Prevalence and Risk Factors of Immunosuppressant Nonadherence in Heart Transplant Recipients: A Single-Center Cross-Sectional Study

References

• Dhital KK, Iyer A, Connellan M, et al. Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series. Lancet. 2015;385(9987):2585–2591. doi:10.1016/S0140-6736(15)60038-125888085
   PubMed Web of Science ®Google Scholar
• Doyle IC, Maldonado AQ, Heldenbrand S, Tichy EM, Trofe-Clark J. Nonadherence to therapy after adult solid organ transplantation: a focus on risks and mitigation strategies. Am J Health Syst Pharm. 2016;73(12):378–389. doi:10.2146/ajhp150650
   Web of Science ®Google Scholar
• Helmy R, Scalso de Almeida S, Denhaerynck K, et al. Prevalence of medication nonadherence to co-medication compared to immunosuppressants in heart transplant recipients: findings from the international cross-sectional BRIGHT study. Clin Ther. 2019;41(1):130–136. doi:10.1016/j.clinthera.2018.11.00730591285
   PubMed Web of Science ®Google Scholar
• Scheel J, Reber S, Stoessel L, et al. Patient-reported non-adherence and immunosuppressant trough levels are associated with rejection after renal transplantation. BMC Nephrol. 2017;18(1):107. doi:10.1186/s12882-017-0517-628356080
   PubMed Web of Science ®Google Scholar
• Senft Y, Kirsch M, Denhaerynck K, et al. Practice patterns to improve pre and post-transplant medication adherence in heart transplant centres: a secondary data analysis of the international BRIGHT study. Eur J Cardiovasc Nurs. 2017;17(4):356–367. doi:10.1177/1474515117747577
   Web of Science ®Google Scholar
• Scheel JF, Schieber K, Reber S, et al. Psychosocial variables associated with immunosuppressive medication non-adherence after renal transplantation. Front Psychiatry. 2018;9:23. doi:10.3389/fpsyt.2018.0002329497386
   PubMed Web of Science ®Google Scholar
• Castleberry AW, Bishawi M, Worni M, et al. Medication nonadherence after lung transplantation in adult recipients. Ann Thorac Surg. 2017;103(1):274–280. doi:10.1016/j.athoracsur.2016.06.06727624294
   PubMed Web of Science ®Google Scholar
• Fine RN, Becker Y, De Geest S, et al. Nonadherence consensus conference summary report. Am J Transplant. 2009;9(1):35–41. doi:10.1111/j.1600-6143.2008.02495.x19133930
   PubMed Web of Science ®Google Scholar
• Denhaerynck K, Dobbels F, Cleemput I, et al. Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: a literature review. Transpl Int. 2005;18(10):1121–1133. doi:10.1111/tri.2005.18.issue-1016162098
   PubMed Web of Science ®Google Scholar
• Belaiche S, Décaudin B, Dharancy S, et al. Factors relevant to medication non-adherence in kidney transplant: a systematic review. Int J Clin Pharm. 2017;39(3):582–593. doi:10.1007/s11096-017-0436-428374343
   PubMed Web of Science ®Google Scholar
• Dew MA, DiMartini AF, De Vito Dabbs A, et al. Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation. 2007;83(7):858–873. doi:10.1097/01.tp.0000258599.65257.a617460556
   PubMed Web of Science ®Google Scholar
• Belaiche S, Décaudin B, Dharancy S, et al. Factors associated with the variability of calcineurin inhibitor blood levels in kidney recipients grafted for more than 1 year. Fundam Clin Pharmacol. 2017;32(1):88–97. doi:10.1111/fcp.1232829069531
   PubMed Web of Science ®Google Scholar
• Massey EK, Tielen M, Laging M, et al. Discrepancies between beliefs and behavior: a prospective study into immunosuppressive medication adherence after kidney transplantation. Transplantation. 2015;99(2):375–380. doi:10.1097/TP.000000000000060825606787
   PubMed Web of Science ®Google Scholar
• Killian MO, Schuman DL, Mayersohn GS, Triplett KN. Psychosocial predictors of medication non-adherence in pediatric organ transplantation: a systematic review. Pediatr Transplant. 2018;22(4):e13188. doi:10.1111/petr.2018.22.issue-429637674
   PubMed Web of Science ®Google Scholar
• Pinsky BW, Takemoto SK, Lentine KL, Burroughs TE, Schnitzler MA, Salvalaggio PR. Transplant outcomes and economic costs associated with patient noncompliance to immunosuppression. Am J Transplant. 2009;9(11):2597–2606. doi:10.1111/ajt.2009.9.issue-1119843035
   PubMed Web of Science ®Google Scholar
• Shneider C, Dunphy C, Shemesh E, Annunziato RA. Assessment and treatment of nonadherence in transplant recipients. Gastroenterol Clin North Am. 2018;47(4):939–948. doi:10.1016/j.gtc.2018.07.01530337042
   PubMed Web of Science ®Google Scholar
• Sabaté E. Adherence to long-term therapies: evidence for action [Internet]. Geneva: World Health Organization; 2003 Available from: http://apps.who.int/medicinedocs/en/d/Js4883e/.18.
   Google Scholar
• Hugon A, Roustit M, Lehmann A, et al. Influence of intention to adhere, beliefs and satisfaction about medicines on adherence in solid organ transplant recipients. Transplantation. 2014;98(2):222–228. doi:10.1097/TP.000000000000022124926826
   PubMed Web of Science ®Google Scholar
• Denhaerynck K, Berben L, Dobbels F, et al. Multi-level factors are associated with immunosuppressant nonadherence in heart transplant recipients: the international BRIGHT study. Am J Transplant. 2017;18(6):1447–1460. doi:10.1111/ajt.14611
   Web of Science ®Google Scholar
• Ruggeri M, Leese M, Thornicroft G, et al. Definition and prevalence of severe and persistent mental illness. Br J Psychiatry. 2000;177(2):149–155. doi:10.1192/bjp.177.2.14911026955
   PubMed Web of Science ®Google Scholar
• Zhang M, Han Y, Yuan Y, et al. Risk factors for new-onset diabetes mellitus after heart transplantation in Chinese patients: a single center experience. Ann Nutr Metab. 2019;74(4):331–338. doi:10.1159/00050013831039573
   PubMed Web of Science ®Google Scholar
• Dobbels F, Berben L, De Geest S, et al. The psychometric properties and practicability of self-report instruments to identify medication nonadherence in adult transplant patients: a systematic review. Transplantation. 2010;90(2):205–219. doi:10.1097/TP.0b013e3181e346cd20531073
   PubMed Web of Science ®Google Scholar
• De Geest S, Zullig LL, Dunbar-Jacob J, et al. ESPACOMP medication adherence reporting guideline (EMERGE). Ann Intern Med. 2018;169(1):30–35. doi:10.7326/M18-054329946690
   PubMed Web of Science ®Google Scholar
• Fellström B, Holmdahl J, Sundvall N, et al. Adherence of renal transplant recipients to once-daily, prolonged-release and twice-daily, immediate-release tacrolimus-based regimens in a real-life setting in Sweden. Transplant Proc. 2018;50(10):3275–3282. doi:10.1016/j.transproceed.2018.06.02730577197
   PubMed Web of Science ®Google Scholar
• Wang C, Wang G, Yi H, et al. Symptom experienced three years after liver transplantation under immunosuppression in adults. PLoS One. 2013;8(11):e80584. doi:10.1371/journal.pone.008058424260427
   PubMed Web of Science ®Google Scholar
• Cossart AR, Staatz CE, Campbell SB, Isbel NM, Cottrell WN. Investigating barriers to immunosuppressant medication adherence in renal transplant patients. Nephrology (Carlton). 2017;24(1):102–110. doi:10.1111/nep.13214
   Web of Science ®Google Scholar
• Griva K, Neo HLM, Vathsala A. Unintentional and intentional non-adherence to immunosuppressive medications in renal transplant recipients. Int J Clin Pharm. 2018;40(5):1234–1241. doi:10.1007/s11096-018-0652-629872960
   PubMed Web of Science ®Google Scholar
• Sacco P, Sultan S, Tuten M, et al. Substance use and psychosocial functioning in a sample of liver transplant recipients with alcohol-related liver disease. Transplant Proc. 2018;50(10):3689–3693. doi:10.1016/j.transproceed.2018.07.00330577256
   PubMed Web of Science ®Google Scholar
• Ware J, Kosinski M, Turner-Bowker D, Gandek B. SF-12v2: How to Score Version 2 of the SF-12 Health Survey. Lincoln, RI, USA: Quality Metric Incorporated; 2002:29–38.
   Google Scholar
• Adhikari UR, Taraphder A, Hazra A, Das T. Medication adherence in kidney transplant recipients in an urban Indian setting. Indian J Nephrol. 2017;27(4):294–300. doi:10.4103/0971-4065.20283528761232
   PubMedGoogle Scholar
• Sabbatini M, Garofalo G, Borrelli S, et al. Efficacy of a reduced pill burden on therapeutic adherence to calcineurin inhibitors in renal transplant recipients: an observational study. Patient Prefer Adherence. 2014;8:73–81. doi:10.2147/PPA24470756
   PubMed Web of Science ®Google Scholar
• Kuo SZ, Haftek M, Lai JC. Factors associated with medication non-adherence in patients with end-stage liver disease. Dig Dis Sci. 2017;62(2):1–7. doi:10.1007/s10620-016-4391-z27853897
   PubMed Web of Science ®Google Scholar
• Weng LC, Yang YC, Huang HL, Chiang YJ, Tsai YH. Factors that determine self-reported immunosuppressant adherence in kidney transplant recipients: a correlational study. J Adv Nurs. 2016;73(1):228–239. doi:10.1111/jan.1310627532342
   PubMed Web of Science ®Google Scholar
• Constantiner M, Rosenthal-Asher D, Tedla F, et al. Differences in attitudes toward immunosuppressant therapy in a multi-ethnic sample of kidney transplant recipients. J Clin Psychol Med Settings. 2018;25(1):11–19. doi:10.1007/s10880-017-9524-929264730
   PubMed Web of Science ®Google Scholar
• Cukor D, Rosenthal DS, Jindal RM, Brown CD, Kimmel PL. Depression is an important contributor to low medication adherence in hemodialyzed patients and transplant recipients. Kidney Int. 2009;75(11):1223–1229. doi:10.1038/ki.2009.5119242502
   PubMed Web of Science ®Google Scholar
• Weng FL, Chandwani S, Kurtyka KM, Zacker C, Chisholm-Burns MA, Demissie K. Prevalence and correlates of medication non-adherence among kidney transplant recipients more than 6 months post-transplant: a cross-sectional study. BMC Nephrol. 2013;14(1):261. doi:10.1186/1471-2369-14-26124289809
   PubMed Web of Science ®Google Scholar
• Myaskovsky L, Jesse MT, Kuntz K, et al. Report from the American society of transplantation psychosocial community of practice adherence task force: real-world options for promoting adherence in adult recipients. Clin Transplant. 2018;32(9):e13353. doi:10.1111/ctr.1335330022527
   PubMed Web of Science ®Google Scholar
• Obi Y, Ichimaru N, Kato T, et al. A single daily dose enhances the adherence to immunosuppressive treatment in kidney transplant recipients: a cross-sectional study. Clin Exp Nephrol. 2013;17(2):310–315. doi:10.1007/s10157-012-0713-423089939
   PubMed Web of Science ®Google Scholar