76
Views
9
CrossRef citations to date
0
Altmetric
Original Research

Overexpression of MPC1 inhibits the proliferation, migration, invasion, and stem cell-like properties of gastric cancer cells

, , , , , , , & show all
Pages 5151-5163 | Published online: 24 Oct 2017

References

  • FerlayJSoerjomataramIDikshitRCancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Int J Cancer20151365E359E38625220842
  • TanASBatyJWDongLFMitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNACell Metab2015211819425565207
  • VialeAPettazzoniPLyssiotisCAOncogene ablation-resistant pancreatic cancer cells depend on mitochondrial functionNature2014514752462863225119024
  • LeBleuVSO’ConnellJTGonzalezHKPGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasisNat Cell Biol20141610992100325241037
  • SanchoPBurgos-RamosETaveraAMYC/PGC-1alpha balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cellsCell Metab201522459060526365176
  • CamardaRZhouAYKohnzRAInhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancerNat Med201622442743226950360
  • BrickerDKTaylorEBSchellJCA mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humansScience201233760909610022628558
  • HerzigSRaemyEMontessuitSIdentification and functional expression of the mitochondrial pyruvate carrierScience20123376090939622628554
  • CompanVPierredonSVanderperreBMonitoring mitochondrial pyruvate carrier activity in real time using a BRET-based biosensor: investigation of the Warburg effectMol Cell201559349150126253029
  • YangCKoBHensleyCTGlutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transportMol Cell201456341442425458842
  • VadvalkarSSMatsuzakiSEysterCADecreased mitochondrial pyruvate transport activity in the diabetic heart: role of mitochondrial pyruvate carrier 2 (MPC2) acetylationJ Biol Chem2017292114423443328154187
  • ZhongYLiXYuDApplication of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitroOncotarget2015635377583776926413751
  • LiXJiYHanGMPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancerBMC Cancer201616189427852261
  • WangLXuMQinJLinSCLeeHJTsaiSYTsaiMJMPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancerOncotarget2016712146731468326895100
  • SchellJCOlsonKAJiangLA role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growthMol Cell201456340041325458841
  • LiYLiXKanQMitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomasOncotarget2017811058107327911865
  • EdgeSBComptonCCThe American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNMAnn Surg Oncol20101761471147420180029
  • ShiHChenSJinHDownregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathwayCancer Sci200910091585159019549253
  • CampRLDolled-FilhartMRimmDLX-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimizationClin Cancer Res200410217252725915534099
  • GentlemanRCCareyVJBatesDMBioconductor: open software development for computational biology and bioinformaticsGenome Biol2004510R8015461798
  • Akhavan-NiakiHSamadaniAAMolecular insight in gastric cancer induction: an overview of cancer stemness genesCell Biochem Biophys201468346347324078401
  • LiXHanGLiXMitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cellsOncotarget2017828463634638028624784
  • YuanLWYamashitaHSetoYGlucose metabolism in gastric cancer: The cutting-edgeWorld J Gastroenterol20162262046205926877609
  • CavalliLRVarella-GarciaMLiangBCDiminished tumorigenic phenotype after depletion of mitochondrial DNACell Growth Differ1997811118911989372242
  • Vander HeidenMGCantleyLCThompsonCBUnderstanding the Warburg effect: the metabolic requirements of cell proliferationScience200932459301029103319460998
  • EboliMLParadiesGGaleottiTPapaSPyruvate transport in tumour-cell mitochondriaBiochim Biophys Acta19774601183187851530
  • SchellJCRutterJThe long and winding road to the mitochondrial pyruvate carrierCancer Metab201311624280073
  • ZhuHLuoHZhuXHuXZhengLZhuXPyruvate kinase M2 (PKM2) expression correlates with prognosis in solid cancers: a meta-analysisOncotarget2017811628164027911861
  • BettumIJGoradSSBarkovskayaAMetabolic reprogramming supports the invasive phenotype in malignant melanomaCancer Lett20153661718326095603
  • LiuJJLiuJYChenJScinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patientsCancer Lett2016376111011727033455
  • LardnerAThe effects of extracellular pH on immune functionJ Leukoc Biol200169452253011310837
  • WilliamsACCollardTJParaskevaCAn acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesisOncogene199918213199320410359525
  • GatenbyRAGawlinskiETThe glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical modelsCancer Res200363143847385412873971
  • WardPSThompsonCBMetabolic reprogramming: a cancer hallmark even warburg did not anticipateCancer Cell201221329730822439925