References
- ArberDAOraziAHasserjianRThe 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemiaBlood2016127202391240527069254
- PapaemmanuilEGerstungMBullingerLGenomic Classification and Prognosis in Acute Myeloid LeukemiaN Engl J Med2016374232209222127276561
- NakaoMYokotaSIwaiTInternal tandem duplication of the flt3 gene found in acute myeloid leukemiaLeukemia19961012191119188946930
- SmallDFLT3 mutations: biology and treatmentHematology Am Soc Hematol Educ Program200617818417124058
- GaleREGreenCAllenCThe impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemiaBlood200811152776278417957027
- WhitmanSPArcherKJFengLAbsence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B studyCancer Res200161197233723911585760
- ThiedeCSteudelCMohrBAnalysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosisBlood200299124326433512036858
- DöhnerHEsteyEGrimwadeDDiagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panelBlood2017129442444727895058
- HoADScheteligJBochtlerTAllogeneic Stem Cell Transplantation Improves Survival in Patients with Acute Myeloid Leukemia Characterized by a High Allelic Ratio of Mutant FLT3-ITDBiol Blood Marrow Transplant201622346246926551637
- HaradaYNagataYKiharaRPrognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 studyLeuk Res201866202729360622
- BerensteinRClass III Receptor Tyrosine Kinases in Acute Leukemia – Biological Functions and Modern Laboratory AnalysisBiomark Insights201510Suppl 3114
- MackarehtschianKHardinJDMooreKABoastSGoffSPLemischkaIRTargeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitorsImmunity1995311471617621074
- BöiersCBuza-VidasNJensenCTExpression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor developmentBlood2010115245061506820393130
- TsapogasPMooneyCJBrownGRolinkAThe Cytokine Flt3-Ligand in Normal and Malignant HematopoiesisInt J Mol Sci2017186E111528538663
- CarowCELevensteinMKaufmannSHExpression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemiasBlood1996873108910968562934
- MizukiMSchwableJSteurCSuppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutationsBlood200310183164317312468433
- LiLPilotoONguyenHBKnock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse modelBlood200811173849385818245664
- HospitalMAGreenASMacielTTFLT3 inhibitors: clinical potential in acute myeloid leukemiaOnco Targets Ther20171060761528223820
- JiangXBugnoJHuCTargeted Treatment of FLT3-Overexpressing Acute Myeloid Leukemia with MiR-150 Nanoparticles Guided By Conjugated FLT3 Ligand PeptidesBlood20151263784
- MolicaMBrecciaMFLT3-ITD in acute promyelocytic leukemia: clinical distinct profile but still controversial prognosisLeuk Res201539439739925666257
- LancetJEFLT3 inhibitors for acute myeloid leukemiaClin Adv Hematol Oncol201513957357526452187
- ChienCDSauterCTIshiiKPreclinical Development of FLT3-Redirected Chimeric Antigen Receptor T Cell Immunotherapy for Acute Myeloid LeukemiaBlood20161281072
- NagaiKHouLLiLArsenic Trioxide Synergizes with FLT3 Tyrosine Kinase Inhibitors to Kill FLT3-ITD+ Leukemic Cells through Depressed Production and Degradation of FLT3 ProteinBlood20161281568
- GrimwadeDIveyAHuntlyBJMolecular landscape of acute myeloid leukemia in younger adults and its clinical relevanceBlood20161271294126660431
- PratzKWSatoTMurphyKMStineARajkhowaTLevisMFLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AMLBlood201011571425143220007803
- LevisMHow and when to use FLT3 inhibitorsClin Lymphoma Myeloma Leuk201717S18S21
- ServeHKrugUWagnerRSorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trialJ Clin Oncol201331253110311823897964
- RölligCServeHHüttmannAAddition of sorafenib versus placebo to standard therapy in patients aged 60 years or younger with newly diagnosed acute myeloid leukaemia (SORAML): a multicentre, phase 2, randomised controlled trialLancet Oncol201516161691169926549589
- StoneRMMandrekarSJSanfordBLMidostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 MutationN Engl J Med2017377545446428644114
- KnapperSRussellNGilkesAA randomized assessment of adding the kinase inhibitor lestaurtinib to first-line chemotherapy for FLT3-mutated AMLBlood201712991143115427872058
- SmithCCLasaterEALinKCCrenolanib is a selective type I pan-FLT3 inhibitorProc Natl Acad Sci U S A2014111145319532424623852
- ZimmermanEITurnerDCBuaboonnamJCrenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemiaBlood2013122223607361524046014
- OhanianMKantarjianHMBorthakurGEfficacy of a Type I FLT3 Inhibitor, Crenolanib, with Idarubicin and High-Dose Ara-C in Multiply Relapsed/Refractory FLT3+AMLBlood2016128274427932331
- StoneRMCollinsRTallmanMSEffect of cytarabine/anthracycline/crenolanib induction on minimal residual disease (MRD) in newly diagnosed FLT3 mutant AMLJournal of Clinical Oncology2017357016
- PratzKCherryMAltmanJKPreliminary Results from a Phase 1 Study of Gilteritinib in Combination with Induction and Consolidation Chemotherapy in Subjects with Newly Diagnosed Acute Myeloid Leukemia (AML)Blood201713072228588020
- SmithCCPaguiriganAJeschkeGRHeterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysisBlood20171301485828490572
- KnapperSBurnettAKLittlewoodTA phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapyBlood2006108103262327016857985
- DeangeloDJStoneRMHeaneyMLPhase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamicsBlood2006108123674368116902153
- FischerTStoneRMDeangeloDJPhase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3J Clin Oncol201028284339434520733134
- LevisMRavandiFWangESResults from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapseBlood2011117123294330121270442
- RavandiFAlattarMLGrunwaldMRPhase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutationBlood2013121234655466223613521
- StratiPKantarjianHRavandiFPhase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndromeAm J Hematol201590427628125530214
- PerlAEAltmanJKCortesJSelective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 studyLancet Oncol2017181061107528645776
- CortesJEKantarjianHMKadiaTMCrenolanib besylate, a type I pan-FLT3 inhibitor, to demonstrate clinical activity in multiply relapsed FLT3-ITD and D835 AMLJournal of Clinical Oncology2016347008
- OhanianMKantarjianHMBorthakurGEfficacy of a Type I FLT3 Inhibitor, Crenolanib, with Idarubicin and High-Dose Ara-C in Multiply Relapsed/Refractory FLT3+ AMLBlood2016128274427932331
- IyerSPJethavaYKaranesCEckardtJRCollinsRSafety Study of Salvage Chemotherapy High-Dose Ara-C/Mitoxantrone (HAM) and Type I FLT3-TKI Crenolanib in First Relapsed/Primary Refractory AMLBlood20161283983
- SchillerGJTallmanMSGoldbergSLFinal results of a randomized phase 2 study showing the clinical benefit of quizartinib (AC220) in patients with FLT3-ITD positive relapsed or refractory acute myeloid leukemiaJournal of Clinical Oncology2014327100
- ChenYBLiSLaneAAPhase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemiaBiol Blood Marrow Transplant201420122042204825239228
- PratzKWGojoIKarpJEProspective Study of Peri-Transplant Use of Sorafenib As Remission Maintenance for FLT3-ITD Patients Undergoing Allogeneic TransplantationBlood20151263164
- LarsonRAMandrekarSJSanfordBLAn Analysis of Maintenance Therapy and Post-Midostaurin Outcomes in the International Prospective Randomized, Placebo-Controlled, Double-Blind Trial (CALGB 10603/RATIFY [Alliance]) for Newly Diagnosed Acute Myeloid Leukemia (AML) Patients with FLT3 MutationsBlood2017130145
- SchmalbrockLKCocciardiSDolnikAClonal Evolution of FLT3-ITD Positive AML in Patients Treated with Midostaurin in Combination with Chemotherapy within the Ratify (CALGB 10603) and AMLSG 16-10 TrialsBlood2017130182
- StoneRMFischerTPaquetteRPhase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemiaLeukemia20122692061206822627678
- RavandiFArana YiCCortesJEFinal report of phase II study of sorafenib, cytarabine and idarubicin for initial therapy in younger patients with acute myeloid leukemiaLeukemia20142871543154524487412
- RavandiFCortesJEJonesDPhase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemiaJ Clin Oncol201028111856186220212254
- FiedlerWKayserSKebenkoMA phase I/II study of sunitinib and intensive chemotherapy in patients over 60 years of age with acute myeloid leukaemia and activating FLT3 mutationsBr J Haematol2015169569470025818407
- WangESStoneRMTallmanMSWalterRBEckardtJRCrenolanibCRA Type I FLT3 TKI, Can be Safely Combined with Cytarabine and Anthracycline Induction Chemotherapy and Results in High Response Rates in Patients with Newly Diagnosed FLT3 Mutant Acute Myeloid Leukemia (AML)Blood20161281071
- CooperBWKindwall-KellerTLCraigMDA phase I study of midostaurin and azacitidine in relapsed and elderly AML patientsClin Lymphoma Myeloma Leuk201515742843225776192
- FiedlerWServeHDöhnerHA phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the diseaseBlood2005105398699315459012
- RandhawaJKKantarjianHMBorthakurGResults of a Phase II Study of Crenolanib in Relapsed/Refractory Acute Myeloid Leukemia Patients (Pts) with Activating FLT3 MutationsBlood2014124389
- CortesJEKantarjianHForanJMPhase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication statusJ Clin Oncol201331293681368724002496
- SchillerGJTallmanMSGoldbergSLFinal results of a randomized phase 2 study showing the clinical benefit of quizartinib (AC220) in patients with FLT3-ITD positive relapsed or refractory acute myeloid leukemiaJournal of Clinical Oncology2014327100
- AbdelallWKantarjianHMBorthakurGThe Combination of Quizartinib with Azacitidine or Low Dose Cytarabine Is Highly Active in Patients (Pts) with FLT3-ITD Mutated Myeloid Leukemias: Interim Report of a Phase I/II TrialBlood2016128164227471233