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CASE REPORT

Clinical Response of Advanced Lung Adenocarcinoma with Class III BRAF G466V Missense Mutation to Dabrafenib and Trametinib: A Case Report

ORCID Icon, , &
Pages 27-31 | Received 16 Nov 2023, Accepted 11 Jan 2024, Published online: 23 Jan 2024

References

  • Lindeman NI, Cagle PT, Aisner DL, et al. Updated molecular testing guideline for the selection of lung cancer patients for treatment with targeted tyrosine kinase inhibitors: guideline from the college of American pathologists, the international association for the study of lung cancer, and the association for molecular pathology. J Thorac Oncol. 2018;13(3):323–358. doi:10.1016/j.jtho.2017.12.001
  • Sheikine Y, Pavlick D, Klempner SJ, et al. BRAF in lung cancers: analysis of patient cases reveals recurrent BRAF Mutations, fusions, kinase duplications, and concurrent alterations. JCO Precis Oncol. 2018;2:PO.17.00172. doi:10.1200/po.17.00172
  • Fiskus W, Mitsiades N. B-raf inhibition in the clinic: present and future. Annu Rev Med. 2016;67(1):29–43. doi:10.1146/annurev-med-090514-030732
  • Fedorenko IV, Paraiso KH, Smalley KS. Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma. Biochem Pharmacol. 2011;82(3):201–209. doi:10.1016/j.bcp.2011.05.015
  • Nguyen-Ngoc T, Bouchaab H, Adjei AA, Peters S. BRAF alterations as therapeutic targets in non-small-cell lung cancer. J Thorac Oncol. 2015;10(10):1396–1403. doi:10.1097/jto.0000000000000644
  • Planchard D, Kim TM, Mazieres J, et al. Dabrafenib in patients with BRAF(V600E)-positive advanced non-small-cell lung cancer: a single-arm, multicentre, open-label, Phase 2 trial. Lancet Oncol. 2016;17(5):642–650. doi:10.1016/s1470-2045(16)00077-2
  • Menzer C, Menzies AM, Carlino MS, et al. Targeted therapy in advanced melanoma with rare BRAF mutations. J Clin Oncol. 2019;37(33):3142–3151. doi:10.1200/jco.19.00489
  • Yao Z, Yaeger R, Rodrik-Outmezguine VS, et al. Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS. Nature. 2017;548(7666):234–238. doi:10.1038/nature23291
  • Sakai T, Matsumoto S, Ueda Y, et al. Clinico-genomic features and targetable mutations in non-small cell lung cancers harboring BRAF non-V600E mutations: a multi-institutional genomic screening study (LC-SCRUM-Asia). J Thorac Oncol. 2023;18(11):1538–1549. doi:10.1016/j.jtho.2023.07.024
  • Fontana E, Valeri N. Class(y) dissection of BRAF heterogeneity: beyond non-V600. Clin Cancer Res. 2019;25(23):6896–6898. doi:10.1158/1078-0432.Ccr-19-2732
  • Riley DS, Barber MS, Kienle GS, et al. CARE guidelines for case reports: explanation and elaboration document. J Clin Epidemiol. 2017;89:218–235. doi:10.1016/j.jclinepi.2017.04.026
  • Detterbeck FC, Boffa DJ, Kim AW, Tanoue LT. The Eighth edition lung cancer stage classification. Chest. 2017;151(1):193–203. doi:10.1016/j.chest.2016.10.010
  • Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228–247. doi:10.1016/j.ejca.2008.10.026
  • Paik PK, Arcila ME, Fara M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol. 2011;29(15):2046–2051. doi:10.1200/jco.2010.33.1280
  • Planchard D, Smit EF, Groen HJM, et al. Dabrafenib plus trametinib in patients with previously untreated BRAF(V600E)-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial. Lancet Oncol. 2017;18(10):1307–1316. doi:10.1016/s1470-2045(17)30679-4
  • Mazieres J, Cropet C, Montané L, et al. Vemurafenib in non-small-cell lung cancer patients with BRAF(V600) and BRAF(nonV600) mutations. Ann Oncol. 2020;31(2):289–294. doi:10.1016/j.annonc.2019.10.022
  • Johnson DB, Zhao F, Noel M, et al. Trametinib activity in patients with solid tumors and lymphomas harboring BRAF non-V600 mutations or fusions: results from NCI-MATCH (EAY131). Clin Cancer Res. 2020;26(8):1812–1819. doi:10.1158/1078-0432.Ccr-19-3443
  • Noeparast A, Teugels E, Giron P, et al. Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib. Oncotarget. 2017;8(36):60094–60108. doi:10.18632/oncotarget.11635
  • Dankner M, Wang Y, Fazelzad R, et al. Clinical activity of mitogen-activated protein kinase-targeted therapies in patients with non-V600 BRAF-mutant tumors. JCO Precis Oncol. 2022;6(6):e2200107. doi:10.1200/po.22.00107
  • Lito P, Saborowski A, Yue J, et al. Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors. Cancer Cell. 2014;25(5):697–710. doi:10.1016/j.ccr.2014.03.011
  • King AJ, Arnone MR, Bleam MR, et al. Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions. PLoS One. 2013;8(7):e67583. doi:10.1371/journal.pone.0067583
  • Rustgi N, Maria A, Toumbacaris N, et al. Combined RAF and MEK inhibition to treat activated non-V600 BRAF-altered advanced cancers. Oncologist. 2023;24:oyad247. doi:10.1093/oncolo/oyad247