Asthma pharmacogenetics and the development of genetic profiles for personalized medicine

References

• [No authors listed]Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic SocietyAm J Respir Crit Care Med200016262341235111112161
   PubMedGoogle Scholar
• ChanMTLeungDYSzeflerSJSpahnJDDifficult-to-control asthma: clinical characteristics of steroid-insensitive asthmaJ Allergy Clin Immunol199810155946019600494
   PubMed Web of Science ®Google Scholar
• SalpeterSRBuckleyNSOrmistonTMSalpeterEEMeta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deathsAnn Intern Med20061441290491216754916
   PubMed Web of Science ®Google Scholar
• CastleWFullerRHallJPalmerJSerevent nationwide surveillance study: comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatmentBMJ19933066884103410378098238
   PubMed Web of Science ®Google Scholar
• NelsonHSWeissSTBleeckerERYanceySWDorinskyPMThe Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterolChest20061291152616424409
   PubMed Web of Science ®Google Scholar
• MeyersDABleeckerERHollowayJWHolgateSTAsthma genetics and personalised medicineLancet Respir Med20142540541524794577
   PubMed Web of Science ®Google Scholar
• DrazenJMSilvermanEKLeeTHHeterogeneity of therapeutic responses in asthmaBr Med Bull20005641054107011359637
   PubMed Web of Science ®Google Scholar
• KalowWTangBKEndrenyiLHypothesis: comparisons of inter-and intra-individual variations can substitute for twin studies in drug researchPharmacogenetics1998842832899731714
   PubMedGoogle Scholar
• IsraelEChinchilliVMFordJGUse of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trialLancet200436494441505151215500895
   PubMed Web of Science ®Google Scholar
• LiXHawkinsGAAmplefordEJGenome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patientsJ Allergy Clin Immunol20131322313320. e31523541324
   PubMed Web of Science ®Google Scholar
• LiXHowardTDMooreWCImportance of hedgehog interacting protein and other lung function genes in asthmaJ Allergy Clin Immunol201112761457146521397937
   PubMed Web of Science ®Google Scholar
• RosellRBivonaTGKarachaliouNGenetics and biomarkers in personalisation of lung cancer treatmentLancet2013382989372073123972815
   PubMed Web of Science ®Google Scholar
• RamseyBWDaviesJMcElvaneyNGA CFTR potentiator in patients with cystic fibrosis and the G551D mutationN Engl J Med2011365181663167222047557
   PubMed Web of Science ®Google Scholar
• PetersSPAnthonisenNCastroMRandomized comparison of strategies for reducing treatment in mild persistent asthmaN Engl J Med2007356202027203917507702
   PubMed Web of Science ®Google Scholar
• SorknessCALemanskeRFJrMaugerDTLong-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller TrialJ Allergy Clin Immunol20071191647217140647
   PubMed Web of Science ®Google Scholar
• SzeflerSJPhillipsBRMartinezFDCharacterization of within-subject responses to fluticasone and montelukast in childhood asthmaJ Allergy Clin Immunol2005115223324215696076
   PubMed Web of Science ®Google Scholar
• TantisiraKGLakeSSilvermanESCorticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroidsHum Mol Genet200413131353135915128701
   PubMed Web of Science ®Google Scholar
• HawkinsGALazarusRSmithRSThe glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroidsJ Allergy Clin Immunol2009123613761383. e137719254810
   PubMed Web of Science ®Google Scholar
• TantisiraKGSmallKMLitonjuaAAWeissSTLiggettSBMolecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathwaysHum Mol Genet200514121671167715879435
   PubMed Web of Science ®Google Scholar
• KimSHYeYMLeeHYSinHJParkHSCombined pharmacogenetic effect of ADCY9 and ADRB2 gene polymorphisms on the bronchodilator response to inhaled combination therapyJ Clin Pharm Ther201136339940521545619
   PubMed Web of Science ®Google Scholar
• TantisiraKGHwangESRabyBATBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroidsProc Natl Acad Sci U S A200410152180991810415604153
   PubMed Web of Science ®Google Scholar
• YeYMLeeHYKimSHPharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatmentJ Clin Pharm Ther200934669370120175803
   PubMed Web of Science ®Google Scholar
• StockmannCFasslBGaedigkRFluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma controlJ Pediatr201316261222. e11227. e223290512
   PubMed Web of Science ®Google Scholar
• TantisiraKGLasky-SuJHaradaMGenomewide association between GLCCI1 and response to glucocorticoid therapy in asthmaN Engl J Med2011365131173118321991891
   PubMed Web of Science ®Google Scholar
• HoskingLBleeckerEGhoshSGLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthmaJ Allergy Clin Immunol2014133258758924131825
   PubMed Web of Science ®Google Scholar
• TantisiraKGDamaskASzeflerSJGenome-wide association identifies the T gene as a novel asthma pharmacogenetic locusAm J Respir Crit Care Med2012185121286129122538805
   PubMed Web of Science ®Google Scholar
• DrazenJMYandavaCNDubeLPharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatmentNat Genet199922216817010369259
   PubMed Web of Science ®Google Scholar
• TelleriaJJBlanco-QuirosAVarillasDALOX5 promoter genotype and response to montelukast in moderate persistent asthmaRespir Med2008102685786118339529
   PubMed Web of Science ®Google Scholar
• KlotsmanMYorkTPPillaiSGPharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukastPharmacogenet Genomics200717318919617460547
   PubMed Web of Science ®Google Scholar
• LimaJJZhangSGrantAInfluence of leukotriene pathway polymorphisms on response to montelukast in asthmaAm J Respir Crit Care Med2006173437938516293801
   PubMed Web of Science ®Google Scholar
• TantisiraKGLimaJSylviaJKlandermanBWeissST5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist lociPharmacogenet Genomics200919324424719214143
   PubMed Web of Science ®Google Scholar
• MougeyELangJEAllayeeHALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthmaClin Exp Allergy201343551252023600541
   PubMed Web of Science ®Google Scholar
• MougeyEBFengHCastroMIrvinCGLimaJJAbsorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor responsePharmacogenet Genomics200919212913819151602
   PubMed Web of Science ®Google Scholar
• KimKALeeHMJooHJParkIBParkJYEffects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humansJ Clin Pharmacol201353111186119323970434
   PubMed Web of Science ®Google Scholar
• TapaninenTKaronenTBackmanJTNeuvonenPJNiemiMSLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskirenPharmacogenet Genomics2013231192423151832
   PubMed Web of Science ®Google Scholar
• GraingerJWoodmanKPearceNPrescribed fenoterol and death from asthma in New Zealand, 1981–7: a further case-control studyThorax19914621051112014490
   PubMed Web of Science ®Google Scholar
• CraneJPearceNBurgessCJacksonRBeasleyREnd of New Zealand asthma epidemicLancet199534589559849857715311
   PubMed Web of Science ®Google Scholar
• PearceNGraingerJAtkinsonMCase-control study of prescribed fenoterol and death from asthma in New Zealand, 1977–81Thorax19904531701752330548
   PubMed Web of Science ®Google Scholar
• PearceNBurgessCCraneJBeasleyRFenoterol, asthma deaths, and asthma severityChest19971124114811509377940
   PubMed Web of Science ®Google Scholar
• StolleyPDAsthma mortality. Why the United States was spared an epidemic of deaths due to asthmaAm Rev Respir Dis197210568838905032708
   PubMed Web of Science ®Google Scholar
• US Food and Drug AdministrationFDA Drug Safety Communication: FDA requires post-market safety trials for long-acting beta-agonists (LABAs)2011 Available from: http://www.fda.gov/Drugs/DrugSafety/ucm251512.htmAccessed July 10, 2012
   Google Scholar
• PetersSPPrennerBMMezzanotteWSMartinPO’BrienCDLong-term safety and asthma control with budesonide/formoterol versus budesonide pressurized metered-dose inhaler in asthma patientsAllergy Asthma Proc200829549951618694544
   PubMed Web of Science ®Google Scholar
• SearsMROttossonARadnerFSuissaSLong-acting beta-agonists: a review of formoterol safety data from asthma clinical trialsEur Respir J2009331213218768573
   PubMed Web of Science ®Google Scholar
• ChowdhuryBASeymourSMLevensonMSAssessing the safety of adding LABAs to inhaled corticosteroids for treating asthmaN Engl J Med2011364262473247521714647
   PubMed Web of Science ®Google Scholar
• HawkinsGATantisiraKMeyersDASequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control studyAm J Respir Crit Care Med2006174101101110916931635
   PubMed Web of Science ®Google Scholar
• OrtegaVEHawkinsGAMooreWCEffect of rare genetic variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma populationLancet Respir Med20142320421324621682
   PubMed Web of Science ®Google Scholar
• DrysdaleCMMcGrawDWStackCBComplex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsivenessProc Natl Acad Sci U S A20009719104831048810984540
   PubMed Web of Science ®Google Scholar
• ChoudhrySUngNAvilaPCPharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthmaAm J Respir Crit Care Med2005171656357015557128
   PubMed Web of Science ®Google Scholar
• LimaJJThomasonDBMohamedMHEberleLVSelfTHJohnsonJAImpact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamicsClin Pharmacol Ther199965551952510340917
   PubMed Web of Science ®Google Scholar
• TaylorDRDrazenJMHerbisonGPYandavaCNHancoxRJTownGIAsthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphismThorax200055976276710950895
   PubMed Web of Science ®Google Scholar
• IsraelEDrazenJMLiggettSBThe effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthmaAm J Respir Crit Care Med20001621758010903223
   PubMed Web of Science ®Google Scholar
• BousquetJBousquetPJGodardPDauresJPThe public health implications of asthmaBull World Health Organ200583754855416175830
   PubMed Web of Science ®Google Scholar
• WechslerMEKunselmanSJChinchilliVMEffect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trialLancet200937497031754176419932356
   PubMed Web of Science ®Google Scholar
• BleeckerERNelsonHSKraftMBeta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionateAm J Respir Crit Care Med2010181767668719910613
   PubMed Web of Science ®Google Scholar
• GreenSAColeGJacintoMInnisMLiggettSBA polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptorJ Biol Chem19932683123116231217901205
   PubMed Web of Science ®Google Scholar
• GreenSARathzDASchusterAJLiggettSBThe Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s)Eur J Pharmacol2001421314114711516429
   PubMed Web of Science ®Google Scholar
• ThomsenMNordestgaardBGSethiAATybjaerg-HansenADahlMbeta2-adrenergic receptor polymorphisms, asthma and COPD: two large population-based studiesEur Respir J201239355856622075484
   PubMed Web of Science ®Google Scholar
• PoonAHTantisiraKGLitonjuaAAAssociation of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthmaPharmacogenet Genomics200818537338218408560
   PubMed Web of Science ®Google Scholar
• DrakeKATorgersonDGGignouxCRA genome-wide association study of bronchodilator response in Latinos implicates rare variantsJ Allergy Clin Immunol2014133237037823992748
   PubMed Web of Science ®Google Scholar
• LitonjuaAALasky-SuJSchneiterKARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohortsAm J Respir Crit Care Med2008178768869418617639
   PubMed Web of Science ®Google Scholar
• VonkJMPostmaDSMaarsinghHBruinenbergMKoppelmanGHMeursHArginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid responsePharmacogenet Genomics201020317918620124949
   PubMed Web of Science ®Google Scholar
• DuanQLGaumeBRHawkinsGARegulatory haplotypes in ARG1 are associated with altered bronchodilator responseAm J Respir Crit Care Med2011183444945420851928
   PubMed Web of Science ®Google Scholar
• IordanidouMParaskakisETavridouAPaschouPChatzimichaelAManolopoulosVGG894T polymorphism of eNOS gene is a predictor of response to combination of inhaled corticosteroids with long-lasting beta2-agonists in asthmatic childrenPharmacogenomics201213121363137222966886
   PubMed Web of Science ®Google Scholar
• HimesBEJiangXHuRGenome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response genePLoS Genet201287e100282422792082
   PubMed Web of Science ®Google Scholar
• DuanQLLasky-SuJHimesBEA genome-wide association study of bronchodilator response in asthmaticsPharmacogenomics J2014141414723508266
   PubMed Web of Science ®Google Scholar
• WenzelSFordLPearlmanDDupilumab in persistent asthma with elevated eosinophil levelsN Engl J Med2013368262455246623688323
   PubMed Web of Science ®Google Scholar
• SlagerREOtulanaBAHawkinsGAIL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor alpha antagonistJ Allergy Clin Immunol20121302516522. e51422541248
   PubMed Web of Science ®Google Scholar
• OrtegaVEMeyersDAPharmacogenetics: Implications of race and ethnicity on defining genetic profiles for personalized medicineJ Allergy Clin Immunol20141331162624369795
   PubMed Web of Science ®Google Scholar
• 1000 Genomes Project ConsortiumAbecasisGRAutonABrooksLDAn integrated map of genetic variation from 1,092 human genomesNature20124917422566523128226
   PubMed Web of Science ®Google Scholar
• OrtegaVEWechslerMEAsthma pharmacogenetics: responding to the call for a personalized approachCurr Opin Allergy Clin Immunol201313439940923799335
   PubMed Web of Science ®Google Scholar
• ChoudhrySQueLGYangZGSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterolPharmacogenet Genomics201020635135820335826
   PubMed Web of Science ®Google Scholar
• HimesBEWuACDuanQLPredicting response to short-acting bronchodilator medication using Bayesian networksPharmacogenomics20091091393141219761364
   PubMed Web of Science ®Google Scholar
• DuanQLDuRLasky-SuJA polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmaticsPharmacogenomics J201313213013622212731
   PubMed Web of Science ®Google Scholar
• BeginPNadeauKCEpigenetic regulation of asthma and allergic diseaseAllergy Asthma Clin Immunol20141012724932182
   PubMed Web of Science ®Google Scholar
• MichelSBusatoFGenuneitJFarm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergyAllergy201368335536423346934
   PubMed Web of Science ®Google Scholar
• Soto-RamirezNArshadSHHollowayJWThe interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 yearsClin Epigenetics201351123286427
   PubMed Web of Science ®Google Scholar
• GaffinJMRabyBAPettyCRbeta-2 adrenergic receptor gene methylation is associated with decreased asthma severity in inner-city schoolchildren: asthma and rhinitisClin Exp Allergy201444568168924131275
   PubMed Web of Science ®Google Scholar
• FuALeadererBPGentJFLeadererDZhuYAn environmental epigenetic study of ADRB2 5′-UTR methylation and childhood asthma severityClin Exp Allergy201242111575158122862293
   PubMed Web of Science ®Google Scholar
• ZhengSLSunJWiklundFCumulative association of five genetic variants with prostate cancerN Engl J Med2008358991091918199855
   PubMed Web of Science ®Google Scholar
• ThanassoulisGPelosoGMPencinaMJA genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart StudyCirc Cardiovasc Genet20125111312122235037
   PubMedGoogle Scholar
• AronsonSJClarkEHVarugheeseMBaxterSBabbLJRehmHLCommunicating new knowledge on previously reported genetic variantsGenet Med452012 [Epub ahead of print.]
   Web of Science ®Google Scholar
• YorkTPVargas-IrwinCAndersonWHvan den OordEJAsthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneityPharmacogenomics200910575376719450127
   PubMed Web of Science ®Google Scholar
• OrtegaVEHawkinsGAPetersSPBleeckerERPharmacogenetics of the beta 2-adrenergic receptor geneImmunol Allergy Clin North Am2007274665684vii17996583
   PubMed Web of Science ®Google Scholar
• TsujiSGenetics of neurodegenerative diseases: insights from high-throughput resequencingHum Mol Genet201019R1R65R7020413655
   PubMed Web of Science ®Google Scholar
• MartinezFDGravesPEBaldiniMSolomonSEricksonRAssociation between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezingJ Clin Invest199710012318431889399966
   PubMed Web of Science ®Google Scholar
• WechslerMELehmanELazarusSCBeta-adrenergic receptor polymorphisms and response to salmeterolAm J Respir Crit Care Med2006173551952616322642
   PubMed Web of Science ®Google Scholar
• BleeckerERPostmaDSLawranceRMMeyersDAAmbroseHJGoldmanMEffect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studiesLancet200737096052118212518156033
   PubMed Web of Science ®Google Scholar
• BleeckerERYanceySWBaitingerLASalmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthmaJ Allergy Clin Immunol2006118480981617030231
   PubMed Web of Science ®Google Scholar
• LeeDKCurrieGPHallIPLimaJJLipworthBJThe arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterolBr J Clin Pharmacol2004571687514678342
   PubMed Web of Science ®Google Scholar
• LipworthBJBasuKDonaldHPTailored second-line therapy in asthmatic children with the Arg16 genotypeClin Sci (Lond)2013124852152823126384
   PubMed Web of Science ®Google Scholar