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Review

Merkel cell carcinoma of the head and neck: pathogenesis, current and emerging treatment options

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Pages 2157-2167 | Published online: 19 Aug 2015

References

  • MerkelFTastzellen and Tastkörperchen bei den Hausthieren und beim MenschenArch Mikrosk Anat187511636
  • WooSHLumpkinEAPatapoutianAMerkel cells and neurons keep in touchTrends Cell Biol2015252748125480024
  • TokerCTrabecular carcinoma of the skinArch Dermatol197210511071105009611
  • TangCKTokerCTrabecular carcinoma of the skin: an ultrastructural studyCancer197842523112321719609
  • HitchcockCLBlandKILaneyRG3rdFranziniDHarrisBCopelandEM3rdNeuroendocrine (Merkel cell) carcinoma of the skin. Its natural history, diagnosis, and treatmentAnn Surg198820722012073277546
  • KoljonenVMerkel cell carcinomaWorld J Surg Oncol20064716466578
  • SmithVACampERLentschEJMerkel cell carcinoma: identification of prognostic factors unique to tumors located in the head and neck based on analysis of SEER dataLaryngoscope201212261283129022522673
  • HeathMJaimesNLemosBClinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU featuresJ Am Acad Dermatol200858337538118280333
  • KempfWMertzKDHofbauerGFTinguelyMSkin cancer in organ transplant recipientsPathobiology201380630230924013135
  • KoljonenVKukkoHTukiainenEIncidence of Merkel cell carcinoma in renal transplant recipientsNephrol Dial Transplant200924103231323519586970
  • EngelsEAFrischMGoedertJJBiggarRJMillerRWMerkel cell carcinoma and HIV infectionLancet2002359930549749811853800
  • AgelliMCleggLXEpidemiology of primary Merkel cell carcinoma in the United StatesJ Am Acad Dermatol200349583284114576661
  • MarcovalJFerreresJRPenínRMPérezDViñalsJMMerkel cell carcinoma: differences between sun-exposed and non-sun-exposed variants – a clinical analysis of 36 casesDermatology2014229320520925278300
  • AgelliMCleggLXBeckerJCRollisonDEThe etiology and epidemiology of Merkel cell carcinomaCurr Probl Cancer2010341143720371072
  • HuberGFModern management of Merkel cell carcinomaCurr Opin Otolaryngol Head Neck Surg201422210911524463300
  • Albores-SaavedraJBatichKChable-MonteroFSagyNSchwartzAMHensonDEMerkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based studyJ Cutan Pathol2010371202719638070
  • HodgsonNCMerkel cell carcinoma: changing incidence trendsJ Surg Oncol20058911415611998
  • BeckerJCMerkel cell carcinomaAnn Oncol201021Suppl 7ii81vii85
  • MollRLöweALauferJFrankeWWCytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodiesAm J Pathol199214024274471371204
  • KaaeJHansenAVBiggarRJMerkel cell carcinoma: incidence, mortality, and risk of other cancersJ Natl Cancer Inst20101021179380120424236
  • FengHShudaMChangYMoorePSClonal integration of a polyomavirus in human Merkel cell carcinomaScience200831958661096110018202256
  • AroraRChangYMoorePSMCV and Merkel cell carcinoma: a molecular success storyCurr Opin Virol20122448949822710026
  • Martel-JantinCPedergnanaVNicolJTMerkel cell polyomavirus infection occurs during early childhood and is transmitted between siblingsJ Clin Virol201358128829123829968
  • TolstovYLKnauerAChenJGAsymptomatic primary Merkel cell polyomavirus infection among adultsEmerg Infect Dis20111781371138021801612
  • SchowalterRMPastranaDVPumphreyKAMoyerALBuckCBMerkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skinCell Host Microbe20107650951520542254
  • CoursagetPSamimiMNicolJTGardairCTouzéAHuman Merkel cell polyomavirus: virological background and clinical implicationsAPMIS2013121875576923781869
  • SignoriniLBelingheriMAmbrogiFHigh frequency of Merkel cell polyomavirus DNA in the urine of kidney transplant recipients and healthy controlsJ Clin Virol201461456557025467862
  • ZhangCLiuFHeZSeroprevalence of Merkel cell polyomavirus in the general rural population of Anyang, ChinaPLoS One201499e10643025184447
  • DalianisTHirschHHHuman polyomaviruses in disease and cancerVirology20134372637223357733
  • ManganaJDziunyczPKerlKDummerRCozzioAPrevalence of Merkel cell polyomavirus among Swiss Merkel cell carcinoma patientsDermatology2010221218418820689250
  • ShudaMKwunHJFengHChangYMoorePSHuman Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulatorJ Clin Invest201112193623363421841310
  • AroraRShudaMGuastafierroASurvivin is a therapeutic target in Merkel cell carcinomaSci Transl Med20124133133r a56
  • HoubenRSchramaDBeckerJCMolecular pathogenesis of Merkel cell carcinomaExp Dermatol200918319319819400830
  • PaulsonKGCarterJJJohnsonLGAntibodies to Merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in Merkel cell carcinoma patientsCancer Res201070218388839720959478
  • SihtoHKukkoHKoljonenVSankilaRBöhlingTJoensuuHClinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinomaJ Natl Cancer Inst20091011393894519535775
  • VeijaTSahiHKoljonenVBohlingTKnuutilaSMosakhaniNmiRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinomaVirchows Arch2015466328929525491743
  • KuwamotoSRecent advances in the biology of Merkel cell carcinomaHum Pathol20114281063107721641014
  • HoubenRGrimmJWillmesCWeinkamRBeckerJCSchramaDMerkel cell carcinoma and Merkel cell polyomavirus: evidence for hit-and-run oncogenesisJ Invest Dermatol2012132125425621850029
  • FischerNBrandnerJFuchsFMollIGrundhoffADetection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology and growth phenotype do not reflect presence of the virusInt J Cancer201012692133214219739110
  • ShudaMFengHKwunHJT antigen mutations are a human tumor-specific signature for Merkel cell polyomavirusProc Natl Acad Sci U S A200810542162721627718812503
  • HoubenRAngermeyerSHaferkampSCharacterization of functional domains in the Merkel cell polyoma virus Large T antigenInt J Cancer20151365E290E30025208506
  • ShahzadNShudaMGheitTThe T antigen locus of Merkel cell polyomavirus downregulates human Toll-like receptor 9 expressionJ Virol20138723130091301924067965
  • GriffithsDAAbdul-SadaHKnightLMMerkel cell polyomavirus small T antigen targets the NEMO adaptor protein to disrupt inflammatory signalingJ Virol20138724138531386724109239
  • KnightLMStakaityteG1WoodJJMerkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migrationJ Virol2015891354725320307
  • KassemATechnauKKurzAKMerkel cell polyomavirus sequences are frequently detected in nonmelanoma skin cancer of immunosuppressed patientsInt J Cancer2009125235636119384948
  • ScolaNWielandUSillingSAltmeyerPStückerMKreuterAPrevalence of human polyomaviruses in common and rare types of non-Merkel cell carcinoma skin cancerBr J Dermatol201216761315132022803598
  • WetzelsCTHoefnagelJGBakkersJMDijkmanHBBlokxWAMelchersWJUltrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lungPLoS One200943e495819305499
  • Sastre-GarauXPeterMAvrilMFMerkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesisJ Pathol20092181485619291712
  • ChunSMYunSJLeeSCWonYHLeeJBMerkel cell polyomavirus is frequently detected in Korean patients with Merkel cell carcinomaAnn Dermatol201325220320723717012
  • HattoriTTakeuchiYTakenouchiTThe prevalence of Merkel cell polyomavirus in Japanese patients with Merkel cell carcinomaJ Dermatol Sci20137029910723517683
  • MatsushitaMIwasakiTKuwamotoSMerkel cell polyomavirus (MCPyV) strains in Japanese Merkel cell carcinomas (MCC) are distinct from Caucasian type MCPyVs: genetic variability and phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCsVirus Genes201448223324224353025
  • Martel-JantinCFilipponeCTortevoyePMolecular epidemiology of Merkel cell polyomavirus: evidence for geographically related variant genotypesJ Clin Microbiol20145251687169024523477
  • RamahiEChoiJFullerCDEngTYMerkel cell carcinomaAm J Clin Oncol201336329930921422993
  • BeckerJMauchCKortmannRDShort German guidelines: Merkel cell carcinomaJ Dtsch Dermatol Ges20086Suppl 1S15S1618801136
  • KnoeppSMHookimKPlacidoJFieldsKLRohMHThe application of immunocytochemistry to cytologic direct smears of metastatic Merkel cell carcinomaDiagn Cytopathol201341872973322144126
  • DanceyALRayattSSSoonCIlchshynABrownISrivastavaSMerkel cell carcinoma: a report of 34 cases and literature reviewJ Plast Reconstr Aesthet Surg200659121294129917113506
  • BobosMHytiroglouPKostopoulosIKarkavelasGPapadimitriouCSImmunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lungAm J Dermatopathol20062829910416625069
  • KontochristopoulosGJStavropoulosPGKrasagakisKGoerdtSZouboulisCCDifferentiation between Merkel cell carcinoma and malignant melanoma: an immunohistochemical studyDermatology2000201212312611053914
  • AgaimyAErlenbach-WünschKKonukiewitzBISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic originMod Pathol2013267995100323503646
  • KaoCSWarrenSIdreesMTMerkel cell carcinoma exhibiting cytoplasmic OCT4 staining: a potential new diagnostic immunohistochemical markerAm J Dermatopathol201436327427623863554
  • LombardiDAccoronaRUngariMMelocchiLBellDNicolaiPPrimary Merkel cell carcinoma of the submandibular gland: when CK20 status complicates the diagnosisHead Neck Pathol20159230931425314950
  • SnowSNLarsonPOHardySMerkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosaDermatol Surg200127216517011207692
  • ChanJKSusterSWenigBMTsangWYChanJBLauALCytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sitesAm J Surg Pathol19972122262349042291
  • FisherCAHarmsPWMcHughJBSmall cell carcinoma in the parotid harboring Merkel cell polyomavirusOral Surg Oral Med Oral Pathol Oral Radiol2014118670371225457888
  • ChenMMRomanSASosaJAJudsonBLThe role of adjuvant therapy in the management of head and neck Merkel cell carcinoma: an analysis of 4815 patientsJAMA Otolaryngol Head Neck Surg2015141213714125474617
  • HendersonSATetzlaffMTPattanaprichakulPDetection of mitotic figures and G2+ tumor nuclei with histone markers correlates with worse overall survival in patients with Merkel cell carcinomaJ Cutan Pathol2014411184685225263506
  • TarantolaTIVallowLAHalyardMYPrognostic factors in Merkel cell carcinoma: analysis of 240 casesJ Am Acad Dermatol201368342543223200197
  • SamimiMTouzéALaudeHVitamin D deficiency is associated with greater tumor size and poorer outcome in Merkel cell carcinoma patientsJ Eur Acad Dermatol Venereol201428329830823368852
  • BehrDSPeitschWKHametnerCPrognostic value of immune cell infiltration, tertiary lymphoid structures and PD-L1 expression in Merkel cell carcinomasInt J Clin Exp Pathol20147117610762125550797
  • SihtoHJoensuuHTumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancerOncoimmunology2012181420142123243614
  • KouzminaMLeikolaJBöhlingTKoljonenVPositive sentinel lymph node biopsy predicts local metastases during the course of disease in Merkel cell carcinomaJ Plast Surg Hand Surg201347213914323402426
  • Santamaria-BarriaJABolandGMYeapBYNardiVDias-SantagataDCusackJCJrMerkel cell carcinoma: 30-year experience from a single institutionAnn Surg Oncol20132041365137323208132
  • IyerJGStorerBE2PaulsonKGRelationships among primary tumor size, number of involved nodes, and survival for 8,044 cases of Merkel cell carcinomaJ Am Acad Dermatol201470463764324521828
  • LemosBDStorerBEIyerJGPathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5,823 cases as the basis of the first consensus staging systemJ Am Acad Dermatol201063575176120646783
  • EdgeSBByrdDRComptonCCAJCC Cancer Staging Manual7th edNew York, NYSpringer2010
  • GuptaSGWangLCPeñasPFGellenthinMLeeSJNghiemPSentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: the Dana-Farber experience and meta-analysis of the literatureArch Dermatol2006142668569016785370
  • MurerKHuberGFHaileSRStoeckliSJComparison of morbidity between sentinel node biopsy and elective neck dissection for treatment of the n0 neck in patients with oral squamous cell carcinomaHead Neck20113391260126421837694
  • PeloschekPNovotnyCMueller-MangCDiagnostic imaging in Merkel cell carcinoma: lessons to learn from 16 cases with correlation of sonography, CT, MRI and PETEur J Radiol201073231732319108971
  • ColganMBTarantolaTIWeaverALThe predictive value of imaging studies in evaluating regional lymph node involvement in Merkel cell carcinomaJ Am Acad Dermatol20126761250125622552001
  • EnzenhoferEUblPCzernyCErovicBMImaging in patients with Merkel cell carcinomaJ Skin Cancer2013201397312323476783
  • ZagerJSBrodskySBermanCGImaging of Merkel cell carcinomaCurr Probl Cancer2010341657620371075
  • AndersonSEBeerKTBanicAMRI of Merkel cell carcinoma: histologic correlation and review of the literatureAJR Am J Roentgenol200518561441144816303995
  • GollubMJGruenDRDershawDDMerkel cell carcinoma: CT findings in 12 patientsAJR Am J Roentgenol199616736176208751663
  • TregliaGKakhkiVRGiovanellaLSadeghiRDiagnostic performance of fluorine-18-fluorodeoxyglucose positron emission tomography in patients with Merkel cell carcinoma: a systematic review and meta-analysisAm J Clin Dermatol201314643744723959776
  • ConcannonRLarcosGSVenessMThe impact of (18)F-FDG PET-CT scanning for staging and management of Merkel cell carcinoma: results from Westmead Hospital, Sydney, AustraliaJ Am Acad Dermatol2010621768420082888
  • HawrylukEBO’ReganKNSheehyNPositron emission tomography/computed tomography imaging in Merkel cell carcinoma: a study of 270 scans in 97 patients at the Dana-Farber/Brigham and Women’s Cancer CenterJ Am Acad Dermatol201368459259923127473
  • MoshiriASNghiemPMilestones in the staging, classification, and biology of Merkel cell carcinomaJ Natl Compr Canc Netw20141291255126225190694
  • SchneiderSThurnherDErovicBMMerkel cell carcinoma: interdisciplinary management of a rare diseaseJ Skin Cancer2013201318934223401779
  • MorandGVitalDPézierTMerkel cell carcinoma of the head and neck: a single institutional experienceJ Skin Cancer2013201332508623365756
  • GillenwaterAMHesselACMorrisonWHMerkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survivalArch Otolaryngol Head Neck Surg2001127214915411177031
  • O’ConnorWJRoenigkRKBrodlandDGMerkel cell carcinoma. Comparison of Mohs micrographic surgery and wide excision in eighty-six patientsDermatol Surg199723109299339357504
  • GollardRWeberRKostyMPGreenwayHTMassulloVHumbersonCMerkel cell carcinoma: review of 22 cases with surgical, pathologic, and therapeutic considerationsCancer20008881842185110760761
  • BoyerJDZitelliJABrodlandDGD’AngeloGLocal control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiationJ Am Acad Dermatol200247688589212451374
  • EllisDLDavisRSEvidence-based management of primary and localized Merkel cell carcinoma: a reviewInt J Dermatol201352101248125823829441
  • BalakrishnanVBerrySStewBSizelandABenefits of combined modality treatment of Merkel cell carcinoma of the head and neck: single institution experienceJ Laryngol Otol2013127990891623952972
  • PoulsenMRischinDMerkel cell carcinoma–current therapeutic optionsExpert Opin Pharmacother20034122187219214640917
  • TuskadaAFujimuraTHashimotoASuccessful local control of cutaneous Merkel cell carcinoma on the eyelid with CyberKnife radiosurgeryEur J Dermatol201323572572624063985
  • VenessMHowleJRadiotherapy alone in patients with Merkel cell carcinoma: the Westmead Hospital experience of 41 patientsAustralas J Dermatol2015561192425369110
  • HrubyGScolyerRAThompsonJFThe important role of radiation treatment in the management of Merkel cell carcinomaBr J Dermatol2013169597598223898924
  • JouaryTLeyralCDrenoBAdjuvant prophylactic regional radiotherapy versus observation in stage I Merkel cell carcinoma: a multicentric prospective randomized studyAnn Oncol20122341074108021750118
  • KokoskaERKokoskaMSCollinsBTStapletonDRWadeTPEarly aggressive treatment for Merkel cell carcinoma improves outcomeAm J Surg199717466886939409598
  • MeeuwissenJABourneRGKearsleyJHThe importance of postoperative radiation therapy in the treatment of Merkel cell carcinomaInt J Radiat Oncol Biol Phys19953123253317836086
  • LewisKGWeinstockMAWeaverALOtleyCCAdjuvant local irradiation for Merkel cell carcinomaArch Dermatol2006142669370016785371
  • JabbourJCummingRScolyerRAHrubyGThompsonJFLeeSMerkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in earlystage disease–results from a review of 82 consecutive cases diagnosed between 1992 and 2004Ann Surg Oncol20071461943195217356954
  • Medina-FrancoJUristMMFiveashJHeslinMJBlandKIBeenkenSWMultimodality treatment of Merkel cell carcinoma: case series and literature review of 1,024 casesAnn Surg Oncol20018320420811314935
  • MojicaPSmithDEllenhornJDAdjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skinJ Clin Oncol20072591043104717369567
  • VenessMJPereraLMcCourtJMerkel cell carcinoma: improved outcome with adjuvant radiotherapyANZ J Surg200575527528115932436
  • HasanSLiuLTripletJLiZMansurDThe role of postoperative radiation and chemoradiation in Merkel cell carcinoma: a systematic review of the literatureFront Oncol2013327624294591
  • FangLParvathaneniUNghiemPSurgery with or without radiotherapy for Merkel cell carcinomaInt J Radiat Oncol2008721 SupplementS508
  • GeorgeTKDi Sant’agnesePABennettJMChemotherapy for metastatic Merkel cell carcinomaCancer1985565103410382990663
  • McAfeeWJMorrisCGMendenhallCMWerningJWMendenhallNPMendenhallWMMerkel cell carcinoma: treatment and outcomesCancer200510481761176416136596
  • RedmondJ3rdPerryJSowrayPVukeljaSJDawsonNChemotherapy of disseminated Merkel-cell carcinomaAm J Clin Oncol19911443053071862761
  • AzaguryMChevallierBAtlanDGraicYDayotJPThomineEVP-16, cisplatin, doxorubicin, and bleomycin in metastatic Merkel cell carcinoma. Report of a case with long-term remissionAm J Clin Oncol19931621021047680840
  • VoogEBironPMartinJPBlayJYChemotherapy for patients with locally advanced or metastatic Merkel cell carcinomaCancer199985122589259510375107
  • WobserMKürzingerNUgurelSBröckerEBBeckerJCTherapy of metastasized Merkel cell carcinoma with liposomal doxorubicin in combination with radiotherapyJ Dtsch Dermatol Ges20097652152519192166
  • SchlaakMPodewskiTVon BartenwerfferWInduction of durable responses by oral etoposide monochemotherapy in patients with metastatic Merkel cell carcinomaEur J Dermatol201222218719122240092
  • TaiPTYuEWinquistEHammondAStittLTonitaJGilchristJChemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 casesJ Clin Oncol200018122493249910856110
  • PollackSVGoslenJBSmall-cell neuroepithelial tumor of skin: a Merkel-cell neoplasm?J Dermatol Surg Oncol1982821161227061751
  • EngTYBoersmaMGFullerCDCavanaughSXValenzuelaFHermanTSTreatment of Merkel cell carcinomaAm J Clin Oncol200427551051515596922
  • EngTYNaguibMFullerCDJonesWE3rdHermanTSTreatment of recurrent Merkel cell carcinoma: an analysis of 46 casesAm J Clin Oncol200427657658315577435
  • AllenPJBowneWBJaquesDPBrennanMFBusamKCoitDGMerkel cell carcinoma: prognosis and treatment of patients from a single institutionJ Clin Oncol200523102300230915800320
  • DeschLKunstfeldRMerkel cell carcinoma: chemotherapy and emerging new therapeutic optionsJ Skin Cancer2013201332715023476782
  • GaribyanLCotterSEHansenJLPalliative treatment for in-transit cutaneous metastases of Merkel cell carcinoma using surface-mold computer-optimized high-dose-rate brachytherapyCancer J201319428328723867506
  • MouchetNCoquartNLebonvalletNComparative transcriptional profiling of human Merkel cells and Merkel cell carcinomaExp Dermatol2014231292893025236165
  • GomezBHeLTsaiYCWuTCViscidiRPHungCFCreation of a Merkel cell polyomavirus small T antigen-expressing murine tumor model and a DNA vaccine targeting small T antigenCell Biosci2013312923856459
  • Fernández-FiguerasMTPuigLMusulénEExpression profiles associated with aggressive behavior in Merkel cell carcinomaMod Pathol20072019010117115023
  • KarthaRVSundramUNSilent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA in Merkel cell carcinoma: implications for tyrosine kinase-based tumorigenesisMod Pathol20082129610418084259
  • SamlowskiWEMoonJTuthillRJA phase II trial of imatinib mesylate in Merkel cell carcinoma (neuroendocrine carcinoma of the skin): a Southwest Oncology Group study (S0331)Am J Clin Oncol201033549549920019577
  • FeinmesserMHalpernMKaganovskyEc-kit expression in primary and metastatic Merkel cell carcinomaAm J Dermatopathol200426645846215618926
  • SuLDFullenDRLoweLUherovaPSchnitzerBValdezRCD117 (KIT receptor) expression in Merkel cell carcinomaAm J Dermatopathol200224428929312142606
  • StrongSShaldersKCarrRSneadDRKIT receptor (CD117) expression in Merkel cell carcinomaBr J Dermatol2004150238438514996126
  • KrasagakisKFragiadakiIMetaxariMKIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of Merkel cell carcinoma in vitroJ Cell Physiol201122641099110920857409
  • di BartolomeoMBajettaEBuzzoniRClinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors. A study by the Italian Trials in Medical Oncology GroupCancer19967724024088625251
  • MeierGWaldherrCHerrmannRMaeckeHMueller-BrandJPlessMSuccessful targeted radiotherapy with 90Y-DOTATOC in a patient with Merkel cell carcinoma. A case reportOncology200466216016315138369
  • FakihaMLetertrePVuillezJPLebeauJRemission of Merkel cell tumor after somatostatin analog treatmentJ Cancer Res Ther20106338238421119285
  • RichettaAGManciniMTorroniATotal spontaneous regression of advanced Merkel cell carcinoma after biopsy: review and a new caseDermatol Surg200834681582218363731
  • WooffJCTritesJRWalshNMBullockMJComplete spontaneous regression of metastatic Merkel cell carcinoma: a case report and review of the literatureAm J Dermatopathol201032661461720520522
  • KrishnaSMKimCNMerkel cell carcinoma in a patient treated with adalimumab: case reportCutis2011872818421416774
  • Linn-RaskerSPvan Albada-KuipersGADuboisSVJanssenKZweersPGMerkel cell carcinoma during treatment with TNF-alpha inhibitors: coincidence or warning?Ned Tijdschr Geneeskd201215622A446422647228
  • InoueTYonedaKManabeMDemitsuTSpontaneous regression of Merkel cell carcinoma: a comparative study of TUNEL index and tumor-infiltrating lymphocytes between spontaneous regression and non-regression groupJ Dermatol Sci200024320321111084302
  • KobaSPaulsonKGNagaseKDiagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinomaPLoS One201277e4146522859987
  • Biver-DalleCUse of interferon-alpha in two patients with Merkel cell carcinoma positive for Merkel cell polyomavirusActa Oncol201150347948020825355
  • WillmesCAdamCAlbMType I and II IFNs inhibit Merkel cell carcinoma via modulation of the Merkel cell polyomavirus T antigensCancer Res20127282120212822389452
  • BalducciMDe BariBManfridaSD’AgostinoGRValentiniVTreatment of Merkel cell carcinoma with radiotherapy and imiquimod (Aldara): a case reportTumori201096350851120845819
  • SchramaDReisfeldRABeckerJCAntibody targeted drugs as cancer therapeuticsNat Rev Drug Discov20065214715916424916
  • GravesCAJonesAReynoldsJNeuroendocrine Merkel cell carcinoma is associated with mutations in key DNA repair, epigenetic and apoptosis pathways: a case-based study using targeted massively parallel sequencingNeuroendocrinology2015101211211925531179
  • XieHLiuTWangNTERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinomaOncotarget2014520100481005725301727