MicroRNA-302s Might Regulate ARL4C-Mediated Gastric Cancer Progression via p53 Signaling: Bioinformatics Analysis and Experiments Validation

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30. doi:10.3322/caac.21590
   PubMed Web of Science ®Google Scholar
• Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H. Gastric cancer. Lancet. 2016;388(10060):2654–2664. doi:10.1016/S0140-6736(16)30354-3
   PubMed Web of Science ®Google Scholar
• Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM. Gastric adenocarcinoma: review and considerations for future directions. Ann Surg. 2005;241(1):27–39. doi:10.1097/01.sla.0000149300.28588.23
   PubMed Web of Science ®Google Scholar
• Vedeld HM, Goel A, Lind GE. Epigenetic biomarkers in gastrointestinal cancers: the current state and clinical perspectives. Semin Cancer Biol. 2018;51:36–49. doi:10.1016/j.semcancer.2017.12.004
   PubMed Web of Science ®Google Scholar
• Burd CG, Strochlic TI, Setty SR. Arf-like GTPases: not so Arf-like after all. Trends Cell Biol. 2004;14(12):687–694. doi:10.1016/j.tcb.2004.10.004
   PubMed Web of Science ®Google Scholar
• Casalou C, Ferreira A, Barral DC. The role of ARF family proteins and their regulators and effectors in cancer progression: a therapeutic perspective. Front Cell Dev Biol. 2020;8:217. doi:10.3389/fcell.2020.00217
   PubMed Web of Science ®Google Scholar
• Donaldson JG, Jackson CL. ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol. 2011;12(6):362–375. doi:10.1038/nrm3117
   PubMed Web of Science ®Google Scholar
• Wang Q, Huang Z, Guo W. microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma. Clin Cancer Res. 2014;20(5):1146–1157. doi:10.1158/1078-0432.CCR-13-1023
   PubMed Web of Science ®Google Scholar
• Shao J, Xu L, Chen L, et al. Arl13b promotes gastric tumorigenesis by regulating Smo trafficking and activation of the hedgehog signaling pathway. Cancer Res. 2017;77(15):4000–4013. doi:10.1158/0008-5472.CAN-16-2461
   PubMed Web of Science ®Google Scholar
• Hamadou WS, Besbes S, Mani R, et al. ARLTS1, potential candidate gene in familial aggregation of hematological malignancies. Bull Cancer. 2017;104(2):123–127. doi:10.1016/j.bulcan.2016.10.016
   PubMed Web of Science ®Google Scholar
• Masojc B, Medrek K, Debniak T, et al. ARLTS1 Trp149Stop mutation and the risk of ovarian cancer. Cancer Res. 2007;67(9):4533. author reply 4534. doi:10.1158/0008-5472.CAN-06-4193
   PubMed Web of Science ®Google Scholar
• Frank B, Hemminki K, Brenner H, Hoffmeister M, Chang-Claude J, Burwinkel B. ARLTS1 variants and risk of colorectal cancer. Cancer Lett. 2006;244(2):172–175. doi:10.1016/j.canlet.2005.12.006
   PubMed Web of Science ®Google Scholar
• Guo F, Yuan D, Zhang J. ARL14Silencing of gene induces lung adenocarcinoma cells to a dormant state. Front Cell Dev Biol. 2019;7:238. doi:10.3389/fcell.2019.00238
   PubMed Web of Science ®Google Scholar
• Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401–404. doi:10.1158/2159-8290.CD-12-0095
   PubMed Web of Science ®Google Scholar
• Gao J, Aksoy BA, Dogrusoz U, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6(269):pl1. doi:10.1126/scisignal.2004088
   PubMed Web of Science ®Google Scholar
• Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–w102. doi:10.1093/nar/gkx247
   PubMed Web of Science ®Google Scholar
• Lin Y, Liu T, Cui T, et al. RNAInter in 2020: RNA interactome repository with increased coverage and annotation. Nucleic Acids Res. 2020;48(D1):D189–D197. doi:10.1093/nar/gkz804
   PubMed Web of Science ®Google Scholar
• Agarwal V, Bell G, Nam J, Bartel D. Predicting effective microRNA target sites in mammalian mRNAs. eLife. 2015;4:4. doi:10.7554/eLife.05005
   Web of Science ®Google Scholar
• Wong N, Wang X. miRDB: an online resource for microRNA target prediction and functional annotations. Nucleic Acids Res. 2015;43(D1):D146–152. doi:10.1093/nar/gku1104
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523. doi:10.1038/s41467-019-09234-6
   PubMed Web of Science ®Google Scholar
• Montojo J, Zuberi K, Rodriguez H, Bader GD, Morris Q. GeneMANIA: fast gene network construction and function prediction for cytoscape. F1000Research. 2014;3:153. doi:10.12688/f1000research.4572.1
   PubMedGoogle Scholar
• Szász A, Lánczky A, Nagy Á, et al. Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1065 patients. Oncotarget. 2016;7(31):49322–49333. doi:10.18632/oncotarget.10337
   PubMedGoogle Scholar
• Naito S, Inoue S, Kinjo M, Tanaka K. Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines. Gan. 1983;74(2):240–247.
   PubMedGoogle Scholar
• Subramanyam D, Lamouille S, Judson R, et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011;29(5):443–448. doi:10.1038/nbt.1862
   PubMed Web of Science ®Google Scholar
• Zhang M, Yang Q, Zhang L, et al. miR-302b is a potential molecular marker of esophageal squamous cell carcinoma and functions as a tumor suppressor by targeting ErbB4. J Exp Clin Cancer Res. 2014;33(1):10. doi:10.1186/1756-9966-33-10
   PubMedGoogle Scholar
• Peng N, Yang X, Zhu C, et al. MicroRNA-302 cluster downregulates enterovirus 71-induced innate immune response by targeting KPNA2. J Immunol. 2018;201(1):145–156. doi:10.4049/jimmunol.1701692
   PubMed Web of Science ®Google Scholar
• Maadi H, Moshtaghian A, Taha M, et al. Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer. Int J Biochem Cell Biol. 2016;81:121–132. doi:10.1016/j.biocel.2016.11.004
   PubMed Web of Science ®Google Scholar
• Ma G, Li Q, Dai W, Yang X, Sang A. Prognostic implications of miR-302a/b/c/d in human gastric cancer. Pathol Oncol Res. 2017;23(4):899–905. doi:10.1007/s12253-017-0282-7
   PubMed Web of Science ®Google Scholar
• Chen L, Min L, Wang X, et al. Loss of RACK1 promotes metastasis of gastric cancer by inducing a miR-302c/IL8 signaling loop. Cancer Res. 2015;75(18):3832–3841. doi:10.1158/0008-5472.CAN-14-3690
   PubMed Web of Science ®Google Scholar
• Balzano F, Cruciani S, Basoli V, et al. MiR200 and miR302: two big families influencing stem cell behavior. Molecules. 2018;23(2):282. doi:10.3390/molecules23020282
   PubMed Web of Science ®Google Scholar
• Gao Z, Zhu X, Dou Y. The miR-302/367 cluster: a comprehensive update on its evolution and functions. Open Biol. 2015;5(12):150138. doi:10.1098/rsob.150138
   PubMed Web of Science ®Google Scholar
• Levine A. p53: 800 million years of evolution and 40 years of discovery. Nat Rev Cancer. 2020;20(8):471–480. doi:10.1038/s41568-020-0262-1
   PubMed Web of Science ®Google Scholar
• Hafner A, Bulyk ML, Jambhekar A, Lahav G. The multiple mechanisms that regulate p53 activity and cell fate. Nat Rev Mol Cell Biol. 2019;20(4):199–210. doi:10.1038/s41580-019-0110-x
   PubMed Web of Science ®Google Scholar
• Uchi R, Kogo R, Kawahara K, et al. PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression. Br J Cancer. 2013;109(8):2199–2206. doi:10.1038/bjc.2013.561
   PubMed Web of Science ®Google Scholar
• Lv B, Ma R, Chen X, et al. E2F1-activated SPIN1 promotes tumor growth via a MDM2-p21-E2F1 feedback loop in gastric cancer. Mol Oncol. 2020;14(10):2629–2645. doi:10.1002/1878-0261.12778
   PubMed Web of Science ®Google Scholar
• Chia N, Tan P. Molecular classification of gastric cancer. Ann Oncol. 2016;27(5):763–769. doi:10.1093/annonc/mdw040
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513(7517):202–209. doi:10.1038/nature13480
   PubMed Web of Science ®Google Scholar