Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy

References

• Mohammad-ZadehLFMosesLGwalzney-BrantSMSerotonin: a reviewJ Vet Pharmacol Ther20083118719918471139
   PubMed Web of Science ®Google Scholar
• Sanders-BushEMayerSE5-Hydroxytryptamine (serotonin): receptor agonists and antagonistsBruntonLLLazoJSParkerKLGoodman and Gilman’s: The Pharmacological Basis of TherapeuticsNew YorkMcGraw-Hill2006
   Google Scholar
• KennaGAMedications acting on the serotonergic system for the treatment of alcohol dependent patientsCurr Pharm Des2010162126213520482508
   PubMed Web of Science ®Google Scholar
• LeschKPBengelDHeilsAAssociation of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory regionScience1996274152715318929413
   PubMed Web of Science ®Google Scholar
• CaspiAHaririARHolmesAUherRMoffittTEGenetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traitsAm J Psychiatry201016750952720231323
   PubMed Web of Science ®Google Scholar
• HaririARMattayVSTessitoreASerotonin transporter genetic variation and the response of the human amygdalaScience200229740040312130784
   PubMed Web of Science ®Google Scholar
• CaspiASugdenKMoffittTEInfluence of life stress on depression: moderation by a polymorphism in the 5-HTT geneScience200330138638912869766
   PubMed Web of Science ®Google Scholar
• MatsushitaSYoshinoAMurayamaMKimuraMMuramatsuTHiguchiSAssociation study of serotonin transporter gene regulatory region polymorphism and alcoholismAm J Med Genet200110544645011449397
   PubMed Web of Science ®Google Scholar
• HuXOrosziGChunJSmithTLGoldmanDSchuckitMAAn expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism riskAlcohol Clin Exp Res20052981615654286
   PubMed Web of Science ®Google Scholar
• LipskyRHHuXZGoldmanDAdditional functional variation at the SLC6 A4 geneAm J Med Genet B Neuropsychiatr Genet200915015318444253
   PubMed Web of Science ®Google Scholar
• KuzelovaHPtacekRMacekMThe serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literatureNeuro Endocrinol Lett20103141020150867
   PubMed Web of Science ®Google Scholar
• RischNHerrellRLehnerTInteraction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysisJAMA20093012462247119531786
   PubMed Web of Science ®Google Scholar
• HeilsATeufelAPetriSAllelic variation of human serotonin transporter gene expressionJ Neurochem199666262126248632190
   PubMed Web of Science ®Google Scholar
• HeilsATeufelAPetriSFunctional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter geneJ Neural Transm Gen Sect19951022472548788073
   PubMed Web of Science ®Google Scholar
• Gonzalez-AnguloAMHennessyBTMillsGBFuture of personalized medicine in oncology: a systems biology approachJ Clin Oncol2010282777278320406928
   PubMed Web of Science ®Google Scholar
• RoerigJLDiagnosis and management of generalized anxiety disorderJ Am Pharm Assoc199939811821
   Google Scholar
• HeinzABrausDFSmolkaMNAmygdala-prefrontal coupling depends on a genetic variation of the serotonin transporterNat Neurosci20058202115592465
   PubMed Web of Science ®Google Scholar
• SurguladzeSAElkinAEckerCGenetic variation in the serotonin transporter modulates neural system-wide response to fearful facesGenes Brain Behav2008754355118266983
   PubMed Web of Science ®Google Scholar
• MunafòMRBrownSMHaririARSerotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysisBiol Psychiatry20086385285717949693
   PubMed Web of Science ®Google Scholar
• MunafòMRFreimerNBNgW5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new dataAm J Med Genet B Neuropsychiatr Genet2009150271281
   Web of Science ®Google Scholar
• Willis-OwenSATurriMGMunafòMRThe serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of associationBiol Psychiatry20055845145616023085
   PubMed Web of Science ®Google Scholar
• American Psychiatric AssociationDiagnostic and Statistical Manual of Mental Disorders DSM-IV-TR Fourth Text RevisionWashington, DCAmerican Psychiatric Association2000
   Google Scholar
• KendlerKSGatzMGardnerCOPedersenNLA Swedish national twin study of lifetime major depressionAm J Psychiatry200616310911416390897
   PubMed Web of Science ®Google Scholar
• VergneDENemeroffCBThe interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depressionCurr Psychiatry Rep2006845245717094925
   PubMedGoogle Scholar
• MunafòMRDurrantCLewisGFlintJGene x environment interactions at the serotonin transporter locusBiol Psychiatry20096521121918691701
   PubMed Web of Science ®Google Scholar
• KargKBurmeisterMSheddenKSenSThe serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderationArch Gen Psychiatry20116844445421199959
   PubMed Web of Science ®Google Scholar
• CoplanJDAbdallahCGKaufmanJEarly-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot studyPsychoneuroendocrinology20113628929320692103
   PubMed Web of Science ®Google Scholar
• ResslerKJBradleyBMercerKBPolymorphisms in CRHR1 and the serotonin transporter loci: gene × gene × environment interactions on depressive symptomsAm J Med Genet B Neuropsychiatr Genet201015381282420029939
   PubMed Web of Science ®Google Scholar
• YuYWTsaiSJChenTJLinCHHongCJAssociation study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disordersMol Psychiatry200271115111912476327
   PubMed Web of Science ®Google Scholar
• SmeraldiEZanardiRBenedettiFDi BellaDPerezJCatalanoMPolymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamineMol Psychiatry199835085119857976
   PubMed Web of Science ®Google Scholar
• YoshidaKItoKSatoKInfluence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patientsProg Neuropsychopharmacol Biol Psychiatry20022638338611817517
   PubMed Web of Science ®Google Scholar
• KimDKLimSWLeeSSerotonin transporter gene polymorphism and antidepressant responseNeuroreport20001121521910683861
   PubMed Web of Science ®Google Scholar
• ZanardiRBenedettiFDi BellaDCatalanoMSmeraldiEEfficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter geneJ Clin Psychopharmacol20002010510710653220
   PubMed Web of Science ®Google Scholar
• PollockBGFerrellREMulsantBHAllelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depressionNeuropsychopharmacology20002358759011027924
   PubMed Web of Science ®Google Scholar
• DurhamLKWebbSMMilosPMClaryCMSeymourABThe serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorderPsychopharmacology200417452552912955294
   PubMed Web of Science ®Google Scholar
• LewisGMulliganJWilesNPolymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trialBr J Psychiatry201119846447121263010
   PubMed Web of Science ®Google Scholar
• Huezo-DiazPUherRSmithRModeration of antidepressant response by the serotonin transporter geneBr J Psychiatry2009195303819567893
   PubMed Web of Science ®Google Scholar
• KeersRUherRHuezo-DiazRInteraction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP projectPharmacogenomics201111138145
   Web of Science ®Google Scholar
• SerrettiAKatoMDe RonchiDKinoshitaTMeta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patientsMol Psychiatry20071224725717146470
   PubMed Web of Science ®Google Scholar
• TaylorMJSenSBhagwagarZAntidepressant response and the serotonin transporter gene-linked polymorphic regionBiol Psychiatry20106853654320615496
   PubMed Web of Science ®Google Scholar
• WhiteKJWallineCCBarkerELSerotonin transporters: implications for antidepressant drug developmentAAPS J20057421433
   Web of Science ®Google Scholar
• MaloneKMHaasGLSweeneyJAMannJJMajor depression and the risk of attempted suicideJ Affect Disord1995341731857560545
   PubMed Web of Science ®Google Scholar
• DuLFaludiGPalkovitsMFrequency of long allele in serotonin transporter gene is increased in depressed suicide victimsBiol Psychiatry19994619620110418694
   PubMed Web of Science ®Google Scholar
• DuLFaludiGPalkovitsMBakishDHrdinaPDSerotonergic genes and suicidalityCrisis200122546011727894
   PubMedGoogle Scholar
• RussMJLachmanHMKashdanTSaitoTBajmakovic-KacilaSAnalysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicidePsychiatry Res200093737810699230
   PubMed Web of Science ®Google Scholar
• AnguelovaMBenkelfatCTureckiGA systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behaviorMol Psychiatry2003864665312874600
   PubMed Web of Science ®Google Scholar
• CraddockNJonesIGenetics of bipolar disorderJ Med Genet19993658559410465107
   PubMed Web of Science ®Google Scholar
• ChoHJMeira-LimaICordeiroQPopulation-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysisMol Psychiatry20051077178115824745
   PubMed Web of Science ®Google Scholar
• AnguelovaMBenkelfatCTureckiGA systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disordersMol Psychiatry2003857459112851635
   PubMed Web of Science ®Google Scholar
• RotondoAMazzantiCDell’OssoLCatechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorderAm J Psychiatry2002159232911772685
   PubMed Web of Science ®Google Scholar
• GoldbergJFTrumanCJAntidepressant-induced mania: an overview of current controversiesBipolar Disord2003540742014636364
   PubMed Web of Science ®Google Scholar
• MundoEWalkerMCateTMacciardiFKennedyJLThe role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findingsArch Gen Psychiatry20015853954411386982
   PubMed Web of Science ®Google Scholar
• RoussevaAHenryCvan den BulkeDAntidepressant-induced mania, rapid cycling and the serotonin transporter gene polymorphismPharmacogenomics J2003310110412746735
   PubMed Web of Science ®Google Scholar
• SerrettiAArtioliPZanardiRGenetic features of anti-depressant induced mania and hypo-mania in bipolar disorderPsychopharmacology200417450451115248044
   PubMed Web of Science ®Google Scholar
• LeeHJLeeMSKangRHInfluence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorderDepress Anxiety20052113513915965993
   PubMed Web of Science ®Google Scholar
• WangZBakerDGHarrerJHamnerMPriceMAmstadterAThe relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphismDepress Anxiety2011281067107321818827
   PubMed Web of Science ®Google Scholar
• XiePKranzlerHRPolingJInteractive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on post-traumatic stress disorder diagnosis in 2 independent populationsArch Gen Psychiatry2009661201120919884608
   PubMed Web of Science ®Google Scholar
• AasMDjurovicSAthanasiuLSerotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disordersSchizophr Bull992011[Epub ahead of print.]
   Google Scholar
• MushtaqDAliAMargoobMAMurtazaIAndradeCAssociation between serotonin transporter gene promoter-region polymorphism and 4- and 12-week treatment response to sertraline in posttraumatic stress disorderJ Affect Disord2011[Epub ahead of print.]
   Google Scholar
• GrabeHJSpitzerCSchwahnCSerotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to post-traumatic stress disorder in the general populationAm J Psychiatry200916692693319487392
   PubMed Web of Science ®Google Scholar
• KilpatrickDGKoenenKCRuggieroKJThe serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adultsAm J Psychiatry20071641693169917974934
   PubMed Web of Science ®Google Scholar
• EnochMAGoldmanDGenetics of alcoholism and substance abusePsychiatr Clin North Am1999228929910385934
   PubMed Web of Science ®Google Scholar
• PrescottCAKendlerKSGenetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twinsAm J Psychiatry199915634409892295
   PubMed Web of Science ®Google Scholar
• KweonYSLeeHKLeeCTLeeKUPaeCUAssociation of the serotonin transporter gene polymorphism with Korean male alcoholicsJ Psychiatr Res20053937137615804387
   PubMed Web of Science ®Google Scholar
• JohnsonBAJavorsMARoacheJDCan serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?Prog Neuropsychopharmacol Biol Psychiatry20083220921617950969
   PubMed Web of Science ®Google Scholar
• McHughRKHofmannSGAsnaaniASawyerATOttoMWThe serotonin transporter gene and risk for alcohol dependence: a meta-analytic reviewDrug Alcohol Depend20101081620060655
   PubMed Web of Science ®Google Scholar
• Ait-DaoudNRoacheJDDawesMACan serotonin transporter genotype predict craving in alcoholism?Alcohol Clin Exp Res2009331329133519426172
   PubMed Web of Science ®Google Scholar
• TartterMARayLAThe serotonin transporter polymorphism (5-HTTLPR) and alcohol problems in heavy drinkers: moderation by depressive symptomsFront Psychiatry201124921852976
   PubMedGoogle Scholar
• FeinnRNellisseryMKranzlerHRMeta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependenceAm J Med Genet B Neuropsychiatr Genet2005133798415635638
   PubMed Web of Science ®Google Scholar
• EnochMAGorodetskyEHodgkinsonCRoyAGoldmanDFunctional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependenceMol Psychiatry2011161139114620838391
   PubMed Web of Science ®Google Scholar
• HermanAIKaissKMMaRSerotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking in young womenAm J Med Genet B Neuropsychiatr Genet2005133747815635592
   PubMed Web of Science ®Google Scholar
• KennaGAZywiakWHMcGearyJEA within-group design of nontreatment seeking 5-HTTLPR genotyped alcohol-dependent subjects receiving ondansetron and sertralineAlcohol Clin Exp Res20093331532319032576
   PubMed Web of Science ®Google Scholar
• KennaGAMcGearyJESwiftRMPharmacotherapy, pharmacogenomics, and the future of alcohol dependence treatment, Part 2Am J Health Syst Pharm2004612380238815581261
   PubMed Web of Science ®Google Scholar
• KennaGAPharmacotherapy of alcohol dependence: Targeting a complex disorderDrug Disc Today: Therapeutic Strategies200527178
   Google Scholar
• KranzlerHRBurlesonJAKornerPPlacebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholicsAm J Psychiatry19951523913977864265
   PubMed Web of Science ®Google Scholar
• PettinatiHMVolpicelliJRKranzlerHRLuckGRukstalisMRCnaanASertraline treatment for alcohol dependence: interactive effects of medication and alcoholic subtypeAlcohol Clin Exp Res2000241041104910924008
   PubMed Web of Science ®Google Scholar
• KranzlerHRArmeliSTennenHDouble-blind, randomized trial of sertraline for alcohol dependence: moderation by age of onset and 5-HTTLPR genotypeJ Clin Psychopharmacol201131223021192139
   PubMed Web of Science ®Google Scholar
• JohnsonBASerotonergic agents and alcoholism treatment: rebirth of the subtype concept – an hypothesisAlcohol Clin Exp Res2000241597160111045870
   PubMed Web of Science ®Google Scholar
• HammoumiSPayenAFavreJDDoes the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence?Alcohol19991710711210064377
   PubMed Web of Science ®Google Scholar
• BleichSBönschDRauhJAssociation of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependenceAlcohol Alcohol20074250951217711874
   PubMed Web of Science ®Google Scholar
• JohnsonBARoacheJDJavorsMAOndansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trialJAMA200028496397110944641
   PubMed Web of Science ®Google Scholar
• JohnsonBAAit-DaoudNSeneviratneCPharmacogenetic approach at the serotonin transporter gene as a method to reduce severe alcohol consumptionAm J Psychiatry201116826527521247998
   PubMed Web of Science ®Google Scholar
• KendlerKSNealeMCSullivanPCoreyLAGardnerCOPrescottCAA population-based twin study in women of smoking initiation and nicotine dependencePsychol Med19992929930810218922
   PubMed Web of Science ®Google Scholar
• HeathACMaddenPASlutskeWSMartinNGPersonality and the inheritance of smoking behavior: a genetic perspectiveBehav Genet1995251031177733853
   PubMed Web of Science ®Google Scholar
• ArinamiTIshiguroHOnaiviESPolymorphisms in genes involved in neurotransmission in relation to smokingEur J Pharmacol200041021522611134671
   PubMed Web of Science ®Google Scholar
• HughesJRSteadLFLancasterTAntidepressants for smoking cessationCochrane Database Syst Rev20071CD00003117253443
   PubMed Web of Science ®Google Scholar
• KremerIBachner-MelmanRReshefAAssociation of the serotonin transporter gene with smoking behaviorAm J Psychiatry200516292493015863794
   PubMed Web of Science ®Google Scholar
• MunafòMRJohnstoneECWileytoEPShieldsPGElliotKMLermanCLack of association of 5-HTTLPR genotype with smoking cessation in a nicotine replacement therapy randomized trialCancer Epidemiol Biomarkers Prev20061539840016492936
   PubMed Web of Science ®Google Scholar
• BiedermanJFaraoneSVAttention-deficit hyperactivity disorderLancet200536623724816023516
   PubMed Web of Science ®Google Scholar
• ThakurGAGrizenkoNSenguptaSMSchmitzNJooberRThe 5-HTTLPR polymorphism of the serotonin transporter gene and short term behavioral response to methylphenidate in children with ADHDBMC Psychiatry2010105020569447
   PubMed Web of Science ®Google Scholar
• SeegerGSchlossPSchmidtMHFunctional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disordersMol Psychiatry2001623523811317229
   PubMed Web of Science ®Google Scholar
• FaraoneSVPerlisRHDoyleAEMolecular genetics of attention-deficit/hyperactivity disorderBiol Psychiatry2005571313132315950004
   PubMed Web of Science ®Google Scholar
• RetzWThomeJBlocherDBaaderMRöslerMAssociation of attention deficit hyperactivity disorder-related psychopathology and personality traits with the serotonin transporter promoter region polymorphismNeurosci Lett200231913313611834311
   PubMed Web of Science ®Google Scholar
• ZoroğluSSErdalMEAlaşehirliBSignificance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorderNeuropsychobiol200245176181
   PubMed Web of Science ®Google Scholar