Targeted drugs for pulmonary arterial hypertension: a network meta-analysis of 32 randomized clinical trials

References

• GalieNHoeperMMHumbertMGuidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)Eur Heart J2009302493253719713419
   PubMed Web of Science ®Google Scholar
• WilkinsMRPaulGAStrangeJWSildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) studyAm J Respir Crit Care Med20051711292129715750042
   PubMed Web of Science ®Google Scholar
• BenzaRLMillerDPBarstRJBadeschDBFrostAEMcGoonMDAn evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL RegistryChest201214244845622281797
   PubMed Web of Science ®Google Scholar
• NazzarenoGalièMHVachieryJLGibbsS2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS)Eur Respir J2015461855185626621899
   PubMed Web of Science ®Google Scholar
• McLaughlinVVShahSJSouzaRHumbertMManagement of pulmonary arterial hypertensionJ Am Coll Cardiol2015651976199725953750
   PubMed Web of Science ®Google Scholar
• OlschewskiHSimonneauGGalieNInhaled iloprost for severe pulmonary hypertensionN Engl J Med200234732232912151469
   PubMed Web of Science ®Google Scholar
• McLaughlinVVGaineSPBarstRJEfficacy and safety of treprostinil: an epoprostenol analog for primary pulmonary hypertensionJ Cardiovasc Pharmacol20034129329912548091
   PubMed Web of Science ®Google Scholar
• RubinLJBadeschDBBarstRJBosentan therapy for pulmonary arterial hypertensionN Engl J Med200234689690311907289
   PubMed Web of Science ®Google Scholar
• GalieNGhofraniHATorbickiASildenafil citrate therapy for pulmonary arterial hypertensionN Engl J Med20053532148215716291984
   PubMed Web of Science ®Google Scholar
• GhofraniHAGalieNGrimmingerFRiociguat for the treatment of pulmonary arterial hypertensionN Engl J Med201336933034023883378
   PubMed Web of Science ®Google Scholar
• PulidoTAdzerikhoIChannickRNMacitentan and morbidity and mortality in pulmonary arterial hypertensionN Engl J Med201336980981823984728
   PubMed Web of Science ®Google Scholar
• CoeytauxRRSchmitKMKraftBDComparative effectiveness and safety of drug therapy for pulmonary arterial hypertension: a systematic review and meta-analysisChest20141451055106324371842
   PubMed Web of Science ®Google Scholar
• ZhengYGMaHHuECLiuGChenGXiongCMOral targeted therapies in the treatment of pulmonary arterial hypertension: a meta-analysis of clinical trialsPulm Pharmacol Ther20142924124925173912
   PubMed Web of Science ®Google Scholar
• ZhangHDZhangRJiangXSunKWuDCJingZCEffects of oral treatments on clinical outcomes in pulmonary arterial hypertension: a systematic review and meta-analysisAm Heart J201517096103103.e1e1426093869
   PubMed Web of Science ®Google Scholar
• JadadARMooreRACarrollDAssessing the quality of reports of randomized clinical trials: is blinding necessary?Control Clin Trials1996171128721797
   PubMedGoogle Scholar
• ChaimaniAHigginsJPMavridisDSpyridonosPSalantiGGraphical tools for network meta-analysis in STATAPLoS One20138e7665424098547
   PubMed Web of Science ®Google Scholar
• WhiteIRBarrettJKJacksonDHigginsJPConsistency and inconsistency in network meta-analysis: model estimation using multivariate meta-regressionRes Synth Methods2012311112526062085
   PubMed Web of Science ®Google Scholar
• DiasSWeltonNJCaldwellDMAdesAEChecking consistency in mixed treatment comparison meta-analysisStat Med20102993294420213715
   PubMed Web of Science ®Google Scholar
• HigginsJPJacksonDBarrettJKLuGAdesAEWhiteIRConsistency and inconsistency in network meta-analysis: concepts and models for multi-arm studiesRes Synth Methods201239811026062084
   PubMed Web of Science ®Google Scholar
• RubinLJMendozaJHoodMTreatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trialAnn Intern Med19901124854912107780
   PubMed Web of Science ®Google Scholar
• BarstRJRubinLJLongWAA comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertensionN Engl J Med19963342963018532025
   PubMed Web of Science ®Google Scholar
• BadeschDBTapsonVFMcGoonMDContinuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trialAnn Intern Med200013242543410733441
   PubMed Web of Science ®Google Scholar
• ChannickRNSimonneauGSitbonOEffects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled studyLancet20013581119112311597664
   PubMed Web of Science ®Google Scholar
• GalieNHumbertMVachieryJLEffects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trialJ Am Coll Cardiol2002391496150211985913
   PubMed Web of Science ®Google Scholar
• SimonneauGBarstRJGalieNContinuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trialAm J Respir Crit Care Med200216580080411897647
   PubMed Web of Science ®Google Scholar
• BarstRJMcGoonMMcLaughlinVBeraprost therapy for pulmonary arterial hypertensionJ Am Coll Cardiol2003412119212512821234
   PubMed Web of Science ®Google Scholar
• HumbertMBarstRJRobbinsIMCombination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2Eur Respir J20042435335915358690
   PubMed Web of Science ®Google Scholar
• HoeperMMLeuchteHHalankMCombining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertensionEur Respir J20062869169417012628
   PubMed Web of Science ®Google Scholar
• BarstRJOudizRJBeardsworthATadalafil monotherapy and as add-on to background bosentan in patients with pulmonary arterial hypertensionJ Heart Lung Transplant20113063264321256048
   PubMed Web of Science ®Google Scholar
• GalieNBarberaJAFrostAEInitial use of ambrisentan plus tadalafil in pulmonary arterial hypertensionN Engl J Med201537383484426308684
   PubMed Web of Science ®Google Scholar
• GalieNBeghettiMGatzoulisMABosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled studyCirculation2006114485416801459
   PubMed Web of Science ®Google Scholar
• GalieNMullerKScaliseAVGrunigEPATENT PLUS: a blinded, randomised and extension study of riociguat plus sildenafil in pulmonary arterial hypertensionEur Respir J2015451314132225657022
   PubMed Web of Science ®Google Scholar
• GalieNOlschewskiHOudizRJAmbrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2Circulation20081173010301918506008
   PubMed Web of Science ®Google Scholar
• GalieNRubinLHoeperMTreatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trialLancet20083712093210018572079
   PubMed Web of Science ®Google Scholar
• HiremathJThanikachalamSParikhKExercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: a placebo-controlled trialJ Heart Lung Transplant20102913714920022264
   PubMed Web of Science ®Google Scholar
• JingZCParikhKPulidoTEfficacy and safety of oral treprostinil monotherapy for the treatment of pulmonary arterial hypertension: a randomized, controlled trialCirculation201312762463323307827
   PubMed Web of Science ®Google Scholar
• JingZCYuZXShenJYVardenafil in pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled studyAm J Respir Crit Care Med20111831723172921471085
   PubMed Web of Science ®Google Scholar
• McLaughlinVChannickRNGhofraniHABosentan added to sildenafil therapy in patients with pulmonary arterial hypertensionEur Respir J20154640541326113687
   PubMed Web of Science ®Google Scholar
• McLaughlinVVBenzaRLRubinLJAddition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trialJ Am Coll Cardiol2010551915192220430262
   PubMed Web of Science ®Google Scholar
• McLaughlinVVOudizRJFrostARandomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertensionAm J Respir Crit Care Med20061741257126316946127
   PubMed Web of Science ®Google Scholar
• SimonneauGRubinLJGalieNAddition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trialAnn Intern Med200814952153018936500
   PubMed Web of Science ®Google Scholar
• TapsonVFJingZCXuKFOral treprostinil for the treatment of pulmonary arterial hypertension in patients receiving background endothelin receptor antagonist and phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C2 study): a randomized controlled trialChest201314495295823669822
   PubMed Web of Science ®Google Scholar
• TapsonVFTorresFKermeenFOral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study): a randomized controlled trialChest20121421383139022628490
   PubMed Web of Science ®Google Scholar
• ZhuangYJiangBGaoHZhaoWRandomized study of adding tadalafil to existing ambrisentan in pulmonary arterial hypertensionHypertens Res20143750751224646647
   PubMed Web of Science ®Google Scholar
• SimonneauGGatzoulisMAAdatiaIUpdated clinical classification of pulmonary hypertensionJ Am Coll Cardiol201362D34D4124355639
   PubMed Web of Science ®Google Scholar
• TuderRMArcherSLDorfmullerPRelevant issues in the pathology and pathobiology of pulmonary hypertensionJ Am Coll Cardiol201362D4D1224355640
   PubMed Web of Science ®Google Scholar
• TaichmanDBOrnelasJChungLPharmacologic therapy for pulmonary arterial hypertension in adults: CHEST guideline and expert panel reportChest201414644947524937180
   PubMed Web of Science ®Google Scholar
• LajoieACLauziereGLegaJCCombination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysisLancet Respir Med2016429130526935844
   PubMed Web of Science ®Google Scholar
• GalieNManesANegroLPalazziniMBacchi-ReggianiMLBranziAA meta-analysis of randomized controlled trials in pulmonary arterial hypertensionEur Heart J20093039440319155250
   PubMed Web of Science ®Google Scholar
• ZhuBWangLSunLCaoRCombination therapy improves exercise capacity and reduces risk of clinical worsening in patients with pulmonary arterial hypertension: a meta-analysisJ Cardiovasc Pharmacol20126034234622691882
   PubMed Web of Science ®Google Scholar
• BaiYSunLHuSWeiYCombination therapy in pulmonary arterial hypertension: a meta-analysisCardiology201112015716522212696
   PubMed Web of Science ®Google Scholar
• ParikhKSRajagopalSArgesKUse of outcome measures in pulmonary hypertension clinical trialsAm Heart J2015170419429.e326385024
   PubMed Web of Science ®Google Scholar
• ChenSLZhangFFXuJPulmonary artery denervation to treat pulmonary arterial hypertension: the single-center, prospective, first-in-man PADN-1 study (first-in-man pulmonary artery denervation for treatment of pulmonary artery hypertension)J Am Coll Cardiol2013621092110023850902
   PubMed Web of Science ®Google Scholar
• ChenSLZhangHXieDJHemodynamic, functional, and clinical responses to pulmonary artery denervation in patients with pulmonary arterial hypertension of different causes: phase II results from the Pulmonary Artery Denervation-1 studyCirc Cardiovasc Interv20158e00283726553699
   PubMed Web of Science ®Google Scholar
• SitbonOChannickRChinKMSelexipag for the Treatment of Pulmonary Arterial HypertensionN Engl J Med2015373262522253326699168
   PubMed Web of Science ®Google Scholar