264
Views
4
CrossRef citations to date
0
Altmetric
Original Research

Overcoming barriers to the use of metformin: patient and provider perspectives

, , &
Pages 1433-1441 | Published online: 22 Aug 2019

References

  • Sanchez-Rangel E, Inzucchi SE. Metformin: clinical use in type 2 diabetes. Diabetologia. 2017;60:1586–1593. doi:10.1007/s00125-017-4336-x28770321
  • American Diabetes Association. 9. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S90–S102. doi:10.2337/dc19-S00930559235
  • Flory JH, Hennessy S. Metformin use reduction in mild to moderate renal impairment: possible inappropriate curbing of use based on food and drug administration contraindications. JAMA Intern Med. 2015;175:458–459. doi:10.1001/jamainternmed.2015.032425561419
  • Hampp C, Borders-Hemphill V, Moeny DG, Wysowski DK. Use of antidiabetic drugs in the U.S., 2003–2012. Diabetes Care. 2014;37(5):1367–1374. doi:10.2337/dc13-228924623020
  • Flory J, Gerhard T, Stempniewicz N, Keating S, Rowan CG. Comparative adherence to diabetes drugs: an analysis of electronic health records and claims data. Diabetes Obes Metab. 2017;19:1184–1187. doi:10.1111/dom.2017.19.issue-828266807
  • Hugtenburg JG, Timmers L, Elders PJ, et al. Definitions, variants, and causes of nonadherence with medication: a challenge for tailored interventions. Patient Prefer Adherence. 2013;7:675–682. doi:10.2147/PPA.S2954923874088
  • Metformin hydrochloride [product label]. U.S. Food and Drug Administration website. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf. Accessed 8 7, 2019
  • Crowley MJ, Diamantidis CJ, McDuffie JR, et al. Clinical outcomes of metformin use in populations with chronic kidney disease, congestive heart failure, or chronic liver disease: a systematic review. Ann Intern Med. 2017;166(3):191–200. doi:10.7326/M16-190128055049
  • Florez H, Luo J, Castillo-Florez S, et al. Impact of metformin-induced gastrointestinal symptoms on quality of life and adherence in patients with type 2 diabetes. Postgrad Med. 2010;122:112–120. doi:10.3810/pgm.2010.03.2128
  • Bonnet F, Scheen A. Understanding and overcoming metformin gastrointestinal intolerance. Diabetes Obes Metab. 2016;19(1):473–481. doi:10.1111/dom.12854
  • Bouchoucha M, Uzzan B, Cohen R. Metformin and digestive disorders. Diabetes Metab. 2011;37:90–96. doi:10.1016/j.diabet.2010.11.00221236717
  • Dujic T, Zhou K, Donnelly LA, et al. Association of organic cation transporter 1 with intolerance to metformin in type 2 diabetes: a GoDARTS study. Diabetes. 2015;64:1786–1793. doi:10.2337/db14-156025510240
  • Huang Y, Sun J, Wang X, et al. Helicobacter pylori infection decreases metformin tolerance in patients with type 2 diabetes mellitus. Diabetes Technol Ther. 2015;17:128–133. doi:10.1089/dia.2014.020325391019
  • Okayasu S, Kitaichi K, Hori A, et al. The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes mellitus. Biol Pharm Bull. 2012;35:933–937. doi:10.1248/bpb.35.93322687486
  • Flory JH, Keating SJ, Siscovick D, Mushlin AI. Identifying prevalence and risk factors for metformin non-persistence: a retrospective cohort study using an electronic health record. BMJ Open. 2018;8(7):e021505. doi:10.1136/bmjopen-2018-021505
  • Trinkley KE, Malone DC, Nelson JA, Saseen JJ. Prescribing attitudes, behaviors and opinions regarding metformin for patients with diabetes: a focus group study. Ther Adv Chronic Dis. 2016;7(5):220–228. doi:10.1177/204062231665732827583122
  • Pope C, Ziebland S, Mays N. Qualitative research in health care: analysing qualitative data. BMJ. 2000;320(7227):114–116. doi:10.1136/bmj.320.7227.11410625273
  • Leung L. Validity, reliability, and generalizability in qualitative research. J Family Med Prim Care. 2015;4(3):324–327. doi:10.4103/2249-4863.16130626288766
  • Guénette L, Lauzier S, Guillaumie L, Giguère G, Grégoire JP, Moisan J. Patients’ beliefs about adherence to oral antidiabetic treatment: a qualitative study. Patient Prefer Adherence. 2015;10(9):413–420. doi:10.2147/PPA.S78628
  • Ju A, Hanson CS, Banks E, et al. Patient beliefs and attitudes to taking statins: systematic review of qualitative studies. Br J Gen Pract. 2018;68(671):e408–e419. doi:10.3399/bjgp18X69636529784867
  • Hirst JA, Farmer AJ, Ali R, et al. Quantifying the effect of metformin treatment and dose on glycemic control. Diabetes Care. 2012;35:446–454. doi:10.2337/dc11-146522275444
  • Schwartz S, Fonseca V, Berner B, et al. Efficacy, tolerability, and safety of a novel once-daily extended-release metformin in patients with type 2 diabetes. Diabetes Care. 2006;29:759 64. doi:10.2337/diacare.29.04.06.dc05-196716567811
  • Gao H, Xiao W, Wang C, et al. The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study. Int J Clin Pract. 2008;62:695–700. doi:10.1111/j.1742-1241.2008.01733.x18412932
  • Donnelly LA, Morris AD, Pearson ER. Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based study. Diabetes Obes Metab. 2009;11:338–342. doi:10.1111/j.1463-1326.2008.00973.x19267712
  • Alsultan M, Al-Omar H, Vandewalle B, et al. Metformin extended versus immediate release in Saudi Arabia: a cost-effectiveness analysis. Value Health. 2017;20(9):A479. doi:10.1016/j.jval.2017.08.456