Epigenetic Mechanism of Enrichment of A549 Lung Cancer Stem Cells with 5-Fu

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. doi:10.3322/caac.21442
   PubMed Web of Science ®Google Scholar
• Torre LA, Siegel RL, Jemal A. Lung cancer statistics. Adv Exp Med Biol. 2016;893:1–19.
   PubMed Web of Science ®Google Scholar
• Shao Y, Liang B, Long F, Jiang SJ. Diagnostic MicroRNA biomarker discovery for non-small-cell lung cancer adenocarcinoma by integrative bioinformatics analysis. Biomed Res Int. 2017;2017:2563085. doi:10.1155/2017/2563085
   PubMed Web of Science ®Google Scholar
• Niklinski J, Niklinska W, Laudanski J, Chyczewska E, Chyczewski L. Prognostic molecular markers in non-small cell lung cancer. Lung Cancer. 2001;34(Suppl 2):S53–S58. doi:10.1016/S0169-5002(01)00345-2
   PubMedGoogle Scholar
• Sy SM, Wong N, Lee TW, et al. Distinct patterns of genetic alterations in adenocarcinoma and squamous cell carcinoma of the lung. Eur J Cancer. 2004;40(7):1082–1094. doi:10.1016/j.ejca.2004.01.012
   PubMed Web of Science ®Google Scholar
• McDoniels-Silvers AL, Nimri CF, Stoner GD, Lubet RA, You M. Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin Cancer Res. 2002;8(4):1127–1138.
   PubMed Web of Science ®Google Scholar
• Avila-Moreno F, Lopez-Gonzalez JS, Galindo-Rodriguez G, Prado-Garcia H, Bajana S, Sanchez-Torres C. Lung squamous cell carcinoma and adenocarcinoma cell lines use different mediators to induce comparable phenotypic and functional changes in human monocyte-derived dendritic cells. Cancer Immunol Immunother. 2006;55(5):598–611. doi:10.1007/s00262-005-0060-3
   PubMed Web of Science ®Google Scholar
• Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21(3):283–296. doi:10.1016/j.ccr.2012.03.003
   PubMed Web of Science ®Google Scholar
• Zwaka TP, Thomson JA. Differentiation of human embryonic stem cells occurs through symmetric cell division. Stem Cells. 2005;23(2):146–149. doi:10.1634/stemcells.2004-0248
   PubMed Web of Science ®Google Scholar
• Kim RJ, Nam JS. OCT4 expression enhances features of cancer stem cells in a mouse model of breast cancer. Lab Anim Res. 2011;27(2):147–152. doi:10.5625/lar.2011.27.2.147
   PubMedGoogle Scholar
• Chang CJ, Chien Y, Lu KH, et al. Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells. Biochem Biophys Res Commun. 2011;415(2):245–251. doi:10.1016/j.bbrc.2011.10.024
   PubMed Web of Science ®Google Scholar
• Hu T, Liu S, Breiter DR, Wang F, Tang Y, Sun S. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res. 2008;68(16):6533–6540. doi:10.1158/0008-5472.CAN-07-6642
   PubMed Web of Science ®Google Scholar
• Chiou SH, Wang ML, Chou YT, et al. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res. 2010;70(24):10433–10444. doi:10.1158/0008-5472.CAN-10-2638
   PubMed Web of Science ®Google Scholar
• Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3(5):330–338. doi:10.1038/nrc1074
   PubMed Web of Science ®Google Scholar
• Chang A. Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer. 2011;71(1):3–10. doi:10.1016/j.lungcan.2010.08.022
   PubMed Web of Science ®Google Scholar
• Li X, Jia L, Jia X, et al. Enrichment of Oct3/4-positive cells from a human bronchial epithelial cell line. Apmis. 2013;121(7):612–625. doi:10.1111/apm.12028
   PubMed Web of Science ®Google Scholar
• Xu G, Yang L, Zhang W, Wei X. All the tested human somatic cells express both Oct4A and Its Pseudogenes but Express Oct4A at much lower levels compared with its pseudogenes and human embryonic stem cells. Stem Cells Dev. 2015;24(13):1546–1557. doi:10.1089/scd.2014.0552
   PubMed Web of Science ®Google Scholar
• Babaie Y, Herwig R, Greber B, et al. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells. 2007;25(2):500–510. doi:10.1634/stemcells.2006-0426
   PubMed Web of Science ®Google Scholar
• Yamagata K, Ueda J, Mizutani E, Saitou M, Wakayama T. Survival and death of epiblast cells during embryonic stem cell derivation revealed by long-term live-cell imaging with an Oct4 reporter system. Dev Biol. 2010;346(1):90–101. doi:10.1016/j.ydbio.2010.07.021
   PubMed Web of Science ®Google Scholar
• Robertson KD. DNA methylation, methyltransferases, and cancer. Oncogene. 2001;20(24):3139–3155. doi:10.1038/sj.onc.1204341
   PubMed Web of Science ®Google Scholar
• Bestor TH. Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J. 1992;11(7):2611–2617. doi:10.1002/j.1460-2075.1992.tb05326.x
   PubMed Web of Science ®Google Scholar
• Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992;69(6):915–926. doi:10.1016/0092-8674(92)90611-F
   PubMed Web of Science ®Google Scholar
• Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99(3):247–257. doi:10.1016/S0092-8674(00)81656-6
   PubMed Web of Science ®Google Scholar
• Gerhauser C, Heilmann K, Pudenz M. Genome-Wide DNA Methylation Profiling in Dietary Intervention Studies: a User’s Perspective. Current Pharmacol Rep. 2015;1(1):31–45. doi:10.1007/s40495-014-0001-y
   Google Scholar
• Smith ZD, Chan MM, Mikkelsen TS, et al. A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature. 2012;484(7394):339–344. doi:10.1038/nature10960
   PubMed Web of Science ®Google Scholar
• Scholer HR, Ruppert S, Suzuki N, Chowdhury K, Gruss P. New type of POU domain in germ line-specific protein Oct-4. Nature. 1990;344(6265):435–439. doi:10.1038/344435a0
   PubMed Web of Science ®Google Scholar
• Rosner MH, Vigano MA, Ozato K, et al. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature. 1990;345(6277):686–692. doi:10.1038/345686a0
   PubMed Web of Science ®Google Scholar
• Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 2010;7(1):36–41. doi:10.1016/j.stem.2010.06.012
   PubMed Web of Science ®Google Scholar
• Mei Q, Xue G, Li X, et al. Methylation-induced loss of miR-484 in microsatellite-unstable colorectal cancer promotes both viability and IL-8 production via CD137L. J Pathol. 2015;236(2):165–174. doi:10.1002/path.4525
   PubMed Web of Science ®Google Scholar
• Sun C, Li S, Yang C, et al. MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6. Biochem Biophys Res Commun. 2016;471(1):82–88. doi:10.1016/j.bbrc.2016.01.175
   PubMed Web of Science ®Google Scholar
• Zhang T, Cai X, Li Q, et al. Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC). Oncotarget. 2016;7(27):42225–42240. doi:10.18632/oncotarget.9944
   PubMedGoogle Scholar
• Sun CC, Li SJ, Li DJ. Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1. Oncotarget. 2016;7(24):35960–35978. doi:10.18632/oncotarget.8482
   PubMed Web of Science ®Google Scholar
• Li J, Wang Y, Luo J, et al. miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells. FEBS Lett. 2012;586(20):3761–3765. doi:10.1016/j.febslet.2012.09.016
   PubMed Web of Science ®Google Scholar
• Xu C, Li S, Chen T, et al. miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer. Oncol Rep. 2016;35(1):497–503. doi:10.3892/or.2015.4392
   PubMed Web of Science ®Google Scholar
• Chen X, Xu B, Han X, et al. Effect of bisphenol A on pluripotency of mouse embryonic stem cells and differentiation capacity in mouse embryoid bodies. Toxicol in Vitro. 2013;27(8):2249–2255. doi:10.1016/j.tiv.2013.09.018
   PubMed Web of Science ®Google Scholar
• Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature. 2008;455(7216):1124–1128. doi:10.1038/nature07299
   PubMed Web of Science ®Google Scholar