94
Views
8
CrossRef citations to date
0
Altmetric
Original Research

Fixed Versus Free Combinations Of Antihypertensive Drugs: Analyses Of Real-World Data Of Persistence With Therapy In Italy

ORCID Icon, ORCID Icon, ORCID Icon, , , , ORCID Icon & ORCID Icon show all
Pages 1961-1969 | Published online: 11 Nov 2019

References

  • WHO. A Global Brief on Hypertension. Geneva: World Health Organization; 2013.
  • Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014;129:e28–e92. doi:10.1161/01.cir.0000441139.02102.8024352519
  • Williams B, Mancia G, Spiering W, et al. ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–3104.30165516
  • Jamerson K, Weber MA, Bakris GL, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359(23):2417–2428. doi:10.1056/NEJMoa080618219052124
  • Burnier M. Antihypertensive combination treatment: state of the art. Curr Hypertens Rep. 2015;17(7):51. doi:10.1007/s11906-015-0562-026068654
  • Blonde L, San Juan ZT, Bolton P. Fixed-dose combination therapy in type 2 diabetes mellitus. Endocr Pract. 2014;20(12):1322–1332. doi:10.4158/EP14259.RA25370323
  • Bramlage P, Schmidt S, Sims H. Fixed-dose vs free-dose combinations for the management of hypertension - an analysis of 81 958 patients. J Clin Hypertens. 2018;20(4):705–715. doi:10.1111/jch.2018.20.issue-4
  • Corrao G, Nicotra F, Parodi A, et al. Cardiovascular protection by initial and subsequent combination of antihypertensive drugs in daily life practice. Hypertension. 2011;58(4):566–572. doi:10.1161/HYPERTENSIONAHA.111.17759221825231
  • Gradman AH, Parise´ H, Lefebvre P, et al. Initial combination therapy reduces the risk of cardiovascular events in hypertensive patients: a matched cohort study. Hypertension. 2013;61:309–318. doi:10.1161/HYPERTENSIONAHA.112.20156623184383
  • Qvarnström M, Kahan T, Kieler H, et al. Persistence to antihypertensive drug classes: a cohort study using the Swedish Primary Care Cardiovascular Database (SPCCD). Costa E, Giardini A, Monaco A, editors. Medicine (Baltimore). 2016;95(40):e4908. doi:10.1097/MD.000000000000490827749548
  • Menditto E, Orlando V, Malo S, et al. Measuring medication adherence in health-related databases In: Adherence to Medical Plans for Active and Healthy Ageing. NY, USA: Nova Science Publisher, Inc.; 2017:189–206.
  • Cammarota S, Bruzzese D, Sarnelli G, et al. Proton pump inhibitors prescribing following the introduction of generic drugs. Eur J Clin Invest. 2012;42(10):1068–1078. doi:10.1111/eci.2012.42.issue-1022681176
  • EDQM. Standard terms. Available from: https://standardterms.edqm.eu/ Accessed 716, 2019.
  • Carey IM, Cook DG, De Wilde S, Bremner SA, Richards N, Caine S. Developing a large electronic primary care database (Doctors’ Independent Network) for research. Int J Med Inform. 2004;73:443–453. doi:10.1016/j.ijmedinf.2004.02.00215171985
  • Iolascon G, Gimigliano F, Moretti A, et al. Rates and reasons for lack of persistence with anti-osteoporotic drugs: analysis of the Campania region database. Clin Cases Min Bone Metab. 2016;13(2):127.
  • Orlando V, Guerriero F, Putignano D, et al. Prescription patterns of antidiabetic treatment in the elderly. Results from Southern Italy. Curr Diabetes Rev. 2016;12(2):100–106. doi:10.2174/1573399811666150701120408
  • Casula M, Catapano AL, Piccinelli R, et al. Assessment and potential determinants of compliance and persistence to antiosteoporosis therapy in Italy. Am J Man Care. 2014;20(5):e138–e145.
  • Putignano D, Bruzzese D, Orlando V, et al. Differences in drug use between men and women: an Italian cross sectional study. BMC Women’s Health. 2017;17(1):73. doi:10.1186/s12905-017-0424-928870183
  • Iolascon G, Gimigliano F, Orlando V, et al. Osteoporosis drugs in real-world clinical practice: an analysis of persistence. Aging Clin Exp Res. 2013;25(1):137–141. doi:10.1007/s40520-013-0127-5
  • Italian Data Protection Authority. General authorisation to process personal data for scientific research purposes - 1 3 2012 [1884019]. 10.1094/PDIS-11-11-0999-PDN
  • Cramer JA, Roy A, Burrell A, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44–47. doi:10.1111/j.1524-4733.2007.00213.x18237359
  • De Geest S, Zullig L, Dunbar-Jacob J. Adherence Reporting Guideline EMERGE. ESPACOMP medication adherence reporting guideline (EMERGE). Ann Intern Med. 2018;169:30–35. doi:10.7326/M18-054329946690
  • Malo S, Aguilar-Palacio I, Feja C, et al. Different approaches to the assessment of adherence and persistence with cardiovascular-disease preventive medications. Curr Med Res Opin. 2017;33(7):1329–1336. doi:10.1080/03007995.2017.132153428422521
  • Menditto E, Cahir C, Aza-Pascual-Salcedo M, et al. Adherence to chronic medication in older populations: application of a common protocol among three European cohorts. Patient Pref Adhere. 2018;12:1975. doi:10.2147/PPA.S164819
  • Halpern MT, Khan ZM, Schmier JK, et al. Recommendations for evaluating compliance and persistence with hypertension therapy using retrospective data. Hypertension. 2006;47(6):1039–1048. doi:10.1161/01.HYP.0000222373.59104.3d16651464
  • Ruzicka M, Leenen FH. Monotherapy versus combination therapy as first line treatment of uncomplicated arterial hypertension. Drugs. 2001;61(7):943–954. doi:10.2165/00003495-200161070-0000411434450
  • Elliott WJ, Plauschinat CA, Skrepnek GH, et al. Persistence, adherence, and risk of discontinuation associated with commonly prescribed antihypertensive drug monotherapies. J Am Board Fam Med. 2007;20(1):72–80. doi:10.3122/jabfm.2007.01.06009417204738
  • Bronsert MR, Henderson WG, Valuck R, et al. Comparative effectiveness of antihypertensive therapeutic classes and treatment strategies in the initiation of therapy in primary care patients: a Distributed Ambulatory Research in Therapeutics Network (DARTNet) study. J Am Board Fam Med. 2013;26(5):529–538. doi:10.3122/jabfm.2013.05.13004824004705
  • Nieuwlaat R, Wilczynski N, Navarro T, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014;20(11):CD000011.
  • Naderi SH, Bestwick JP, Wald DS. Adherence to drugs that prevent cardiovascular disease: meta-analysis on 376,162 patients. Am J Med. 2012;125(9):882–887. doi:10.1016/j.amjmed.2011.12.01322748400
  • Illario M, Vollenbroek-Hutten M, Molloy DW, et al. Active and healthy ageing and independent living. J Aging Res. 2015;2015:542183. doi:10.1155/2015/54218326346624
  • Illario M, Vollenbroek-Hutten MM, Molloy DW, et al. Active and healthy ageing and independent living 2016. J Aging Res. 2016;2016:8062079. doi:10.1155/2016/806207927818798
  • Giardini A, Martin MT, Cahir C, et al. Toward appropriate criteria in medication adherence assessment in older persons: position paper. Aging Clin Exp Res. 2016;28(3):371–381. doi:10.1007/s40520-015-0435-z26630945
  • Costa E, Giardini A, Savin M, et al. Interventional tools to improve medication adherence: review of literature. Patient Pref Adhere. 2015;9:1303–1314. doi:10.2147/PPA.S87551
  • Sokol MC, McGuigan KA, Verbrugge RR, et al. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care. 2005;43(6):521–530. doi:10.1097/01.mlr.0000163641.86870.af15908846
  • Cilurzo F, Musazzi UM, Franzè S, Selmin F, Minghetti P. Orodispersible dosage forms: biopharmaceutical improvements and regulatory requirements. Drug Disc Today. 2018;23(2):251–259. doi:10.1016/j.drudis.2017.10.003
  • Kronish IM, Ye S. Adherence to cardiovascular medications: lessons learned and future directions. Prog Cardiovasc Dis. 2013;55(6):590–600. doi:10.1016/j.pcad.2013.02.00123621969
  • Newby LK, LaPointe NM, Chen AY, et al. Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease. Circulation. 2006;113(2):203–212. doi:10.1161/CIRCULATIONAHA.105.50563616401776
  • Menditto E, Guerriero F, Orlando V, et al. Self-assessment of adherence to medication: a case study in Campania region community-dwelling population. J Aging Res. 2015;2015:682503. doi:10.1155/2015/68250326346487
  • Scala D, Menditto E, Armellino MF, et al. Italian translation and cultural adaptation of the communication assessment tool in an outpatient surgical clinic. BMC Health Serv Res. 2016;16(1):163. doi:10.1186/s12913-016-1411-927130440
  • Sultana J, Musazzi UM, Ingrasciotta Y, et al. Medication is an additional source of phosphate intake in chronic kidney diseases patients. Nutr Metab Cardiovasc Dis. 2015;25:959–967. doi:10.1016/j.numecd.2015.06.00126165250
  • Perrone V, Veronesi C, Gambera M, et al. Treatment with free triple combination therapy of atorvastatin, perindopril, amlodipine in hypertensive patients: a real- world population study in Italy. High Blood Press Cardiovasc Prev. 2019. doi:10.1007/s40292-019-00336-2
  • Degli Esposti E, Sturani A, Di Martino M, et al. Long-term persistence with antihypertensive drugs in new patients. J Hum Hypertens. 2002;16(6):439–444. doi:10.1038/sj.jhh.100141812037702
  • EMA. Guideline on clinical development of fixed combination medicinal products. London, 23 3 2017 EMA/CHMP/158268/2017 Committee for Human Medicinal Products (CHMP).
  • Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010;55(2):399–407. doi:10.1161/HYPERTENSIONAHA.109.13981620026768
  • Verma AA, Khuu W, Tadrous M, et al. Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: a population-based retrospective cohort study. PLoS Med. 2018;15(6):e1002584. doi:10.1371/journal.pmed.100258429889841
  • Webster R. Fixed-dose combination medications for non-communicable diseases. Heart. 2019;105(3):176–177. doi:10.1136/heartjnl-2018-31385930181197
  • Reinhold K, Jurgen S, Antonios D. Single-pill triple fixed dose combination therapy with single component drug monitoring in treatment-resistant hypertension: a pilot study. Curr Vasc Pharmacol. 2018;16(2):197–203. doi:10.2174/157016111566617082115555528828980
  • Du LP, Cheng ZW, Zhang YX, et al. The impact of fixed-dose combination versus free-equivalent combination therapies on adherence for hypertension: a meta-analysis. J Clin Hypertens. 2018;20(5):902–907. doi:10.1111/jch.13272
  • Schulz M, Krueger K, Schuessel K, et al. Medication adherence and persistence according to different antihypertensive drug classes: a retrospective cohort study of 255,500 patients. Int J Cardiol. 2016;220:668–676. doi:10.1016/j.ijcard.2016.06.26327393848
  • Grimmsmann T, Himmel W. Comparison of therapy persistence for fixed versus free combination antihypertensives: a retrospective cohort study. BMJ Open. 2016;6:e011650. doi:10.1136/bmjopen-2016-011650
  • Sherrill B, Halpern M, Khan S, et al. Single-pill vs free‐equivalent combination therapies for hypertension: a meta‐analysis of health care costs and adherence. J Clin Hypertens. 2011;13(12):898–909. doi:10.1111/jch.2011.13.issue-12