3,908
Views
358
CrossRef citations to date
0
Altmetric
Review

Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors

&
Pages 1299-1307 | Published online: 22 Jul 2016

References

  • International Diabetes Federation [webpage on the Internet]IDF Diabetes AtlasSixth Edition2014 Available from: www.idf.org/sites/default/files/EN_6E_Atlas_Full_0.pdfAccessed April 7, 2015
  • Centers for Disease Control and PreventionNational Diabetes Statistics Report: Estimates of Diabetes and its Burden in the United States2014 Available from: https://www.cdc.gov/diabetes/.../statsreport14/national-diabetes-report-web.pdfAccessed April 7, 2015
  • ChengYJImperatoreGGeissLSSecular changes in the age-specific prevalence of diabetes among US adults: 1988–2010Diabetes Care20133692690269623637354
  • SelvinEParrinelloCMSacksDBCoreshJTrends in prevalence and control of diabetes in the United States, 1988–1994 and 1999–2010Ann Intern Med2014160851752524733192
  • DallTMYangWHalderPThe economic burden of elevated blood glucose levels in 2012: diagnosed and undiagnosed diabetes, gestational diabetes mellitus, and prediabetesDiabetes Care201437123172317925414388
  • NassehKFrazeeSGVisariaJVlahiotisATianYCost of medication nonadherence associated with diabetes, hypertension, and dyslipidemiaAm J Pharm Benefits201242e41e47
  • CurrieCJPeyrotMMorganCLThe impact of treatment noncompliance on mortality in people with type 2 diabetesDiabetes Care20123561279128422511257
  • HoPMRumsfeldJSMasoudiFAEffect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitusArch Intern Med2006166171836184117000939
  • LindMGarcia-RodriguezLABoothGLMortality trends in patients with and without diabetes in Ontario, Canada and the UK from 1996 to 2009: a population-based studyDiabetologia201356122601260824114114
  • SeuringTArchangelidiOSuhrckeMThe economic costs of type 2 diabetes: a global systematic reviewPharmacoeconomics201533881183125787932
  • HandelsmanYBloomgardenZTGrunbergerGAmerican association of clinical endocrinologists and American college of endocrinology – clinical practice guidelines for developing a diabetes mellitus comprehensive care plan – 2015Endocr Pract201521suppl 118725869408
  • InzucchiSEBergenstalRMBuseJBManagement of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the study of diabetesDiabetes Care201538114014925538310
  • AliMKMcKeever BullardKImperatoreGCenters for Disease Control and Prevention (CDC)Characteristics associated with poor glycemic control among adults with self-reported diagnosed diabetes – National Health and Nutrition Examination Survey, United States, 2007–2010MMWR Morb Mortal Wkly Rep201261suppl3237
  • FordESTrends in the control of risk factors for cardiovascular disease among adults with diagnosed diabetes: findings from the National Health and Nutrition Examination Survey 1999–2008J Diabetes20113433734721767347
  • WongNDPataoCWongKMalikSFranklinSSIloejeUTrends in control of cardiovascular risk factors among US adults with type 2 diabetes from 1999 to 2010: comparison by prevalent cardiovascular disease statusDiab Vasc Dis Res201310650551323975724
  • EgedeLEGebregziabherMEcholsCLynchCPLongitudinal effects of medication nonadherence on glycemic controlAnn Pharmacother201448556257024586059
  • CramerJABenedictAMuszbekNKeskinaslanAKhanZMThe significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a reviewInt J Clin Pract2008621768717983433
  • FarrAMSheehanJJCurkendallSMSmithDMJohnstonSSKalsekarIRetrospective analysis of long-term adherence to and persistence with DPP-4 inhibitors in US adults with type 2 diabetes mellitusAdv Ther201431121287130525504156
  • KrassISchiebackPDhippayomTAdherence to diabetes medication: a systematic reviewDiabet Med201532672573725440507
  • CliffordSPerez-NievesMSkalickyAMReaneyMCoyneKSA systematic literature review of methodologies used to assess medication adherence in patients with diabetesCurr Med Res Opin20143061071108524432796
  • IglayKCartierSERosenVMMeta-analysis of studies examining medication adherence, persistence, and discontinuation of oral antihyperglycemic agents in type 2 diabetesCurr Med Res Opin20153171283129626023805
  • BuysmanEKLiuFHammerMLangerJImpact of medication adherence and persistence on clinical and economic outcomes in patients with type 2 diabetes treated with liraglutide: a retrospective cohort studyAdv Ther201532434135525832470
  • LokhandwalaTSmithNSternhufvudCSörstadiusELeeWCMukherjeeJA retrospective study of persistence, adherence, and health economic outcomes of fixed-dose combination versus loose-dose combination of oral anti-diabetes drugsJ Med Econ201619320321226473990
  • CurkendallSMThomasNBellKFJuneauPLWeissAJPredictors of medication adherence in patients with type 2 diabetes mellitusCurr Med Res Opin201329101275128623815104
  • FischerMAStedmanMRLiiJPrimary medication non-adherence: analysis of 195,930 electronic prescriptionsJ Gen Intern Med201025428429020131023
  • KarterAJSubramanianUSahaCBarriers to insulin initiation: the translating research into action for diabetes insulin starts projectDiabetes Care201033473373520086256
  • EgedeLEGebregziabherMDismukeCEMedication nonadherence in diabetes: longitudinal effects on costs and potential cost savings from improvementDiabetes Care201235122533253922912429
  • DiBonaventuraMWintfeldNHuangJGorenAThe association between nonadherence and glycated hemoglobin among type 2 diabetes patients using basal insulin analogsPatient Prefer Adherence2014887388224971002
  • RoebuckMCLibermanJNGemmill-ToyamaMBrennanTAMedication adherence leads to lower health care use and costs despite increased drug spendingHealth Aff (Millwood)2011301919921209444
  • BreitscheidelLStamenitisSDippelFWSchöffskiOEconomic impact of compliance to treatment with antidiabetes medication in type 2 diabetes mellitus: a review paperJ Med Econ201013181519947905
  • JhaAKAubertREYaoJTeagardenJREpsteinRSGreater adherence to diabetes drugs is linked to less hospital use and could save nearly $5 billion annuallyHealth Aff (Millwood)20123181836184622869663
  • KirkmanMSRowan-MartinMTLevinRDeterminants of adherence to diabetes medications: findings from a large pharmacy claims databaseDiabetes Care201538460460925573883
  • PolonskyWHSkinnerTCPerceived treatment efficacy: an overlooked opportunity in diabetes careClin Diabetes20102828992
  • GadkariASMcHorneyCAMedication nonfulfillment rates and reasons: narrative systematic reviewCurr Med Res Opin201026368370520078320
  • McAdam-MarxCBellowsBKUnniSDeterminants of glycaemic control in a practice setting: the role of weight loss and treatment adherence (the DELTA study)Int J Clin Pract201468111309131725113816
  • WalzLPetterssonBRosenqvistUDeleskogAJournathGWändellPImpact of symptomatic hypoglycemia on medication adherence, patient satisfaction with treatment, and glycemic control in patients with type 2 diabetesPatient Prefer Adherence2014859360124812495
  • LopezJMAnnunziataKBaileyRARupnowMFMoriskyDEImpact of hypoglycemia on patients with type 2 diabetes mellitus and their quality of life, work productivity, and medication adherencePatient Prefer Adherence2014868369224855344
  • BronMMarynchenkoMYangHYuAPWuEQHypoglycemia, treatment discontinuation, and costs in patients with type 2 diabetes mellitus on oral antidiabetic drugsPostgrad Med2012124112413222314122
  • HajósTRPolonskyWHPouwerFGonder-FrederickLSnoekFJToward defining a cutoff score for elevated fear of hypoglycemia on the hypoglycemia fear survey worry subscale in patients with type 2 diabetesDiabetes Care201437110210823990513
  • Gonder-FrederickLAVajdaKASchmidtKMExamining the behaviour subscale of the hypoglycaemia fear survey: an international studyDiabet Med201330560360923324032
  • Garcia-PérezLEAlvarezMDillaTGil-GuillénVOrozco-BeltránDAdherence to therapies in patients with type 2 diabetesDiabetes Ther20134217519423990497
  • ClaxtonAJCramerJPierceCA systematic review of the associations between dose regimens and medication complianceClin Ther20012381296131011558866
  • ColemanCILimoneBSobierajDMDosing frequency and medication adherence in chronic diseaseJ Manag Care Pharm201218752753922971206
  • SainiSDSchoenfeldPKaulbackKDubinskyMCEffect of medication dosing frequency on adherence in chronic diseasesAm J Manag Care2009156e22e3319514806
  • de VriesSTKeersJCVisserRMedication beliefs, treatment complexity, and nonadherence to different drug classes in patients with type 2 diabetesJ Psychosom Res201476213413824439689
  • DavisSNWeiWGargSClinical impact of initiating insulin glargine therapy with disposable pen versus vial in patients with type 2 diabetes mellitus in a managed care settingEndocr Pract201117684585221550952
  • BuysmanEConnerCAagrenMBouchardJLiuFAdherence and persistence to a regimen of basal insulin in a pre-filled pen compared to vial/syringe in insulin-naïve patients with type 2 diabetesCurr Med Res Opin20112791709171721740289
  • GrabnerMChuJRaparlaSQuimboRZhouSConoshentiJClinical and economic outcomes among patients with diabetes mellitus initiating insulin glargine pen versus vialPostgrad Med2013125320421323748521
  • XieLZhouSPinskyBWBuysmanEKBaserOImpact of initiating insulin glargine disposable pen versus vial/syringe on real-world glycemic outcomes and persistence among patients with type 2 diabetes mellitus in a large managed care plan: a claims database analysisDiabetes Technol Ther201416956757524735083
  • EaddyMTCookCLO’DayKBurchSPCantrellCRHow patient cost-sharing trends affect adherence and outcomes: a literature reviewP T2012371455522346336
  • PietteJDHeislerMWagnerTHProblems paying out-of-pocket medication costs among older adults with diabetesDiabetes Care200427238439114747218
  • YalaSMDuruOKEttnerSLTurkNMangioneCMBrownAFPatterns of prescription drug expenditures and medication adherence among medicare part D beneficiaries with and without the low-income supplementBMC Health Serv Res20141466525526892
  • AikensJEPietteJDDiabetic patients’ medication underuse, illness outcomes, and beliefs about antihyperglycemic and antihypertensive treatmentsDiabetes Care2009321192418852334
  • FootHLa CazeAGujralGCottrellNThe necessity-concerns framework predicts adherence to medication in multiple illness conditions: a meta-analysisPatient Educ Couns201699570671726613666
  • MannDMPoniemanDLeventhalHHalmEAPredictors of adherence to diabetes mediations: the role of disease and medication beliefsJ Behav Med200932327828419184390
  • GrantBColelloSHCulture change through patient engagementNurs Manage20104110444620864874
  • PolonskyWHFisherLGuzmanSVilla-CaballeroLEdelmanSVPsychological insulin resistance in patients with type 2 diabetes: the scope of the problemDiabetes Care200528102543254516186296
  • PolonskyWHFisherLHesslerDBruhnDBestJHPatient perspectives on once-weekly medications for diabetesDiabetes Obes Metab201113214414921199266
  • RatanawongsaNKarterAJParkerMMCommunication and medication adherence: the diabetes study of Northern CaliforniaJAMA Intern Med20131733201208
  • BauerAMParkerMMSchillingerDAssociations between antidepressant adherence and shared decision-making, patient-provider trust, and communication among adults with diabetes: diabetes study of Northern California (DISTANCE)J Gen Intern Med20142981139114724706097
  • KerseNBuetowSMainousAG3rdYoungGCosterGArrollBPhysician-patient relationship and medication compliance: a primary care investigationAnn Fam Med20042545546115506581
  • PolonskyWHFisherLHesslerDEdelmanSVWhat is so tough about self-monitoring of blood glucose? Perceived obstacles among patients with type 2 diabetesDiabet Med2014311404623819529
  • PietteJDHeislerMKreinSKerrEAThe role of patient-physician trust in moderating medication nonadherence due to cost pressuresArch Intern Med2005165151749175516087823
  • DemonceauJRupparTKristantoPABC project teamIdentification and assessment of adherence-enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: a systematic literature review and meta-analysisDrugs201373654556223588595
  • NieuwlaatRWilczynskiNNavarroTInterventions for enhancing medication adherenceCochrane Database Syst Rev201411CD00001125412402
  • SapkotaSBrienJAGreenfieldJRAslaniPA systematic review of interventions addressing adherence to anti-diabetic medications in patients with type 2 diabetes – components of interventionsPLoS One2015106e012858126053004
  • Vignon ZomahounHTde BruinMGuillaumieLEffectiveness and content analysis of interventions to enhance oral antidiabetic drug adherence in adults with type 2 diabetes: systematic review and meta-analysisValue Health201518453054026091607
  • WilliamsJLWalkerRJSmallsBLCampbellJAEgedeLEEffective interventions to improve medication adherence in type 2 diabetes: a systematic reviewDiabetes Manag (Lond)201441294825214893
  • ZulligLLGelladWFMoaddebJImproving diabetes medication adherence: successful, scalable interventionsPatient Prefer Adherence2015913914925670885
  • AntoineSLPieperDMathesTEikermannMImproving the adherence of type 2 diabetes mellitus patients with pharmacy care: a systematic review of randomized controlled trialsBMC Endocr Disord2014145325001374
  • SapkotaSBrienJAGreenfieldJAslaniPA systematic review of interventions addressing adherence to anti-diabetic medications in patients with type 2 diabetes-impact on adherencePLoS One2015102e011829625710465
  • BaronMABuseJAzeemRKjemsLRosenstockJA randomised, double-blind, placebo-controlled, 39 week trial of ITCA 650 as add-on therapy in type 2 diabetesAbstract 112 presented at the 51st Annual Meeting of the European Association for the Study of DiabetesSeptember 16, 2015Stockholm, Sweden
  • HenryRRRosenstockJDenhamDSPrabhakarPKjemsLBaronMAEfficacy and tolerability of 39 weeks of ITCA 650 (continuous subcutaneous exenatide) in poorly controlled T2DM with high baseline A1c (>10%)Abstract 1107-P presented at the 75th American Diabetes Association Scientific SessionsJune 6, 2015San Diego, CA