Exploring Potentially Modifiable Factors That Influence Treatment Non-Adherence Amongst Pediatric Growth Hormone Deficiency: A Qualitative Study

References

• Fisher BG, Acerini CL. Understanding the growth hormone therapy adherence paradigm: a systematic review. Horm Res Paediatr. 2013;79(4):189–196. doi:10.1159/000350251
   PubMed Web of Science ®Google Scholar
• Haverkamp F, Johansson L, Dumas H, et al. Observations of nonadherence to recombinant human growth hormone therapy in clinical practice. Clin Ther. 2008;30(2):307–316. doi:10.1016/j.clinthera.2008.02.017
   PubMed Web of Science ®Google Scholar
• Neilson NV, Flynn O, Kuntze CN, et al. Medicines adherence: involving patients in decisions about prescribed medicines and supporting adherence full guideline. 2009; Available from: www.rcgp.org.uk.
   Google Scholar
• Hartmann K, Ittner J, Müller-Rossberg E, et al. Growth hormone treatment adherence in prepubertal and pubertal children with different growth disorders. Horm Res Paediatr. 2013;80(1):1–5. doi:10.1159/000351800
   PubMed Web of Science ®Google Scholar
• Mohseni S, Heydari Z, Qorbani M, Radfar M. Adherence to growth hormone therapy in children and its potential barriers. J Pediatr Endocrinol Metab. 2018;31(1):13–20. doi:10.1515/jpem-2017-0157
   PubMed Web of Science ®Google Scholar
• Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487–497. doi:10.1056/NEJMra050100
   PubMed Web of Science ®Google Scholar
• Aydın B, Aycan Z, Şıklar Z, et al. Adherence to growth hormone therapy: results of a multicenter study. Endocr Pract. 2014;20(1):46–51. doi:10.4158/EP13194.OR
   PubMed Web of Science ®Google Scholar
• Lass N, Reinehr T. Low treatment adherence in pubertal children treated with thyroxin or growth hormone. Horm Res Paediatr. 2015;84(4):240–247. doi:10.1159/000437305
   PubMed Web of Science ®Google Scholar
• Dumas H, Panayiotopoulos P, Parker D, Pongpairochana V. Understanding and meeting the needs of those using growth hormone injection devices. BMC Endocr Disord. 2006;6(1):5. doi:10.1186/1472-6823-6-5
   PubMedGoogle Scholar
• Reh CS, Geffner ME. Somatotropin in the treatment of growth hormone deficiency and turner syndrome in pediatric patients: a review. Clin Pharmacol. 2010;2:111–122. doi:http://doi.10.2147/CPAA.S6525
   PubMedGoogle Scholar
• Bagnasco F, Di Iorgi N, Roveda A, et al. Prevalence and correlates of adherence in children and adolescents treated with growth hormone: a multicenter italian study. Endocr Pract. 2017;23(8):929–941. doi:10.4158/EP171786.OR
   PubMed Web of Science ®Google Scholar
• Kremidas D, Wisniewski T, Divino VM, et al. Administration burden associated with recombinant human growth hormone treatment: perspectives of patients and caregivers. J Pediatr Nurs. 2013;28(1):55–63. doi:10.1016/j.pedn.2011.12.006
   PubMed Web of Science ®Google Scholar
• Oyarzabal M, Aliaga M, Chueca M, Echarte G, Ulied A. Multicentre survey on compliance with growth hormone therapy: what can be improved? Acta Paediatr. 1998;87(4):387–391. doi:10.1111/j.1651-2227.1998.tb01464.x
   PubMed Web of Science ®Google Scholar
• Human growth hormone (somatropin) for the treatment of growth failure in children guidance and guidelines. NICE; 2010. Available from https://www.nice.org.uk/guidance/ta188.
   Google Scholar
• Cutfield WS, Derraik JGB, Gunn AJ, et al. Non-compliance with growth hormone treatment in children is common and impairs linear growth. PLoS One. 2011;6(1): e16223.
   PubMed Web of Science ®Google Scholar
• Polak M, Blair J, Kotnik P, Pournara E, Pedersen BT, Rohrer TR. Early growth hormone treatment start in childhood growth hormone deficiency improves near adult height: analysis from NordiNet® international outcome study. Eur J Endocrinol. 2017;177(5):421–429. doi:10.1530/EJE-16-1024
   Web of Science ®Google Scholar
• Sabaté E, World Health Organization. Adherence to Long-Term Therapies: Evidence for Action. World Health Organization; 2003:194.
   Google Scholar
• Vrijens B, De Geest S, Hughes DA, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691–705. doi:10.1111/j.1365-2125.2012.04167.x
   PubMed Web of Science ®Google Scholar
• Bozzola M, Pagani S, Iughetti L, Maffeis C, Bozzola E, Meazza C. Adherence to growth hormone therapy: a practical approach. Horm Res Paediatr. 2014;81(5):331–335. doi:10.1159/000357975
   Web of Science ®Google Scholar
• Koledova E, Stoyanov G, Ovbude L, Davies PSW. Adherence and long-term growth outcomes: results from the easypodTM connect observational study (ECOS) in paediatric patients with growth disorders. Endocr Connect. 2018;7(8):914–923. doi:10.1530/EC-18-0172
   PubMed Web of Science ®Google Scholar
• Khan R, Socha-Dietrich K. Investing in medication adherence improves health outcomes and health system efficiency: adherence to medicines for diabetes, hypertension, and hyperlipidaemia. OECD Health Work Pap. 2018;(105). doi:10.1787/8178962c-en
   Google Scholar
• Graham S, Weinman J, Auyeung V. Identifying potentially modifiable factors associated with treatment non-adherence in paediatric growth hormone deficiency: a systematic review. Horm Res Paediatr. 2018;90(4):1–7. doi:10.1159/000493211
   Web of Science ®Google Scholar
• Haverkamp F, Gasteyger C. A review of biopsychosocial strategies to prevent and overcome early-recognized poor adherence in growth hormone therapy of children. J Med Econ. 2011;14(4):448–457. doi:10.3111/13696998.2011.590829
   PubMedGoogle Scholar
• Kardas P, Lewek P, Matyjaszczyk M. Determinants of patient adherence: a review of systematic reviews. Front Pharmacol. 2013;4:91. doi:10.3389/fphar.2013.00091
   PubMed Web of Science ®Google Scholar
• Mathes T, Jaschinski T, Pieper D. Adherence influencing factors – a systematic review of systematic reviews. Arch Public Health. 2014;72(1):37. doi:10.1186/2049-3258-72-37
   Google Scholar
• De Pedro S, Murillo M, Salinas I, et al. Variability in adherence to rhGH treatment: socioeconomic causes and effect on children’s growth. Growth Horm IGF Res. 2016;26:32–35. doi:10.1016/j.ghir.2015.12.002
   PubMed Web of Science ®Google Scholar
• Gács G, Hosszu E. The effect of socio-economic conditions on the time of diagnosis and compliance during treatment in growth hormone deficiency. Acta Paediatr Hung. 1991;31(2):215–221.
   Google Scholar
• Horne R, Weinman J. Patients’ beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res. 1999;47(6):555–567. doi:10.1016/S0022-3999(99)00057-4.
   PubMed Web of Science ®Google Scholar
• Weinman J, Graham S, Canfield M, et al. The intentional non-adherence scale (INAS): initial development and validation. J Psychosom Res. 2018;115:110–116. doi:10.1016/j.jpsychores.2018.10.010
   PubMed Web of Science ®Google Scholar
• Weinman J, Petrie KJ. Illness perceptions: a new paradigm for psychosomatics? J Psychosom Res. 1997;42(2):113–116. doi:10.1016/S0022-3999(96)00294-2
   PubMed Web of Science ®Google Scholar
• Horne R, Chapman SCE, Parham R, Freemantle N, Forbes A, Cooper V. Understanding patients’ adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the necessity-concerns framework. Xia Y, editor. PLoS One. 2013;8(12):e80633.
   PubMed Web of Science ®Google Scholar
• Petrie KJ, Weinman J. Why illness perceptions matter. Clin Med. 2006;6(6):536–539. doi:10.7861/clinmedicine.6-6-536
   PubMed Web of Science ®Google Scholar
• Broadbent E, Petrie KJ, Main J, Weinman J. The brief illness perception questionnaire. J Psychosom Res. 2006;60(6):631–637. doi:10.1016/j.jpsychores.2005.10.020
   PubMed Web of Science ®Google Scholar
• Matsui DM. Drug compliance in pediatrics. Clinical and research issues. Pediatr Clin North Am. 1997;44(1):1–14. doi:10.1016/S0031-3955(05)70459-4
   Web of Science ®Google Scholar
• van Dongen N, Kaptein AA. Parents’ views on growth hormone treatment for their children: psychosocial issues. Patient Prefer Adherence. 2012;6:547–553. doi:10.2147/PPA.S33157
   PubMed Web of Science ®Google Scholar
• Marini MG, Chesi P, Mazzanti L, et al. Stories of experiences of care for growth hormone deficiency: the CRESCERE project. Future Sci OA. 2016;2(1):fso.15.82. doi:10.4155/fso.15.82
   Google Scholar
• Alsaigh R, Coyne I. Mothers’ experiences of caring for children receiving growth hormone treatment. J Pediatr Nurs. 2019;49(1):e63–73. doi:10.1016/j.pedn.2019.09.005
   Web of Science ®Google Scholar
• Brod M, Højbjerre L, Alolga SL, Beck JF, Wilkinson L, Rasmussen MH. Understanding treatment burden for children treated for growth hormone deficiency. Patient. 2017;10(5):653–666.
   Google Scholar
• Brod M, Alolga SL, Beck JF, Wilkinson L, Højbjerre L, Rasmussen MH. Understanding burden of illness for child growth hormone deficiency. Qual Life Res. 2017;26(7):1673–1686. doi:10.1007/s11136-017-1529-1
   PubMed Web of Science ®Google Scholar
• Rosenfeld R, Bakker B. Compliance and persistence in pediatric and adult patients receiving growth hormone therapy. Endocr Pract. 2008;14(2):143–154. doi:10.4158/EP.14.2.143
   PubMedGoogle Scholar
• Kapoor RR, Burke SA, Sparrow SE, et al. Monitoring of concordance in growth hormone therapy. Arch Dis Child. 2008;93(2):147–148. doi:10.1136/adc.2006.114249
   PubMed Web of Science ®Google Scholar
• Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3(2):77–101. doi:10.1191/1478088706qp063oa
   Google Scholar
• Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6(1):42. doi:10.1186/1748-5908-6-42
   PubMed Web of Science ®Google Scholar
• Jackson C, Eliasson L, Barber N, Weinman J. Applying COM-B to medication adherence. Eur Health Psychol. 2014;16(1):7–17.
   Google Scholar