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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

Anti-RhoC siRNAs inhibit the proliferation and invasiveness of breast cancer cells via modulating the KAI1, MMP9, and CXCR4 expression

Xu-Dong Xu1 Department of Thyroid and Breast Surgery, The Fifth Hospital of Wuhan, Hanyang District
,
Han-Bin Shen1 Department of Thyroid and Breast Surgery, The Fifth Hospital of Wuhan, Hanyang District
,
Li Zhu2 Department of Oncology
,
Jian-Qin Lu2 Department of Oncology
,
Lin Zhang3 Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
,
Zhi-Yong Luo3 Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
&
Ya-Qun Wu3 Department of Thyroid and Breast Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1827-1834 | Published online: 23 Mar 2017

References

  • RobertsonFMBondyMYangWInflammatory breast cancer: the disease, the biology, the treatmentCA Cancer J Clin201060635137520959401
  • AndersonWFSchairerCChenBEHanceKWLevinePHEpidemiology of inflammatory breast cancer (IBC)Breast Dis2005–200622923
  • VegaFMRidleyAJRho GTPases in cancer cell biologyFEBS Lett2008582142093210118460342
  • JaffeABHallARho GTPases: biochemistry and biologyAnnu Rev Cell Dev Biol20052124726916212495
  • HakemASanchez-SweatmanOYou-TenARhoC is dispensable for embryogenesis and tumor initiation but essential for metastasisGenes Dev200519171974197916107613
  • ClarkEAGolubTRLanderESHynesROGenomic analysis of metastasis reveals an essential role for RhoCNature2000406679553253510952316
  • LinMDiVitoMMMerajverSDBoyanapalliMvan GolenKLRegulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1Mol Cancer2005412115969750
  • WangWYangLYHuangGWGenomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosisBr J Cancer200490122349235515150600
  • van GolenKLWuZFQiaoXTBaoLWMerajverSDRhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotypeCancer Res200060205832583811059780
  • MaLTeruya-FeldsteinJWeinbergRATumour invasion and metastasis initiated by microRNA-10b in breast cancerNature2007449716368268817898713
  • van GolenKLBaoLWPanQMillerFRWuZFMerajverSDMitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancerClin Exp Metastasis200219430131112090470
  • PilléJYDenoyelleCVaretJAnti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivoMol Ther200511226727415668138
  • SuwaHOhshioGImamuraTOverexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreasBr J Cancer19987711471529459160
  • XieSZhuMLvGZhangQWangGThe role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cellsMed Oncol20122931802180921674277
  • DorsettYTuschlTsiRNAs: applications in functional genomics and potential as therapeuticsNat Rev Drug Discov20043431832915060527
  • AshiharaEKawataEMaekawaTFuture prospect of RNA interference for cancer therapiesCurr Drug Targets201011334536020210759
  • GondiCSRaoJSConcepts in in vivo siRNA delivery for cancer therapyJ Cell Physiol2009220228529119391103
  • HossbachMGruberJOsbornMWeberKTuschlTGene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAsRNA Biol200632828917114944
  • CroftDROlsonMFThe Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanismsMol Cell Biol200626124612462716738326
  • KleerCGTeknosTNIslamMRhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neckClin Cancer Res200612154485449016899593
  • JacksonPMarreirosARussellPJKAI1 tetraspanin and metastasis suppressorInt J Biochem Cell Biol200537353053415618009
  • BeiderKAbrahamMBeginMInteraction between CXCR4 and CCL20 pathways regulates tumor growthPLoS One200944e512519340288
  • SmithMCLukerKEGarbowJRCXCR4 regulates growth of both primary and metastatic breast cancerCancer Res200464238604861215574767
  • MehnerCHocklaAMillerERanSRadiskyDCRadiskyESTumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancerOncotarget2014592736274924811362

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