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Original Research

Lay People’s Ethical Attitudes To Placebo Treatment: A Q-Methodology Study

ORCID Icon, , & ORCID Icon
Pages 1599-1617 | Published online: 27 Sep 2019

References

  • Hróbjartsson A, Norup M. The use of placebo interventions in medical practice – a national questionnaire survey of Danish clinicians. Eval Health Prof. 2003;26(2):153–165. doi:10.1177/016327870302600200212789709
  • Nitzan U, Lichtenberg P. Questionnaire survey on use of placebo. Bmj. 2004;329:944–946. doi:10.1136/bmj.38236.646678.5515377572
  • Gray G, Flynn P. A survey of placebo use in a general hospital. Gen Hosp Psychiatry. 1981;3:199–203.7286642
  • Thomson RJ, Buchanan WJ. Placebos and general practice: attitudes to, and use of the placebo effect. N Z Med J. 1982;95:492–494.6955683
  • Sherman R, Hickner J. Academic physicians use placebos in clinical practice and believe in the mind-body connection. J Gen Intern Med. 2008;23:7–10. doi:10.1007/s11606-007-0332-z
  • Tilburt JC, Emanuel EJ, Kaptchuk TJ, Curlin FA, Miller FG. Prescribing “placebo treatments”: results of national survey of US internists & rheumatologists. Bmj. 2008;33:a1938. doi:10.1136/bmj.a1938
  • Fässler M, Meissner K, Schneider A, Linde K. Frequency and circumstances of placebo use in clinical practice–a systematic review of empirical studies. BMC Med. 2010;8:15. doi:10.1186/1741-7015-8-1520178561
  • Howick J, Bishop FL, Heneghan C, et al. Placebo use in the United Kingdom: results from a national survey of primary care practitioners. PLoS One. 2013;8(3):e58247. doi:10.1371/journal.pone.005824723526969
  • Sokol DK. Can deceiving patients be morally acceptable? BMJ. 2007;334(7601):984–986. doi:10.1136/bmj.39184.419826.8017494019
  • Wang RS, Hall KT, Giulianini F, Passow D, Kaptchuk TJ, Loscalzo J. Network analysis of the genomic basis of the placebo effect. JCI Insight. 2017;2(11):e93911. doi:10.1172/jci.insight.88864
  • Teasdale K, Kent G. The use of deception in nursing. J Med Ethics. 1995;21(2):77–81. doi:10.1136/jme.21.2.777608943
  • Bishop FL, Aizlewood L, Adams AE. When and why placebo-prescribing is acceptable and unacceptable: a focus group study of patients’ views. PLoS One. 2014;9(7):e101822. doi:10.1371/journal.pone.010182225006673
  • Moerman DE, Jonas WB. Deconstructing the placebo effect and finding the meaning response. Ann Intern Med. 2002;136(6):471–476. doi:10.7326/0003-4819-136-6-200203190-0001111900500
  • Kienle GS, Kiene H. The powerful placebo effect: fact or fiction? J Clin Epidemiol. 1997;50(12):1311–1318. doi:10.1016/s0895-4356(97)00203-59449934
  • Fillingim RB, Price DD. What is controlled for in placebo-controlled trials? Mayo Clin Proc. 2005;80(9):1119–1121. doi:10.4065/80.9.111916178490
  • Zhou ES, Hall KT, Michaud AL, Blackmon JE, Partridge AH, Recklitis CJ. Open-label placebo reduces fatigue in cancer survivors: a randomized trial. Support Care Cancer. 2018. doi:10.1007/s00520-018-4477-6
  • Hammami MM, Al-Gaai EA, Alvi S, Hammami MB. Interaction between drug and placebo effects: a cross-over balanced placebo design trial. Trials. 2010;11:110. doi:10.1186/1745-6215-11-11021092089
  • Hammami MM, Hammami S, Al-Swayeh R, Al-Gaai E, Farah FA, De Padua SJ. Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design. BMC Med Res Methodol. 2016;16(1):166. doi:10.1186/s12874-016-0269-127899067
  • Lund K, Vase L, Petersen GL, Jensen TS, Finnerup NB. Randomised controlled trials may underestimate drug effects: balanced placebo trial design. PLoS One. 2014;9(1):e84104. doi:10.1371/journal.pone.008410424416197
  • Glackin SN. Placebo treatments, informed consent and ‘the grip of a false picture’. J Med Ethics. 2015;41(8):669–672. doi:10.1136/medethics-2014-10233225323316
  • Fassler M, Gnadinger M, Rosemann T, Biller-Andorno N. Placebo interventions in practice: a questionnaire survey on the attitudes of patients and physicians. B J Gen Pract. 2011;61(583):101–107. doi:10.3399/bjgp11X556209
  • Asai A, Kadooka Y. Reexamination of the ethics of placebo use in clinical practice. Bioethics. 2013;27(4):186–193. doi:10.1111/j.1467-8519.2011.01943.x22296589
  • Petersen GL, Finnerup NB, Colloca L, et al. The magnitude of nocebo effects in pain: a meta-analysis. Pain. 2014;155(8):1426–1434. doi:10.1016/j.pain.2014.04.01624780622
  • Jackson J. Telling the truth. J Med Ethics. 1991;17(1):5–9. doi:10.1136/jme.17.1.52033634
  • Marsili N. Lying as a scalar phenomenon In: Cantarini S, Abraham W, Leiss E, editors. Certainty-uncertainty – And the Attitudinal Space in Between. John Benjamins Publishing, Amsterdam, The Netherlands; 2014
  • Alexander L, Sherwin E. Deception in Morality and Law. Cornell Law Faculty Publications; 2003:854 Available from: https://scholarship.law.cornell.edu/facpub/854.
  • Higgs R. On telling patients the truth In: Lockwood M, editor. Moral Dilemmas in Modern Medicine. Oxford: Oxford University Press; 1985
  • Benn P. Medicine, lies and deceptions. J Med Ethics. 2001;27(2):130–134. doi:10.1136/jme.27.2.13011314158
  • Bakhurst D. On lying and deceiving. J Med Ethics. 1992;18(2):63–66. doi:10.1136/jme.18.2.631619626
  • Chan TE. Regulating the placebo effect in clinical practice. Med Law Rev. 2015;23(1):1–26. doi:10.1093/medlaw/fwu02625227708
  • Barnhill A, Miller FG. The ethics of placebo treatments in clinical practice: a reply to Glackin. J Med Ethics. 2015;41(8):673–676. doi:10.1136/medethics-2014-10265126100361
  • Pugh J, Kahane G, Maslen H, Savulescu J. Lay attitudes toward deception in medicine: theoretical considerations and empirical evidence. AJOB Empir Bioeth. 2015;7(1):31–38. doi:10.1080/23294515.2015.1021494826682239
  • Hull SC, Colloca L, Avins A. Patients’ attitudes about the use of placebo treatments: telephone survey. Bmj. 2013;347:f3757. doi:10.1136/bmj.f375723819963
  • Chen G, Johnson MH. Patients’ attitudes to the use of placebos: results from a New Zealand survey. N Z Med J. 2009;122(1296):35–46.19652679
  • Lynöe N, Mattsson B, Sandlund M. The attitudes of patients and physicians towards placebo treatment: a comparative study. Soc Sci Med. 1993;36(6):767–774. doi:10.1016/0277-9536(93)90037-58480221
  • Hammami MM, Al Gaai E, Hammami S, Attala S. Exploring end of life priorities in Saudi males: usefulness of Q-methodology. BMC Palliat Care. 2015;14:66. doi:10.1186/s12904-015-0064-526611147
  • Hammami MM, Hammami S, Amer HA, Khodr NA. Typology of end-of-life priorities in Saudi females: averaging analysis and Q-methodology. Patient Prefer Adherence. 2016;10:781–794. eCollection 2016. doi:10.2147/PPA.S105578.27274205
  • Hammami S, Farah FA, Hammami MM. Surrogate end-of-life decisions: projection or simulation? Gen Med (los Ngel). 2016;4 247. doi:10.4172/2327-5146.1000247.
  • Hammami MM, Abuhdeeb K, Hammami MB, De Padua SJS, Al-Balki A. Prediction of life story narrative for end-of-life surrogate’s decision-making is inadequate: a Q-methodology study. BMC Med Ethics. 2019;20:28. doi:10.1186/s12910-019-0368-831053127
  • Gillon R. Ethics needs principles – four can encompass the rest – and respect for autonomy should be “first among equals”. J Med Ethics. 2003;29:307–312. doi:10.1136/jme.29.5.30714519842
  • Gillon R. Medical ethics: four Principles plus attention to scope. Bmj. 1994;309:184. doi:10.1136/bmj.309.6948.1848044100
  • Beauchamp T. Methods and principles in biomedical ethics. J Med Ethics. 2003;29:269–274. doi:10.1136/jme.29.5.26914519835
  • Chan HM. Sharing death and dying: advance directives, autonomy and the family. Bioethics. 2004;18(2):87–103.15146852
  • Callahan D. Principlism and communitarianism. J Med Ethics. 2003;29:287–291. doi:10.1136/jme.29.5.28714519838
  • Campbell A. The virtues (and vices) of the four principles. J Med Ethics. 2003;29:292–296. doi:10.1136/jme.29.5.29214519839
  • Graham J, Haidt J, Nosek B. Liberals and conservatives rely on different moral foundations. J Pers Soc Psychol. 2009;96(5):1029–1046. doi:10.1037/a001514119379034
  • Gillon R. Is there an important moral distinction for medical ethics between lying and other forms of deception? J Med Ethics. 1993;19(3):131–132. doi:10.1136/jme.19.3.1318230141
  • Hoenemeyer TW, Kaptchuk TJ, Mehta TS, Fontaine KR. Open-label placebo treatment for cancer-related fatigue: a randomized-controlled clinical trial. Sci Rep. 2018;8(1):2784. doi:10.1038/s41598-018-20993-y29426869
  • Kaptchuk TJ, Friedlander E, Kelley JM, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One. 2010;5(12):e15591. doi:10.1371/journal.pone.001559121203519
  • Kelley JM, Kaptchuk TJ, Cusin C, Lipkin S, Fava M. Open label placebo for major depressive disorder: a pilot randomized controlled trial. Psychother Psychosom. 2012;81(5):312–314. doi:10.1159/00033705322854752
  • Carvalho C, Caetano JM, Cunha L, Rebouta P, Kaptchuk TJ, Kirsch I. Open-label placebo treatment in chronic low back pain: a randomized controlled trial. Pain. 2016;157(12):2766–2772. doi:10.1097/j.pain.000000000000047327755279
  • Petrie KJ, Rief W. Psychobiological mechanisms of placebo and nocebo effects: pathways to improve treatments and reduce side effects. Annu Rev Psychol. 2019;70:599–625. doi:10.1146/annurev-psych-010418-10290730110575
  • Zion SR 1, Crum AJ. Mindsets matter: a new framework for harnessing the placebo effect in modern medicine. Int Rev Neurobiol. 2018;138:137–160. doi:10.1016/bs.irn.2018.02.00229681322
  • Cushman F. Crime and punishment: distinguishing the roles of causal and intentional analyses in moral judgment. Cognition. 2008;108:353–380. doi:10.1016/j.cognition.2008.03.00618439575
  • Gardiner P. A virtue ethics approach to moral dilemmas in medicine. J Med Ethics. 2003;29:297–302. doi:10.1136/jme.29.5.29714519840
  • Haidt J. The emotional dog and its rational tail: a social intuitionist approach to moral judgment. Psychol Rev. 2001;108(4):814–834.11699120