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Review

Clinical utility of guanfacine extended release in the treatment of ADHD in children and adolescents

Pages 877-885 | Published online: 30 Jun 2015

References

  • FordTGoodmanRMeltzerHThe British child and adolescent mental health survey 1999: the prevalence of DSM-IV disordersJ Am Acad Child Adolesc Psychiatry200342101203121114560170
  • SayalKFordTGoodmanRTrends in recognition of and service use for attention-deficit hyperactivity disorder in Britain, 1999–2004Psychiatr Serv201061880381020675839
  • American Psychiatric Association, American Psychiatric AssociationDSM-5 Task ForceDiagnostic and Statistical Manual of Mental Disorders: DSM-55thWashington, DCAmerican Psychiatric Association2013
  • Vande VoortJLHeJPJamesonNDMerikangasKRImpact of the DSM-5 attention-deficit/hyperactivity disorder age-of-onset criterion in the US adolescent populationJ Am Acad Child Adolesc Psychiatry201453773674424954823
  • WillcuttEGThe prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic reviewNeurotherapeutics20129349049922976615
  • BloomBJonesLIFreemanGSummary health statistics for U.S. children: National Health Interview Survey, 2012Vital Health Stat201310258181
  • PolanczykGde LimaMSHortaBLBiedermanJRohdeLAThe worldwide prevalence of ADHD: a systematic review and metaregression analysisAm J Psychiatry2007164694294817541055
  • PolanczykGVSalumGASugayaLSCayeARohdeLAAnnual research review: a meta-analysis of the worldwide prevalence of mental disorders in children and adolescentsJ Child Psychol Psychiatry201556334536525649325
  • PolanczykGRohdeLAEpidemiology of attention-deficit/hyperactivity disorder across the lifespanCurr Opin Psychiatry200720438639217551354
  • FroehlichTELanphearBPEpsteinJNBarbaresiWJKatusicSKKahnRSPrevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of US childrenArch Pediatr Adolesc Med2007161985786417768285
  • FrankeBNealeBMFaraoneSVGenome-wide association studies in ADHDHum Genet20091261135019384554
  • FaraoneSVPerlisRHDoyleAEMolecular genetics of attention-deficit/hyperactivity disorderBiol Psychiatry200557111313132315950004
  • SprichSBiedermanJCrawfordMHMundyEFaraoneSVAdoptive and biological families of children and adolescents with ADHDJ Am Acad Child Adolesc Psychiatry200039111432143711068899
  • HawiZCumminsTDTongJThe molecular genetic architecture of attention deficit hyperactivity disorderMol Psychiatry201520328929725600112
  • Salatino-OliveiraAGenroJPPolanczykGCadherin-13 gene is associated with hyperactive/impulsive symptoms in attention/deficit hyperactivity disorderAm J Med Genet B Neuropsychiatr Genet2015168B316216925739828
  • LeschKPMerkerSReifANovakMDances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHDEur Neuropsychopharmacol201223647949122939004
  • SagvoldenTJohansenEBAaseHRussellVAA dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypesBehav Brain Sci2005283397419 [discussion 419–368]16209748
  • HasueRHShammah-LagnadoSJOrigin of the dopaminergic innervation of the central extended amygdala and accumbens shell: a combined retrograde tracing and immunohistochemical study in the ratJ Comp Neurol20024541153312410615
  • OadesRDHallidayGMVentral tegmental (A10) system: neurobiology. 1. Anatomy and connectivityBrain Res198743421171653107759
  • SchultzWGetting formal with dopamine and rewardNeuron200236224126312383780
  • JohansenEBKilleenPRRussellVAOrigins of altered reinforcement effects in ADHDBehav Brain Funct20095719226460
  • SagvoldenTAaseHZeinerPBergerDAltered reinforcement mechanisms in attention-deficit/hyperactivity disorderBehav Brain Res199894161719708840
  • PaloyelisYAshersonPKuntsiJAre ADHD symptoms associated with delay aversion or choice impulsivity? A general population studyJ Am Acad Child Adolesc Psychiatry200948883784619564796
  • PaloyelisYMehtaMAFaraoneSVAshersonPKuntsiJStriatal sensitivity during reward processing in attention-deficit/hyperactivity disorderJ Am Acad Child Adolesc Psychiatry2012517722e732e72922721595
  • PlichtaMMVasicNWolfRCNeural hyporesponsiveness and hyperresponsiveness during immediate and delayed reward processing in adult attention-deficit/hyperactivity disorderBiol Psychiatry200965171418718573
  • FooteSLBloomFEAston-JonesGNucleus locus ceruleus: new evidence of anatomical and physiological specificityPhysiol Rev19836338449146308694
  • Aston-JonesGRajkowskiJCohenJLocus coeruleus and regulation of behavioral flexibility and attentionProg Brain Res200012616518211105646
  • Cohen-YavinIYoran-HegeshRStrousRDKotlerMWeizmanASpivakBEfficacy of reboxetine in the treatment of attention-deficit/hyperactivity disorder in boys with intolerance to methylphenidate: an open-label, 8-week, methylphenidate-controlled trialClin Neurophar-macol2009324179182
  • StahlSMThe prefrontal cortex is out of tune in attention-deficit/hyperactivity disorderJ Clin Psychiatry200970795095119653972
  • SaraSJLearning by neurones: role of attention, reinforcement and behaviourC R Acad Sci19983212–31931989759340
  • BerridgeCWWaterhouseBDThe locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processesBrain Res Brain Res Rev2003421338412668290
  • DevilbissDMBerridgeCWLow-dose methylphenidate actions on tonic and phasic locus coeruleus dischargeJ Pharmacol Exp Ther200631931327133516980569
  • CarboniESilvagniADopamine reuptake by norepinephrine neurons: exception or rule?Crit Rev Neurobiol2004161–212112815581407
  • MinerLHSchroeterSBlakelyRDSesackSRUltrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminalsJ Comp Neurol2003466447849414566944
  • VanicekTSpiesMRami-MarkCThe norepinephrine transporter in attention-deficit/hyperactivity disorder investigated with positron emission tomographyJAMA Psychiatry201471121340134925338091
  • DingYSSinghalTPlaneta-WilsonBPET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRTSynapse2010641303819728366
  • SimmlerLDRickliASchrammYHoenerMCLiechtiMEPharmacological profiles of aminoindanes, piperazines, and pipradrol derivativesBiochem Pharmacol201488223724424486525
  • HannestadJGallezotJDPlaneta-WilsonBClinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivoBiol Psychiatry201068985486020691429
  • van de GiessenEBooijJThe SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young menEur J Nucl Med Mol Imaging20103781507151120309682
  • PunjaSZorzelaLHartlingLUrichukLVohraSLong-acting versus short-acting methylphenidate for paediatric ADHD: a systematic review and meta-analysis of comparative efficacyBMJ Open201333
  • KhajehpiriZMahmoudi-GharaeiJFaghihiTKarimzadehIKhaliliHMohammadiMAdverse reactions of methylphenidate in children with attention deficit-hyperactivity disorder: report from a referral centerJ Res Pharm Pract20143413013625535621
  • MillerGMThe emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activityJ Neurochem2011116216417621073468
  • ViggianoDRuoccoLAArcieriSSadileAGInvolvement of nor-epinephrine in the control of activity and attentive processes in animal models of attention deficit hyperactivity disorderNeural Plast2004111–213314915303310
  • GoodmanDWLisdexamfetamine dimesylate: the first prodrug stimulantPsychiatry (Edgmont)200748394520532026
  • FaraoneSVBiedermanJRoeCComparative efficacy of Adderall and methylphenidate in attention-deficit/hyperactivity disorder: a meta-analysisJ Clin Psychopharmacol200222546847312352269
  • ManosMJShortEJFindlingRLDifferential effectiveness of methylphenidate and Adderall in school-age youths with attention-deficit/hyperactivity disorderJ Am Acad Child Adolesc Psychiatry199938781381910405498
  • FaraoneSVUpadhyayaHPThe effect of stimulant treatment for ADHD on later substance abuse and the potential for medication misuse, abuse, and diversionJ Clin Psychiatry20076811e2818052554
  • StahlSMNeurotransmission of cognition, part 3. Mechanism of action of selective NRIs: both dopamine and norepinephrine increase in prefrontal cortexJ Clin Psychiatry200364323023112716261
  • HanwellaRSenanayakeMde SilvaVComparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysisBMC Psychiatry20111117622074258
  • StuhecMMundaBSvabVLocatelliIComparative efficacy and acceptability of atomoxetine, lisdexamfetamine, bupropion and methylphenidate in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis with focus on bupropionJ Affect Disord201517814915925813457
  • AwuduGABesagFMCardiovascular effects of methylphenidate, amphetamines and atomoxetine in the treatment of attention-deficit hyperactivity disorder: an updateDrug Saf201437966167625124483
  • BangsMETauscher-WisniewskiSPolzerJMeta-analysis of suicide-related behavior events in patients treated with atomoxetineJ Am Acad Child Adolesc Psychiatry200847220921818176331
  • de JongeATimmermansPBvan ZwietenPAQuantitative aspects of alpha adrenergic effects induced by clonidine-like imidazolidines. I. Central hypotensive and peripheral hypertensive activitiesJ Pharmacol Exp Ther198222237057116125586
  • SalleeFRThe role of alpha2-adrenergic agonists in attention-deficit/hyperactivity disorderPostgrad Med20101225788720861591
  • JainRSegalSKollinsSHKhayrallahMClonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorderJ Am Acad Child Adolesc Psychiatry201150217117921241954
  • KollinsSHJainRBramsMClonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHDPediatrics20111276e1406e141321555501
  • Shionogi Pharma IKAPVAY (clonidine hydrochloride) extended-release tablets, oral [Package Insert]2010
  • UhlenSWikbergJEDelineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compoundEur J Pharmacol199120222352431666366
  • SastreMGarcia-SevillaJAAlpha 2-adrenoceptor subtypes identified by [3H]RX821002 binding in the human brain: the agonist guanoxabenz does not discriminate different forms of the predominant alpha 2A subtypeJ Neurochem1994633107710857914222
  • WangMRamosBPPaspalasCDAlpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortexCell2007129239741017448997
  • SwartzBEKovalikEThomasKTorgersenDMandelkernMAThe effects of an alpha-2 adrenergic agonist, guanfacine, on rCBF in human cortex in normal controls and subjects with focal epilepsyNeuropsychopharmacology200023326327510942850
  • AveryRAFranowiczJSStudholmeCvan DyckCHArnstenAFThe alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory taskNeuropsychopharmacology200023324024910942848
  • ClerkinSMSchulzKPHalperinJMGuanfacine potentiates the activation of prefrontal cortex evoked by warning signalsBiol Psychiatry200966430731219520360
  • GyiresKZadoriZSTorokTMatyusPalpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actionsNeurochem Int200955744745319477210
  • FranowiczJSArnstenAFActions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtypePsychopharmacology (Berl)2002162330431212122489
  • BoremanCDArnoldLEHallucinations associated with initiation of guanfacineJ Am Acad Child Adolesc Psychiatry20034212138714627872
  • ShireINTUNIV (guanfacine) extended-release tablets [Package Insert]2009
  • BiedermanJMelmedRDPatelASPD503 Study GroupA randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorderPediatrics20081211e73e8418166547
  • ConnorDFFindlingRLKollinsSHEffects of guanfacine extended release on oppositional symptoms in children aged 6–12 years with attention-deficit hyperactivity disorder and oppositional symptoms: a randomized, double-blind, placebo-controlled trialCNS Drugs201024975576820806988
  • KollinsSHLópezFAVinceBDPsychomotor functioning and alertness with guanfacine extended release in subjects with attention-deficit/hyperactivity disorderJ Child Adolesc Psychopharmacol201121211112021476931
  • NewcornJHSteinMAChildressACRandomized, double-blind trial of guanfacine extended release in children with attention-deficit/hyperactivity disorder: morning or evening administrationJ Am Acad Child Adolesc Psychiatry201352992193023972694
  • SalleeFRMcGoughJWigalTDonahueJLyneABiedermanJGuanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder: a placebo-controlled trialJ Am Acad Child Adolesc Psychiatry200948215516519106767
  • ScahillLChappellPBKimYSA placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorderAm J Psychiatry200115871067107411431228
  • RizzoRMartinoDGuanfacine for the treatment of attention deficit hyperactivity disorder in children and adolescentsExpert Rev Neurother201515434735425800130
  • RuggieroSClavennaARealeLCapuanoARossiFBonatiMGuan-facine for attention deficit and hyperactivity disorder in pediatrics: a systematic review and meta-analysisEur Neuropsychopharmacol201424101578159025156577
  • SalleeFRKollinsSHWigalTLEfficacy of guanfacine extended release in the treatment of combined and inattentive only subtypes of attention-deficit/hyperactivity disorderJ Child Adolesc Psychopharmacol201222320621422612526
  • HervasAHussMJohnsonMEfficacy and safety of extended-release guanfacine hydrochloride in children and adolescents with attention-deficit/hyperactivity disorder: a randomized, controlled, phase III trialEur Neuropsychopharmacol201424121861187225453486
  • HirotaTSchwartzSCorrellCUAlpha-2 agonists for attention-deficit/hyperactivity disorder in youth: a systematic review and meta-analysis of monotherapy and add-on trials to stimulant therapyJ Am Acad Child Adolesc Psychiatry201453215317324472251
  • ZetterqvistJAshersonPHalldnerLLangstromNLarssonHStimulant and non-stimulant attention deficit/hyperactivity disorder drug use: total population study of trends and discontinuation patterns 2006–2009Acta Psychiatr Scand20131281707722943458
  • YoungJRuginoTDammermanRLyneANewcornJHEfficacy of guanfacine extended release assessed during the morning, afternoon, and evening using a modified conners’ parent rating scale-revised: short formJ Child Adolesc Psychopharmacol201424843544125286026
  • FDAIntuniv (Guanfacine Extended-Release); Pediatric Post-Marketing Adverse Event ReviewSilver SpringCenter for Drug Evaluation and Research2011