Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2

References

• SiegelRNaishadhamDJemalACancer statistics, 2013CA Cancer J Clin2013631113023335087
   PubMed Web of Science ®Google Scholar
• BornscheinJRokkasTSelgradMMalfertheinerPGastric cancer: clinical aspects, epidemiology and molecular backgroundHelicobacter201116Suppl 1455221896085
   PubMed Web of Science ®Google Scholar
• MéricJBRotteySOlaussenKCyclooxygenase-2 as a target for anticancer drug developmentCrit Rev Oncol Hematol2006591516416531064
   PubMed Web of Science ®Google Scholar
• RiedlKKrysanKPõldMMultifaceted roles of cyclooxygenase-2 in lung cancerDrug Resist Updat20047316918415296859
   PubMed Web of Science ®Google Scholar
• TuckerONDannenbergAJYangEKCyclooxygenase-2 expression is up-regulated in human pancreatic cancerCancer Res199959598799010070951
   PubMed Web of Science ®Google Scholar
• ChengJFanXMRole of cyclooxygenase-2 in gastric cancer development and progressionWorld J Gastroenterol201319427361736824259966
   PubMed Web of Science ®Google Scholar
• BoccaCIevolellaMAutelliRExpression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasivenessExpert Opin Ther Targets201418212113524325753
   PubMed Web of Science ®Google Scholar
• ElderDJHaltonDECrewTEParaskevaCApoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2 selective non-steroidal anti-inflammatory drug NS-398Int J Cancer200086455356010797271
   PubMed Web of Science ®Google Scholar
• SolomonSDWittesJFinnPVCardiovascular risk of celecoxib in 6 randomized placebo-controlled trials: the cross trial safety analysisCirculation2008117162104211318378608
   PubMed Web of Science ®Google Scholar
• CuiXWangYKokudoNFangDTangWTraditional Chinese medicine and related active compounds against hepatitis B virus infectionBiosci Trends201042394720448340
   PubMed Web of Science ®Google Scholar
• JiangWLiBZhengXArtesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillinInt Immunopharmacol20111181065107321396483
   PubMed Web of Science ®Google Scholar
• YangZDingJYangCImmunomodulatory and anti-inflammatory properties of artesunate in experimental colitisCurr Med Chem201219264541455122834815
   PubMed Web of Science ®Google Scholar
• ChengCNgDSChanTKAnti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic modelsAllergy201368219520323253152
   PubMed Web of Science ®Google Scholar
• ShiJQZhangCCSunXLAntimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activationCNS Neurosci Ther201319426226823406388
   PubMed Web of Science ®Google Scholar
• LiTChenHYangZLiuXGZhangLMWangHEvaluation of the immunosuppressive activity of artesunate in vitro and in vivoInt Immunopharmacol201316230631223583335
   PubMed Web of Science ®Google Scholar
• BachmeierBFichtnerIKillianPHKronskiEPfefferUEfferthTDevelopment of resistance towards artesunate in MDA-MB-231 human breast cancer cellsPLoS One201165e2055021637790
   PubMed Web of Science ®Google Scholar
• JinMShenXZhaoCIn vivo study of effects of artesunate nanoliposomes on human hepatocellular carcinoma xenografts in nude miceDrug Deliv2013203–412713323731485
   PubMed Web of Science ®Google Scholar
• DuJHZhangHDMaZJJiKMArtesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivoCancer Chemother Pharmacol201065589590219690861
   PubMed Web of Science ®Google Scholar
• BangYJKimYWYangHKCLASSIC trial investigatorsAdjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trialLancet2012379981331532122226517
   PubMed Web of Science ®Google Scholar
• JianPYanfangTZhuanZJianWXuemingZJianNMMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancerBMC Cancer20111120021615884
   PubMed Web of Science ®Google Scholar
• SchreiberAHärterGSchubertABunjesDMertensTMichelDAntiviral treatment of cytomegalovirus infection and resistant strainsExp Opin Pharmacother2009102191209
   PubMed Web of Science ®Google Scholar
• HoWEPehHYChanTKWongWSArtemisinins: pharmacological actions beyond anti-malarialPharmacol Ther2014142112613924316259
   PubMed Web of Science ®Google Scholar
• ZhouCPanWWangXPChenTSArtesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cellsJ Cell Physiol2012227123778378622378505
   PubMed Web of Science ®Google Scholar
• BerdelleNNikolovaTQuirosSEfferthTKainaBArtesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cellsMol Cancer Ther201110122224223321998290
   PubMed Web of Science ®Google Scholar
• SertelSEichhornTSimonCHPlinkertPKJohnsonSWEfferthTPharmacogenomic identification of c-Myc/Max-regulated genes associated with cytotoxicity of artesunate towards human colon, ovarian and lung cancer cell linesMolecules20101542886291020428086
   PubMed Web of Science ®Google Scholar
• TangDLotzeMTKangRZehHJApoptosis promotes early tumorigenesisOncogene201130161851185421151175
   PubMed Web of Science ®Google Scholar
• MasferrerJLLeahyKMKokiATAntiangiogenic and antitumor activities of cyclooxygenase-2 inhibitorsCancer Res20006051306131110728691
   PubMed Web of Science ®Google Scholar
• ShengHShaoJKirklandSCInhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2J Clin Invest1997999225422599151799
   PubMed Web of Science ®Google Scholar
• SinghTVaidMKatiyarNSharmaSKatiyarSKBerberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2 and prostaglandin E2 receptorsCarcinogenesis2011321869220974686
   PubMed Web of Science ®Google Scholar
• ReichRMartinGRIdentification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cellsProstaglandins19965111178900440
   PubMed Web of Science ®Google Scholar
• DuboisRNAbramsonSBCroffordLCyclooxygenase in biology and diseaseFASEB J19981212106310739737710
   PubMed Web of Science ®Google Scholar
• SongJSuHZhouYYGuoLLCyclooxygenase-2 expression is associated with poor overall survival of patients with gastric cancer: a meta-analysisDig Dis Sci201459243644524178897
   PubMed Web of Science ®Google Scholar
• MrenaJWikstenJPThielACyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuRClin Cancer Res200511207362736816243808
   PubMed Web of Science ®Google Scholar
• AkhtarMChengYMagnoRMPromoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cellsCancer Res20016162399240311289104
   PubMed Web of Science ®Google Scholar
• ShengHShaoJWashingtonMKDuBoisRNProstaglandin E2 increases growth and motility of colorectal carcinoma cellsJ Biol Chem200127621180751808111278548
   PubMed Web of Science ®Google Scholar
• MoalicSLiagreBLe BailJCBeneytoutJLDose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398, a selective cyclooxygenase-2 inhibitorInt J Oncol200118353354011179483
   PubMed Web of Science ®Google Scholar
• EndersGACyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-betaBr J Cancer200797101388139217955050
   PubMed Web of Science ®Google Scholar
• ChenXLSuBSSunRQZhangJWangYLRelationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinomaWorld J Gastroenterol20051181228123115754411
   PubMed Web of Science ®Google Scholar
• HanJAKimJIOngusahaPPP53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosisEMBO J200221215635564412411481
   PubMed Web of Science ®Google Scholar