References
- MüllerDJKennedyJLGenetics of antipsychotic treatment emergent weight gain in schizophreniaPharmacogenomics20067686388716981847
- MuenchJHamerAMAdverse effects of antipsychotic medicationsAm Fam Physician201081561762220187598
- KimSFHuangASSnowmanAMAntipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinaseProc Natl Acad Sci U S A200710493456345917360666
- GebhardtSTheisenFMHaberhausenMBody weight gain induced by atypical antipsychotics: an extension of the monozygotic twin and sib pair studyJ Clin Pharm Ther201035220721120456740
- FaulknerGCohnTRemingtonGInterventions to reduce weight gain in schizophreniaSchizophr Bull200733365465617449900
- MeltzerHYMatsubaraSLeeJCThe ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugsPsychopharmacol Bull19892533903922576319
- NasrallahHAAtypical antipsychotic-induced metabolic side effects: insights from receptor-binding profilesMol Psychiatry2008131273517848919
- TheisenFMHaberhausenMFirngesMANo evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulationPharmacogenomics J20077427528116983399
- ReynoldsGPKirkSLMetabolic side effects of antipsychotic drug treatment: pharmacological mechanismsPharmacol Ther2010125116917919931306
- CliftonPGLeeMDDourishCTSimilarities in the action of Ro 60-0175, a 5-HT2C receptor agonist and d-fenfluramine on feeding patterns in the ratPsychopharmacology (Berl)2000152325626711105935
- BonhausDWWeinhardtKKTaylorMRS-102221: a novel high affinity and selective 5-HT2C receptor antagonistNeuropharmacology1997364–56216299225287
- TecottLHSunLMAkanaSFEating disorder and epilepsy in mice lacking 5-HT2c serotonin receptorsNature199537465225425467700379
- SchaffhauserAOMadieheAMBraymerHDBrayGAYorkDAEffects of a high-fat diet and strain on hypothalamic gene expression in ratsObes Res200210111188119612429884
- NonogakiKNozueKOkaYHyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay miceEndocrinology2006147125893590016973729
- Von MeyenburgCLanghansWHrupkaBJEvidence for a role of the 5-HT2C receptor in central lipopolysaccharide-,interleuikin-1 beta-, and leptin-induced anorexiaPharmacol Biochem Behav20037441025103112667918
- ReynoldsGPHillMJKirkSLThe 5-HT2C receptor and antipsychotic-induced weight gain: mechanisms and geneticsJ Psychopharmacol2006204 Supp151816785265
- BanasSMDolySBoutourlinskyKDeconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effectsNeuropsychopharmacology201136242343320927048
- ThomsenWJGrottickAJMenzaghiFLorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterizationJ Pharmacol Exp Ther2008325257758718252809
- SmithSRWeissmanNJAndersonCMMulticenter, placebo-controlled trial of lorcaserin for weight managementN Engl J Med2010363324525620647200
- LappalainenJZhangLDeanMIdentification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C)Genomics19952722742797557992
- EllingrodVLPerryPJRingoldJCWeight gain associated with the −759C/T polymorphism of the 5HT2C receptor and olanzapineAm J Med Genet B Neuropsychiatr Genet2005134B1767815666332
- GodlewskaBROlajossy-HilkesbergerLCiwoniukMOlanzapine-induced weight gain is associated with the −759C/T and −697G/C polymorphisms of the HTR2C genePharmacogenomics J20099423424119434072
- LaneH-YLiuY-CHuangC-LRisperidone-related weight gain: genetic and nongenetic predictorsJ Clin Psychopharmacol200626212813416633140
- Opgen-RheinCBrandlEJMüllerDJAssociation of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German samplePharmacogenomics201011677378020504252
- MillerDDEllingrodVLHolmanTLBuckleyPFArndtSClozapine-induced weight gain associated with the 5HT2C receptor −759C/T polymorphismAm J Med Genet B Neuropsychiatr Genet2005133B19710015635667
- ReynoldsGPZhangZ-JZhangX-BAssociation of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphismLancet200235993232086208712086765
- RyuSChoEYParkT−759C/T polymorphism of 5-HT2C receptor gene and early phase weight gain associated with antipsychotic drug treatmentProg Neuropsychopharmacol Biol Psychiatry200731367367717275977
- TemplemanLAReynoldsGPArranzBSanLPolymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosisPharmacogenet Genomics200515419520015864111
- De LucaVMüllerDJHwangRHTR2C haplotypes and antipsychotics-induced weight gain: X-linked multimarker analysisHum Psychopharmacol200722746346717702092
- KuzmanMRMedvedVBozinaNHotujacLSainIBilusicHThe influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patientsPsychiatry Res2008160330831518718676
- MulderHFrankeBvan der-Beek van derAAThe association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional studyPharmacogenomics J20077531832417016522
- ParkYMChoJHKangSGLack of association between the −759C/T polymorphism of the 5-HT2C receptor gene and olanzapine-induced weight gain among Korean schizophrenic patientsJ Clin Pharm Ther2008331556018211617
- TsaiSJHongCJYuYWLinCH−759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gainLancet20023609347179012480466
- UjikeHNomuraAMoritaYMultiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort studyJ Clin Psychiatry20086991416142219193342
- YevtushenkoOOCooperSJO’NeillRDohertyJKWoodsideJVReynoldsGPInfluence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophreniaBr J Psychiatry2008192642442818515891
- De LucaVMüllerDJde BartolomeisAKennedyJLAssociation of the HTR2C gene and antipsychotic-induced weight gain: a meta-analysisInt J Neuropsychopharmacol200710569770417291373
- SicardMNZaiCCTiwariAKPolymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysisPharmacogenomics201011111561157121121776
- Alvarez-JiménezMGonzález-BlanchCCrespo-FacorroBAntipsychotic-induced weight gain in chronic and first-episode psychotic disorders: a systemic critical reappraisalCNS Drugs200822754756218547125
- GunesAMelkerssonKIScordoMGDahlM-LAssociation between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapineJ Clin Psychopharmocol20092916568
- HillMJReynoldsGP5-HT2C receptor gene polymorphisms associated with antipsychotic drug action alter promoter activityBrain Res20071149141717376412
- YuanXYamadaKIshiyama-ShigemotoSKoyamaWNonakaKIdentification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetesDiabetologia200043337337610768099
- BucklandPRHoogendoornBGuyCASmithSKColemanSLO’DonovanMCLow gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gainAm J Psychiatry2005162361361515741483
- McCarthySMottagui-TabarSMizunoYComplex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptinHum Genet2005117654555716021472
- MeyerJSaamWMössnerREvolutionary conserved microsatellites in the promoter region of the 5-hydroxytryptamine receptor 2C gene (HTR2C) are not associated with bipolar disorder in femalesJ Neural Transm20021095–693994612111480
- DragoASerrettiAFocus on HTR2C: a possible suggestion for genetic studies of complex disordersAm J Med Genet B Neuropsychiatr Genet2009105B560163718802918
- FentressHMGrindeEMazurkiewiczJEBackstromJRHerrick-DavisKSanders-BushEPharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoformsPharmacogenomics J20055424425415912142
- OkadaMNorthupJKOzakiNRusselJTLinnoilaMGoldmanDModification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring aminoacid substitutionMol Psychiatry200491556414699441
- HannonJHoyerDMolecular biology of 5-HT receptorsBehav Brain Res2008195119821318571247
- RietschelMNaberDFimmersRMöllerHJProppingPMöthemNMEfficacy and side effects of clozapine not associated with variation in the 5-HT2C receptorNeuroreport199788199920039223092
- PoppJLeuchtSHeresSSteimerWDRD4 48 bp VNTR but not 5-HT 2C Cys23Ser receptor polymorphism is related to antipsychotic-induced weight gainPharmacogenomics J200991717718332898
- HongCJLinCHYuYWYangKHTsaiSJGenetic variants of the serotonin system and weight change during clozapine treatmentPharmacogenetics200111326526811337942
- BasileVSMasellisMMcIntyreRSMeltzerHYLiebermanJAKennedyJLGenetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzleJ Clin Psychiatry20016223 Suppl456611603885