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ORIGINAL RESEARCH

An Aging-Related lncRNA Signature Establishing for Breast Cancer Prognosis and Immunotherapy Responsiveness Prediction

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Pages 251-270 | Received 21 Nov 2023, Accepted 18 May 2024, Published online: 23 May 2024

References

  • Sung H, Ferlay J, Siegel RL. et al. Global cancer Statistics 2020: GLOBOCAN Estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca a Cancer J Clinicians. 2021;71(3):209–249. doi:10.3322/caac.21660
  • Liang Y, Zhang H, Song X, Yang Q. Metastatic heterogeneity of breast cancer: molecular mechanism and potential therapeutic targets. Semi Cancer Biol. 2020;60:14–27. doi:10.1016/j.semcancer.2019.08.012
  • Bryan S, Witzel I, Borgmann K, Oliveira-Ferrer L. Molecular mechanisms associated with brain metastases in HER2-positive and triple negative breast cancers. Cancers. 2021;13(16). doi:10.3390/cancers13164137
  • Yu Z, Song M, Chouchane L, Ma X. Functional genomic analysis of breast cancer metastasis: implications for diagnosis and therapy. Cancers. 2021;13(13). doi:10.3390/cancers13133276
  • Palanca-Ballester C, Rodriguez-Casanova A, Torres S, et al. Cancer epigenetic biomarkers in liquid biopsy for high incidence malignancies. Cancers. 2021;13(12). doi:10.3390/cancers13123016
  • Kong Z, Han Q, Zhu B, Wan L, Feng E. Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis. Thorac Cancer. 2023;14(19):1831–1842. doi:10.1111/1759-7714.14928
  • Yang M, Lu H, Liu J, Wu S, Kim P, Zhou X. lncRNAfunc: a knowledgebase of lncRNA function in human cancer. Nucleic Acids Res. 2022;50(D1):D1295–D1306. doi:10.1093/nar/gkab1035
  • Ao YQ, Gao J, Jiang JH, Wang HK, Wang S, Ding JY. Comprehensive landscape and future perspective of long noncoding RNAs in non-small cell lung cancer: it takes a village. Mol Ther. 2023;23:00502. doi:10.1016/j.ymthe.2023.09.015
  • Liu Y, Zhang P, Wu Q, et al. Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63. Nat Commun. 2021;12(1):5232. doi:10.1038/s41467-021-25552-0
  • Deng L, Wang J, Song J, et al. Long noncoding RNA SNHG1 promotes breast cancer progression by regulating the miR-641/RRS1 axis. Sci Rep. 2024;14(1):3265. doi:10.1038/s41598-024-52953-0
  • Ge X, Lei S, Wang P, Wang W, Wang W. The metabolism-related lncRNA signature predicts the prognosis of breast cancer patients. Sci Rep. 2024;14(1):3500. doi:10.1038/s41598-024-53716-7
  • Yang Q, Fu Y, Wang J, Yang H, Zhang X. Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer. J Zhejiang Univ Sci B. 2023;24(12):1123–1140. doi:10.1631/jzus.B2300067
  • Kramer I, Hooning MJ, Mavaddat N, et al. Breast cancer polygenic risk score and contralateral breast cancer risk. Am J Hum Genet. 2020;107(5):837–848. doi:10.1016/j.ajhg.2020.09.001
  • Ma D, Chen C, Wu J, Wang H, Wu D. Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer. Breast Cancer. 2019;26(1):74–83. doi:10.1007/s12282-018-0891-3
  • Zhao Y, Liu L, Zhao J, et al. Construction and verification of a hypoxia-related 4-lncRNA model for prediction of breast cancer. Int J Gene Med. 2021;14:4605–4617. doi:10.2147/IJGM.S322007
  • Raju GSR, Pavitra E, Bandaru SS, et al. HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer. Mol Cancer. 2023;22(1):65. doi:10.1186/s12943-023-01765-3
  • Khaliefa AK, Desouky EM, Hozayen WG, Shaaban SM, Hasona NA. miRNA-1246, HOTAIR, and IL-39 signature as potential diagnostic biomarkers in breast cancer. Noncoding RNA Res. 2023;8(2):205–210. doi:10.1016/j.ncrna.2023.02.002
  • Semeraro MD, Smith C, Kaiser M, et al. Physical activity, a modulator of aging through effects on telomere biology. Aging. 2020;12(13):13803–13823. doi:10.18632/aging.103504
  • Li H, Wei C, Zhou R, et al. Mouse models in modeling aging and cancer. Exp Gerontology. 2019;120:88–94. doi:10.1016/j.exger.2019.03.002
  • Pinzone MR, Berretta M, Doerr HW, Nunnari G, Cacopardo B. The complexity of aging: cancer risk among elderly people and infectious risk among those with cancer. Anti Can Agent Med Chem. 2013;13(9):1444–1448. doi:10.2174/18715206113136660346
  • Chatsirisupachai K, Palmer D, Ferreira S, de Magalhães JP. A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence. Aging Cell. 2019;18(6):1–5. doi:10.1111/acel.13041
  • Tang YF, Wang YZ, Wen GB, Jiang JJ. Prognostic model of kidney renal clear cell carcinoma using aging-related long noncoding RNA signatures identifies THBS1-IT1 as a potential prognostic biomarker for multiple cancers. Aging. 2023;15(17):8630–8663. doi:10.18632/aging.204949
  • Hanahan D. Hallmarks of Cancer: new Dimensions. Cancer Discov. 2022;12(1):31–46. doi:10.1158/2159-8290.CD-21-1059
  • Xu Q, Chen Y. An aging-related gene signature-based model for risk stratification and prognosis prediction in lung adenocarcinoma. Front Cell Develop Biol. 2021;9:1–14. doi:10.3389/fcell.2021.685379
  • Chen X, Wang L, Hong L, et al. Identification of aging-related genes associated with clinical and prognostic features of hepatocellular carcinoma. Front Genetics. 2021;12:1–16. doi:10.3389/fgene.2021.661988
  • Zhang X, Zhang H, Li J, et al. 6-lncRNA assessment model for MONITORING AND Prognosis of HER2-positive breast cancer: based on transcriptome data. Pathol Oncol Res. 2021;27:609083. doi:10.3389/pore.2021.609083
  • Ping L, Zhang K, Ou X, Qiu X, Xiao X. A novel pyroptosis-associated long non-coding RNA signature predicts prognosis and tumor immune microenvironment of patients with breast cancer. Front Cell Develop Biol. 2021;9:727183. doi:10.3389/fcell.2021.727183
  • Luo D, Yao W, Wang Q, et al. The nomogram based on the 6-lncRNA model can promote the prognosis prediction of patients with breast invasive carcinoma. Sci Rep. 2021;11(1):1–17. doi:10.1038/s41598-021-00364-w
  • Zhang M, Ma J, Guo Q, Ding S, Wang Y, Pu H. CD8+ T cell-associated gene signature correlates with prognosis risk and immunotherapy response in patients with lung adenocarcinoma. Front Immunol. 2022;13:1–19. doi:10.3389/fimmu.2022.806877
  • Jiang P, Gu S, Pan D, et al. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nature Med. 2018;24(10):1550–1558. doi:10.1038/s41591-018-0136-1
  • Tabl AA, Alkhateeb A, ElMaraghy W, Rueda L, Ngom A. A machine learning approach for identifying gene biomarkers guiding the treatment of breast cancer. Front Genet. 2019;10:256. doi:10.3389/fgene.2019.00256
  • Haybittle JL, Blamey RW, Elston CW, et al. A prognostic index in primary breast cancer. Br J Cancer. 1982;45(3):361–366. doi:10.1038/bjc.1982.62
  • Zhou L, Rueda M, Alkhateeb A. Classification of breast cancer Nottingham prognostic index using high-dimensional embedding and residual neural network. Cancers. 2022;14(4):934. doi:10.3390/cancers14040934
  • Yan S, Wang W, Zhu B, Pan X, Wu X, Tao W. Construction of nomograms for predicting pathological complete response and tumor shrinkage size in breast cancer. Cancer Manag Res. 2020;12:8313–8323. doi:10.2147/CMAR.S270687
  • Jiawei W, Xiajun B, Tian S, Xuzheng G, Zhenwang Z. Comprehensive analysis of PLKs expression and prognosis in breast cancer. Cancer Genet. 2022;268–269:83–92. doi:10.1016/j.cancergen.2022.09.007
  • Peng Y, Mei W, Ma K, Zeng C. Circulating tumor DNA and Minimal Residual Disease (MRD) in solid tumors: current horizons and future perspectives. Front Oncol. 2021;11:763790. doi:10.3389/fonc.2021.763790
  • Carapeto PV, Aguayo-Mazzucato C. Effects of exercise on cellular and tissue aging. Aging. 2021;13(10):14522–14543. doi:10.18632/aging.203051
  • Zhu J, Wang F, Shi L, et al. Accelerated aging in breast cancer survivors and its association with mortality and cancer recurrence. Breast Cancer Res Treat. 2020;180(2):449–459. doi:10.1007/s10549-020-05541-5
  • Molinaro AM, Hervey-Jumper S, Morshed RA, et al. Association of maximal extent of resection of contrast-enhanced and non-contrast-enhanced tumor with survival within molecular subgroups of patients with newly diagnosed glioblastoma. JAMA Oncol. 2020;6(4):495–503. doi:10.1001/jamaoncol.2019.6143
  • Gnanavel M, Murugesan A, Mani SK, Kandhavelu M, Yli-Harja O. Identifying the miRNA signature association with aging-related senescence in glioblastoma. Int J Mol Sci. 2021;22(2):1–14. doi:10.3390/ijms22020517
  • Luo H, Tao C, Long X, Huang K, Zhu X. A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma. Aging. 2021;13(12):16198–16218. doi:10.18632/aging.203146
  • Yue T, Chen S, Zhu J, et al. The aging-related risk signature in colorectal cancer. Aging. 2021;13(5):7330–7349. doi:10.18632/aging.202589
  • Xu Q, Chen S, Hu Y, Huang W. Landscape of immune microenvironment under immune cell infiltration pattern in breast cancer. Front Immunol. 2021;12:711433. doi:10.3389/fimmu.2021.711433
  • Yang J, Jiang Q, Liu L, et al. Identification of prognostic aging-related genes associated with immunosuppression and inflammation in head and neck squamous cell carcinoma. Aging. 2020;12(24):25778–25804. doi:10.18632/aging.104199
  • Zhang Y, Yan Y, Ning N, Shen Z, Ye Y. A signature of 24 aging‑related gene pairs predict overall survival in gastric cancer. Biomed Eng Online. 2021;20(1):1–14. doi:10.1186/s12938-021-00871-x
  • Zhang Q, Xiu B, Zhang L, et al. Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization. J Immunother Cancer. 2022;10(10):e004666. doi:10.1136/jitc-2022-004666
  • Liu J, Lao L, Chen J, et al. The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer. Nat Cancer. 2021;2(4):457–473. doi:10.1038/s43018-021-00196-7
  • Zhao Y, Yu Z, Ma R, et al. lncRNA-Xist/miR-101-3p/KLF6/C/EBPα axis promotes TAM polarization to regulate cancer cell proliferation and migration. Mol Ther Nucleic Acids. 2021;23:536–551. doi:10.1016/j.omtn.2020.12.005
  • Huang Z, Yu P, Tang J. Characterization of triple-negative breast cancer MDA-MB-231 cell spheroid model. Onco Targets Ther. 2020;13:5395–5405. doi:10.2147/OTT.S249756
  • Wei Y, Li Y, Chen Y, et al. ALDH1: a potential therapeutic target for cancer stem cells in solid tumors. Front Oncol. 2022;12:1026278. doi:10.3389/fonc.2022.1026278
  • Wu H, Huang D, Zhou H, et al. Metformin: a promising drug for human cancers. Oncol Lett. 2022;24(1):204. doi:10.3892/ol.2022.13325
  • Li H, Shi W, Shen T, et al. Network pharmacology-based strategy for predicting therapy targets of Ecliptae Herba on breast cancer. Medicine. 2023;102(41):e35384. doi:10.1097/MD.0000000000035384