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Original Research

O-GlcNAcylation Enhances NUSAP1 Stability and Promotes Bladder Cancer Aggressiveness

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Pages 445-454 | Published online: 15 Jan 2021

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66(1):7–30. doi:10.3322/caac.21332
  • Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. doi:10.3322/caac.21262
  • Wu X, Xu B, Yang C, et al. Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the hedgehog signaling pathway. J Exp Clin Cancer Res. 2017;36(1):127. doi:10.1186/s13046-017-0597-y
  • Fang L, Zhang M, Chen L, et al. Downregulation of nucleolar and spindle-associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma. Oncol Rep. 2016;36(3):1506–1516. doi:10.3892/or.2016.4955
  • Okamoto A, Higo M, Shiiba M, et al. Down-regulation of nucleolar and spindle-associated protein 1 (NUSAP1) expression suppresses tumor and cell proliferation and enhances anti-tumor effect of paclitaxel in oral squamous cell carcinoma. PLoS One. 2015;10(11):e0142252. doi:10.1371/journal.pone.0142252
  • Gordon CA, Gong X, Ganesh D, Brooks JD. NUSAP1 promotes invasion and metastasis of prostate cancer. Oncotarget. 2017;8(18):29935–29950. doi:10.18632/oncotarget.15604
  • Gordon CA, Gulzar ZG, Brooks JD. NUSAP1 expression is upregulated by loss of RB1 in prostate cancer cells. The Prostate. 2015;75(5):517–526. doi:10.1002/pros.22938
  • Chen L, Yang L, Qiao F, et al. High levels of nucleolar spindle-associated protein and reduced levels of BRCA1 expression predict poor prognosis in triple-negative breast cancer. PLoS One. 2015;10(10):e0140572. doi:10.1371/journal.pone.0140572
  • Gulzar ZG, McKenney JK, Brooks JD. Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1. Oncogene. 2013;32(1):70–77. doi:10.1038/onc.2012.27
  • Apweiler R, Hermjakob H, Sharon N. On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database. Biochim Biophys Acta. 1999;1473(1):4–8. doi:10.1016/S0304-4165(99)00165-8
  • Li Y, Wang L, Liu J, et al. O-GlcNAcylation modulates Bmi-1 protein stability and potential oncogenic function in prostate cancer. Oncogene. 2017;36(45):6293–6305. doi:10.1038/onc.2017.223
  • Srikanth B, Vaidya MM, Kalraiya RD. O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18. J Biol Chem. 2010;285(44):34062–34071. doi:10.1074/jbc.M109.098996
  • Torres CR, Hart GW. Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc. J Biol Chem. 1984;259(5):3308–3317.
  • Onodera Y, Nam JM, Bissell MJ. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 2014;124(1):367–384. doi:10.1172/JCI63146
  • Butkinaree C, Park K, Hart GW. O-linked beta-N-acetylglucosamine (O-GlcNAc): extensive crosstalk with phosphorylation to regulate signaling and transcripti21qon in response to nutrients and stress. Biochim Biophys Acta. 2010;1800(2):96–106. doi:10.1016/j.bbagen.2009.07.018
  • Zachara NE, Hart GW. O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress. Biochim Biophys Acta. 2004;1673(1–2):13–28. doi:10.1016/j.bbagen.2004.03.016
  • Rozanski W, Krzeslak A, Forma E, et al. Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level. Clin Lab. 2012;58(5–6):579–583.
  • Trinca GM, Goodman ML, Papachristou EK, et al. O-GlcNAc-dependent regulation of progesterone receptor function in breast cancer. Horm Cancer. 2018;9(1):12–21. doi:10.1007/s12672-017-0310-9
  • de Queiroz RM, Madan R, Chien J, Dias WB, Slawson C. Changes in O-linked N-acetylglucosamine (O-GlcNAc) homeostasis activate the p53 pathway in ovarian cancer cells. J Biol Chem. 2016;291(36):18897–18914. doi:10.1074/jbc.M116.734533
  • Kamigaito T, Okaneya T, Kawakubo M, Shimojo H, Nishizawa O, Nakayama J. Overexpression of O-GlcNAc by prostate cancer cells is significantly associated with poor prognosis of patients. Prostate Cancer Prostatic Dis. 2014;17(1):18–22. doi:10.1038/pcan.2013.56
  • Guo H, Zhang B, Nairn AV, et al. O-linked N-acetylglucosamine (O-GlcNAc) expression levels epigenetically regulate colon cancer tumorigenesis by affecting the cancer stem cell compartment via modulating expression of transcriptional factor MYBL1. J Biol Chem. 2017;292(10):4123–4137. doi:10.1074/jbc.M116.763201
  • Phueaouan T, Chaiyawat P, Netsirisawan P, et al. Aberrant O-GlcNAc-modified proteins expressed in primary colorectal cancer. Oncol Rep. 2013;30(6):2929–2936. doi:10.3892/or.2013.2794
  • Shi Y, Tomic J, Wen F, et al. Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia. Leukemia. 2010;24(9):1588–1598. doi:10.1038/leu.2010.152
  • Ma Z, Vosseller K. O-GlcNAc in cancer biology. Amino Acids. 2013;45(4):719–733. doi:10.1007/s00726-013-1543-8
  • Li L, Zhou Y, Sun L, et al. NuSAP is degraded by APC/C-Cdh1 and its overexpression results in mitotic arrest dependent of its microtubules’ affinity. Cell Signal. 2007;19(10):2046–2055. doi:10.1016/j.cellsig.2007.05.017
  • Raemaekers T, Ribbeck K, Beaudouin J, et al. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. J Cell Biol. 2003;162(6):1017–1029. doi:10.1083/jcb.200302129
  • Ribbeck K, Groen AC, Santarella R, et al. NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell. 2006;17(6):2646. doi:10.1091/mbc.e05-12-1178
  • Chen DT, Nasir A, Culhane A, et al. Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res Treat. 2010;119(2):335–346. doi:10.1007/s10549-009-0344-y
  • Satow R, Shitashige M, Kanai Y, et al. Combined functional genome survey of therapeutic targets for hepatocellular carcinoma. Clin Cancer Res. 2010;16(9):2518–2528. doi:10.1158/1078-0432.CCR-09-2214
  • Kokkinakis DM, Liu X, Neuner RD. Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma. Mol Cancer Ther. 2005;4(9):1338–1348. doi:10.1158/1535-7163.MCT-05-0141