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Original Research

Epigenetic Study of Esophageal Carcinoma Based on Methylation, Gene Integration and Weighted Correlation Network Analysis

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Pages 3133-3149 | Published online: 13 May 2021

References

  • Torre LA, Bray F, Siegel RL, Ferlay J. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. doi:10.3322/caac.21262
  • Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J clin oncol. 2006;24:2137–2150. doi:10.1200/JCO.2005.05.2308
  • Cowie A, Noble F, Underwood T. Strategies to improve outcomes in esophageal adenocarcinoma. Expert Rev Anticancer Ther. 2014;14:677–687. doi:10.1586/14737140.2014.895668
  • Probst A, Aust D, Märkl B, Anthuber M, Messmann H. Early esophageal cancer in Europe: endoscopic treatment by endoscopic submucosal dissection. Endoscopy. 2015;47:113–121. doi:10.1055/s-0034-1391086
  • Alsop BR, Sharma P. Esophageal cancer. Gastroenterol Clin North Am. 2016;45:399–412. doi:10.1016/j.gtc.2016.04.001
  • Parry K, Visser E, van Rossum PS, Mohammad NH, Ruurda JP, van Hillegersberg R. Prognosis and treatment after diagnosis of recurrent esophageal carcinoma following esophagectomy with curative intent. Ann Surg Oncol. 2015;22(Suppl 3):S1292–1300. doi:10.1245/s10434-015-4840-5
  • Long L, Pang XX, Lei F, et al. SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer. Cell Mol Life Sci. 2018;75:2643–2661. doi:10.1007/s00018-018-2757-4
  • Guo Y, Bao Y, Ma M, et al. Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma. Oncotarget. 2017;8:33285–33299. doi:10.18632/oncotarget.16635
  • Liu Y, Zhang M, He T, et al. Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.Clin Epigenetics. 2020;12:22.
  • Zhang A, Wang W, Chen Z, et al. SHARPIN inhibits esophageal squamous cell carcinoma progression by modulating hippo signaling. Neoplasia (New York, NY). 2020;22:76–85. doi:10.1016/j.neo.2019.12.001
  • Zhu L, Zhang X, Fu X, et al. TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β-catenin pathway. J Transl Med. 2018;16:7.
  • Kinoshita R, Iwadate M, Umeyama H, Taguchi YH. Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets. BMC Syst Biol. 2014;8(Suppl 1):S4. doi:10.1186/1752-0509-8-S1-S4
  • Huang J, Wang G, Tang J, et al. DNA methylation status of PAX1 and ZNF582 in esophageal squamous cell carcinoma. Int J Environ Res Public Health. 2017;14. doi:10.3390/ijerph14020216
  • Issa JPJ, Baylin SB, Herman JG. DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia. 1997;11(Suppl 1):S7.
  • Das M, Sharma SK, Sekhon GS, Mahanta J, Phukan RK, Jalan BK. p16 gene silencing along with p53 single-nucleotide polymorphism and risk of esophageal cancer in Northeast India. Tumor Biol. 2017;39(5):1010428317698384. doi:10.1177/1010428317698384
  • Zhou C, Li J, Li Q. CDKN2A methylation in esophageal cancer: a meta-analysis. Oncotarget. 2017;8:50071–50083. doi:10.18632/oncotarget.18412
  • Qiang Y, Li Q. Intake of dietary one-carbon metabolism-related B vitamins and the risk of esophageal cancer: a dose-response meta-analysis. Nutrients. 2018;10.
  • Anders S, Huber W. Differential expression analysis for sequence count data. Genome Biol. 2010;11:R106. doi:10.1186/gb-2010-11-10-r106
  • Warden CD, Lee H, Tompkins JD, et al. COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis. Nucleic Acids Res. 2019;47:8335–8336. doi:10.1093/nar/gkz663
  • Wen J, Yang H, Liu MZ, et al. Gene expression analysis of pretreatment biopsies predicts the pathological response of esophageal squamous cell carcinomas to neo-chemoradiotherapy. Ann Oncol. 2014;25:1769–1774. doi:10.1093/annonc/mdu201
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif). 2001;25:402–408. doi:10.1006/meth.2001.1262
  • Raja UM, Gopal G, Rajkumar T. Intragenic DNA methylation concomitant with repression of ATP4B and ATP4A gene expression in gastric cancer is a potential serum biomarker. Asian Pacific J Cancer Prevention. 2012;13:5563–5568. doi:10.7314/APJCP.2012.13.11.5563
  • Calvete O, Reyes J, Zuñiga S, et al. Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour. Hum Mol Genet. 2015;24:2914–2922. doi:10.1093/hmg/ddv054
  • Cao D, Zhao D, Jia Z, et al. Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model. Life Sci. 2020;242:117214. doi:10.1016/j.lfs.2019.117214
  • Zali MR, Zadeh-Esmaeel MM, Rezaei Tavirani M, Rezaei Tavirani S, Norouzinia M, Rezaei-Tavirani M. Barrett’s esophagus network analysis revealed that arginine, alanine, aspartate, glutamate, valine, leucine and isoleucine can be biomarkers. Gastroenterol Hepatol Bed to Bench. 2018;11:S98–s104.
  • Callaghan JM, Tan SS, Khan MA, et al. Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase beta-subunit. Am J Physiol. 1995;268:F363–374. doi:10.1152/ajprenal.1995.268.3.F363
  • Xu HL, Hsing AW, Vogtmann E, et al. Variants in CCK and CCKAR genes to susceptibility to biliary tract cancers and stones: a population-based study in Shanghai, China. J Gastroenterol Hepatol. 2013;28:1476–1481. doi:10.1111/jgh.12278
  • Miyasaka K, Takata Y, Funakoshi A. Association of cholecystokinin A receptor gene polymorphism with cholelithiasis and the molecular mechanisms of this polymorphism. J Gastroenterol. 2002;37(Suppl 14):102–106. doi:10.1007/BF03326426
  • Chattopadhyay I, Singh A, Phukan R, et al. Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India. Mutat Res. 2010;696:130–138. doi:10.1016/j.mrgentox.2010.01.001
  • Yu B, Lv X, Su L, et al. MiR-148a functions as a tumor suppressor by targeting CCK-BR via Inactivating STAT3 and Akt in human gastric cancer. PLoS One. 2016;11:e0158961. doi:10.1371/journal.pone.0158961
  • Rai R, Kim JJ, Tewari M, Shukla HS. Heterogeneous expression of cholecystokinin and gastrin receptor in stomach and pancreatic cancer: an immunohistochemical study. J Cancer Res Ther. 2016;12:411–416. doi:10.4103/0973-1482.168970
  • Kanda M, Shimizu D, Tanaka H, et al. Metastatic pathway-specific transcriptome analysis identifies MFSD4 as a putative tumor suppressor and biomarker for hepatic metastasis in patients with gastric cancer. Oncotarget. 2016;7(12):13667–13679. doi:10.18632/oncotarget.7269
  • Brown J, Stepien AJ, Willem P. Landscape of copy number aberrations in esophageal squamous cell carcinoma from a high endemic region of South Africa. BMC Cancer. 2020;20:281. doi:10.1186/s12885-020-06788-3
  • Wangerin H, Kristiansen G. CD57 expression in incidental, clinically manifest, and metastatic carcinoma of the prostate. Biomed Res Int. 2014;2014:356427. doi:10.1155/2014/356427
  • Espinosa P, Urra JM. Decreased expression of the CD57 molecule in t lymphocytes of patients with chronic fatigue syndrome. Mol Neurobiol. 2019;56:6581–6585. doi:10.1007/s12035-019-1549-7
  • García-Ayllón MS, Botella-López A, Cuchillo-Ibañez I, et al. HNK-1 carrier glycoproteins are decreased in the alzheimer’s disease brain. Mol Neurobiol. 2017;54:188–199. doi:10.1007/s12035-015-9644-x
  • Rowe GC, Asimaki A, Graham EL, et al. Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβ. Am J Physiol Heart Circ Physiol. 2017;312:H662–h671. doi:10.1152/ajpheart.00446.2016
  • Yu S, Wong YC, Wang XH, et al. Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer. Oncogene. 2008;27:3313–3328. doi:10.1038/sj.onc.1210986
  • Sengupta D, Bhargava DK, Dixit A, et al. ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells. Br J Cancer. 2014;110:2144–2158. doi:10.1038/bjc.2014.53
  • Madhu Krishna B, Chaudhary S, Mishra DR, et al. Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer. BMC Cancer. 2018;18:607. doi:10.1186/s12885-018-4528-x
  • Chong IY, Cunningham D, Barber LJ, et al. The genomic landscape of oesophagogastric junctional adenocarcinoma. J Pathol. 2013;231:301–310. doi:10.1002/path.4247
  • Kim JH, Choi YK, Byun JK, et al. Estrogen-related receptor γ is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27. Exp Mol Med. 2016;48:e213. doi:10.1038/emm.2015.115
  • Kang MH, Choi H, Oshima M, Cheong JH, Kim S, Lee JH. Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun. 2018;9:1920.
  • Shen Z, Hu Y, Zhou C. ESRRG promoter hypermethylation as a diagnostic and prognostic biomarker in laryngeal squamous cell carcinoma. J Clin Lab Anal. 2019;33:e22899.
  • Yu S, Wang X, Ng CF, Chen S, Chan FL. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67:4904–4914. doi:10.1158/0008-5472.CAN-06-3855
  • Madhavan S, Gusev Y, Singh S, Riggins RB. ERRγ target genes are poor prognostic factors in Tamoxifen-treated breast cancer. J Exp Clin Cancer Res. 2015;34:45. doi:10.1186/s13046-015-0150-9
  • Yamamoto T, Mori T, Sawada M, et al. Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer. Int j Gynecol Cancer. 2012;22:1509–1516. doi:10.1097/IGC.0b013e31826fd623
  • Umeda S, Kanda M, Sugimoto H, et al. Downregulation of GPR155 as a prognostic factor after curative resection of hepatocellular carcinoma. BMC Cancer. 2017;17:610. doi:10.1186/s12885-017-3629-2
  • Lee J, Lee J, Kim JH. Identification of matrix metalloproteinase 11 as a prognostic biomarker in pancreatic cancer. Anticancer Res. 2019;39:5963–5971. doi:10.21873/anticanres.13801
  • Xu G, Zhang B, Ye J, et al. Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression. Int J Biol Sci. 2019;15:2320–2329. doi:10.7150/ijbs.33750
  • Liu HC, Zhang Y, Wang XL, et al. Upregulation of the TPX2 gene is associated with enhanced tumor malignance of esophageal squamous cell carcinoma. Biomed Pharmacother. 2013;67(8):751–755. doi:10.1016/j.biopha.2013.04.004
  • Huang DH, Jian J, Li S, Zhang Y, Liu LZ. TPX2 silencing exerts anti‑tumor effects on hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway. Int J Mol Med. 2019;44:2113–2122. doi:10.3892/ijmm.2019.4371
  • Song T, Xu A, Zhang Z, et al. CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075. J Cell Physiol. 2019;234(8):14296–14305. doi:10.1002/jcp.28128