ALYREF Drives Cancer Cell Proliferation Through an ALYREF-MYC Positive Feedback Loop in Glioblastoma

References

• Liou TG, Adler FR, Cahill BC, Cox DR. Correction: lung transplantation and survival in children with cystic fibrosis. N Engl J Med. 2008;359(5):536. doi:10.1056/NEJMc086289
   PubMed Web of Science ®Google Scholar
• Stupp R, Hegi ME, Mason WP, et al.; R. European Organisation for, T. Treatment of Cancer Brain, G. Radiation Oncology, G. National Cancer Institute of Canada Clinical Trials. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10:459–466. doi:10.1016/S1470-2045(09)70025-7
   PubMed Web of Science ®Google Scholar
• Weinstein JN, Collisson EA, Mills GB, et al.; N. Cancer Genome Atlas Research. The cancer genome atlas pan-cancer analysis project. Nat Genet. 2013;45(10):1113–1120. doi:10.1038/ng.2764
   PubMed Web of Science ®Google Scholar
• Becker PB; E.P. Consortium. A user’s guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol. 2011;9(4):e1001046. doi:10.1371/journal.pbio.1001046
   PubMed Web of Science ®Google Scholar
• Bernstein BE, Stamatoyannopoulos JA, Costello JF, et al. The NIH roadmap epigenomics mapping consortium. Nat Biotechnol. 2010;28:1045–1048. doi:10.1038/nbt1010-1045
   PubMed Web of Science ®Google Scholar
• Pangeni RP, Zhang Z, Alvarez AA, et al. Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma. Epigenetics. 2018;13:432–448. doi:10.1080/15592294.2018.1469892
   PubMed Web of Science ®Google Scholar
• Luo E-C, Nathanson JL, Tan FE, et al. Large-scale tethered function assays identify factors that regulate mRNA stability and translation. Nat Struct Mol Biol. 2020;27(10):989–1000. doi:10.1038/s41594-020-0477-6
   PubMed Web of Science ®Google Scholar
• Gerstberger S, Hafner M, Tuschl T. A census of human RNA-binding proteins. Nat Rev Genet. 2014;15(12):829–845. doi:10.1038/nrg3813
   PubMed Web of Science ®Google Scholar
• Montalbano M, McAllen S, Puangmalai N, et al. RNA-binding proteins musashi and tau soluble aggregates initiate nuclear dysfunction. Nat Commun. 2020;11(1):4305. doi:10.1038/s41467-020-18022-6
   PubMed Web of Science ®Google Scholar
• Wang ZL, Li B, Luo YX, et al. Comprehensive genomic characterization of RNA-binding proteins across human cancers. Cell Rep. 2018;22:286–298. doi:10.1016/j.celrep.2017.12.035
   PubMed Web of Science ®Google Scholar
• Takayama K-I, Suzuki T, Fujimura T, et al. Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF. Proc Natl Acad Sci U S A. 2017;114(39):10461–10466. doi:10.1073/pnas.1706076114
   PubMed Web of Science ®Google Scholar
• Kosti A, de Araujo PR, Li WQ, et al. The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation. Genome Biol. 2020;21:195. doi:10.1186/s13059-020-02115-y
   PubMed Web of Science ®Google Scholar
• Song X, Wan X, Huang T, et al. SRSF3-regulated RNA alternative splicing promotes glioblastoma tumorigenicity by affecting multiple cellular processes. Cancer Res. 2019;79:5288–5301. doi:10.1158/0008-5472.CAN-19-1504
   PubMed Web of Science ®Google Scholar
• Fan J, Wang K, Du X, et al. ALYREF links 3ʹ-end processing to nuclear export of non-polyadenylated mRNAs. EMBO J. 2019;38. doi:10.15252/embj.201899910
   Web of Science ®Google Scholar
• Shi M, Zhang H, Wu X, et al. ALYREF mainly binds to the 5ʹ and the 3ʹ regions of the mRNA in vivo. Nucleic Acids Res. 2017;45:9640–9653. doi:10.1093/nar/gkx597
   PubMed Web of Science ®Google Scholar
• Fan J, Kuai B, Wu G, et al. Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export. EMBO J. 2017;36:2870–2886. doi:10.15252/embj.201696139
   PubMed Web of Science ®Google Scholar
• Stubbs SH, Conrad NK. Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy. Nucleic Acids Res. 2015;43(1):504–519. doi:10.1093/nar/gku1278
   PubMed Web of Science ®Google Scholar
• Chi B, Wang Q, Wu G, et al. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Nucleic Acids Res. 2013;41(2):1294–1306. doi:10.1093/nar/gks1188
   PubMed Web of Science ®Google Scholar
• Dominguez-Sanchez MS, Saez C, Japon MA, Aguilera A, Luna R. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 2011;11(1):77. doi:10.1186/1471-2407-11-77
   PubMedGoogle Scholar
• Saito Y, Kasamatsu A, Yamamoto A, et al. ALY as a potential contributor to metastasis in human oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2013;139(4):585–594. doi:10.1007/s00432-012-1361-5
   PubMed Web of Science ®Google Scholar
• Shang Y, Li Y, Zhang Y, Wang J. ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma. Biochem Biophys Res Commun. 2019;515(4):572–578. doi:10.1016/j.bbrc.2019.06.004
   PubMed Web of Science ®Google Scholar
• Gajduskova P, Ruiz de Los Mozos I, Rajecky M, Hluchy M, Ule J, Blazek D. CDK11 is required for transcription of replication-dependent histone genes. Nat Struct Mol Biol. 2020;27(5):500–510. doi:10.1038/s41594-020-0406-8
   PubMedGoogle Scholar
• Wang G, Wang J, Zhao H, Wang J, Tony SS. To, the role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy. Arch Biochem Biophys. 2015;580:84–92. doi:10.1016/j.abb.2015.07.005
   PubMed Web of Science ®Google Scholar
• Li F, Zhao H, Su M, et al. HnRNP-F regulates EMT in bladder cancer by mediating the stabilization of snail1 mRNA by binding to its 3ʹ UTR. EBioMedicine. 2019;45:208–219. doi:10.1016/j.ebiom.2019.06.017
   PubMed Web of Science ®Google Scholar
• Kataoka K, Shiraishi Y, Takeda Y, et al. Aberrant PD-L1 expression through 3ʹ-UTR disruption in multiple cancers. Nature. 2016;534:402–406. doi:10.1038/nature18294
   PubMed Web of Science ®Google Scholar
• Li X, Qian X, Peng LX, et al. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol. 2016;18:561–571. doi:10.1038/ncb3338
   PubMed Web of Science ®Google Scholar
• Lovnicki J, Gan Y, Feng T, et al. LIN28B promotes the development of neuroendocrine prostate cancer. J Clin Invest. 2020;130(10):5338–5348. doi:10.1172/JCI135373
   PubMed Web of Science ®Google Scholar
• Mohibi S, Chen X, Zhang J. Cancer the’RBP’eutics-RNA-binding proteins as therapeutic targets for cancer. Pharmacol Ther. 2019;203:107390. doi:10.1016/j.pharmthera.2019.07.001
   PubMed Web of Science ®Google Scholar
• Ning JF, Stanciu M, Humphrey MR, et al. Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nat Commun. 2019;10:2910. doi:10.1038/s41467-019-10993-5
   PubMed Web of Science ®Google Scholar
• Zhao K, Wang Q, Wang Y, et al. EGFR/c-myc axis regulates TGFbeta/hippo/notch pathway via epigenetic silencing miR-524 in gliomas. Cancer Lett. 2017;406:12–21. doi:10.1016/j.canlet.2017.07.022
   PubMed Web of Science ®Google Scholar
• Du J, Zhang G, Qiu H, Yu H, Yuan W. A novel positive feedback loop of linc02042 and c-Myc mediated by YBX1 promotes tumorigenesis and metastasis in esophageal squamous cell carcinoma. Cancer Cell Int. 2020;20(1):75. doi:10.1186/s12935-020-1154-x
   PubMed Web of Science ®Google Scholar
• Dong Z, Cui H. The emerging roles of RNA modifications in glioblastoma. Cancers. 2020;12(3):736. doi:10.3390/cancers12030736
   PubMed Web of Science ®Google Scholar
• Yang X, Yang Y, Sun B-F, et al. 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Res. 2017;27(5):606–625. doi:10.1038/cr.2017.55
   PubMed Web of Science ®Google Scholar
• Bufalieri F, Caimano M, Lospinoso Severini L, et al. The RNA-binding ubiquitin ligase MEX3A affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of RIG-I. Cancers. 2020;12(2):321. doi:10.3390/cancers12020321
   PubMed Web of Science ®Google Scholar
• Correa BR, de Araujo PR, Qiao M, et al. Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma. Genome Biol. 2016;17:125. doi:10.1186/s13059-016-0990-4
   PubMed Web of Science ®Google Scholar
• Panzeri V, Manni I, Capone A, et al. The RNA-binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinoma. Mol Oncol. 2020. doi:10.1002/1878-0261.12847
   PubMed Web of Science ®Google Scholar
• Federico A, Rienzo M, Abbondanza C, Costa V, Ciccodicola A, Casamassimi A. Pan-cancer mutational and transcriptional analysis of the integrator complex. Int J Mol Sci. 2017;18. doi:10.3390/ijms18050936
   Web of Science ®Google Scholar