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Original Research

Disruption of NF-κB signaling by fluoxetine attenuates MGMT expression in glioma cells

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Pages 2199-2208 | Published online: 20 Aug 2015

References

  • JohannessenTCBjerkvigRMolecular mechanisms of temozolomide resistance in glioblastoma multiformeExpert Rev Anticancer Ther201212563564222594898
  • FanCHLiuWLCaoHWenCChenLJiangGO6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomasCell Death Dis20134e87624157870
  • ParkDMSathornsumeteeSRichJNMedical oncology: treatment and management of malignant gliomasNat Rev Clin Oncol201072757720118976
  • SiegalTWhich drug or drug delivery system can change clinical practice for brain tumor therapy?Neuro Oncol201315665666923502426
  • KetterTAAcute and maintenance treatments for bipolar depressionJ Clin Psychiatry2014754e1024813411
  • HenryMESchmidtMEHennenJA comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: a 19-F MRS studyNeuropsychopharmacology20053081576158315886723
  • MukherjeeJDasMKYangZYLewREvaluation of the binding of the radiolabeled antidepressant drug, 18F-fluoxetine in the rodent brain: an in vitro and in vivo studyNucl Med Biol19982576056109804041
  • LiuKHYangSTLinYKFluoxetine, an antidepressant, suppresses glioblastoma by evoking AMPAR-mediated calcium-dependent apoptosisOncotarget2015675088510125671301
  • FuJYangQYSaiKTGM2 inhibition attenuates ID1 expression in CD44-high glioma-initiating cellsNeuro Oncol201315101353136523877317
  • OkadaMSatoAShibuyaKJNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expressionInt J Oncol201444259159924316756
  • LavonIFuchsDZrihanDNovel mechanism whereby nuclear factor kappaB mediates DNA damage repair through regulation of O(6)-methylguanine-DNA-methyltransferaseCancer Res200767188952895917875738
  • SatoASunayamaJMatsudaKMEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axisStem Cells201129121942195121957016
  • WeilerMBlaesJPuschSmTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapyProc Natl Acad Sci U S A2014111140941424367102
  • GroganPTSarkariaJNTimmermannBNCohenMSOxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through AKT/mTOR pathway inhibitory modulationInvest New Drugs201432460461724718901
  • KohsakaSWangLYachiKSTAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expressionMol Cancer Ther20121161289129922532597
  • HuangHLinHZhangXLiJResveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-κB-dependent pathwayOncol Rep20122762050205622426504
  • RyuCHYoonWSParkKYValproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cellsJ Biomed Biotechnol2012201298749522701311
  • KushwahaDRamakrishnanVNgKA genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomasOncotarget20145124026403924994119
  • QuintavalleCManganiDRoscignoGMiR-221/222 target the DNA methyltransferase MGMT in glioma cellsPLoS One201389e7446624147153
  • AbdulMLogothetisCJHooseinNMGrowth-inhibitory effects of serotonin uptake inhibitors on human prostate carcinoma cell linesJ Urol199515412472507776439
  • LevkovitzYGil-AdIZeldichEDayagMWeizmanADifferential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvementJ Mol Neurosci2005271294216055945
  • BlagosklonnyMVA new science-business paradigm in anticancer drug developmentTrends Biotechnol200321310310612628364
  • TriscottJLeeCHuKDisulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomideOncotarget20123101112112323047041
  • YangJMRuiBBChenCAcetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-κB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cellsNeuroscience201427529630424952332
  • ShapovalovYZettelMSpielmanSCFluoxetine modulates breast cancer metastasis to the brain in a murine modelBMC Cancer20141459825129445