54
Views
5
CrossRef citations to date
0
Altmetric
Original Research

Genetic polymorphisms of PAI-1 and PAR-1 are associated with acute normal tissue toxicity in Chinese rectal cancer patients treated with pelvic radiotherapy

, , , , , , , , , , , & show all
Pages 2291-2301 | Published online: 27 Aug 2015

References

  • JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
  • SiegelRDeSantisCVirgoKCancer treatment and survivorship statistics, 2012CA Cancer J Clin201262422024122700443
  • ZhuJLianPLiuFPhase II trial of first-line chemoradiotherapy with intensity-modulated radiation therapy followed by chemotherapy for synchronous unresectable distant metastases rectal adenocarcinomaRadiat Oncol201381023295152
  • SauerRLierschTMerkelSPreoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 yearsJ Clin Oncol201230161926193322529255
  • RödelCLierschTBeckerHGerman Rectal Cancer Study GroupPreoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trialLancet Oncol201213767968722627104
  • ShadadAKSullivanFJMartinJDEganLJGastrointestinal radiation injury: symptoms, risk factors and mechanismsWorld J Gastroenterol201319218519823345941
  • AndreyevJGastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patientsLancet Oncol20078111007101717976611
  • HovdenakNFajardoLFHauer-JensenMAcute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapyInt J Radiat Oncol Biol Phys20004841111111711072170
  • DoyenJBenezeryKFollanaPPredictive factors for early and late local toxicities in anal cancer treated by radiotherapy in combination with or without chemotherapyDis Colon Rectum201356101125113324022529
  • Vozenin-BrotonsMCMilliatFLinardCGene expression profile in human late radiation enteritis obtained by high-density cDNA array hybridizationRadiat Res2004161329931114982484
  • Strup-PerrotCMathéDLinardCGlobal gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritisAm J Physiol Gastrointest Liver Physiol20042874G875G88515178550
  • OngZYGibsonRJBowenJMPro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositisRadiat Oncol201052220233440
  • FrançoisAMilliatFGuipaudOBenderitterMInflammation and immunity in radiation damage to the gut mucosaBiomed Res Int2013201312324123586015
  • HneinoMFrancoisABuardVThe TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathwayPLoS One201275e3567222567107
  • WangJZhengHSungCCRichterKKHauer-JensenMCellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathyAm J Pathol19981535153115409811345
  • MilliatFSabourinJCTarletGEssential role of plasminogen activator inhibitor type-1 in radiation enteropathyAm J Pathol2008172369170118276785
  • AbderrahmaniRFrançoisABuardVPAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injuryPLoS One201274e3574022563394
  • AbderrahmaniRFrançoisABuardVEffects of pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 in radiation-induced intestinal injuryInt J Radiat Oncol Biol Phys200974394294819480973
  • WangJKulkarniAChintalaMFinkLMHauer-JensenMInhibition of protease-activated receptor 1 ameliorates intestinal radiation mucositis in a preclinical rat modelInt J Radiat Oncol Biol Phys201385120821422580123
  • QueirozKCShiKDuitmanJProtease-activated receptor-1 drives pancreatic cancer progression and chemoresistanceInt J Cancer2014135102294230424436106
  • AndreassenCNAlsnerJOvergaardMOvergaardJPrediction of normal tissue radiosensitivity from polymorphisms in candidate genesRadiother Oncol200369212713514643949
  • ParliamentMBMurrayDSingle nucleotide polymorphisms of DNA repair genes as predictors of radioresponseSemin Radiat Oncol201020423224020832015
  • EdgeSBComptonCCThe American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNMAnn Surg Oncol20101761471147420180029
  • ZhuJLiuFGuWConcomitant boost IMRT-based neoadjuvant chemoradiotherapy for clinical stage II/III rectal adenocarcinoma: results of a phase II studyRadiat Oncol201497024606870
  • TrottiAColevasADSetserACTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatmentSemin Radiat Oncol200313317618112903007
  • DuldulaoMPLeeWNelsonRAGene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancerCancer201311951106111223096768
  • SchirmerMAMerglerCPRave-FränkMAcute toxicity of radiochemotherapy in rectal cancer patients: a risk particularly for carriers of the TGFB1 Pro25 variantInt J Radiat Oncol Biol Phys201283114915722000747
  • ArtmanTSchillingDGnannJMollsMMulthoffGBayerCIrradiation-induced regulation of plasminogen activator inhibitor type-1 and vascular endothelial growth factor in six human squamous cell carcinoma lines of the head and neckInt J Radiat Oncol Biol Phys201076257458220117293
  • ScharpfeneckerMKruseJJSprongDRussellNSTen DijkePStewartFAIonizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cellsInt J Radiat Oncol Biol Phys200973250651319147015
  • BayerCSchillingDHoetzelJPAI-1 levels predict response to fractionated irradiation in 10 human squamous cell carcinoma lines of the head and neckRadiother Oncol200886336136818077030
  • AngeneteELangenskiöldMPalmgrenIFalkPOreslandTIvarssonMLuPA and PAI-1 in rectal cancer – relationship to radiotherapy and clinical outcomeJ Surg Res20091531465318533186
  • NiemantsverdrietMde JongELangendijkJAKampingaHHCoppesRPSynergistic induction of profibrotic PAI-1 by TGF-β and radiation depends on p53Radiother Oncol2010971333520435362
  • FearnsCLoskutoffDJInduction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alphaAm J Pathol199715025795909033272
  • BellingFRibeiroAWörnleMPAR-1 mediates the thrombin-induced mesothelial cell overproduction of VEGF and PAI-1Int J Artif Organs20133629710423280079
  • NylanderMOsmanARamströmSAklintELarssonALindahlTLThe role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human plateletsThromb Res20121294e51e5822283974
  • WangJZhengHOuXFinkLMHauer-JensenMDeficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosisAm J Pathol200216062063207212057911
  • FlynnANBuretAGProteinase-activated receptor 1 (PAR-1) and cell apoptosisApoptosis20049672973715505415
  • VergnolleNClinical relevance of proteinase activated receptors (pars) in the gutGut200554686787415888798
  • VergnolleNHollenbergMDWallaceJLPro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1)Br J Pharmacol199912651262126810205017
  • ChinACVergnolleNMacNaughtonWKWallaceJLHollenbergMDBuretAGProteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeabilityProc Natl Acad Sci U S A200310019111041110912960392
  • TakahashiHWilkinsonGRCaracoYPopulation differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patientsClin Pharmacol Ther200373325326312621390
  • KulloIJDingKPatterns of population differentiation of candidate genes for cardiovascular diseaseBMC Genet200784817626638