Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3–MMP2 signaling

References

• GLOBOCAN [webpage on the Internet]Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 20122012 Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspxAccessed September 28, 2018
   Google Scholar
• ReckMPopatSReinmuthNMetastatic non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-upAnn Oncol201425Suppl 3iii27iii3925115305
   PubMed Web of Science ®Google Scholar
• BaiXMengLSunHLiZZhangXHuaSMicroRNA-196b inhibits cell growth and metastasis of lung cancer cells by targeting Runx2Cell Physiol Biochem201743275776728950255
   PubMedGoogle Scholar
• Dela CruzCSTanoueLTMatthayRALung cancer: epidemiology, etiology, and preventionClin Chest Med201132460564422054876
   PubMed Web of Science ®Google Scholar
• ChenWZhengRBaadePDCancer statistics in China, 2015CA Cancer J Clin201666211513226808342
   PubMed Web of Science ®Google Scholar
• PierluigiBD’AngeloCFallarinoFThymosin alpha1: the regulator of regulators?Ann N Y Acad Sci201011941520536444
   PubMed Web of Science ®Google Scholar
• GoldsteinALSlaterFDWhiteAPreparationWAPreparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin)Proc Natl Acad Sci U S A1966563101010175230175
   PubMed Web of Science ®Google Scholar
• HooperJAMcdanielMCThurmanGBCohenGHSchulofRSGoldsteinALPurification and properties of bovine thymosinAnn N Y Acad Sci1975249125144236717
   PubMed Web of Science ®Google Scholar
• FanYZChangHYuYLiuJWangRThymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell linesPeptides20062792165217316644063
   PubMed Web of Science ®Google Scholar
• LiJLiuCHWangFSThymosin alpha 1: biological activities, applications and genetic engineering productionPeptides201031112151215820699109
   PubMed Web of Science ®Google Scholar
• MorettiSOikonomouVGaraciERomaniLThymosin α1: burying secrets in the thymusExpert Opin Biol Ther201515Suppl 15158
   Web of Science ®Google Scholar
• JiangJWangXTianJLiLLinQThymosin plus cisplatin with vinorelbine or gemcitabine for non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trialsThorac Cancer20112421322027755854
   PubMed Web of Science ®Google Scholar
• CheepsattayakornACheepsattayakornRLung cancer chemotherapy, new treatment and related patentsRecent Pat Anticancer Drug Discov20149337238124844233
   PubMed Web of Science ®Google Scholar
• MoodyTWFagarasanMZiaFCesnjajMGoldsteinALThymosin alpha 1 down-regulates the growth of human non-small cell lung cancer cells in vitro and in vivoCancer Res19935321521452188221658
   PubMed Web of Science ®Google Scholar
• GuoYChangHLiJThymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathwayApoptosis20152081109112126002438
   PubMed Web of Science ®Google Scholar
• MoodyTWThymosin alpha1 as a chemopreventive agent in lung and breast cancerAnn N Y Acad Sci2007111229730417567944
   PubMed Web of Science ®Google Scholar
• ZhouQWangYCheGEstablishment and their biological characteristics of clonal cell subpopulations (NL9980 and L9981) from a human lung large cell carcinoma cell line (WCQH-9801)Zhongguo Fei Ai Za Zhi20036646446821310132
   PubMedGoogle Scholar
• DLXXEffect of thymosin a1 on the apoptosis of lung cancer cell A549Chin J Clin Pharmacol2016321917761779
   Google Scholar
• AbdelhamedSOguraKYokoyamaSSaikiIHayakawaYAKT-STAT3 pathway as a downstream target of EGFR signaling to regulate PD-L1 expression on NSCLC cellsJ Cancer20167121579158627698894
   PubMed Web of Science ®Google Scholar
• OtaKAzumaKKawaharaAInduction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancerClin Cancer Res201521174014402126019170
   PubMed Web of Science ®Google Scholar
• GaraciEPicaFMatteucciCHistorical review on thymosin α1 in oncology: preclinical and clinical experiencesExpert Opin Biol Ther201515Suppl 13139
   PubMed Web of Science ®Google Scholar
• LinKChengJYangTLiYZhuBEGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-κBBiochem Biophys Res Commun20154631–29510125998384
   PubMed Web of Science ®Google Scholar
• SoriaJCMarabelleABrahmerJRGettingerSImmune checkpoint modulation for non-small cell lung cancerClin Cancer Res201521102256226225979932
   PubMed Web of Science ®Google Scholar
• MuCYHuangJAChenYChenCZhangXGHigh expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturationMed Oncol201128368268820373055
   PubMed Web of Science ®Google Scholar
• OkumaYHishimaTKashimaJHommaSHigh PD-L1 expression indicates poor prognosis of HIV-infected patients with non-small cell lung cancerCancer Immunol Immunother201867349550529243049
   PubMed Web of Science ®Google Scholar
• TakamoriSToyokawaGOkamotoIClinical significance of PD-L1 expression in brain metastases from non-small cell lung cancerAnticancer Res201838155355729277823
   PubMed Web of Science ®Google Scholar
• ChenLGibbonsDLGoswamiSMetastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppressionNat Commun20145524125348003
   PubMed Web of Science ®Google Scholar
• AsgarovaAAsgarovKGodetYPD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinomaOncoimmunology201875e142317029721376
   PubMed Web of Science ®Google Scholar
• KimSKohJKimMYPD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lungHum Pathol20165871427473266
   PubMed Web of Science ®Google Scholar
• ZhangJGaoJLiYCirculating PD-L1 in NSCLC patients and the correlation between the level of PD-L1 expression and the clinical characteristicsThorac Cancer20156453453826273411
   PubMed Web of Science ®Google Scholar
• ZhaoLLiCLiuFA blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathwayOnco Targets Ther2017102115212628442920
   PubMed Web of Science ®Google Scholar
• LeeMMChenYYLiuPYHsuSSheuMJPipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2Chem Biol Interact2015236193025899827
   PubMed Web of Science ®Google Scholar
• ChambersAFMatrisianLMChanging views of the role of matrix metalloproteinases in metastasisJ Natl Cancer Inst19978917126012709293916
   PubMed Web of Science ®Google Scholar
• KleinerDEStetler-StevensonWGMatrix metalloproteinases and metastasisCancer Chemother Pharmacol199943SupplS42S5110357558
   PubMed Web of Science ®Google Scholar
• TokurakuMSatoHMurakamiSOkadaYWatanabeYSeikiMActivation of the precursor of gelatinase A/72 kDa type IV collagenase/ MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasisInt J Cancer19956453553597591310
   PubMed Web of Science ®Google Scholar
• RojianiMVAlidinaJEspositoNRojianiAMExpression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinomaInt J Clin Exp Pathol20103877578121151391
   PubMed Web of Science ®Google Scholar
• PoudelBKiHHLuyenBTLeeYMKimYHKimDKTriticumoside induces apoptosis via caspase-dependent mitochondrial pathway and inhibits migration through downregulation of MMP2/9 in human lung cancer cellsActa Biochim Biophys Sin201648215316026758192
   PubMedGoogle Scholar
• JungOLeeJLeeYJTimosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and β-catenin signaling pathwaysBioorg Med Chem Lett201626163963396727422337
   PubMed Web of Science ®Google Scholar
• LeeKRLeeJSSongJEHaSJHongEKInonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9Int J Oncol20144562533254025270791
   PubMed Web of Science ®Google Scholar
• ByunHJDarvinPKangDYSilibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cellsOncol Rep20173763270327828440514
   PubMed Web of Science ®Google Scholar
• YanWTuBLiuYYSuppressive effects of plumbagin on invasion and migration of breast cancer cells via the inhibition of STAT3 signaling and down-regulation of inflammatory cytokine expressionsBone Res20131436237026273514
   PubMed Web of Science ®Google Scholar
• EttingerDSWoodDEAisnerDLNon-small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncologyJ Natl Compr Canc Netw201715450453528404761
   PubMed Web of Science ®Google Scholar