145
Views
4
CrossRef citations to date
0
Altmetric
Original Research

Cost effectiveness of interventions to improve adherence to statin therapy in ASCVD patients in the United States

&
Pages 1375-1389 | Published online: 15 Aug 2019

References

  • Khavjou O, Phelps D, Leib A. Cardiovascular disease burden: a costly burden for America. Am Heart Assoc. 2016.
  • Centers for Disease Control and Prevention. Heart Disease Facts. https://www.cdc.gov/heartdisease/facts.htm. Accessed 10 3, 2016.
  • Centers for Disease Control and Prevention. High Cholesterol in the United States. http://www.cdc.gov/cholesterol/facts.htm. Accessed 103, 2016.
  • Baigent C, Keech A, Kearney PM, et al.; Cholesterol Treatment Trialists (CCT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005;366:1267–1278. doi:10.1016/S0140-6736(05)67394-116214597
  • Consumer Reports. Best Buy Drugs: Evaluating Statin Drugs to Treat High Cholesterol and Heart Disease. New York, NY: Consumer Reports;2014.
  • Lin I, Sung J, Sanchez RJ, et al. Patterns of statin use in a real-world population of patients at high cardiovascular risk. J Manag Care Spec Pharm. 2016;22(6):685–698. doi:10.18553/jmcp.2016.22.6.68527231796
  • Newby LK, Lapoint NMA, Chen AY, et al. Long-term adherence to evidence based secondary prevention therapies in coronary artery disease. Circulation. 2006;113:203–212. doi:10.1161/CIRCULATIONAHA.105.50563616401776
  • Choudhry NK, Setoguchi S, Levin R, Winkelmayer WC, Schrank W. Trends in adherence to secondary prevention medications in elderly post-myocardial infarction patients. Pharmacoepidemiol Drug Saf. 2008;17(12):1189–1196. doi:10.1002/pds.167118956426
  • Lemstra M, Blackburn D. Nonadherence to statin therapy: discontinuation after a single fill. Can J Cardiol. 2012;28:567–573. doi:10.1016/j.cjca.2012.03.01822658124
  • Brookheart AM, Patrick AR, Schneeweiss S, et al. Physician follow-up and provider continuity are associated with long-term medication adherence. Arch Intern Med. 2007;167:847–852. doi:10.1001/archinte.167.8.84717452550
  • Pittman DG, Chen W, Bowlin SJ, Foody JM. Adherence to statins, subsequent healthcare costs, and cardiovascular hospitalizations. Am J Cardiol. 2011;107(11):1662–1666. doi:10.1016/j.amjcard.2011.01.05221439533
  • Bijlsma M, Vansteelandt S, Janssen F, Hak E. The effect of adherence to statin therapy on cardiovascular mortality: quantification of unmeasured bias using falsification end-points. BMC Public Health. 2016;16:303. doi:10.1186/s12889-016-2986-027067123
  • Haukka J, Niskanen L, Partonen T, Lonnqvist J, Tiihonen J. Statin usage and all-cause and disease-specific mortality in a nationwide study. Pharmacoepidemiol Drug Saf. 2012;21:61–69. doi:10.1002/pds.225521956915
  • Wei L, Fahey T, MacDonald TM. Adherence to statin or aspirin or both in patients with established cardiovascular disease: exploring healthy behavior vs. drug effects and 10-year follow-up of outcome. Br J Clin Pharmacol. 2008;66(1):110–116. doi:10.1111/j.1365-2125.2008.03212.x18492127
  • De Vera M, Bhole V, Burns LC, Lacaille D. Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review. Br J Clin Pharmacol. 2014;78(4):684–698. doi:10.1111/bcp.1233925364801
  • Hamood H, Hamood R, Green MS, Almog R. Effect of adherence to evidence-based therapy after acute myocardial infarction on all-cause mortality. Pharmacoepidemiol Drug Saf. 2015;24:1093–1104. doi:10.1002/pds.384026183333
  • Chen PS, Cheng CL, Yang YH, Li YH. Statin adherence after ischemic stroke or transient ischemic attack is associated with clinical outcome. Circ J. 2016;80:731–737. doi:10.1253/circj.CJ-15-075326742588
  • Herttua K, Martikainen P, Batty GD, Kivimaki M. Poor adherence to statin and antihypertensive therapies as risk factors for fatal stroke. J Am Coll Cardiol. 2016;67(13):1507–1515. doi:10.1016/j.jacc.2016.01.04427150680
  • Ho PM, Magid DJ, Shetterly SM, et al. Medication non-adherence is associated with a broad range of adverse outcomes in patients with coronary artery disease. Am Heart J. 2008;155:772–779. doi:10.1016/j.ahj.2007.12.01118371492
  • Rasmussen JN, Chong A, Alter DA. Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. JAMA. 2007;297:177–186. doi:10.1001/jama.297.2.17717213401
  • Poluzzi E, Piccinni C, Carta P, et al. Cardiovascular events in statin recipients: impact of adherenc to treatment in a 3-year record linkage study. Eur J Clin Pharmacol. 2011;67:407–414. doi:10.1007/s00228-010-0958-321152908
  • Siebert W, Alagoz O, Bayloumi AM, et al. State-transition modelling: a report of the ISPOR-SMDM modelling good research practices task force-3. Value Health. 2012;15:812–820. doi:10.1016/j.jval.2012.06.01422999130
  • National Inpatient Sample 2014. Healthcare cost and utilization project. https://hcupnet-archive.ahrq.gov/. Accessed 512, 2017.
  • D’Agostino RB, Russell MW, Huse DM, et al. Primary and subsequent coronary risk appraisal: new results from the Framingham Study. Am Heart J. 2000;139(2):272–281. doi:10.1067/mhj.2000.9646910650300
  • Hankey GJ, Jamrozik K, Broadhurst RJ, et al. Long-term risk of first recurrent stroke in the Perth community stroke study. Stroke. 1998;29:2491–2500.9836757
  • Heart Protection Study Collaborative Group. Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20 536 people with cerebrovascular disease or other high-risk condition. Lancet. 2004;363:757–767. doi:10.1016/S0140-6736(04)15690-015016485
  • The Long-term Intervention with Pravastatin in ischaemic disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 1998;339(19):1349–1357. doi:10.1056/NEJM1998110533919029841303
  • Rublee DA, Chen SY, Mardekian J, Wu N, Rao P, Boulanger L. Evaluation of cardiovascular morbidity associated with adherence to atorvastatin therapy. Am J Ther. 2012;19:24–32. doi:10.1097/MJT.0b013e3181ee707e20838204
  • Arias E, Heron M, Xu J. National vital statistics reports, United States life tables 2012. Natl Health Stat. 2016;65(8):1-65.
  • Vupputuri S, Joski P, Kilpatrick R, et al. LDL cholesterol response and statin adherence among high-risk patients initiating treatment. Am J Manag Care. 2016;22(3):e106–e115.26978237
  • Sullivan PW, Ghushchyan V. Preference-based EQ-5D index scores for chronic conditions in the United States. Med Decis Making. 2006;26(4):410–420. doi:10.1177/0272989X0629049516855129
  • Arrieta A, Page TF, Veledar E, Nasir K. Economic evaluation of PCSK9 inhibitors in reducing cardiovascular risk from health system and private payer perspectives. PLOSone. 2017;12:e0169761. doi:10.1371/journal.pone.0169761
  • Shiffman, D, Arellano AR, Caulfield MP, et al. Use of low density lipoprotein particle number levels as an aid in statin treatment decisions for intermediate risk patients: a cost effectiveness analysis. BMC Cardiovasc Disord. 2016;16:251. doi:10.1186/s12872-016-0371-727927162
  • National Inpatient Sample 2014. Healthcare cost and utilization project. https://hcupnet-archive.ahrq.gov/. Accessed 330, 2017.
  • Chapman RH, Ferrufino CP, Kowal SL, Classi P, Roberts CS. The costs and effectiveness of adherence-improving interventions for antihypertensive and lipid-lowering drugs. Int J Clin Pract. 2010;64(2):169–181. doi:10.1111/j.1742-1241.2009.02196.x20089007
  • Centers for Medicare & Medicaid Services. Current procedure terminology, physician fee schedule. https://www.cms.gov/apps/physician-fee-schedule/license-agreement.aspx, Accessed 717, 2017.
  • Medi-Span Price Rx Database. http://www.wolterskluwercdi.com/price-rx/. Accessed 512, 2017.
  • Erickson KF, Japa S, Owens DK, et al. Cost-effectiveness of statins for primary cardiovascular prevention in chronic kidney disease. J Am Coll Cardiol. 2013;61(12):1250–1258. doi:10.1016/j.jacc.2012.12.03423500327
  • Siegel JE, Torrance GW, Russell LB, Luce BR, Weinstein MC, Gold MR. Guidelines for pharmacoeconomic studies. Recommendations from the panel on cost effectiveness in health and medicine. Panel on cost effectiveness in health and medicine. Pharmacoeconomics. 1997;11(2):159–168. doi:10.2165/00019053-199711020-0000510172935
  • Coberly C, Morrow G, McGinnis M, et al. Increased adherence to cardiac standards of care during participation in cardiac disease management programs. Dis Manage. 2008;11(2):111–118. doi:10.1089/dis.2008.112725
  • Calvert SB, Kramer JM, Anstrom KJ, Kaltenbach LA, Stafford JA, LaPoint NM. Patient-focused intervention to improve long-term adherence to evidence-based medications: a randomised trial. Am Heart J. 2012;163(657–665.e1). doi:10.1016/j.ahj.2012.02.010
  • Damush TM, Myers L, Anderson JA, et al. The effect of a locally adapted, secondary stroke risk factor self-management program on medication adherence among veterans with stroke/TIA. Transl Behav Med. 2016;6:457–468.27349906
  • Harbman P. The development and testing of a nurse practitioner secondary prevention intervention for patients after acute myocardial infarction: a prospective cohort study. Int J Nurs Stud. 2014;51:1542–1568. doi:10.1016/j.ijnurstu.2014.04.00424836930
  • Ma Y, Ockene IS, Rosal MC, Merriam PA, Ockene JK, Gandhi PJ. Randomised trial of a pharmacist-delivered intervention for improving lipid-lowering medication adherence among patients with coronary heart disease. Cholesterol. 2010;383281. doi:10.1155/2010/38328121490915
  • Jelinek M, Vale MJ, Liew D, et al. The COACH program produces sustained improvements in cardiovascular risk factors and adherence to recommended medications – two years follow-up. Heart Lung Circ. 2009;18:388–392. doi:10.1016/j.hlc.2009.06.00119648058
  • Park LG, Howie-Esquivel J, Chung ML, Dracup K. The test messaging intervention to promote medication adherence for patients with coronary heart disease: a randomised controlled trial. Patient Educ Couns. 2014;94:261–268. doi:10.1016/j.pec.2013.10.02724321403
  • Reddy A, Huseman TL, Canamucio A. Patient and partner feedback reports to improve statin medication adherence: a randomised control trial. J Gen Intern Med. 2016;32(3):256–261. doi:10.1007/s11606-016-3858-027612487
  • Vollmer WM, Owen-Smith AA, Tom JO. Improving adherence to cardiovascular disease medications with information technology. Am J Manag Care. 2014;20(11):SP502–SP510.25811824
  • Hohmann C, Neumann-Haefelin T, Klotz JM, Freidank A, Radziwill R. Providing systematic detailed information on medication upon hospital discharge as an important step towards improved transitional care. J Clin Ther. 2014;39:286–291.
  • Hohmann C, Neumann-Haefelin T, Klotz JM, Freidank A, Radziwill R. Adherence to hospital discharge medication in patients with ischemic stroke: a prospective, interventional 2-phase study. Stroke. 2013;44:522–524. doi:10.1161/STROKEAHA.112.67884723223505
  • Van Driel ML, Morledge MD, Ulep R, Shaffer JP, Davies P, Deichmann R. Interventions to improve adherence to lipid-lowering medication (Review). Cochrane Database Syst Rev. 2016;12. doi:10.1002/14651858.CD003091.pub4
  • Jörntѐn-Karlsson M, Pintat S, Molloy-Bland M, Berg S, Ahlqvist M. Patient-centered interventions to improve adherence to statins: a narrative synthesis of systematically identified studies. Drugs. 2016;76:1447–1465. doi:10.1007/s40265-016-0640-x27677773
  • Smith DH, O’Keefe-Rosetti M, Owen-Smith AA, et al. Improving adherence to cardiovascular therapies: an economic evaluation of a randomized pragmatic trial. Value Health. 2016;19(2):176–184. doi:10.1016/j.jval.2015.11.01327021751
  • Vegter S, Oosterhof P, van Boven JFM, Stuurman-Bieze AGG, Hiddink EG, Postma MJ. Improving adherence to lipid-lowering therapy in a community pharmacy intervention program: a cost-effectiveness analysis. J Manag Care Pharm. 2014;20(7):722–732.
  • Stuurman-Bieze AG, Hiddink EG, van Boven JF, Vegter S. Proactive pharmaceutical care interventions improve patients’ adherence to lipid lowering medication. Ann Pharmacother. 2013;47(11):1448–1456. doi:10.1177/106002801350114624259595
  • Ford I, Murray H, McCowan C, Packard CJ. Long-term safety and efficacy of lowering low-density lipoprotein cholesterol with statin therapy: 20-year follow-up of West of Scotland Coronary Prevention Study. Circulation. 2016;133(11):1073–1080. doi:10.1161/CIRCULATIONAHA.115.01901426864092