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Review

Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine

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Pages 21-29 | Published online: 02 Mar 2012

References

  • MarisJMRecent advances in neuroblastomaN Engl J Med2010362232202221120558371
  • ModakSCheungNKNeuroblastoma: Therapeutic strategies for a clinical enigmaCancer Treat Rev201036430731720227189
  • ModakSCheungNKDisialoganglioside directed immunotherapy of neuroblastomaCancer Invest2007251677717364560
  • YuALGilmanALOzkaynakMFAnti-GD2 antibody with GMCSF, interleukin-2, and isotretinoin for neuroblastomaN Engl J Med2010363141324133420879881
  • CheungNKSowersRVickersAJCheungIYKushnerBHGorlickRFCGR2A polymorphism is correlated with clinical outcome after immunotherapy of neuroblastoma with anti-GD2 antibody and granulocyte macrophage colony-stimulating factorJ Clin Oncol200624182885289016682723
  • MorozVMachinDFaldumAChanges over three decades in outcome and the prognostic influence of age-at-diagnosis in young patients with neuroblastoma: a report from the International Neuroblastoma Risk Group ProjectEur J Cancer201147456157121112770
  • CaneteAGerrardMRubieHPoor survival for infants with MYCN-amplif ied metastatic neuroblastoma despite intensif ied treatment: the International Society of Paediatric Oncology European Neuroblastoma ExperienceJ Clin Oncol20092771014101919171715
  • De BernardiBNicolasBBoniLDisseminated neuroblastoma in children older than one year at diagnosis: comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for NeuroblastomaJ Clin Oncol20032181592160112697885
  • MatthayKKVillablancaJGSeegerRCTreatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children’s Cancer GroupN Engl J Med1999341161165117310519894
  • LondonWBCastelVMonclairTClinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group projectJ Clin Oncol201129243286329221768459
  • SchillingFHSpixCBertholdFNeuroblastoma screening at one year of ageN Engl J Med2002346141047105311932471
  • WoodsWGGaoRNShusterJJScreening of infants and mortality due to neuroblastomaN Engl J Med2002346141041104611932470
  • MarisJMHogartyMDBagatellRCohnSLNeuroblastomaLancet200736995792106212017586306
  • CarenHAbelFKognerPMartinssonTHigh incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumoursBiochem J2008416215315918990089
  • GeorgeRESandaTHannaMActivating mutations in ALK provide a therapeutic target in neuroblastomaNature2008455721597597818923525
  • MosseYPLaudenslagerMLongoLIdentification of ALK as a major familial neuroblastoma predisposition geneNature2008455721593093518724359
  • NakagawaraAAzarCGScavardaNJBrodeurGMExpression and function of TRK-B and BDNF in human neuroblastomasMol Cell Biol19941417597678264643
  • NorrisREMinturnJEBrodeurGMMarisJMAdamsonPCPreclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastomaCancer Chemother Pharmacol20116861469147521484309
  • MinturnJEEvansAEVillablancaJGPhase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium studyCancer Chemother Pharmacol20116841057106521340605
  • LiZThieleCJTargeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathwayExpert Opin Ther Targets200711121611162118020981
  • SarteletHOlignyLLVassalGAKT pathway in neuroblastoma and its therapeutic implicationExpert Rev Anticancer Ther20088575776918471048
  • ManningBDCantleyLCAKT/PKB signaling: navigating downstreamCell200712971261127417604717
  • ShawRJCantleyLCRas, PI(3)K and mTOR signalling controls tumour cell growthNature2006441709242443016724053
  • BrazilDPParkJHemmingsBAPKB binding proteins. Getting in on the AktCell2002111329330312419241
  • Blume-JensenPHunterTOncogenic kinase signallingNature2001411683535536511357143
  • FrankeTFYangSIChanTOThe protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseCell19958157277367774014
  • VivancoISawyersCLThe phosphatidylinositol 3-Kinase AKT pathway in human cancerNat Rev Cancer20022748950112094235
  • CullyMYouHLevineAJMakTWBeyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesisNat Rev Cancer20066318419216453012
  • BellacosaAKumarCCDi CristofanoATestaJRActivation of AKT kinases in cancer: implications for therapeutic targetingAdv Cancer Res200594298616095999
  • EngelmanJALuoJCantleyLCThe evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismNat Rev Genet20067860661916847462
  • HennessyBTSmithDLRamPTLuYMillsGBExploiting the PI3K/AKT pathway for cancer drug discoveryNat Rev Drug Discov2005412988100416341064
  • LuoJManningBDCantleyLCTargeting the PI3K-Akt pathway in human cancer: rationale and promiseCancer Cell20034425726214585353
  • CantleyLCNeelBGNew insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathwayProc Natl Acad Sci U S A19999684240424510200246
  • OpelDPorembaCSimonTDebatinKMFuldaSActivation of Akt predicts poor outcome in neuroblastomaCancer Res200767273574517234785
  • Izycka-SwieszewskaEDrozynskaERzepkoRAnalysis of PI3K/ AKT/mTOR signalling pathway in high risk neuroblastic tumoursPol J Pathol201061419219821290341
  • JohnsenJISegerstromLOrregoAInhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivoOncogene200827202910292218026138
  • SarteletHOhtaSBarretteSHigh level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastomaHistopathology201056560761620459571
  • LiZJaboinJDennisPAThieleCJGenetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/ TrkB rescue of neuroblastoma cells from chemotherapy-induced cell deathCancer Res20056562070207515781614
  • KimBvan GolenCMFeldmanELInsulin-like growth factor-I signaling in human neuroblastoma cellsOncogene200423113014114712218
  • CoulterDWBlattJD’ErcoleAJMoats-StaatsBMIGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growthAnticancer Res2008283A1509151618630505
  • EvangelopoulosMEWeisJKruttgenASignalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFROncogene200524203309331815735700
  • ChiuBMirkinBMadonnaMBMitogenic and apoptotic actions of epidermal growth factor on neuroblastoma cells are concentration- dependentJ Surg Res2006135220921216872636
  • ServideiTRiccardiASanguinettiMDominiciCRiccardiRIncreased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivationJ Cell Physiol2006208122022816575905
  • BeierleEANagaramADaiWIyengarMChenMKVEGF-mediated survivin expression in neuroblastoma cellsJ Surg Res20051271212815882878
  • NganESSitFYLeeKImplications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progressionClin Cancer Res200713386887517289879
  • BeppuKNakamuraKLinehanWMRapisardaAThieleCJTopotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cellsCancer Res200565114775478115930297
  • MookherjeePQuintanillaRRohMSZmijewskaAAJopeRSJohnsonGVMitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell deathJ Cell Biochem2007102119621017340627
  • FrancoisFGrimesMLPhosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosisJ Neurochem19997341773177610501228
  • DattaSRBrunetAGreenbergMECellular survival: a play in three AktsGenes Dev199913222905292710579998
  • DozzaBSmithMAPerryGTabatonMStrocchiPRegulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cellsJ Neurochem20048951224123215147515
  • ZhouXWWinbladBGuanZPeiJJInteractions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cellsJ Alzheimers Dis200917492993719542610
  • LinRJLinYCChenJmicroRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastomaCancer Res201070207841785020805302
  • FoleyNHBrayIMTivnanAMicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2Mol Cancer201098320409325
  • ChenYTakitaJChoiYLOncogenic mutations of ALK kinase in neuroblastomaNature2008455721597197418923524
  • Janoueix-LeroseyILequinDBrugieresLSomatic and germline activating mutations of the ALK kinase receptor in neuroblastomaNature2008455721596797018923523
  • HoebeeckJMichelsEPattynFAberrant methylation of candidate tumor suppressor genes in neuroblastomaCancer Lett2009273233634618819746
  • MunozJLazcozPIndaMMHomozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell linesInt J Cancer2004109567367914999773
  • KimSKangJQiaoJThomasRPEversBMChungDHPhosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomasJ Pediatr Surg200439451652115065019
  • BroniszAGajkowskaBDomanska-JanikKPKC and Raf-1 inhibition- related apoptotic signalling in N2a cellsJ Neurochem20028161176118412068066
  • ZhuWBijurGNStylesNALiXRegulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cellsBrain Res Mol Brain Res20041261455615207915
  • ShuklaNNAmeurNYilmazIOncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling PathwaysClin Cancer Res2011 [Epub ahead of print.]
  • WeinsteinIBJoeAKMechanisms of disease: Oncogene addiction – a rationale for molecular targeting in cancer therapyNat Clin Pract Oncol20063844845716894390
  • BarnettSFBilodeauMTLindsleyCWThe Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validationCurr Top Med Chem20055210912515853641
  • PalSKReckampKYuHFiglinRAAkt inhibitors in clinical development for the treatment of cancerExpert Opin Investig Drugs2010191113551366
  • HilgardPKlennerTStekarJNossnerGKutscherBEngelJD-21266, a new heterocyclic alkylphospholipid with antitumour activityEur J Cancer19973334424469155530
  • VinkSRvan BlitterswijkWJSchellensJHVerheijMRationale and clinical application of alkylphospholipid analogues in combination with radiotherapyCancer Treat Rev200733219120217287087
  • KondapakaSBSinghSSDasmahapatraGPSausvilleEARoyKKPerifosine, a novel alkylphospholipid, inhibits protein kinase B activationMol Cancer Ther20032111093110314617782
  • GillsJJDennisPAPerifosine: update on a novel Akt inhibitorCurr Oncol Rep200911210211019216841
  • LoPiccoloJGranvilleCAGillsJJDennisPATargeting Akt in cancer therapyAnticancer Drugs200718886187417667591
  • RuiterGAZerpSFBartelinkHvan BlitterswijkWJVerheijMAnti- cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathwayAnticancer Drugs200314216717312569304
  • LiXLuworRLuYLiangKFanZEnhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cellsOncogene200625452553516170346
  • ChiariniFDel SoleMMongiorgiSThe novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanismLeukemia20082261106111618385752
  • ElrodHALinYDYuePThe alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathwayMol Cancer Ther2007672029203817604333
  • TazzariPLTabelliniGRicciFSynergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cellsCancer Res200868229394940319010914
  • FestucciaCGravinaGLMuziPAkt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitorsProstate200868996597418361408
  • FlorykDThompsonTCPerifosine induces differentiation and cell death in prostate cancer cellsCancer Lett2008266221622618395973
  • NyakernMCappelliniAMantovaniIMartelliAMSynergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathwaysMol Cancer Ther2006561559157016818515
  • FeiHRChenGWangJMWangFZPerifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylationCytotechnology201062544946020842425
  • EngelJBSchonhalsTHauslerSInduction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancersArch Gynecol Obstet2011283360361020405296
  • KumarAFillmoreHLKadianRBroaddusWCTyeGWVan MeterTEThe alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastomaMol Cancer Res20097111813182119887560
  • CatleyLHideshimaTChauhanDAlkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma modelExp Hematol20073571038104617588472
  • HideshimaTCatleyLYasuiHPerifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cellsBlood2006107104053406216418332
  • HideshimaTCatleyLRajeNInhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cellsBr J Haematol2007138678379117760810
  • MomotaHNerioEHollandECPerifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivoCancer Res200565167429743516103096
  • LeleuXJiaXRunnelsJThe Akt pathway regulates survival and homing in Waldenstrom macroglobulinemiaBlood2007110134417442617761832
  • HennessyBTLuYPoradosuEPharmacodynamic markers of perifosine efficacyClin Cancer Res200713247421743118094426
  • BecherOJHambardzumyanDWalkerTRPreclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem gliomaCancer Res20107062548255720197468
  • HambardzumyanDBecherOJRosenblumMKPandolfiPPManova-TodorovaKHollandECPI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivoGenes Dev200822443644818281460
  • Van UmmersenLBingerKVolkmanJA phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancerClin Cancer Res200410227450745615569974
  • CrulMRosingHde KlerkGJPhase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumoursEur J Cancer200238121615162112142051
  • UngerCBerdelWHanauskeARSindermannHEngelJMrossKFirst-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumoursEur J Cancer201046592092520079628
  • BaileyHHMahoneyMREttingerDSPhase II study of daily oral perifosine in patients with advanced soft tissue sarcomaCancer2006107102462246717058289
  • GhobrialIMRoccaroAHongFClinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom’s macroglobulinemiaClin Cancer Res20101631033104120103671
  • BendellJCNemunaitisJVukeljaSJRandomized placebo- controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancerJ Clin Oncol201129334394440021969495
  • RichardsonPGWolfJJakubowiakAPerifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trialJ Clin Oncol201129324243424921990396
  • LiZTanFLiewehrDJSteinbergSMThieleCJIn vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosineJ Natl Cancer Inst20101021175877020463309
  • LiZOhDYNakamuraKThieleCJPerifosine-induced inhibition of akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivoCancer2011117235412542221590687
  • DasmahapatraGPDidolkarPAlleyMCGhoshSSausvilleEARoyKKIn vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell linesClin Cancer Res200410155242525215297428
  • RahmaniMReeseEDaiYCoadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen speciesCancer Res20056562422243215781658
  • DavidESinhaRChenJSunSYKaufmanJLLonialSPerifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptorsClin Cancer Res200814165090509818698026
  • HustonALeleuXJiaXTargeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironmentClin Cancer Res200814386587418245550
  • PitterKLGalbanCJGalbanSPerifosine and CCI 779 cooperate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastomaPLoS One201161e1454521267448
  • EngelJBHonigASchonhalsTPerifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylationEur J Obstet Gynecol Reprod Biol20081411646918687514
  • PapaVTazzariPLChiariniFProapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cellsLeukemia200822114716017928881
  • BecherOJHambardzumyanDWalkerTRPreclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem gliomaCancer Res20107062548255720197468
  • IyerREvansAEQiXLestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastomaClin Cancer Res20101651478148520179224
  • BecherOJTrippettTKolesarJPhase I study of single-agent perifosine for recurrent pediatric solid tumors [abstract]J Clin Oncol20102815s9540
  • BecherOJKhakooYModakSPhase I study of single agent perifosine for recurrent pediatric solid tumors [abstract]Advances in Neuroblastoma Research2010POC2
  • Rodrik-OutmezguineVSChandarlapatySPaganoNCmTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signalingCancer Discov20111324825922140653
  • SpuntSLGruppSAVikTAPhase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumorsJ Clin Oncol201129212933294021690471
  • GeoergerBKieranMWGruppSPhase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcomaEur J Cancer201248225326222033322