Peripherally acting μ-opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy

References

• CheyWDWebsterLSostekMLappalainenJBarkerPNTackJNaloxegol for opioid-induced constipation in patients with noncancer painN Engl J Med2014370252387239624896818
   PubMed Web of Science ®Google Scholar
• NilssonMPoulsenJLBrockCOpioid-induced bowel dysfunction in healthy volunteers assessed with questionnaires and MRIEur J Gastroenterol Hepatol201628551452426795566
   PubMed Web of Science ®Google Scholar
• PoulsenJLNilssonMBrockCSandbergTHKroghKDrewesAMThe impact of opioid treatment on regional gastrointestinal transitJ Neurogastroenterol Motil201622228229126811503
   PubMed Web of Science ®Google Scholar
• WaldAConstipation: advances in diagnosis and treatmentJAMA2016315218519126757467
   PubMed Web of Science ®Google Scholar
• McCafferyMPaseroCLPain ratings: the fifth vital signAm J Nurs199797215169025664
   PubMed Web of Science ®Google Scholar
• International Pain Summit Of The International Association For The Study Of PainDeclaration of Montreal: declaration that access to pain management is a fundamental human rightJ Pain Palliat Care Pharmacother2011251293121426215
   PubMedGoogle Scholar
• NelsonADCamilleriMChronic opioid induced constipation in patients with nonmalignant pain: challenges and opportunitiesTher Adv Gastroenterol201584206220
   PubMed Web of Science ®Google Scholar
• BellTAnnunziataKLeslieJBOpioid-induced constipation negatively impacts pain management, productivity, and health-related quality of life: findings from the national health and wellness surveyJ Opioid Manag20095313714419662923
   PubMedGoogle Scholar
• AkbaraliHIInkisarADeweyWLSite and mechanism of morphine tolerance in the gastrointestinal tractNeurogastroenterol Motil201426101361136725257923
   PubMed Web of Science ®Google Scholar
• WaldAConstipation: pathophysiology and managementCurr Opin Gastroenterol2015311454925394234
   PubMed Web of Science ®Google Scholar
• BagnolDMansourAAkilHWatsonSJCellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tractNeuroscience19978125795919300443
   PubMed Web of Science ®Google Scholar
• McKayJLinakerBTurnbergLInfluence of opiates on ion transport across rabbit ileal mucosaGastroenterology1981802792846256253
   PubMed Web of Science ®Google Scholar
• FickelJBagnolDWatsonSJAkilHOpioid receptor expression in the rat gastrointestinal tract: a quantitative study with comparison to the brainBrain Res Mol Brain Res1997461–2189191072
   PubMedGoogle Scholar
• SmithHMcCleaneGThompsonGOptimizing Pharmacologic Outcomes: Assessing and Managing Opioid Side EffectsNew York, NYOxford University Press2013
   Google Scholar
• GuptaAImproving the recognition and diagnosis of opioid-induced constipation in clinical practiceJ Fam Pract20156410 suppl 1 pii: jfp_6410l
   Web of Science ®Google Scholar
• No authors listedNaloxegol for opioid-induced constipationDrug Ther Bull2015531213814026660436
   PubMedGoogle Scholar
• GaertnerJSiemensWCamilleriMDefinitions and outcome measures of clinical trials regarding opioid-induced constipation: a systematic reviewJ Clin Gastroenterol201549191625356996
   PubMed Web of Science ®Google Scholar
• ArceDErmocillaCCostaHEvaluation of constipationAm Fam Physician20021122832290
   Google Scholar
• DrossmanDAFunctional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IVGastroenterology2016 pii: S0016-5085(16)00223-7
   Web of Science ®Google Scholar
• SzigethyESchwartzMDrossmanDNarcotic bowel syndrome and opioid-induced constipationCurr Gastroenterol Rep2014161041025183577
   PubMedGoogle Scholar
• LongstrethGFThompsonWGCheyWDHoughtonLAMearinFSpillerRCFunctional bowel disordersGastroenterology200613051480149116678561
   PubMed Web of Science ®Google Scholar
• AnantharamuTSharmaSGuptaAKDahiyaNSingh BrashierDBSharmaAKNaloxegol: first oral peripherally acting mu opioid receptor antagonists for opioid-induced constipationJ Pharmacol Pharmacother20156318819226312011
   PubMedGoogle Scholar
• ArgoffCEBrennanMJCamilleriMConsensus recommendations on initiating prescription therapies for opioid-induced constipationPain Med201516122324233726582720
   PubMed Web of Science ®Google Scholar
• HunoldKMSmithSAPlatts-MillsTFConstipation prophylaxis is rare for adults prescribed outpatient opioid therapy from U.S. Emergency DepartmentsAcad Emerg Med20152291118112126291177
   PubMed Web of Science ®Google Scholar
• SiemensWGaertnerJBeckerGAdvances in pharmacotherapy for opioid-induced constipation – a systematic reviewExpert Opin Pharmacother201516451553225539282
   PubMed Web of Science ®Google Scholar
• BadkeARosielleDAOpioid induced constipation part I: established management strategies #294J Palliat Med201518979980026241645
   PubMed Web of Science ®Google Scholar
• PappagalloMIncidence, prevalence, and management of opioid bowel dysfunctionAm J Surg20011825A suppl11S18S11755892
   PubMed Web of Science ®Google Scholar
• Koopmans-KleinGWagemansMFWartenbergHCVan MegenYJHuygenFJThe efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot studyExpert Rev Gastroenterol Hepatol20152617
   Google Scholar
• ThomasJOpioid-induced bowel dysfunctionJ Pain Symptom Manage200835110311317981003
   PubMed Web of Science ®Google Scholar
• LoCasaleRJDattoCJMargolisMKTackJCoyneKSThe impact of opioid-induced constipation among chronic pain patients with sufficient laxative useInt J Clin Pract201569121448145626344578
   PubMed Web of Science ®Google Scholar
• WeberHCOpioid-induced constipation in chronic noncancer painCurr Opin Endocrinol Diabetes Obes2016231111726702846
   PubMedGoogle Scholar
• Alvimopan (Entereg) for postoperative ileusMed Lett Drugs Ther2008501300939419037186
   PubMed Web of Science ®Google Scholar
• Naloxegol (Movantik) for opioid-induced constipationJAMA2016315219419526757469
   PubMed Web of Science ®Google Scholar
• BrunerHAtayeeREndmondsKBuckholzGClinical utility of naloxogel in the treatment of opioid-induced constipationJ Pain Res2015828929426109876
   PubMed Web of Science ®Google Scholar
• Garnock-JonesKPNaloxegol: a review of its use in patients with opioid-induced constipationDrugs201575441942525666542
   PubMed Web of Science ®Google Scholar
• CamilleriMBharuchaAEUenoREffect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteersAm J Physiol Gastrointest Liver Physiol20062905G942G94716603730
   PubMed Web of Science ®Google Scholar
• RaoSWeberHCNew treatment targets for the management of irritable bowel syndromeCurr Opin Endocrinol Diabetes Obes201421191424300740
   PubMedGoogle Scholar
• JohansonJFUenoRLubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safetyAliment Pharmacol Ther200725111351136117509103
   PubMed Web of Science ®Google Scholar
• No authors listedTarginact – opioid pain relief without constipation?Drug Ther Bull2010481213814121123290
   PubMedGoogle Scholar
• RaoSSRattanakovitKPatcharatrakulTDiagnosis and management of chronic constipation in adultsNat Rev Gastroenterol Hepatol201613529530527033126
   PubMed Web of Science ®Google Scholar
• FordACBrennerDMSchoenfeldPSEfficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysisAm J Gastroenterol20131081015661574 quiz 157523752879
   PubMed Web of Science ®Google Scholar
• WebsterLJansenJPPeppinJAlvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer painPain2008137242844018164818
   PubMed Web of Science ®Google Scholar
• CryerBKatzSVallejoRPopescuAUenoRA randomized study of lubiprostone for opioid-induced constipation in patients with chronic noncancer painPain Med201415111825183424716835
   PubMed Web of Science ®Google Scholar
• SpieringsELRauckRBrewerRMarcuardSVallejoRLong-term safety and efficacy of lubiprostone in opioid-induced constipation in patients with chronic noncancer painPain Pract Epub2015829
   PubMed Web of Science ®Google Scholar
• IyerSSRandazzoBPTzanisELEffect of subcutaneous methylnaltrexone on patient-reported constipation symptomsValue Health201114117718321211500
   PubMed Web of Science ®Google Scholar
• MichnaEBlonskyERSchulmanSSubcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled studyJ Pain201112555456221429809
   PubMed Web of Science ®Google Scholar
• NalamachuSRPergolizziJTaylorRJrEfficacy and tolerability of subcutaneous methylnaltrexone in patients with advanced illness and opioid-induced constipation: a responder analysis of 2 randomized, placebo-controlled trialsPain Pract201515656457124815199
   PubMed Web of Science ®Google Scholar
• ViscusiERBarrettACPatersonCForbesWPEfficacy and safety of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain: a placebo crossover analysisReg Anesth Pain Med2016411939826650429
   PubMed Web of Science ®Google Scholar
• TackJLappalainenJDivaUTummalaRSostekMEfficacy and safety of naloxegol in patients with opioid-induced constipation and laxative-inadequate responseUnited European Gastroenterol J201535471480
   PubMed Web of Science ®Google Scholar
• BlagdenMHaferJDuerrHHoppMBosseBLong-term evaluation of combined prolonged-release oxycodone and naloxone in patients with moderate-to-severe chronic pain: pooled analysis of extension phases of two phase III trialsNeurogastroenterol Motil201426121792180125346155
   PubMed Web of Science ®Google Scholar
• KoopmansGSimpsonKDe AndresJLuxEAWagemansMVan MegenYFixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxativesCurr Med Res Opin201430112389239625265132
   PubMed Web of Science ®Google Scholar
• LowensteinOLeyendeckerPHoppMCombined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trialExpert Opin Pharmacother200910453154319243306
   PubMed Web of Science ®Google Scholar
• MeissnerWLeyendeckerPMueller-LissnerSA randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipationEur J Pain2009131566418762438
   PubMed Web of Science ®Google Scholar
• PoelaertJKoopmans-KleinGDiohATreatment with prolonged-release oxycodone/naloxone improves pain relief and opioid-induced constipation compared with prolonged-release oxycodone in patients with chronic severe pain and laxative-refractory constipationClin Ther201537478479225757607
   PubMed Web of Science ®Google Scholar
• SandersMJonesSLowensteinOJansenJPMilesHSimpsonKNew formulation of sustained release naloxone can reverse opioid induced constipation without compromising the desired opioid effectsPain Med20151681540155026110375
   PubMed Web of Science ®Google Scholar
• SimpsonKLeyendeckerPHoppMFixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer painCurr Med Res Opin200824123503351219032132
   PubMed Web of Science ®Google Scholar
• UeberallMAMueller-SchwefeGHSafety and efficacy of oxycodone/naloxone vs. oxycodone vs. morphine for the treatment of chronic low back pain: results of a 12 week prospective, randomized, open-label blinded endpoint streamlined study with prolonged-release preparationsCurr Med Res Opin20153171413142925942606
   PubMed Web of Science ®Google Scholar
• WebsterLRBrennerDMBarrettACPatersonCBorteyEForbesWPAnalysis of opioid-mediated analgesia in phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer painJ Pain Res2015877178026586963
   PubMed Web of Science ®Google Scholar
• MorlionBClemensKEDunlopWQuality of life and healthcare resource in patients receiving opioids for chronic pain: a review of the place of oxycodone/naloxoneClin Drug Investig2015351111
   Web of Science ®Google Scholar
• MercadanteSGiarratanoACombined oral prolonged-release oxycodone and naloxone in chronic pain managementExpert Opin Investig Drugs2013221161166
   PubMed Web of Science ®Google Scholar
• HolzerPNon-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?Curr Pharm Des201218376010602022747544
   PubMed Web of Science ®Google Scholar
• FDA [webpage on the Internet]Entereg (alvimopan) capsulesMedWatch The FDA Safety Information and Adverse Event Reporting Program2013 Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm194328.htmAccessed January 27, 2016
   Google Scholar
• WebsterLCheyWDTackJLappalainenJDivaUSostekMRandomised clinical trial: the long-term safety and tolerability of naloxegol in patients with pain and opioid-induced constipationAliment Pharmacol Ther201440777177925112584
   PubMed Web of Science ®Google Scholar
• WebsterLDharSEldonMMasuokaLLappalainenJSostekMA phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipationPain201315491542155023726675
   PubMed Web of Science ®Google Scholar
• ZhangYWilliamsDAZaidiSA17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridylcarboxamido)morphinan (NAP) modulating the Mu opioid receptor in a biased fashionACS Chem Neurosci20167329730426716358
   PubMed Web of Science ®Google Scholar
• TrinkleyKESillBEPorterKNahataMCPrescribing patterns for outpatient treatment of constipation, irritable bowel syndrome-related constipation, and opioid-induced constipation: a retrospective cross-sectional studyJ Manag Care Spec Pharm201521111077108726521119
   PubMed Web of Science ®Google Scholar
• WanYCormanSGaoXLiuSPatelHModyREconomic burden of opioid-induced constipation among long-term opioid users with noncancer painAm Health Drug Benefits2015829310226005516
   PubMedGoogle Scholar
• DunlopWUhlRKhanITaylorABartonGQuality of life benefits and cost impact of prolonged release oxycodone/naloxone versus prolonged release oxycodone in patients with moderate-to-severe non-malignant pain and opioid-induced constipation: a UK cost-utility analysisJ Med Econ201215356457522313329
   PubMedGoogle Scholar
• GoereeRGoereeJCost-effectiveness analysis of oxycodone with naloxone versus oxycodone alone for the management of moderate-to-severe pain in patients with opioid-induced constipation in CanadaJ Med Econ201530115
   Google Scholar