar
• TononGModiSWuLt(11;19)(q21;p13) Translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathwayNat Genet200333220821312539049
   PubMed Web of Science ®Google Scholar
• TroesterMAHerschkowitzJIOhDSGene expression patterns associated with p53 status in breast cancerBMC Cancer2006627617150101
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas NetworkComprehensive molecular portraits of human breast tumorsNature20124907418617023000897
   PubMed Web of Science ®Google Scholar
• BenoitRCooneyAGiguereVIngrahamHLazarMMuscatGInternational Union of Pharmacology – LXVI: orphan nuclear receptorsPharmacol Rev200658479883617132856
   PubMed Web of Science ®Google Scholar
• WärnmarkATreuterEWrightAPGustafssonJAActivation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activationMol Endocrinol200317101901190912893880
   PubMedGoogle Scholar
• BoudotAKerdivelGLecomteSCOUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migrationBMC Cancer20141440724906407
   PubMed Web of Science ®Google Scholar
• XuMQinJTsaiSYTsaiMThe role of the orphan nuclear receptor COUP-TFII in tumorigenesisActa Pharmacol Sin2015361323625283503
   PubMed Web of Science ®Google Scholar
• HedrickELeeSOKimGNuclear receptor 4A1 (NR4A1) as a drug target for renal cell adenocarcinomaPLoS One2015106e012830826035713
   PubMedGoogle Scholar
• DuJXuRRORα, a potential tumor suppressor and therapeutic target of breast cancerInt J Mol Sci20121312157551576623443091
   PubMedGoogle Scholar
• XiongGWangCEversBMZhouBPXuRRORα suppresses breast tumor invasion by inducing SEMA3F expressionCancer Res20127271728173922350413
   PubMed Web of Science ®Google Scholar
• HongEJLevasseurMPDufourCRPerryMCGiguèreVLoss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbancesProc Natl Acad Sci U S A201311044179751798024127579
   PubMed Web of Science ®Google Scholar
• GiguèreVTranscriptional control of energy homeostasis by the estrogen-related receptorsEndocr Rev200829667769618664618
   PubMed Web of Science ®Google Scholar
• DebloisGGiguèreVOestrogen-related receptors in breast cancer: control of cellular metabolism and beyondNat Rev Cancer2012131273623192231
   PubMedGoogle Scholar
• AriaziEAClarkGMMertzJEEstrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancerCancer Res200262226510651812438245
   PubMedGoogle Scholar
• SuzukiSTakagiKMikiYNucleobindin 2 in human breast carcinoma as a potent prognostic factorCancer Sci2012103113614321988594
   PubMed Web of Science ®Google Scholar
• HardieDGRossFAHawleySAAMPK: a nutrient and energy sensor that maintains energy homeostasisNat Rev Mol Cell Biol201213425126222436748
   PubMed Web of Science ®Google Scholar
• Audet-WalshEPapadopoliDJGravelSPThe PGC-1α/ERRα axis represses one-carbon metabolism and promotes sensitivity to anti-folate therapy in breast cancerCell Rep201614492093126804918
   PubMedGoogle Scholar
• DebloisGSt-PierreJGiguèreVThe PGC-1/ERR signaling axis in cancerOncogene201332303483349023208510
   PubMed Web of Science ®Google Scholar
• BiancoSSaillandJVanackerJMERRs and cancers: effects on metabolism and on proliferation and migration capacitiesJ Steroid Biochem Mol Biol20121303–518018521414406
   PubMedGoogle Scholar
• ZielloJEJovinISHuangYHypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemiaYale J Biol Med2007802516018160990
   PubMedGoogle Scholar
• KlimcakovaEChénardVMcGuirkSPGC-1α promotes the growth of ErbB2/neu-induced mammary tumors by regulating nutrient supplyCancer Res20127261538154622266114
   PubMedGoogle Scholar
• St-PierreJDroriSUldryMSuppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivatorsCell2006127239740817055439
   PubMed Web of Science ®Google Scholar
• ChakravartyDNairSSSanthammaBExtranuclear functions of ER impact invasive migration and metastasis by breast cancer cellsCancer Res201070104092410120460518
   PubMedGoogle Scholar
• Garcia-BecerraRSantosNDiazLCamachoJMechanisms of resistance to endocrine therapy in breast cancer: focus on signaling pathways, miRNAs and genetically based resistanceInt J Mol Sci2013141108145
   Web of Science ®Google Scholar
• LearyADowsettMCombination therapy with aromatase inhibitors: the next era of breast cancer treatment?Br J Cancer200695666166616926831
   PubMedGoogle Scholar
• HammondMEHayesDFDowsettMAmerican Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version)Arch Pathol Lab Med20101347e48e7220586616
   PubMed Web of Science ®Google Scholar
• HayashiSIEguchiHTanimotoKThe expression and function of estrogen receptor α and β in human breast cancer and its clinical applicationEndocr Relat Cancer200310219320212790782
   PubMed Web of Science ®Google Scholar
• ProssnitzERBartonMThe G-protein-coupled estrogen receptor GPER in health and diseaseNat Rev Endocrinol201171271572621844907
   PubMed Web of Science ®Google Scholar
• VanhaesebroeckBGuillermet-GuibertJGrauperaMBilangesBThe emerging mechanisms of isoform-specific PI3K signallingNat Rev Mol Cell Biol201011532934120379207
   PubMed Web of Science ®Google Scholar
• ShanwareNPBrayKAbrahamRTThe PI3K, metabolic, and autophagy networks: interactive partners in cellular health and diseaseAnnu Rev Pharmacol Toxicol20135318910623294306
   PubMedGoogle Scholar
• DeBerardinisRJChandelNSFundamentals of cancer metabolismSci Adv201625e160020027386546
   PubMed Web of Science ®Google Scholar
• YuanTLCantleyLCPI3K pathway alterations in cancer: variations on a themeOncogene200827415497551018794884
   PubMed Web of Science ®Google Scholar
• CantleyLCThe phosphoinositide 3-kinase pathwayScience200229655731655165712040186
   PubMed Web of Science ®Google Scholar
• LiuPChengHRobertsTMZhaoJJTargeting the phosphoinositide 3-kinase pathway in cancerNat Rev Drug Discov20098862764419644473
   PubMed Web of Science ®Google Scholar
• BaselgaJTargeting the phosphoinositide-3 (PI3) kinase pathway in breast cancerOncologist201116Suppl 11219
   PubMed Web of Science ®Google Scholar
• ChinYRYoshidaTMarusykABeckAHPolyakKTokerATargeting Akt3 signaling in triple-negative breast cancerCancer Res201474396497324335962
   PubMed Web of Science ®Google Scholar
• LeeJJLohKYapYPI3K/Akt/mTOR inhibitors in breast cancerCancer Biol Med201512434235426779371
   PubMed Web of Science ®Google Scholar
• PaplomataEO’ReganRThe PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkersTher Adv Med Oncol20146415416625057302
   PubMed Web of Science ®Google Scholar
• UtermarkTRaoTChengHThe p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesisGenes Dev201226141573158622802530
   PubMed Web of Science ®Google Scholar
• RosnerMHengstschlägerMCytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components Rictor and sin1Hum Mol Genet200817192934294818614546
   PubMed Web of Science ®Google Scholar
• MorrisonMMYoungCDWangSmTOR directs breast morphogenesis through the PKC-α-Rac1 signaling axisPLoS Genet2015117e100529126132202
   PubMed Web of Science ®Google Scholar
• RexerBNChanthaphaychithSDahlmanKBArteagaCLDirect inhibition of PI3K in combination with dual HER2 inhibitors is required for optimal antitumor activity in HER2+ breast cancer cellsBreast Cancer Res2014161R924451154
   PubMed Web of Science ®Google Scholar
• BaderAGKangSZhaoLVogtPKOncogenic PI3K deregulates transcription and translationNat Rev Cancer200551292192916341083
   PubMed Web of Science ®Google Scholar
• MuellnerMKUrasIZGappBVA chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancerNat Chem Biol201171178779321946274
   PubMed Web of Science ®Google Scholar
• BolósVMiraEMartínez-PovedaBNotch activation stimulates migration of breast cancer cells and promotes tumor growthBreast Cancer Res2013154R5423826634
   PubMedGoogle Scholar
• RiggioMPerroneMCPoloMLAKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteinsSci Rep201774424428287129
   PubMed Web of Science ®Google Scholar
• VanhaesebroeckBAlessiDRThe PI3K-PDK1 connection: more than just a road to PKBBiochem J2000346356157610698680
   PubMedGoogle Scholar
• MassacesiCdi TomasoEUrbanPPI3K inhibitors as new cancer therapeutics: implications for clinical trial designOnco Targets Ther2016920321026793003
   PubMed Web of Science ®Google Scholar
• OkkenhaugKGrauperaMVanhaesebroeckBTargeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis, and immunotherapyCancer Discov20166101090110527655435
   PubMed Web of Science ®Google Scholar
• FrumanDARommelCPI3K and cancer: lessons, challenges and opportunitiesNat Rev Drug Discov201413214015624481312
   PubMed Web of Science ®Google Scholar
• PaezJGEGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyScience200430456761497150015118125
   PubMed Web of Science ®Google Scholar
• RossomandoAJPayneDMWeberMJSturgillTWEvidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinaseProc Natl Acad Sci U S A19898618694069432550926
   PubMedGoogle Scholar
• KosakoHGotohYMatsudaSIshikawaMNishidaEXenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylationEMBO J1992118290329081322292
   PubMedGoogle Scholar
• FerrellJEJrTripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputsTrends Biochem Sci199621124604669009826
   PubMedGoogle Scholar
• HuangCYFerrellJEJrUltrasensitivity in the mitogen-activated protein kinase cascadeProc Natl Acad Sci U S A1996931910078100838816754
   PubMedGoogle Scholar
• DhillonASHaganSRathOKolchWMAP kinase signalling pathways in cancerOncogene200726223279329017496922
   PubMed Web of Science ®Google Scholar
• ChangLKarinMMammalian MAP kinase signalling cascadesNature20014106824374011242034
   PubMed Web of Science ®Google Scholar
• PearsonGRobinsonFGibsonTBMitogen-activated protein (MAP) kinase pathways: regulation and physiological functionsEndocr Rev200122215318311294822
   PubMed Web of Science ®Google Scholar
• CargnelloMRouxPPActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesMicrobiol Mol Biol Rev20017515083
   Google Scholar
• PayneDMRossomandoAJMartinoPIdentification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)EMBO J19911048858921849075
   PubMedGoogle Scholar
• AhnNGCampbellJSSegerRJensenALGravesLMKrebsEGMetabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residuesProc Natl Acad Sci U S A19939011514351478389470
   PubMed Web of Science ®Google Scholar
• RobbinsDJZhenEOwakiHRegulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitroJ Biol Chem19932687509751068444886
   PubMed Web of Science ®Google Scholar
• CrewsCMAlessandriniAEriksonRLThe primary structure of MEK, a protein kinase that phosphorylates the ERK gene productScience199225850814784801411546
   PubMed Web of Science ®Google Scholar
• WuJHarrisonJKVincentLAMolecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinaseProc Natl Acad Sci U S A19939011731778380494
   PubMedGoogle Scholar
• AlessiDRSaitoYCampbellDGIdentification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1EMBO J1994137161016198157000
   PubMed Web of Science ®Google Scholar
• ZhengCFGuanKLActivation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residuesEMBO J1994135112311318131746
   PubMedGoogle Scholar
• FerrellJEJrBhattRRMechanistic studies of the dual phosphorylation of mitogen-activated protein kinaseJ Biol Chem19972723019008190169228083
   PubMedGoogle Scholar
• LiuYShepherdEGNelinLDMAPK phosphatases: regulating the immune responseNat Rev Immunol20077320221217318231
   PubMed Web of Science ®Google Scholar
• KyriakisJMAppHZhangXFRaf-1 activates MAP kinasekinaseNature199235863854174211322500
   PubMed Web of Science ®Google Scholar
• ZhengCFGuanKLCloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2J Biol Chem19932681511435114398388392
   PubMedGoogle Scholar
• MorrisonDKCutlerREThe complexity of Raf-1 regulationCurr Opin Cell Biol1997921741799069260
   PubMedGoogle Scholar
• WhitehurstCEOwakiHBruderJTRappURGeppertTDThe MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cellsJ Biol Chem199527010559455997534298
   PubMedGoogle Scholar
• HobbsGADerCJRossmanKLRAS isoforms and mutations in cancer at a glanceJ Cell Sci201612971287129226985062
   PubMed Web of Science ®Google Scholar
• SantenRJSongRXMcPhersonRThe role of mitogen-activated protein (MAP) kinase in breast cancerJ Steroid Biochem Mol Biol200280223925611897507
   PubMedGoogle Scholar
• AhmadDANegmOHAlabdullahMLClinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancersBreast Cancer Res Treat2016159345746727592113
   PubMed Web of Science ®Google Scholar
• KatoSEndohHMasuhiroYActivation of the estrogen receptor through phosphorylation by mitogen-activated protein kinaseScience19952705241149114947491495
   PubMed Web of Science ®Google Scholar
• JoelPBSmithJSturgillTWFisherTLBlenisJLanniganDAPP90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167Mol Cell Biol1998184197819849528769
   PubMed Web of Science ®Google Scholar
• LangeCAShenTHorwitzKBPhosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasomeProc Natl Acad Sci U S A20009731032103710655479
   PubMedGoogle Scholar
• WengLPSmithWMBrownJLEngCPTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer modelHum Mol Genet200110660561611230180
   PubMed Web of Science ®Google Scholar
• KimDHSimTNovel small molecule Raf kinase inhibitors for targeted cancer therapeuticsArch Pharm Res201235460561522553052
   PubMed Web of Science ®Google Scholar
• MatsudaYFukumotoMSorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiledMed Mol Morphol201144418318922179180
   PubMedGoogle Scholar
• GenoveseMCInhibition of p38: has the fat lady sung?Arthritis Rheum200960231732019180514
   PubMed Web of Science ®Google Scholar
• DarnellJKerrIStarkGJak-STAT pathways and transcriptional activation in responseScience19942645164141514218197455
   PubMed Web of Science ®Google Scholar
• WardACTouwIYoshimuraAThe Jak-Stat pathway in normal and perturbed hematopoiesisBlood2000951192910607680
   PubMed Web of Science ®Google Scholar
• IgazPTóthSFalusABiological and clinical significance of the JAK-STAT pathway: lessons from knockout miceInflamm Res200150943544111603847
   PubMedGoogle Scholar
• O’SheaJJGadinaMSchreiberRDCytokine signaling in 2002: new surprises in the Jak/Stat pathwayCell2002109SupplS121S13111983158
   PubMed Web of Science ®Google Scholar
• TaniguchiTCytokine signaling through nonreceptor protein-tyrosine kinasesScience199526852082512557716517
   PubMedGoogle Scholar
• IhleJNSignaling by the cytokine receptor superfamily in normal and transformed hematopoietic cellsAdv Cancer Res19966823658712070
   PubMed Web of Science ®Google Scholar
• JatianiSSBakerSJSilvermanLRReddyEPJak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapiesGenes Cancer201011097999321442038
   PubMedGoogle Scholar
• ShuaiKLiaoJSongMMEnhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1Mol Cell Biol1996169493249418756652
   PubMedGoogle Scholar
• KisselevaTBhattacharyaSBraunsteinJSignaling through the JAK/STAT pathway, recent advances and future challengesGene20022851–212412039028
   PubMed Web of Science ®Google Scholar
• SchindlerCCytokines and JAK-STAT signalingExp Cell Res1999253171410579906
   PubMedGoogle Scholar
• DarnellJESTATs and gene regulationScience19972775332163016359287210
   PubMed Web of Science ®Google Scholar
• LevyDEDarnellJEJrSTATs: transcriptional control and biological impactNat Rev Mol Cell Biol20023965166212209125
   PubMed Web of Science ®Google Scholar
• NiwaHBurdonTChambersISmithASelf-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3Genes Dev19981213204820609649508
   PubMed Web of Science ®Google Scholar
• HughesKWatsonCJThe spectrum of STAT functions in mammary gland developmentJAKSTAT20121315115824058764
   PubMedGoogle Scholar
• AbellKBilancioAClarksonRWStat3-induced apoptosis requires a molecular switch in PI(3)K subunit compositionNat Cell Biol20057439239815793565
   PubMedGoogle Scholar
• HaricharanSLiYSTAT signaling in mammary gland differentiation, cell survival and tumorigenesisMol Cell Endocrinol2014382156056923541951
   PubMedGoogle Scholar
• ClarksonRWBolandMPKritikouEAThe genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary developmentMol Endocrinol200620367568516293640
   PubMedGoogle Scholar
• O’SheaJJSchwartzDMVillarinoAVGadinaMMcInnesIBLaurenceAThe JAK-STAT pathway: impact on human disease and therapeutic interventionAnnu Rev Med201566131132825587654
   PubMedGoogle Scholar
• GreenmanCStephensPRBignellGPatterns of somatic mutation in human cancer genomesNature2007446713215315817344846
   PubMed Web of Science ®Google Scholar
• JeongEGKimMSNamHKSomatic mutations of JAK1 and JAK3 in acute leukemias and solid cancersClin Cancer Res200814123716372118559588
   PubMedGoogle Scholar
• CaffarelMMZaragozaRPensaSLiJGreenARWatsonCJConstitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesisCell Death Differ201219351152221941370
   PubMedGoogle Scholar
• ZhangYToyKAKleerCGMetaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transitionMod Pathol201225217818422080057
   PubMedGoogle Scholar
• ChanSRVermiWLuoJSTAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomasBreast Cancer Res2012141R1622264274
   PubMedGoogle Scholar
• WeichselbaumRRIshwaranHYoonTAn interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancerProc Natl Acad Sci U S A200810547184901849519001271
   PubMed Web of Science ®Google Scholar
• WatsonCJMillerWRElevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extractsBr J Cancer19957148408447710952
   PubMedGoogle Scholar
• DiazNMintonSCoxCActivation of Stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated Src and survivin expressionClin Cancer Res2006121202816397019
   PubMed Web of Science ®Google Scholar
• CharpinCSecqVGiusianoSA signature predictive of disease outcome in breast carcinomas, identified by quantitative immunocytochemical assaysInt J Cancer200912492124213419142869
   PubMedGoogle Scholar
• HynesNEWatsonCJMammary gland growth factors: roles in normal development and in cancerCold Spring Harb Perspect Biol201028a00318620554705
   PubMed Web of Science ®Google Scholar
• HenryMDTriplettAAOhKBSmithGHWagnerKParity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic miceOncogene200423416980698515286714
   PubMedGoogle Scholar
• MeydanNGrunbergerTDadiHInhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitorNature199637965666456488628398
   PubMed Web of Science ®Google Scholar
• ThompsonJECubbonRMCummingsRTPhotochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitorBioorganic Med Chem Lett200212812191223
   PubMed Web of Science ®Google Scholar
• LucetISFantinoEStylesMThe structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitorBlood2006107117618316174768
   PubMed Web of Science ®Google Scholar
• BuchertMBurnsCJErnstMTargeting JAK kinase in solid tumors: emerging opportunities and challengesOncogene201535893995125982279
   PubMedGoogle Scholar
• GarciaRBowmanTLNiuGConstitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cellsOncogene200120202499251311420660
   PubMed Web of Science ®Google Scholar
• KumarJFraserFWRileyCAhmedNMcCullochDRWardACGranulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancerBr J Cancer2014110113314524220695
   PubMed Web of Science ®Google Scholar
• HaddadBRGuLMirttiTSTAT5A/B gene locus undergoes amplification during human prostate cancer progressionAm J Pathol201318262264227523660011
   PubMedGoogle Scholar
• Catlett-FalconeRLandowskiTHOshiroMMConstitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cellsImmunity199910110511510023775
   PubMed Web of Science ®Google Scholar
• BanerjeeSBiehlAGadinaMHasniSSchwartzDMJAK-STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospectsDrugs201777552154628255960
   PubMed Web of Science ®Google Scholar
• Costa-PereiraAPTinininiSStroblBMutational switch of an IL-6 response to an interferon-γ-like responseProc Natl Acad Sci U S A200299128043804712060750
   PubMedGoogle Scholar
• FurqanMAkinleyeAMukhiNMittalVChenYLiuDSTAT inhibitors for cancer therapyJ Hematol Oncol201369024308725
   PubMed Web of Science ®Google Scholar
• ChenJBaiLBernardDStructure-based design of conformationally constrained, cell-permeable STAT3 inhibitorsACS Med Chem Lett201012858920596242
   PubMed Web of Science ®Google Scholar
• LiuALiuYJinZXZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cellsPLoS One2012710e4662423056374
   PubMedGoogle Scholar
• SiddiqueeKZhangSGuidaWCSelective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activityProc Natl Acad Sci U S A2007104187391739617463090
   PubMed Web of Science ®Google Scholar
• TurksonJZhangSMoraLBBurnsASebtiSJoveRA novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cellsJ Biol Chem200528038329793298816046414
   PubMed Web of Science ®Google Scholar
• JingNLiYXiongWShaWJingLTweardyDJG-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosisCancer Res200464186603660915374974
   PubMed Web of Science ®Google Scholar
• KunigalSLakkaSSSodadasuPKEstesNRaoJSStat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancerInt J Oncol20093451209122019360334
   PubMedGoogle Scholar
• YangZCaiJHXieSJTherapeutic effects of signal transducer and activator of transcription 3 siRNA on human breast cancer in xenograft miceChin Med J (Engl)2011124121854186121740845
   PubMedGoogle Scholar
• YuQCVerheyenEMZengYAMammary development and breast cancer: a Wnt perspectiveCancers (Basel)201687126
   Google Scholar
• TanakaKKitagawaYKadowakiTDrosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of Wingless in the endoplasmic reticulumJ Biol Chem200227715128161282311821428
   PubMed Web of Science ®Google Scholar
• KimYMKahnMThe role of the Wnt signaling pathway in cancer stem cells: prospects for drug developmentRes Rep Biochem2014411226566491
   PubMedGoogle Scholar
• PohlSGBrookNAgostinoMArfusoFKumarAPDharmarajanAWnt signaling in triple-negative breast cancerOncogenesis201764e31028368389
   PubMedGoogle Scholar
• KomiyaYHabasRWnt signal transduction pathwaysOrganogenesis200842687519279717
   PubMedGoogle Scholar
• YostCTorresMMillerJRHuangEKimelmanDMoonRTThe axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3Genes Dev19961012144314548666229
   PubMed Web of Science ®Google Scholar
• JangGKimJChoSBlockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotypeSci Rep201551246526202299
   PubMed Web of Science ®Google Scholar
• PolakisPWnt signaling and cancerGenes Dev200014151837185110921899
   PubMed Web of Science ®Google Scholar
• Boras-GranicKWysolmerskiJJWnt signaling in breast organogenesisOrganogenesis20084211612219279723
   PubMedGoogle Scholar
• VeltmaatJMVan VeelenWThieryJPBellusciSIdentification of the mammary line in mouse by Wnt10b expressionDev Dyn2004229234935614745960
   PubMedGoogle Scholar
• BriskenCHeinemanAChavarriaTEssential function of Wnt-4 in mammary gland development downstream of progesterone signaling serviceGenes Dev200061765065410733525
   PubMedGoogle Scholar
• HsuWShakyaRCostantiniFImpaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic miceJ Cell Biol200115561055106411739413
   PubMedGoogle Scholar
• IncassatiAChandramouliAEelkemaRCowinPKey signaling nodes in mammary gland development and cancer: β-cateninBreast Cancer Res201012621321067528
   PubMedGoogle Scholar
• RoartyKSerraRWnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growthDevelopment2007134213929393917898001
   PubMedGoogle Scholar
• CleversHNusseRWnt/β-catenin signaling and diseaseCell201214961192120522682243
   PubMed Web of Science ®Google Scholar
• HoweLRBrownAMWnt signaling and breast cancerCancer Biol Ther200431364114739782
   PubMed Web of Science ®Google Scholar
• KhramtsovAIKhramtsovaGFTretiakovaMHuoDOlopadeOIGossKHWnt/β-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcomeAm J Pathol201017662911292020395444
   PubMed Web of Science ®Google Scholar
• YangWYanHXChenLWnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cellsCancer Res200868114287429518519688
   PubMed Web of Science ®Google Scholar
• LinSYXiaWWangJCβ-Catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progressionProc Natl Acad Sci U S A20009784262426610759547
   PubMed Web of Science ®Google Scholar
• MacDonaldBTTamaiKHeXWnt/β-catenin signaling: components, mechanisms, and diseasesDev Cell200917192619619488
   PubMed Web of Science ®Google Scholar
• SmidMWangYZhangYSubtypes of breast cancer show preferential site of relapseCancer Res20086893108311418451135
   PubMed Web of Science ®Google Scholar
• PolakisPThe many ways of Wnt in cancerCurr Opin Genet Dev2007171455117208432
   PubMed Web of Science ®Google Scholar
• CleversHWnt/β-catenin signaling in development and diseaseCell2006127346948017081971
   PubMed Web of Science ®Google Scholar
• BrownAMWnt signaling in breast cancer: have we come full circle?Breast Cancer Res20013635135511737884
   PubMedGoogle Scholar
• NagahataTShimadaTHaradaAAmplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancersCancer Sci200394651551812824876
   PubMedGoogle Scholar
• PrasadCPGuptaSDRathGRalhanRWnt signaling pathway in invasive ductal carcinoma of the breast: relationship between β-catenin, dishevelled and cyclin D1 expressionOncology2007731–211211718337623
   PubMedGoogle Scholar
• KlemmFBleckmannASiamLβ-Catenin-independent WNT signaling in basal-like breast cancer and brain metastasisCarcinogenesis201132343444221173432
   PubMedGoogle Scholar
• NishitaMEnomotoMYamagataKMinamiYCell/tissue-tropic functions of Wnt5a signaling in normal and cancer cellsTrends Cell Biol201020634635420359892
   PubMedGoogle Scholar
• HenryCQuadirAHawkinsNJExpression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signallingJ Cancer Res Clin Oncol2014141224325425209439
   PubMedGoogle Scholar
• ZengRHuangJZhongMZMultiple roles of WNT5A in breast cancerMed Sci Monit2016225058506728005837
   PubMedGoogle Scholar
• ZhongZShanMWangJLiuTShiQPangDDecreased Wnt5a expression is a poor prognostic factor in triple-negative breast cancerMed Sci Monit2016221726721633
   PubMed Web of Science ®Google Scholar
• BjörklundPSvedlundJOlssonAKAkerströmGWestinGThe internally truncated LRP5 receptor presents a therapeutic target in breast cancerPLoS One200941e424319158955
   PubMedGoogle Scholar
• ZhanTRindtorffNBoutrosMWnt signaling in cancerOncogene201736111461147327617575
   PubMed Web of Science ®Google Scholar
• WangYBuFRoyerCASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1Nat Cell Biol201416111092110425344754
   PubMed Web of Science ®Google Scholar
• GujralTSChanMPeshkinLSorgerPKKirschnerMWMacBeathGA noncanonical Frizzled 2 pathway regulates epithelial-mesenchymal transition and metastasisCell2014159484485625417160
   PubMed Web of Science ®Google Scholar
• WuZQLiXYHuCYFordMKleerCGWeissSJCanonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic breast cancer 1, early onset (BRCA1) repressionProc Natl Acad Sci U S A201210941166541665923011797
   PubMed Web of Science ®Google Scholar
• PishvaianMJByersSWBiomarkers of WNT signalingCancer Biomark200734–526327417917155
   PubMedGoogle Scholar
• SatoNYamabukiTTakanoAWnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapyCancer Res201070135326533620551066
   PubMed Web of Science ®Google Scholar
• NuñezFBravoSCruzatFMontecinoMde FerrariGVWnt/β-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cellsPLoS One201164e1856221494638
   PubMed Web of Science ®Google Scholar
• WangZZhangHHouJClinical implications of β-catenin protein expression in breast cancerInt J Clin Exp Pathol2015811149891499426823833
   PubMedGoogle Scholar
• LiuJPanSHsiehMHTargeting Wnt-driven cancer through the inhibition of Porcupine by LGK974Proc Natl Acad Sci U S A201311050202242022924277854
   PubMed Web of Science ®Google Scholar
• AnzanoMARobertsABMeyersCASynergistic interaction of two classes of transforming growth factors from murine sarcoma cellsCancer Res19824211477647786290046
   PubMed Web of Science ®Google Scholar
• MosesHLRobertsABDerynckRThe discovery and early days of TGF-β: a historical perspectiveCold Spring Harb Perspect Biol201687a02186527328871
   PubMed Web of Science ®Google Scholar
• TuckerRFShipleyGDMosesHLHolleyRWGrowth inhibitor from BSC-1 cells closely related to platelet type β transforming growth factorScience198422646757057076093254
   PubMedGoogle Scholar
• RobertsABWakefieldLMThe two faces of transforming growth factor β in carcinogenesisProc Natl Acad Sci U S A2003100158621862312861075
   PubMed Web of Science ®Google Scholar
• MassaguéJTGFβ signalling in contextNat Rev Mol Cell Biol2012131061663022992590
   PubMed Web of Science ®Google Scholar
• MassaguéJSeoaneJWottonDSmad transcription factorsGenes Dev200519232783281016322555
   PubMed Web of Science ®Google Scholar
• LamouilleSXuJDerynckRMolecular mechanisms of epithelial-mesenchymal transitionNat Rev Mol Cell Biol201415317819624556840
   PubMed Web of Science ®Google Scholar
• DanielCWRobinsonSDRegulation of mammary growth and function by TGF-βMol Reprod Dev19923221451511637552
   PubMedGoogle Scholar
• SilbersteinGBDanielCWReversible inhibition of mammary gland growth by transforming growth factor-βScience198723748122912933474783
   PubMedGoogle Scholar
• PierceDFJrJohnsonMDMatsuiYInhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β1Genes Dev1993712A230823178253379
   PubMedGoogle Scholar
• BottingerEPJakubczakJLHainesDCBagnallKWakefieldLMTransgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthraceneCancer Res19975724556455709407968
   PubMedGoogle Scholar
• EwanKBShyamalaGRavaniSALatent transforming growth factor-β activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferationAm J Pathol200216062081209312057913
   PubMedGoogle Scholar
• JhappanCGeiserAGKordonECTargeting expression of a transforming growth factor β1 transgene to the pregnant mammary gland inhibits alveolar development and lactationEMBO J1993125183518458491177
   PubMedGoogle Scholar
• KordonECMcKnightRAJhappanCHennighausenLMerlinoGSmithGHEctopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell populationDev Biol1995168147617883078
   PubMedGoogle Scholar
• RobinsonSDRobertsABDanielCWTGFβ suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels during pregnancyJ Cell Biol199312012452518416990
   PubMedGoogle Scholar
• StrangeRLiFSaurerSBurkhardtAFriisRRApoptotic cell death and tissue remodelling during mouse mammary gland involutionDevelopment1992115149581638991
   PubMedGoogle Scholar
• BierieBGorskaAEStoverDGMosesHLTGF-β promotes cell death and suppresses lactation during the second stage of mammary involutionJ Cell Physiol20092191576819086032
   PubMedGoogle Scholar
• WelchDRFabraANakajimaMTransforming growth factor β stimulates mammary adenocarcinoma cell invasion and metastatic potentialProc Natl Acad Sci U S A19908719767876822217201
   PubMed Web of Science ®Google Scholar
• DalalBIKeownPAGreenbergAHImmunocytochemical localization of secreted transforming growth factor-β1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinomaAm J Pathol199314323813898393616
   PubMed Web of Science ®Google Scholar
• XieWMertensJCReissDJAlterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray studyCancer Res200262249750511809701
   PubMed Web of Science ®Google Scholar
• OftMPeliJRudazCSchwarzHBeugHReichmannETGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cellsGenes Dev19961019246224778843198
   PubMedGoogle Scholar
• Seton-RogersSELuYHinesLMCooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cellsProc Natl Acad Sci U S A200410151257126214739340
   PubMed Web of Science ®Google Scholar
• MuraokaRSDumontNRitterCABlockade of TGF-β inhibits mammary tumor cell viability, migration, and metastasesJ Clin Invest2002109121551155912070302
   PubMed Web of Science ®Google Scholar
• MuraokaRSKohYRoebuckLRIncreased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1Mol Cell Biol200323238691870314612410
   PubMedGoogle Scholar
• SiegelPMShuWCardiffRDMullerWJMassaguéJTransforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasisProc Natl Acad Sci U S A2003100148430843512808151
   PubMedGoogle Scholar
• TanEJThuaultSCajaLCarlettiTHeldinCHMoustakasARegulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transitionJ Biol Chem2012287107134714522241470
   PubMedGoogle Scholar
• ThuaultSTanEJPeinadoHCanoAHeldinCHMoustakasAHMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transitionJ Biol Chem200828348334373344618832382
   PubMed Web of Science ®Google Scholar
• BlancoMJMoreno-BuenoGSarrioDCorrelation of Snail expression with histological grade and lymph node status in breast carcinomasOncogene200221203241324612082640
   PubMed Web of Science ®Google Scholar
• YangJManiSADonaherJLTwist, a master regulator of morphogenesis, plays an essential role in tumor metastasisCell2004117792793915210113
   PubMed Web of Science ®Google Scholar
• GregoryPABertAGPatersonELThe miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Nat Cell Biol200810559360118376396
   PubMed Web of Science ®Google Scholar
• GuleiDMehterovNLingHStantaGBraicuCBerindan-NeagoeIThe “good-cop bad-cop” TGF-β role in breast cancer modulated by non-coding RNAsBiochim Biophys Acta2017186171661167528411077
   PubMedGoogle Scholar
• BrackenCPGregoryPAKolesnikoffNA double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transitionCancer Res200868197846785418829540
   PubMed Web of Science ®Google Scholar
• KorpalMLeeESHuGKangYThe miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2J Biol Chem200828322149101491418411277
   PubMed Web of Science ®Google Scholar
• ParkSMGaurABLengyelEPeterMEThe miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Genes Dev200822789490718381893
   PubMed Web of Science ®Google Scholar
• Perdigao-HenriquesRPetroccaFAltschulerGmiR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexesOncogene201635215817225798844
   PubMed Web of Science ®Google Scholar
• KimNHKimHSLiXYA p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transitionJ Cell Biol2011195341743322024162
   PubMed Web of Science ®Google Scholar
• NietoMAHuangRYJacksonRAThieryJPEMT: 2016Cell20161661214527368099
   PubMed Web of Science ®Google Scholar
• Al-HajjMWichaMSBenito-HernandezAMorrisonSJClarkeMFProspective identification of tumorigenic breast cancer cellsProc Natl Acad Sci U S A200310073983398812629218
   PubMed Web of Science ®Google Scholar
• ShipitsinMCampbellLLArganiPMolecular definition of breast tumor heterogeneityCancer Cell200711325927317349583
   PubMed Web of Science ®Google Scholar
• ManiSAGuoWLiaoMJThe epithelial-mesenchymal transition generates cells with properties of stem cellsCell2008133470471518485877
   PubMed Web of Science ®Google Scholar
• ScheelCEatonENLiSHParacrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breastCell2011145692694021663795
   PubMed Web of Science ®Google Scholar
• BrunaAGreenwoodWLe QuesneJTGFβ induces the formation of tumour-initiating cells in claudinlow breast cancerNat Commun20123105522968701
   PubMedGoogle Scholar
• SatoMKadotaMTangBAn integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancerBreast Cancer Res2014163R5724890385
   PubMedGoogle Scholar
• VidakovicATRuedaOMVervoortSJContext-specific effects of TGF-β/SMAD3 in cancer are modulated by the epigenomeCell Rep201513112480249026686634
   PubMedGoogle Scholar
• AkhurstRJHataATargeting the TGFβ signalling pathway in diseaseNat Rev Drug Discov2012111079081123000686
   PubMed Web of Science ®Google Scholar
• SalnikovAVRoswallPSundbergCGardnerHHeldinNERubinKInhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinomaLab Invest200585451252115711566
   PubMedGoogle Scholar
• HerbertzSSawyerJSStauberAJClinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-β signaling pathwayDrug Des Devel Ther2015944794499
   PubMed Web of Science ®Google Scholar
• AnidoJSaez-BorderiasAGonzalez-JuncaATGF-β receptor inhibitors target the CD44high/Id1high glioma-initiating cell population in human glioblastomaCancer Cell201018665566821156287
   PubMed Web of Science ®Google Scholar
• BholaNEBalkoJMDuggerTCTGF-β inhibition enhances chemotherapy action against triple-negative breast cancerJ Clin Invest201312331348135823391723
   PubMed Web of Science ®Google Scholar
• BandyopadhyayAWangLAgyinJDoxorubicin in combination with a small TGFβ inhibitor: a potential novel therapy for meta-static breast cancer in mouse modelsPLoS One201054e1036520442777
   PubMedGoogle Scholar
• BrunenDWillemsSMKellnerUMidgleyRSimonIBernardsRTGF-β: an emerging player in drug resistanceCell Cycle201312182960296823974105
   PubMed Web of Science ®Google Scholar
• FischerKRDurransALeeSEpithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistanceNature2015527757947247626560033
   PubMed Web of Science ®Google Scholar
• SenRBaltimoreDMultiple nuclear factors interact with the immunoglobulin enhancer sequencesCell19864657057163091258
   PubMed Web of Science ®Google Scholar
• GilmoreTDThe Rel/NF-κB signal transduction pathway: introductionOncogene199918496842684410602459
   PubMed Web of Science ®Google Scholar
• ModuleSHuxfordTGhoshGA structural guide to proteins of the NF-κB signaling moduleCold Spring Harb Perspect Biol200913a00007520066103
   PubMedGoogle Scholar
• GhoshGVan DuyneGGhoshSSiglerPBStructure of NF-κB p50 homodimer bound to a κB siteNature199537365123033107530332
   PubMed Web of Science ®Google Scholar
• MüllerCWReyFASodeokaMVerdineGLHarrisonSCStructure of the NF-kappa B p50 homodimer bound to DNANature199537365123113177830764
   PubMed Web of Science ®Google Scholar
• ChenFEHuangDBChenYQGhoshGCrystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNANature199839166654104139450761
   PubMedGoogle Scholar
• MayMGhoshSRel/NF-κB and IκB proteins: an overviewCancer Biol1997826373
   PubMed Web of Science ®Google Scholar
• ChenFGhoshGRegulation of DNA binding by Rel/NF-κB transcription factors: structural viewsOncogene199918496845685210602460
   PubMedGoogle Scholar
• ChenZParentLManiatisTSite-specific phosphorylation of IκBα a by a novel ubiquitination-dependent protein kinase activityCell19968468538628601309
   PubMed Web of Science ®Google Scholar
• YamaokaSCourtoisGBessiaCComplementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activationCell1998937123112409657155
   PubMed Web of Science ®Google Scholar
• YaronAGonenHAlkalayIInhibition of NF-κB cellular function via specific targeting of the IκB-ubiquitin ligaseEMBO J19971621648664949351830
   PubMedGoogle Scholar
• YaronAHatzubaiADavisMIdentification of the receptor component of the IκBa-ubiquitin ligaseNature199839667115905949859996
   PubMedGoogle Scholar
• Ben-NeriahYRegulatory functions of ubiquitination in the immune systemNat Immunol200231202611753406
   PubMed Web of Science ®Google Scholar
• SheppardKRoseDHaqueZTranscriptional activation by NF-κB requires multiple coactivatorsMol Cell Biol19991996367637810454583
   PubMedGoogle Scholar
• SunSCNon-canonical NF-κB signaling pathwayCell Res2010211718521173796
   PubMedGoogle Scholar
• XiaoGHarhajESunSCNF-κB-inducing kinase regulates the processing of NF-κB2 p100Mol Cell20017240140911239468
   PubMed Web of Science ®Google Scholar
• MukherjeeSPBeharMBirnbaumHAHoffmannAWrightPEGhoshGAnalysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcriptionPLoS Biol2013119e100164724019758
   PubMedGoogle Scholar
• BrantleyDMYullFEMuraokaRSHicksDJCookCMKerrLDDynamic expression and activity of NF-κB during post-natal mammary gland morphogenesisMech Dev2000971–214915511025216
   PubMedGoogle Scholar
• GeymayerSDopplerWActivation of NF-κB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated β-casein gene expressionFASEB J20001491159117010834938
   PubMedGoogle Scholar
• ClarksonRWHeeleyJLChapmanRNF-κB inhibits apoptosis in murine mammary epitheliaJ Biol Chem200027517127371274210777569
   PubMedGoogle Scholar
• DemiccoEKavanaghKRomieuRRelB/p52 NF-κB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IκB-α expression and promote carcinogenesis of the mammary glandMol Cell Biol20052522101361014716260626
   PubMedGoogle Scholar
• ConnellyLRobinsonCChontMA transgenic model reveals important roles for the NF-κB alternative pathway (p100/p52) in mammary development and links to tumorigenesisJ Biol Chem200728213100281003517261585
   PubMedGoogle Scholar
• BrantleyDChenCMuraokaRNuclear factor-κB (NF-κB) regulates proliferation and branching in mouse mammary epitheliumMol Biol Cell20011251445145511359934
   PubMed Web of Science ®Google Scholar
• CaoYBonizziGSeagrovesTIKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland developmentCell2001107676377511747812
   PubMedGoogle Scholar
• BaxterFOIKK/2 induces TWEAK and apoptosis in mammary epithelial cellsDevelopment2006133173485349416887827
   PubMedGoogle Scholar
• ConnellyLBarhamWOnishkoHMInhibition of NF-κB activity in mammary epithelium increases tumor latency and decreases tumor burdenOncogene201130121402141221076466
   PubMed Web of Science ®Google Scholar
• TorresLSernaEBoschANF-κB as node for signal amplification during weaningCell Physiol Biochem201128583384622178936
   PubMedGoogle Scholar
• ZaragozáRMirallesVJRusADWeaning induces NOS-2 expression through NF-κB modulation in the lactating mammary gland: importance of GSHBiochem J2005391Pt 358158815954866
   PubMedGoogle Scholar
• PerkinsNNF-κB: tumor promoter or suppressor?Trends Cell Biol2004142646915102437
   PubMedGoogle Scholar
• KarinMCaoYGretenFRLiZWNF-κB in cancer: from innocent bystander to major culpritNat Rev Cancer20022430131012001991
   PubMed Web of Science ®Google Scholar
• RochaSMartinAMMeekDWNeilDPerkinsNDP53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-κB subunit with histone deacetylase 1Mol Cell Biol200323134713472712808109
   PubMedGoogle Scholar
• KimDWSovakMAZanieskiGActivation of NF-κB/Rel occurs early during neoplastic transformation of mammary cellsCarcinogenesis200021587187910783306
   PubMed Web of Science ®Google Scholar
• PrattMATibboERobertsonSJThe canonical NF-κB pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor populationOncogene200928302710272219483731
   PubMedGoogle Scholar
• NakshatriHBhatPMartinDGoutletRSledgeGConstitutive activation of NF-κB during progression of breast cancer to hormone-independent growthMol Cell Biol1997177362936399199297
   PubMed Web of Science ®Google Scholar
• SovakMBellasRKimDAberrant nuclear factor-κB/Rel expression and the pathogenesis of breast cancerJ Clin Invest199710012295229609399940
   PubMedGoogle Scholar
• CogswellPCGuttridgeDCFunkhouserWKSelective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3Oncogene20001991123113110713699
   PubMedGoogle Scholar
• ZhouYEppenberger-CastoriSEppenbergerUBenzCThe NFκB pathway and endocrine-resistant breast cancerEndocr Relat Cancer200512Suppl 1S37S4616113098
   PubMedGoogle Scholar
• HouMFLinSBYuanSSThe clinical significance between activation of nuclear factor κB transcription factor and overexpression of HER-2/neu oncoprotein in Taiwanese patients with breast cancerClin Chim Acta20033341–213714412867284
   PubMedGoogle Scholar
• BiswasDKShiQBailySNF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosisProc Natl Acad Sci U S A200410127101371014215220474
   PubMed Web of Science ®Google Scholar
• LiuHLeeEGajdosCApoptotic action of 17β-estradiol in raloxifene-resistant MCF-7 cells in vitro and in vivoJ Natl Cancer Inst200395211586159714600091
   PubMedGoogle Scholar
• BoehmJZhaoJYaoJKimSIntegrative genomic approaches identify IKBKE as a breast cancer oncogeneCell200712961065107917574021
   PubMed Web of Science ®Google Scholar
• HuttiJEShenRRAbbottDWPhosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKε promotes cell transformationMol Cell2010344461472
   Google Scholar
• ParkBZhangHZengQNF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSFNat Med2007131626917159986
   PubMed Web of Science ®Google Scholar
• HuberMAAzoiteiNBaumannBNF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progressionJ Clin Invest2004114456958115314694
   PubMed Web of Science ®Google Scholar
• TurnerNCReis-FilhoJSBasal-like breast cancer and the BRCA1 phenotypeOncogene200625435846585316998499
   PubMed Web of Science ®Google Scholar
• ShehataMTeschendorffASharpGPhenotypic and functional characterisation of the luminal cell hierarchy of the mammary glandBreast Cancer Res2012145R13423088371
   PubMedGoogle Scholar
• SauALauRCabritaMAPersistent activation of NF-κB in BRCA1-deficient mammary progenitors drives aberrant proliferation and accumulation of DNA damageCell Stem Cell2016191526527292187
   PubMed Web of Science ®Google Scholar
• ShostakKChariotANF-κB, stem cells and breast cancer: the links get strongerBreast Cancer Res201113421421867572
   PubMed Web of Science ®Google Scholar
• SmithSMLyuYLCaiLNF-κB affects proliferation and invasiveness of breast cancer cells by regulating CD44 expressionPLoS One201499e10696625184276
   PubMed Web of Science ®Google Scholar
• YeoSKFrenchRSpadaFClarksonROpposing roles of NFκB2 gene products p100 and p52 in the regulation of breast cancer stem cellsBreast Cancer Res Treat2017162346547728190248
   PubMedGoogle Scholar
• GodwinPBairdAMHeaveySBarrMPO’ByrneKJGatelyKTargeting nuclear factor-κB to overcome resistance to chemotherapyFront Oncol2013312023720710
   PubMedGoogle Scholar
• AhmedKMCaoNLiJJHER-2 and NF-κB as the targets for therapy-resistant breast cancerAnticancer Res2006266B4235424317201139
   PubMed Web of Science ®Google Scholar
• JiangZLiuJCChungPEEganSEZacksenhausETargeting HER2+ breast cancer: the TBK1/IKKε axisOncoscience20141224
   Google Scholar
• TapiaMAGonzález-NavarreteIDalmasesAInhibition of the canonical IKK/NFκB pathway sensitizes human cancer cells to doxorubicinCell Cycle20076182284229217890907
   PubMed Web of Science ®Google Scholar
• GilmoreTHerscovitchMInhibitors of NF-κB signaling: 785 and countingOncogene200625516887689917072334
   PubMed Web of Science ®Google Scholar
• OrlowskiRZDeesECThe role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancerBreast Cancer Res2003511712559038
   PubMed Web of Science ®Google Scholar
• AwadaAAlbanellJCanneyPABortezomib/docetaxel combination therapy in patients with anthracycline-pretreated advanced/metastatic breast cancer: a phase I/II dose-escalation studyBr J Cancer20089891500150718454159
   PubMedGoogle Scholar
• WakefieldARole of Bcl3 in the normal and neoplastic mammary gland2011 Available from: http://orca.cf.ac.uk/55135Accessed October 12, 2017
   Google Scholar
• BjörnströmLSjöbergMMechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genesMol Endocrinol200519483384215695368
   PubMedGoogle Scholar
• RoySSVadlamudiRKRole of estrogen receptor signaling in breast cancer metastasisInt J Breast Cancer2012201265469822295247
   PubMedGoogle Scholar
• LiYWuYAbbatielloTSlug contributes to cancer progression by direct regulation of ERα signaling pathwayInt J Oncol20154641461147225652255
   PubMedGoogle Scholar
• RobinsonMJCobbMHMitogen-activated protein kinase pathwaysCurr Opin Cell Biol1997921801869069255
   PubMed Web of Science ®Google Scholar
• ChungJYParkYCYeHWuHAll TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transductionJ Cell Sci2002115Pt 467968811865024
   PubMed Web of Science ®Google Scholar
• ParkSZhaoDHatanpaaKJRIP1 activates PI3K-Akt via a dual mechanism involving NF-κB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTENCancer Res200969104107411119435890
   PubMedGoogle Scholar
• LeeSAndrieuCSaltelFIκB kinase phosphorylates Dok1 serines in response to TNF, IL-1, or radiationProc Natl Acad Sci U S A200410150174161742115574499
   PubMedGoogle Scholar
• RawlingsJSRoslerKMHarrisonDAThe JAK/STAT signaling pathwayJ Cell Sci200411781281128315020666
   PubMed Web of Science ®Google Scholar
• BandAMLaihoMCrosstalk of TGF-β and estrogen receptor signaling in breast cancerJ Mammary Gland Biol Neoplasia201116210911521390570
   PubMed Web of Science ®Google Scholar
• KamdjeAHEtetPFVecchioLNew targeted therapies for breast cancer: a focus on tumor microenvironmental signals and chemoresistant breast cancersWorld J Clin cases201421276978625516852
   PubMedGoogle Scholar