Adherence to Oral Nutritional Supplements After Being Discharged from the Hospital is Low but Improves Outcome in Patients with Advanced Chronic Liver Disease

References

• Národné centrum zdravotníckych infromácií. Zdravotnícka Ročenka Slovenskej Republiky 2018; 2019.
   Google Scholar
• Carvalho L, Parise ER. Evaluation of nutritional status of nonhospitalized patients with liver cirrhosis. Arq Gastroenterol. 2006;43(4):269–274. doi:10.1590/s0004-28032006000400005
   PubMedGoogle Scholar
• Kuftinec G, Ram Bhamidimarri K, Pearlman M. Malnutrition in cirrhosis: frequent but overlooked. Liver Transplant off Publ Am Assoc Study Liver Dis Int Liver Transplant Soc. 2019;25(12):1743–1744. doi:10.1002/lt.25660
   Google Scholar
• Ferreira LG, Ferreira Martins AI, Cunha CE, Anastácio LR, Lima AS, Correia MITD. Negative energy balance secondary to inadequate dietary intake of patients on the waiting list for liver transplantation. Nutrition. 2013;29(10):1252–1258. doi:10.1016/j.nut.2013.04.008
   PubMed Web of Science ®Google Scholar
• Cardenas A. Commentary: oral or enteral nutritional supplementation in cirrhosis. Aliment Pharmacol Ther. 2013;37(10):1022–1023. doi:10.1111/apt.12302
   Web of Science ®Google Scholar
• Montano-Loza AJ, Meza-Junco J, Prado CMM, et al. Muscle wasting is associated with mortality in patients with cirrhosis. Clin Gastroenterol Hepatol. 2012;10(2):166–173, 173.e1. doi:10.1016/j.cgh.2011.08.028
   PubMed Web of Science ®Google Scholar
• Stickel F, Inderbitzin D, Candinas D. Role of nutrition in liver transplantation for end-stage chronic liver disease. Nutr Rev. 2008;66(1):47–54. doi:10.1111/j.1753-4887.2007.00005.x
   PubMed Web of Science ®Google Scholar
• Plauth M, Bernal W, Dasarathy S, et al. ESPEN guideline on clinical nutrition in liver disease. Clin Nutr. 2019;38(2):485–521. doi:10.1016/j.clnu.2018.12.022
   PubMed Web of Science ®Google Scholar
• European Association for the Study of the Liver. EASL clinical practice guidelines on nutrition in chronic liver disease. J Hepatol. 2019;70(1):172–193. doi:10.1016/j.jhep.2018.06.024
   PubMed Web of Science ®Google Scholar
• Cabre E, Gonzalez-Huix F, Abad-Lacruz A, et al. Effect of total enteral nutrition on the short-term outcome of severely malnourished cirrhotics: a randomized controlled trial. Gastroenterology. 1990;98(3):715–720. doi:10.1016/0016-5085(90)90293-a
   PubMed Web of Science ®Google Scholar
• Dupont B, Dao T, Joubert C, et al. Randomised clinical trial: enteral nutrition does not improve the long-term outcome of alcoholic cirrhotic patients with jaundice. Aliment Pharmacol Ther. 2012;35(10):1166–1174. doi:10.1111/j.1365-2036.2012.05075.x
   PubMed Web of Science ®Google Scholar
• Mizubuti YGG, Vieira ELM, Silva TA, et al. Comparing the effects of whey and casein supplementation on nutritional status and immune parameters in patients with chronic liver disease: a randomized double-blind controlled trial. Br J Nutr. 2020:1–12. doi:10.1017/S0007114520003219
   Web of Science ®Google Scholar
• Ginzburg Y, Shmilovitz I, Monastyrsky N, Endevelt R, Shahar DR. Barriers for nutritional care in the transition from hospital to the community among older patients. Clin Nutr ESPEN. 2018;25:56–62. doi:10.1016/j.clnesp.2018.04.004
   Web of Science ®Google Scholar
• Chen C-J, Wang L-C, Kuo H-T, Fang Y-C, Lee H-F. Significant effects of late evening snack on liver functions in patients with liver cirrhosis: a meta-analysis of randomized controlled trials. J Gastroenterol Hepatol. 2019;34(7):1143–1152. doi:10.1111/jgh.14665
   Web of Science ®Google Scholar
• Tandon P, Raman M, Mourtzakis M, Merli M. A practical approach to nutritional screening and assessment in cirrhosis. Hepatology. 2017;65(3):1044–1057. doi:10.1002/hep.29003
   PubMed Web of Science ®Google Scholar
• Tandon P, Tangri N, Thomas L, et al. A rapid bedside screen to predict unplanned hospitalization and death in outpatients with cirrhosis: a prospective evaluation of the clinical frailty scale. Am J Gastroenterol. 2016;111(12):1759–1767. doi:10.1038/ajg.2016.303
   PubMed Web of Science ®Google Scholar
• Liljeberg E, Andersson A, Lövestam E, Nydahl M. Incomplete descriptions of oral nutritional supplement interventions in reports of randomized controlled trials. Clin Nutr. 2018;37(1):61–71. doi:10.1016/j.clnu.2017.03.024
   Web of Science ®Google Scholar
• De Geest S, Sabaté E. Adherence to long-term therapies: evidence for action. Eur J Cardiovasc Nurs J Work Gr Cardiovasc Nurs Eur Soc Cardiol. 2003;2(4):323. doi:10.1016/S1474-5151(03)00091-4
   PubMedGoogle Scholar
• Burnier M. Is there a threshold for medication adherence? Lessons learnt from electronic monitoring of drug adherence. Front Pharmacol. 2018;9(1540):1–8. doi:10.3389/fphar.2018.01540
   Web of Science ®Google Scholar
• Brown MT, Bussell JK. Medication adherence: WHO cares? Mayo Clin Proc. 2011;86(4):304–314. doi:10.4065/mcp.2010.0575
   PubMed Web of Science ®Google Scholar
• Fischer MA, Stedman MR, Lii J, et al. rimary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25(4):284–290. doi:10.1007/s11606-010-1253-9
   PubMed Web of Science ®Google Scholar
• Jüngst C, Gräber S, Simons S, Wedemeyer H, Lammert F. Medication adherence among patients with chronic diseases: a survey-based study in pharmacies. QJM. 2019;112(7):505–512. doi:10.1093/qjmed/hcz058
   PubMed Web of Science ®Google Scholar
• Polis S, Zang L, Mainali B, et al. Factors associated with medication adherence in patients living with cirrhosis. J Clin Nurs. 2016;25(1–2):204–212. doi:10.1111/jocn.13083
   PubMed Web of Science ®Google Scholar
• Marina Heeb R, Greif Higer G, Lutz J, et al. A comparative, multicenter, observational study of medication adherence in liver cirrhosis patients and dialysis patients using electronic event measurement. J Pharm Care Heal Syst. 2017;04(04):186. doi:10.4172/2376-0419.1000186
   Google Scholar
• Ney M, Vandermeer B, van Zanten SJ, Ma MM, Gramlich L, Tandon P. Meta-analysis: oral or enteral nutritional supplementation in cirrhosis. Aliment Pharmacol Ther. 2013;37(7):672–679. doi:10.1111/apt.12252
   Web of Science ®Google Scholar
• Skladany L, Koller T, Molcan P, et al. Prognostic usefulness of serum myostatin in advanced chronic liver disease: its relation to gender and correlation with inflammatory status. J Physiol Pharmacol. 2019;70:3. doi:10.26402/jpp.2019.3.03
   Web of Science ®Google Scholar
• EASL Clinical Practice. Guidelines on nutrition in chronic liver disease. J Hepatol. 2019;70(1):172–193. doi:10.1016/j.jhep.2018.06.024
   Web of Science ®Google Scholar
• Lai JC, Tandon P. How I approach it: improving nutritional status in patients with cirrhosis. Am J Gastroenterol. 2018;113(11):1574–1576. doi:10.1038/s41395-018-0080-1
   Web of Science ®Google Scholar
• Hirsch S, Bunout D, de la Maza P, et al. Controlled trial on nutrition supplementation in outpatients with symptomatic alcoholic cirrhosis. JPEN J Parenter Enteral Nutr. 1993;17(2):119–124. doi:10.1177/0148607193017002119
   Web of Science ®Google Scholar
• Saunders J, Brian A, Wright M, Stroud M. Malnutrition and nutrition support in patients with liver disease. Frontline Gastroenterol. 2010;1(2):105–111. doi:10.1136/fg.2009.000414
   Google Scholar
• Tandon P, Ismond KP, Riess K, et al. Exercise in cirrhosis: translating evidence and experience to practice. J Hepatol. 2018;69(5):1164–1177. doi:10.1016/j.jhep.2018.06.017
   PubMed Web of Science ®Google Scholar
• Muller E, Dominguez-Gil B, Martin D. The declaration of istanbul on organ trafficking and transplant tourism (2018 Edition). Transplantation. 2019;103(2):218–219. doi:10.1097/TP.0000000000002540
   Web of Science ®Google Scholar
• Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2012;48:452. doi:10.1038/bmt.2012.244
   PubMed Web of Science ®Google Scholar
• World Health Organization. Adherence to Long-Term Therapies: Evidence for Action; 2003.
   Google Scholar
• Gajdosik J. Adherence to treatment – an important part of reaching therapeutic effects on chronic conditions. AtheroRev. 2017;2(1):15–19.
   Google Scholar
• Hayward KL, Patel PJ, Valery PC, et al. Medication-related problems in outpatients with decompensated cirrhosis: opportunities for harm prevention. Hepatol Commun. 2019;3(5):620–631. doi:10.1002/hep4.1334
   PubMed Web of Science ®Google Scholar
• Hayward KL, Valery PC, Cottrell WN, et al. Prevalence of medication discrepancies in patients with cirrhosis: a pilot study. BMC Gastroenterol. 2016;16(1):114. doi:10.1186/s12876-016-0530-4
   PubMed Web of Science ®Google Scholar
• Thomson MJ, Lok AS, Tapper EB. Optimizing medication management for patients with cirrhosis: evidence-based strategies and their outcomes. Liver Int off J Int Assoc Study Liver. 2018;38(11):1882–1890. doi:10.1111/liv.13892
   PubMed Web of Science ®Google Scholar
• Serper M, Patzer RE, Reese PP, et al. Medication misuse, nonadherence, and clinical outcomes among liver transplant recipients. Liver Transpl. 2015;21(1):22–28. doi:10.1002/lt.24023
   Web of Science ®Google Scholar
• Kuo SZ, Haftek M, Lai JC. Factors associated with medication non-adherence in patients with end-stage liver disease. Dig Dis Sci. 2017;62(2):543–549. doi:10.1007/s10620-016-4391-z
   PubMed Web of Science ®Google Scholar
• Hayward KL, Valery PC, Martin JH, et al. Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World J Gastroenterol. 2017;23(40):7321–7331. doi:10.3748/wjg.v23.i40.7321
   PubMed Web of Science ®Google Scholar
• Liljeberg E, Andersson A, Blom Malmberg K, Nydahl M. High adherence to oral nutrition supplements prescribed by dietitians: a cross-sectional study on hospital outpatients. Nutr Clin Pract off Publ Am Soc Parenter Enter Nutr. 2019;34(6):887–898. doi:10.1002/ncp.10243
   Web of Science ®Google Scholar
• Hubbard GP, Elia M, Holdoway A, Stratton RJ. A systematic review of compliance to oral nutritional supplements. Clin Nutr. 2012;31(3):293–312. doi:10.1016/j.clnu.2011.11.020
   PubMed Web of Science ®Google Scholar
• Morando F, Rosi S, Gola E, et al. Adherence to a moderate sodium restriction diet in outpatients with cirrhosis and ascites: a real-life cross-sectional study. Liver Int off J Int Assoc Study Liver. 2015;35(5):1508–1515. doi:10.1111/liv.12583
   PubMed Web of Science ®Google Scholar
• Moreno C, Deltenre P, Senterre C, et al. Intensive enteral nutrition is ineffective for patients with severe alcoholic hepatitis treated with corticosteroids. Gastroenterology. 2016;150(4):903–910.e8. doi:10.1053/j.gastro.2015.12.038
   Web of Science ®Google Scholar
• Stratton RJ, Hébuterne X, Elia M. A systematic review and meta-analysis of the impact of oral nutritional supplements on hospital readmissions. Ageing Res Rev. 2013;12(4):884–897. doi:10.1016/j.arr.2013.07.002
   PubMed Web of Science ®Google Scholar
• Cutler RL, Fernandez-Llimos F, Frommer M, Benrimoj C, Garcia-Cardenas V. Economic impact of medication non-adherence by disease groups: a systematic review. BMJ Open. 2018;8(1):e016982. doi:10.1136/bmjopen-2017-016982
   PubMed Web of Science ®Google Scholar
• Rodriguez F, Maron DJ, Knowles JW, Virani SS, Lin S, Heidenreich PA. Association of statin adherence with mortality in patients with atherosclerotic cardiovascular disease. JAMA Cardiol. 2019;4(3):206–213. doi:10.1001/jamacardio.2018.4936
   PubMed Web of Science ®Google Scholar
• Seguy D, Hubert H, Robert J, Meunier JP, Guérin O, Raynaud-Simon A. Compliance to oral nutritional supplementation decreases the risk of hospitalisation in malnourished older adults without extra health care cost: prospective observational cohort study. Clin Nutr. 2019. doi:10.1016/j.clnu.2019.08.005
   Web of Science ®Google Scholar
• Smith TR, Cawood AL, Walters ER, Guildford N, Stratton RJ. Ready-made oral nutritional supplements improve nutritional outcomes and reduce health care use-a randomised trial in older malnourished people in primary care. Nutrients. 2020;12(2):517. doi:10.3390/nu12020517
   Web of Science ®Google Scholar
• Norman K, Kirchner H, Freudenreich M, Ockenga J, Lochs H, Pirlich M. Three month intervention with protein and energy rich supplements improve muscle function and quality of life in malnourished patients with non-neoplastic gastrointestinal disease–a randomized controlled trial. Clin Nutr. 2008;27(1):48–56. doi:10.1016/j.clnu.2007.08.011
   PubMed Web of Science ®Google Scholar
• Iwasa M, Iwata K, Hara N, et al. Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis. Nutrition. 2013;29(11–12):1418–1421. doi:10.1016/j.nut.2013.05.016
   Web of Science ®Google Scholar
• Lai JC, Dodge JL, Sen S, Covinsky K, Feng S. Functional decline in patients with cirrhosis awaiting liver transplantation: results from the functional assessment in liver transplantation (FrAILT) study. Hepatology. 2016;63(2):574–580. doi:10.1002/hep.28316
   Web of Science ®Google Scholar
• Praktiknjo M, Clees C, Pigliacelli A, et al. Sarcopenia is associated with development of acute-on-chronic liver failure in decompensated liver cirrhosis receiving transjugular intrahepatic portosystemic shunt. Clin Transl Gastroenterol. 2019;10(4):e00025. doi:10.14309/ctg.0000000000000025
   Web of Science ®Google Scholar
• Serper M, Kaplan DE, Shults J, et al. Quality measures, all-cause mortality, and health care use in a national cohort of veterans with cirrhosis. Hepatology. 2019;70(6):2062–2074. doi:10.1002/hep.30779
   Web of Science ®Google Scholar
• Kanwal F, Tapper EB, Ho C, et al. Development of quality measures in cirrhosis by the practice metrics committee of the American Association for the study of liver diseases. Hepatology. 2019;69(4):1787–1797. doi:10.1002/hep.30489
   PubMed Web of Science ®Google Scholar