ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches

References

• DalbethNMerrimanTRStampLKGoutLancet2016388100552039205227112094
   PubMed Web of Science ®Google Scholar
• DalbethNPoolBGambleGDCellular characterization of the gouty tophus: a quantitative analysisArthritis Rheum20106251549155620131281
   PubMed Web of Science ®Google Scholar
• ChoiHKAtkinsonKKarlsonEWCurhanGObesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up studyArch Internal Med2005165774274815824292
   PubMed Web of Science ®Google Scholar
• KöttgenAAlbrechtETeumerAGenome-wide association analyses identify 18 new loci associated with serum urate concentrationsNat Genet201345214515423263486
   PubMed Web of Science ®Google Scholar
• MerrimanTRAn update on the genetic architecture of hyperuricemia and goutArthritis Res Ther2015179825889045
   PubMed Web of Science ®Google Scholar
• DoyleLAYangWAbruzzoLVA multidrug resistance transporter from human MCF-7 breast cancer cellsProc Natl Acad Sci U S A1998952615665156709861027
   PubMed Web of Science ®Google Scholar
• WongKBriddonSJHollidayNDKerrIDPlasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniquesBiochim Biophys Acta201618631192926453803
   PubMed Web of Science ®Google Scholar
• XuJLiuYYangYBatesSZhangJTCharacterization of oligomeric huma half-ABC transporter ATP-binding cassette G2J Biol Chem2004279197811978915001581
   PubMed Web of Science ®Google Scholar
• AllenJDBrinkhuisRFWijnholdsJSchinkelAHThe mouse Bcrp1/Mxr/Abcp gene amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicinCancer Res199959174237424110485464
   PubMed Web of Science ®Google Scholar
• RossDDYangWAbruzzoLVAtypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell linesJ Natl Cancer Inst199991542943310070941
   PubMedGoogle Scholar
• LeslieEMDeeleyRGColeSPMultidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defenseToxicol Applied Pharmacol20052043216237
   PubMed Web of Science ®Google Scholar
• PadmanabhanRChenKGGilletJPRegulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cellsStem Cells201230102175218722887864
   PubMed Web of Science ®Google Scholar
• SzepesiÁMatulaZSzigetiAABCG2 is a selectable marker for enhanced multilineage differentiation potential in periodontal ligament stem cellsStem Cells Dev2014242244252
   Web of Science ®Google Scholar
• WagenerFADankersACvan SummerenFHeme oxygenase-1 and breast cancer resistance protein protect against hemeinduced toxicityCurr Pharmaceutical Design2013191526982707
   Web of Science ®Google Scholar
• JonkerJWBuitelaarMWagenaarEThe breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyriaProc Natl Acad Sci U S A20029924156491565412429862
   PubMed Web of Science ®Google Scholar
• HorseyAJCoxMHSarwatSKerrIDThe multidrug transporter ABCG2: still more questions than answersBiochemical Soc Trans2016443824830
   PubMed Web of Science ®Google Scholar
• WoodwardOMKöttgenAKöttgenMABCG transporters and diseaseFEBS J2011278183215322521554546
   PubMed Web of Science ®Google Scholar
• DehghanAKöttgenAYangQAssociation of three genetic loci with uric acid concentration and risk of gout: a genome-wide association studyLancet200837296541953196118834626
   PubMed Web of Science ®Google Scholar
• WoodwardOMKottgenACoreshJBoerwinkleEGugginoWBKottgenMIdentification of a urate transporter, ABCG2, with a common functional polymorphism causing goutProc Natl Acad Sci U S A200910625103381034219506252
   PubMed Web of Science ®Google Scholar
• SaisonCHeliasVBallifBANull alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system JuniorNat Genet201244217417722246505
   PubMed Web of Science ®Google Scholar
• ZelinskiTCoghlanGLiuX-QReidMEABCG2 null alleles define the Jr (a-) blood group phenotypeNat Genet201244213113222246507
   PubMed Web of Science ®Google Scholar
• DeppeSRippergerAWeissJErgünSBenndorfRAImpact of genetic variability in the ABCG2 gene on ABCG2 expression, function, and interaction with AT1 receptor antagonist telmisartanBiochem Biophys Res Comm201444341211121724388985
   PubMed Web of Science ®Google Scholar
• ImaiYNakaneMKageKC421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistanceMol Cancer Ther20021861161612479221
   PubMed Web of Science ®Google Scholar
• KobayashiDIeiriIHirotaTFunctional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placentaDrug Metab Dispos20053319410115475413
   PubMed Web of Science ®Google Scholar
• KondoCSuzukiHItodaMFunctional analysis of SNPs variants of BCRP/ABCG2Pharm Res200421101895190315553238
   PubMed Web of Science ®Google Scholar
• MizuaraiSAozasaNKotaniHSingle nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2Int J Cancer2004109223824614750175
   PubMed Web of Science ®Google Scholar
• MorisakiKRobeyRWÖzvegy-LaczkaCSingle nucleotide polymorphisms modify the transporter activity of ABCG2Cancer Chemother Pharmacol200556216117215838659
   PubMed Web of Science ®Google Scholar
• TamuraAWakabayashiKOnishiYRe-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2Cancer Sci200798223123917297656
   PubMed Web of Science ®Google Scholar
• FurukawaTWakabayashiKTamuraAMajor SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradationsPharm Res200926246947918958403
   PubMed Web of Science ®Google Scholar
• PrasadBLaiYLinYUnadkatJDInterindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotypeJ Pharm Sci2013102378779323280364
   PubMed Web of Science ®Google Scholar
• LeeJYKinchLNBorekDMCrystal structure of the human sterol transporter ABCG5/ABCG8Nature201653356156427144356
   PubMed Web of Science ®Google Scholar
• WoodwardOMTukayeDNCuiJGout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small moleculesProc Natl Acad Sci U S A20131105223522823493553
   PubMed Web of Science ®Google Scholar
• SarankóHTordaiHTelbiszAEffects of the gout-causing Q141K polymorphism and a CFTR ∆508 mimicking mutation on processing and stability of the ABCG2 proteinBiochem Biophys Res Commun2103437140145
   Google Scholar
• YuWKim ChiawPBearCEProbing conformational rescue induced by a chemical corrector of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutantJ Biol Chem2011286247142472521602569
   PubMed Web of Science ®Google Scholar
• WoodwardOMABCG2: the molecular mechanisms of urate secretion and goutAm J Physiol Renal Physiol2015309F485F48826136557
   PubMed Web of Science ®Google Scholar
• BassevilleATamakiAIeranoCHistone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporterCancer Res201272143642365122472121
   PubMed Web of Science ®Google Scholar
• RippergerABenndorfRAThe C421A (Q141K) polymorphism enhances the 3′-untranslated region (3′-UTR)-dependent regulation of ATP-binding cassette transporter ABCG2Biochem Pharmacol201610413914726903388
   PubMed Web of Science ®Google Scholar
• ToKKRobeyRWKnutsenTZhanZRiedTBatesSEEscape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2Mol Cancer Ther20098102959296819825807
   PubMed Web of Science ®Google Scholar
• NakanishiTRossDDBreast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expressionChin J Cancer201231739922098950
   PubMed Web of Science ®Google Scholar
• HeXWangJWeiWHypoxia regulates ABCG2 activity through the activation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cellsCancer Biol Ther20161718819826785721
   PubMed Web of Science ®Google Scholar
• KrishnamurthyPRossDDNakanishiTThe stem cell marjer Bcrp/ABCG2 enhances hypoxic cell survival through interactions with hemeJ Biol Chem20042792412824225
   Web of Science ®Google Scholar
• MogiMYangJLambertCFAkt signaling regulates side population cell phenotype via Bcrp1 translocationJ Biol Chem2003278390683907512851395
   PubMed Web of Science ®Google Scholar
• BleauAMHambardzumyanDOzawaTPTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cellsCell Stem Cell20096226235
   Web of Science ®Google Scholar
• HuCFHuangYYWangYJGaoFGUpregulation for ABCG2 via the PI3K-Akt pathway contributes to acidic microenvironment-induced cisplatin resistance in A549 and LTEP-a-2 ling cancer cellsOncol Rep20163645546127221310
   PubMed Web of Science ®Google Scholar
• HuangFFZhangLWuDSPTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemiaPLoS One20149e8829824603487
   PubMed Web of Science ®Google Scholar
• JiaYChenJZhuHJiaZHCuiMHAberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genesOncol Rep20153452296230426324021
   PubMed Web of Science ®Google Scholar
• WangJZhuXXLiuLSIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathwayEndocrine20165344345227022940
   PubMed Web of Science ®Google Scholar
• SzatmariIVamosiGBrazdaPPeroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cellsJ Biol Chem2006281238122382316785230
   PubMed Web of Science ®Google Scholar
• EePLKamalakaranSTonettiDIdentification of a novel estrogen responsive element in the breast cancer resistance protein geneCancer Res20041512471251
   Web of Science ®Google Scholar
• EvseenkoDAPaxtonJWKeelanJAIndependent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factorsDrug Metab Disppos200735595601
   PubMed Web of Science ®Google Scholar
• ChangFWFanHCLiuJMEstrogen enhances the expression of the multidrug transporter gene ABCG2 – increasing drug resistance of breast cancer cells through estrogen receptorsInt J Mol Sic201718E163
   Web of Science ®Google Scholar
• ChangW-CWuY-JJChungW-HGenetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritisRheumatology201756345746628394398
   PubMed Web of Science ®Google Scholar
• Galmés-PascualBMNadal-CasellasABauza-ThorbrüggeM17β-estradiol imrpoves hepatic mitochondrial biogenesis and function through PGC1BJ Endcrinol2017232297308
   Web of Science ®Google Scholar
• HentschkeMSüsensUBorgmeyerUPGC-1 and PERC, coactivators of the estrogen receptor-related receptor gammaBiochem Biophys Res Commun200229987287912470660
   PubMed Web of Science ®Google Scholar
• ScarpullaRCTranscriptional paradigms in mammalian mitochondrial biogenesis and functionPhysiol Rev20088861163818391175
   PubMed Web of Science ®Google Scholar
• MerrimanTRBoocockJDalbethNMitochondrial genetic variation and susceptibility to gout in PolynesiansAnn Rheum Dis201675S2115
   Google Scholar
• MerrimanTTerkeltaubRPPARGC1B: insight into the expression of the gouty inflammation phenotype: PPARGC1B and gouty inflammationRheumatology201756332332528003496
   PubMed Web of Science ®Google Scholar
• OkadaYSimXGoMJMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populationsNat Genet201244890490922797727
   PubMed Web of Science ®Google Scholar
• CharlesBAShrinerDDoumateyAA genome-wide association study of serum uric acid in African AmericansBMC Med Genomics201141721294900
   PubMed Web of Science ®Google Scholar
• TinAWoodwardOMKaoWHLGenome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function alleleHum Mol Genet201120204056106821768215
   PubMed Web of Science ®Google Scholar
• RenYCJinTBSunXDPKD2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patientsGenet Mol Res201615
   Web of Science ®Google Scholar
• SullJWYangSJKimSJeeSHThe ABCG2 polymorphism rs2725220 is associated with hyperuricemia in the Korean populationGenom Inform201412231235
   PubMedGoogle Scholar
• ShimizuTSugiuraTWakayamaTPDZK1 regulates breast cancer resistance protein in small intestineDrug Metab Dispos201139112148215421816982
   PubMed Web of Science ®Google Scholar
• HuffmanJEAlbrechtETeumerAModulation of genetic associations with serum urate levels by body-mass-index in humansPLoS One2015103e011975225811787
   PubMed Web of Science ®Google Scholar
• SpeliotesEKWillerCJBerndtSIAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass indexNat Genet2010421193794820935630
   PubMed Web of Science ®Google Scholar
• StahlEChoiHCadzowMFlynnTToplessRMerrimanTRConditional analysis of 30 serum urate loci identifies 25 additional independent effectsArthritis Rheum201466S1294
   Web of Science ®Google Scholar
• WenCYeeSLiangXGenome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug responseClin Pharm Therap2015975518525
   PubMed Web of Science ®Google Scholar
• JiriMZhangLLanBGenetic variation in the ABCG2 gene is associated with gout risk in the Han Chinese populationClin Rheumatol20163515916326506822
   PubMed Web of Science ®Google Scholar
• TuH-PKoAM-SChiangS-LJoint effects of alcohol consumption and ABCG2 Q141K on chronic tophaceous gout riskJ Rheumatol201441474975824532835
   PubMed Web of Science ®Google Scholar
• ZhouDLiuYZhangXFunctional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male populationInt J Mol Sci20141559149915924857923
   PubMed Web of Science ®Google Scholar
• HulsMBrownCDAWindassASThe breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membraneKidney Int20087322022517978814
   PubMed Web of Science ®Google Scholar
• MandalAKMountDBThe molecular physiology of uric acid homeostasisAnn Rev Physiol20157732334525422986
   PubMed Web of Science ®Google Scholar
• MatsuoHTakadaTIchidaKCommon defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese populationSci Trans Med2009155ra11
   PubMed Web of Science ®Google Scholar
• IchidaKMatsuoHTakadaTDecreased extra-renal urate excretion is a common cause of hyperuricemiaNat Commun2012376422473008
   PubMed Web of Science ®Google Scholar
• MatsuoHNakayamaASakiyamaMABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overloadSci Rep20144375524441388
   PubMed Web of Science ®Google Scholar
• TorresRJde MiguelEBailénRTubular urate transporter gene polymorphisms differentiate patients with gout who have normal and decreased urinary acid excretionJ Rheumatol201441186387025128519
   PubMed Web of Science ®Google Scholar
• KannangaraDRPhipps-GreenAJDalbethNHyperuricemia: contributions of urate transporter ABCG2 and the fractional renal clearance of urateAnn Rheum Dis2016751363136626835700
   PubMed Web of Science ®Google Scholar
• DalbethNHouseMGambleGDInfluence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challengeArthritis Res Ther201430R34
   Web of Science ®Google Scholar
• KimYSKimYParkGGenetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean populationKorean J Intern Med201530691326552468
   PubMed Web of Science ®Google Scholar
• LiCLiZLiuSGenome-wide association analysis identifies three new risk loci for gout arthritis in Han ChineseNat Commun20156704125967671
   PubMed Web of Science ®Google Scholar
• MatsuoHYamamotoKNakaokaHGenome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypesAnn Rheum Dis201675465265925646370
   PubMed Web of Science ®Google Scholar
• Phipps-GreenAJHollis-MoffattJDalbethNA strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Maori, case and control sample setsHum Mol Genet2010194813481920858603
   PubMed Web of Science ®Google Scholar
• WanWXuXZhaoDBPangYFWangYXPolymorphisms of uric acid transporter proteins in the pathogenesis of gout in a Chinese Han populationGenet Mol Res2015142546155025867401
   PubMed Web of Science ®Google Scholar
• StarkKReinhardWGrasslMCommon polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary heart diseasePLoS One20094e772919890391
   PubMed Web of Science ®Google Scholar
• Phipps-GreenAMerrimanMToplessRTwenty-eight loci that influence serum urate levels: analysis of association with goutAnn Rheum Dis20167512413025187157
   PubMed Web of Science ®Google Scholar
• MerrimanTRPhipps-GreenABoocockJPleiotropic effect of ABCG2 in gout2016 ACR/ARHP Annual MeetingNovember 11–16, 2016Washington, DC Abstract Number 2276
   Google Scholar
• HeWPhipps-GreenAStampLKMerrimanTRDalbethNPopulation-specific association between ABCG2 variants and tophaceous disease in people with goutArthritis Res Ther2017194328270222
   PubMed Web of Science ®Google Scholar
• XiaCQLiuNMiwaGTGanLSInteractions of cyclosporin a with breast cancer resistance proteinDrug Metab Dispos20073557658217220244
   PubMed Web of Science ®Google Scholar
• LinHYRocherLLMcQuillanMDCyclosporine-induced hyperuricemia and goutN Engl J Med19903223343362296276
   PubMed Web of Science ®Google Scholar
• WatsonSDigiacintoJLDavisMWEffect of cyclosporine on the pharmacokinetics of colchicine in healthy subjectsPostgrad Med201212418919622913907
   PubMed Web of Science ®Google Scholar
• MartinonFPetrilliVMayorATardivelATschoppJGout-associated uric acid crystals activate the NALP3 inflammasomeNature2006440708123724116407889
   PubMed Web of Science ®Google Scholar
• SkeldonAMFarajMSalehMCaspases and inflammasomes in metabolic inflammationImmunol Cell Biol201492430431324518981
   PubMed Web of Science ®Google Scholar
• Giamarellos-BourboulisEJMouktaroudiMBodarECrystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1β by mononuclear cells through a caspase 1-mediated processAnn Rheum Dis200968227327818390571
   PubMed Web of Science ®Google Scholar
• JoostenLANeteaMGMylonaEEngagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal–induced gouty arthritisArthritis Rheum201062113237324820662061
   PubMed Web of Science ®Google Scholar
• ThackerSGZarzourAChenYHigh-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activationImmunology2016149330631927329564
   PubMed Web of Science ®Google Scholar
• Williams-BeyYBoularanCVuralAOmega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-κB activation and enhancing autophagyPLoS One201496e9795724911523
   PubMed Web of Science ®Google Scholar
• QingYFZhouJGZhangQBAssociation of TLR4 gene rs2149356 polymorphism with primary gouty arthritis in a case-control studyPLoS One20138e6484523738004
   PubMed Web of Science ®Google Scholar
• RasheedHMcKinneyCStampLKThe toll-like receptor 4 (TLR4) variant rs2149356 and risk of gout in European and Polynesian sample setsPLoS One201611e1047939
   Web of Science ®Google Scholar
• ChenYRenXLiCCARD8 rs2034211 polymorphism is associated with gout in a Chinese male populationCell Physiol Biochem2015351394140025790751
   PubMedGoogle Scholar
• LeeSWLeeSSOhDHGenetic association for P2X7R rs3751142 and CARD8 rs2043211 polymorphisms for susceptibility of gout in Korean men: multi-center studyJ Korean Med Sci2016311566157027550484
   PubMed Web of Science ®Google Scholar
• McKinneyCStampLKDalbethNMultiplicative interaction of functional inflammasome genetic variants in determining the risk of goutArthritis Res Ther20151728826462562
   PubMed Web of Science ®Google Scholar
• ShenSCallaghanDJuzwikCXiongHHuangPZhangWABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer’s diseaseJ Neurochem201011461590160420626554
   PubMed Web of Science ®Google Scholar
• SautinYYNakagawaTZharikovSJohnsonRJAdverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stressAm J Physiol20072932C584C596
   PubMed Web of Science ®Google Scholar
• LanaspaMASanchez-LozadaLGChoiY-JUric acid induces hepatic steatosis by generation of mitochondrial oxidative stress potential role in fructose-dependent and-independent fatty liverJ Biol Chem201228748407324074423035112
   PubMed Web of Science ®Google Scholar
• van der HeijdenJWOerlemansRTakPPInvolvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomideArthritis Rheum200960366967719248091
   PubMed Web of Science ®Google Scholar
• von Wedel-ParlowMWoltePGallaHJRegulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitroJ Neurochem2009111111111819656257
   PubMed Web of Science ®Google Scholar
• PollerBDreweJKrahenbuhlSHuwylerJGutmannHRegulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrierCell Mol Neurobiol2010301637019629677
   PubMed Web of Science ®Google Scholar
• Le VeeMLecureurVStiegerBFardelORegulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6Drug Metab Dispos200937368569319074973
   PubMed Web of Science ®Google Scholar
• DingRJinSPabonKScottoKWA role for ABCG2 beyond drug transport: Regulation of autophagyAutophagy201612573775126983466
   PubMed Web of Science ®Google Scholar
• ZhongZUmemuraASanchez-LopezENF-κB restricts inflammasome activation via elimination of damaged mitochondriaCell2016164589691026919428
   PubMed Web of Science ®Google Scholar
• ZhouRYazdiASMenuPTschoppJA role for mitochondria in NLRP3 inflammasome activationNature2011469732922122521124315
   PubMed Web of Science ®Google Scholar
• JhangJJChengYTHoCYYenGCMonosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cellsCell Mol Immunol201512442443425109682
   PubMed Web of Science ®Google Scholar
• ToKKRobeyRZhanZBangioloLBatesSEUpregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathwayMol Cancer Res20119451652721357443
   PubMed Web of Science ®Google Scholar
• BeckerMSchumacherHRWortmannRFebuxostat compared with allopurinol in patients with hyperuricaemia and goutN Engl J Med20053532450246116339094
   PubMed Web of Science ®Google Scholar
• StampLMerrimanTBarclayMInadequate response to allopurinol in the treatment of gout – defining the population and potential causesSemin Arthritis Rheum201444217017424925693
   PubMed Web of Science ®Google Scholar
• SaitoYStampLCaudleKClinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Human Leukocyte Antigen B (HLA-B) Genotype and Allopurinol Dosing: 2015 updateClin Pharm Ther20169913637
   PubMed Web of Science ®Google Scholar
• RobertsRWallaceMPhipps-GreenAABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with goutPharmacogenomics J Epub2016126
   Web of Science ®Google Scholar
• TurnheimKKrivanekPOberbauerRPharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjectsBr J Clin Pharmacol199948450150910583019
   PubMed Web of Science ®Google Scholar
• BhatnagarVRichardELWuWAnalysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signalingClin Kidney J20169344445327274832
   PubMed Web of Science ®Google Scholar
• YanoHTamuraYKobayashiKTanemotoMUchidaSUric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney diseaseClin Exp Nephrol2014181505523584883
   PubMed Web of Science ®Google Scholar
• WuWDnyanmoteAVNigamSKRemote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesisMol Pharmacol201179579580521325265
   PubMed Web of Science ®Google Scholar
• AmesBNCathcartRSchwiersEHochsteinPUric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesisProc Natl Acad Sci U S A19817811685868626947260
   PubMed Web of Science ®Google Scholar
• Desuzinges-MandonEArnaudOMartinezLABCG2 transports and transfers heme to albumin through its large extracellular loopJ Biol Chem201028543331233313320705604
   PubMed Web of Science ®Google Scholar
• BellomoGVenanziSVerduraCAssociation of uric acid with change in kidney function in healthy normotensive individualsAm J Kidney Dis201056226427220385436
   PubMed Web of Science ®Google Scholar
• RobinsonPCChoiHKDoRMerrimanTRInsight into rheumatological cause and effect through the use of Mendelian randomizationNat Rev Rheumatol201612848649627411906
   PubMed Web of Science ®Google Scholar
• HughesKFlynnTde ZoysaJDalbethNMerrimanTRMendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal functionKidney Int201385234435124048376
   PubMed Web of Science ®Google Scholar
• TestaAMallamaciFSpotoBAssociation of a polymorphism in a gene encoding a urate transporter with CKD progressionClin J Am Soc Nephrol2014961059106524742479
   PubMed Web of Science ®Google Scholar
• DankersACMutsaersHADijkmanHBHyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP)Biochim Biophys Acta20131832101715172223665398
   PubMed Web of Science ®Google Scholar
• CrișanTOCleophasMCOostingMSoluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1RaAnn Rheum Dis201675475576225649144
   PubMed Web of Science ®Google Scholar
• KaszaIVáradyGAndrikovicsHExpression levels of the ABCG2 multidrug transporter in human erythrocytes correspond to pharmacologically relevant genetic variationsPLoS One20127e4842323166586
   PubMed Web of Science ®Google Scholar
• LiRMiaoLXiangYA meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout riskInt J Clin Exp Pathol201589812982326617691
   PubMed Web of Science ®Google Scholar
• DongZGuoSYangYAssociation between ABCG2 Q141K polymorphism and gout risk affected by ethnicity and gender: a systematic review and meta-analysisInt J Rheum Dis20151838239125639607
   PubMed Web of Science ®Google Scholar