Circular RNA circDNM3OS Functions as a miR-145-5p Sponge to Accelerate Cholangiocarcinoma Growth and Glutamine Metabolism by Upregulating MORC2

References

• Li G, Liu T, Zhang B, Chen W, Ding Z. Genome-wide identification of a competing endogenous RNA network in cholangiocarcinoma. J Cell Biochem. 2019;120(11):18995–19003. doi:10.1002/jcb.29222
   PubMed Web of Science ®Google Scholar
• Razumilava N, Gores GJ. Cholangiocarcinoma. Lancet. 2014;383(9935):2168–2179. doi:10.1016/S0140-6736(13)61903-0
   PubMed Web of Science ®Google Scholar
• Fitzmaurice C, Allen C, Barber RM, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 Cancer Groups, 1990 to 2015: a systematic analysis for the Global Burden of Disease Study. JAMA Oncol. 2017;3(4):524–548. doi:10.1001/jamaoncol.2016.5688
   PubMed Web of Science ®Google Scholar
• Bridgewater J, Galle PR, Khan SA, et al. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol. 2014;60(6):1268–1289.
   PubMed Web of Science ®Google Scholar
• Yeh C-N, Chen M-H, Chang Y-C, et al. Over-expression of TNNI3K is associated with early-stage carcinogenesis of cholangiocarcinoma. Mol Carcinog. 2019;58(2):270–278. doi:10.1002/mc.22925
   PubMed Web of Science ®Google Scholar
• Michalak KP, Maćkowska-Kędziora A, Sobolewski B, Woźniak P. Key roles of glutamine pathways in reprogramming the cancer metabolism. Oxid Med Cell Longev. 2015;2015:964321. doi:10.1155/2015/964321
   PubMed Web of Science ®Google Scholar
• Xiao D, Zeng L, Yao K, Kong X, Wu G, Yin Y. The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications. Amino Acids. 2016;48(9):2067–2080. doi:10.1007/s00726-016-2254-8
   PubMed Web of Science ®Google Scholar
• Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest. 2013;123(9):3678–3684. doi:10.1172/JCI69600
   PubMed Web of Science ®Google Scholar
• Altman BJ, Stine ZE, Dang CV. From Krebs to clinic: glutamine metabolism to cancer therapy. Nat Rev Cancer. 2016;16(10):619–634.
   PubMed Web of Science ®Google Scholar
• Liu J, Li D, Luo H, Zhu X. Circular RNAs: the star molecules in cancer. Mol Aspects Med. 2019;70:141–152. doi:10.1016/j.mam.2019.10.006
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675–691. doi:10.1038/s41576-019-0158-7
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yang T, Xiao J. Circular RNAs: promising biomarkers for human diseases. EBioMedicine. 2018;34:267–274. doi:10.1016/j.ebiom.2018.07.036
   PubMed Web of Science ®Google Scholar
• Li G, Qin Y, Qin S, Zhou X, Zhao W, Zhang D. Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells. Life Sci. 2020;259:118269. doi:10.1016/j.lfs.2020.118269
   PubMed Web of Science ®Google Scholar
• Zhang L, Guo Y. Silencing circular RNA-ZNF652 represses proliferation and EMT process of renal carcinoma cells via raising miR-205. Artif Cells Nanomed Biotechnol. 2020;48(1):648–655. doi:10.1080/21691401.2020.1725532
   PubMed Web of Science ®Google Scholar
• Zhao X, Zhang X, Zhang Z, et al. Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma. Aging (Albany NY). 2020;12(22):23251–23274. doi:10.18632/aging.104099
   PubMedGoogle Scholar
• Lu Q, Fang T. Circular RNA SMARCA5 correlates with favorable clinical tumor features and prognosis, and increases chemotherapy sensitivity in intrahepatic cholangiocarcinoma. J Clin Lab Anal. 2020;34(4):e23138. doi:10.1002/jcla.23138
   PubMed Web of Science ®Google Scholar
• Li D, Tang Z, Gao Z, Shen P, Liu Z, Dang X. Circular RNA CDR1as exerts oncogenic properties partially through regulating MicroRNA 641 in cholangiocarcinoma. Mol Cell Biol. 2020;40:15. doi:10.1128/MCB.00042-20
   Web of Science ®Google Scholar
• Xu Y, Yao Y, Liu Y, et al. Elevation of circular RNA circ_0005230 facilitates cell growth and metastasis via sponging miR-1238 and miR-1299 in cholangiocarcinoma. Aging (Albany NY). 2019;11(7):1907–1917. doi:10.18632/aging.101872
   PubMedGoogle Scholar
• Zeng B, Ye H, Chen J, et al. LncRNA TUG1 sponges miR-145 to promote cancer progression and regulate glutamine metabolism via Sirt3/GDH axis. Oncotarget. 2017;8(69):113650–113661. doi:10.18632/oncotarget.21922
   PubMedGoogle Scholar
• Li J, Li X, Wu L, Pei M, Li H, Jiang Y. miR-145 inhibits glutamine metabolism through c-myc/GLS1 pathways in ovarian cancer cells. Cell Biol Int. 2019;43(8):921–930. doi:10.1002/cbin.11182
   PubMed Web of Science ®Google Scholar
• Wang S, Hu Y, Lv X, et al. Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication. Clin Sci. 2019;133(18):1935–1953. doi:10.1042/CS20190589
   Web of Science ®Google Scholar
• Xu Y, Leng K, Yao Y, et al. A novel circular RNA, circ-CCAC1, contributes to CCA progression, induces angiogenesis, and disrupts vascular endothelial barriers. Hepatology. 2020. doi:10.1002/hep.31493
   Web of Science ®Google Scholar
• Chu K-J, Ma Y-S, Jiang X-H, et al. Whole-transcriptome sequencing identifies key differentially expressed mRNAs, miRNAs, lncRNAs, and circRNAs associated with CHOL. Mol Ther Nucleic Acids. 2020;21:592–603. doi:10.1016/j.omtn.2020.06.025
   PubMedGoogle Scholar
• Xu Y, Yao Y, Leng K, et al. Increased expression of circular RNA circ_0005230 indicates dismal prognosis in breast cancer and regulates cell proliferation and invasion via miR-618/CBX8 signal pathway. Cell Physiol Biochem. 2018;51(4):1710–1722. doi:10.1159/000495675
   PubMedGoogle Scholar
• Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the rosetta stone of a hidden RNA language? Cell. 2011;146(3):353–358. doi:10.1016/j.cell.2011.07.014
   PubMed Web of Science ®Google Scholar
• Zhou K, Song B, Wei M, Fang J, Xu Y. MiR-145-5p suppresses the proliferation, migration and invasion of gastric cancer epithelial cells via the NOD_LIKE_RECEPTOR axis. Cancer Cell Int. 2020;20:416. doi:10.1186/s12935-020-01483-6
   PubMed Web of Science ®Google Scholar
• Sun M, Zhao W, Chen Z, et al. Circ_0058063 regulates CDK6 to promote bladder cancer progression by sponging miR-145-5p. J Cell Physiol. 2019;234(4):4812–4824. doi:10.1002/jcp.27280
   PubMed Web of Science ®Google Scholar
• Chen Z-L, Li X-N, Ye C-X, Chen H-Y, Wang Z-J. Elevated levels of circRUNX1 in colorectal cancer promote cell growth and metastasis via miR-145-5p/IGF1 signalling. Onco Targets Ther. 2020;13:4035–4048. doi:10.2147/OTT.S254133
   PubMed Web of Science ®Google Scholar
• Wang B, Dong W, Li X. miR-145-5p acts as a novel tumor suppressor in hepatocellular carcinoma through targeting RAB18. Technol Cancer Res Treat. 2019;18:1533033819850189. doi:10.1177/1533033819850189
   Web of Science ®Google Scholar
• Chen L, Heikkinen L, Wang C, Yang Y, Sun H, Wong G. Trends in the development of miRNA bioinformatics tools. Brief Bioinform. 2019;20(5):1836–1852. doi:10.1093/bib/bby054
   PubMed Web of Science ®Google Scholar
• Xie H-Y, Zhang T-M, Hu S-Y, Shao Z-M, Li D-Q. Dimerization of MORC2 through its C-terminal coiled-coil domain enhances chromatin dynamics and promotes DNA repair. Cell Commun Signal. 2019;17(1):160. doi:10.1186/s12964-019-0477-5
   PubMed Web of Science ®Google Scholar
• Sánchez-Solana B, Li D-Q, Kumar R. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. Biochim Biophys Acta. 2014;1843(2):316–326. doi:10.1016/j.bbamcr.2013.11.012
   PubMed Web of Science ®Google Scholar
• Liao X-H, Zhang Y, Dong W-J, Shao Z-M, Li D-Q. Chromatin remodeling protein MORC2 promotes breast cancer invasion and metastasis through a PRD domain-mediated interaction with CTNND1. Oncotarget. 2017;8(58):97941–97954. doi:10.18632/oncotarget.18556
   PubMedGoogle Scholar
• Pan Z, Ding Q, Guo Q, et al. MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance. Int J Oncol. 2018;53(1):59–72. doi:10.3892/ijo.2018.4333
   PubMed Web of Science ®Google Scholar
• Liao G, Liu X, Wu D, et al. MORC2 promotes cell growth and metastasis in human cholangiocarcinoma and is negatively regulated by miR-186-5p. Aging (Albany NY). 2019;11(11):3639–3649. doi:10.18632/aging.102003
   PubMedGoogle Scholar