82
Views
2
CrossRef citations to date
0
Altmetric
Case Report

Genetic Analysis and Targeted Therapy Using Buparlisib and MK2206 in a Patient with Triple Metachronous Cancers of the Kidney, Prostate, and Squamous Cell Carcinoma of the Lung: A Case Report

, , , , , , , , & ORCID Icon show all
Pages 2839-2845 | Published online: 28 Apr 2021

References

  • Mariotto AB, Rowland JH, Ries LA, Scoppa S, Feuer EJ. Multiple cancer prevalence: a growing challenge in long-term survivorship. Cancer Epidemiol Biomarkers Prev. 2007;16(3):566–571. doi:10.1158/1055-9965.EPI-06-0782
  • Hayat MJ, Howlader N, Reichman ME, Edwards BK. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist. 2007;12(1):20–37. doi:10.1634/theoncologist.12-1-20
  • Fujita S, Masago K, Takeshita J, et al. Multiple primary malignancies in patients with non-small cell lung cancer. Intern Med. 2015;54(3):325–331. doi:10.2169/internalmedicine.54.2921
  • Afghahi A, Sledge GW. Targeted Therapy for Cancer in the Genomic Era. Cancer J. 2015;21(4):294–298. doi:10.1097/PPO.0000000000000135
  • Filipits M. New developments in the treatment of squamous cell lung cancer. CurrOpinOncol. 2014;26(2):152–158.
  • The Cancer Genome Atlas Research Network. Comprehensive genomic and characterization of squamous cell lung cancers. Nature. 2012;489:519–525. doi:10.1038/nature11404
  • Monnet I, Audigier-Valette C, Girard N, et al. Real-life effectiveness of Erlotinib as second-line treatment of stage IIIB/IV squamous non-small cell lung cancer: results of the PEPiTA observational study. Lung Cancer. 2016;98:84–90. doi:10.1016/j.lungcan.2016.05.016
  • Peters S, Stahel RA, Dafni U, et al. EMPHASIS-lung Collaborative Group.Randomized Phase III Trial of Erlotinib versus Docetaxel in Patients with Advanced Squamous Cell Non-Small Cell Lung Cancer Failing First-Line Platinum-Based Doublet Chemotherapy Stratified by VeriStrat Good versus VeriStrat Poor. The European Thoracic Oncology Platform (ETOP) EMPHASIS-lung Trial. J Thorac Oncol. 2017;12(4):752–762.
  • Paik PK, Varghese AM, Sima CS, et al. Response to Erlotinib in patients with EGFR mutant advanced non-small cell lung cancers with a squamous or squamous-like component. Mol Cancer Ther. 2012;11(11):2535–2540. doi:10.1158/1535-7163.MCT-12-0163
  • Vansteenkiste JF, Canon JL, De Braud F, et al. Safety and Efficacy of Buparlisib (BKM120) in Patients with PI3K Pathway-Activated Non-Small Cell Lung Cancer: results from the Phase II BASALT-1 Study. J Thorac Oncol. 2015;10(9):1319–1327. doi:10.1097/JTO.0000000000000607
  • Adjei AA, Bennouna J, Leighl NB, et al. Safety and efficacy of buparlisib (BKM120) and chemotherapy in advanced, squamous non-small cell lung cancer (sqNSCLC): Results from the phase Ib/II BASALT-2 and BASALT-3 studies. J Clin Oncol. 2016;34(15_suppl.):e20522. doi:10.1200/JCO.2016.34.15_suppl.e20522
  • Lara PN, Longmate J, Mack PC, et al. Phase II Study of the AKT Inhibitor MK-2206 plus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Who Previously Progressed on Erlotinib. Clin Cancer Res. 2015;21(19):4321–4326. doi:10.1158/1078-0432.CCR-14-3281
  • Papadimitrakopoulou V, Lee JJ, Wistuba II, et al. The BATTLE-2 Study: a Biomarker-IntegratedTargeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer. J Clin Oncol. 2016;34(30):3638–3647. doi:10.1200/JCO.2015.66.0084
  • Shingarev R, Jaimes EA. Renal cell carcinoma: new insights and challenges for a clinician scientist. Am J Physiol Renal Physiol. 2017;313(2):F145–F154. doi:10.1152/ajprenal.00480.2016
  • McKay RR, De Velasco G, Werner L, et al. A Phase 1 study of Buparlisib and bevacizumab in patients with metastatic renal cell carcinoma progressing on vascular endothelial growth factor-targeted therapies. Cancer. 2016;122(15):2389–2398. doi:10.1002/cncr.30056
  • Jonasch E, Hasanov E, Corn PG, et al. A randomized Phase 2 study of MK-2206 versus everolimus in refractory renal cell carcinoma. Ann Oncol. 2017;28(4):804–808. doi:10.1093/annonc/mdw676